Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

Lin, Chia-Yu; Higginbotham, D. Allan; Judd, Robert L.; White, B. Douglas

doi:10.1152/ajpendo.00489.2001

Cited by 124Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesPancreatic function and diabetes

Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

Lin, Chia-Yu, Higginbotham, D. Allan, Judd, Robert L., White, B. Douglas·2002·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00489.2001

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Abstract

This study examined the effect of intracerebroventricular leptin on insulin sensitivity in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were cannulated in the lateral ventricle and, after recovery, administered either intravenous STZ (50 mg/kg) to induce diabetes or citrate buffer. Chronic leptin (10 μg/10 μl icv) or vehicle injections were administered daily for 14 days beginning 2 days after establishment of hyperglycemia in the diabetic animals. At the end of the 2 wk of injections, insulin sensitivity was measured by the steady-state plasma glucose (SSPG) method. Blood glucose concentrations were dramatically reduced and normalized by the 4th day in diabetic animals receiving intracerebroventricular leptin treatment. Diabetic animals exhibited insulin resistance, whereas intracerebroventricular leptin significantly enhanced insulin sensitivity, as indicated by decreased SSPG. Circulating leptin levels were not increased in animals injected with intracerebroventricular leptin. Thus the increased peripheral insulin sensitivity appears to be due solely to the presence of leptin in the brain, not to leptin acting peripherally. These data imply that inadequate central leptin signaling may lead to insulin resistance.

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Intracerebroventricular administration of leptin normalizes blood glucose levels in STZ-diabetic rats at doses that are ineffective when administered peripherally.
“i.c.v. administration of leptin normalizes blood glucose levels in STZ-diabetic rats at doses that are ineffective when administered peripherally (43, 82, 104, 190).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [104]

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streptozotocin-induced diabetic rats Central leptin increases insulin sensitivity in
Lin, C.-Y., Higginbotham, D. A., Judd, R. L., & White, B. D. (2016)
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Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin‐induced diabetic rats
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Authors: Lin, C.-Y., Higginbotham, D. A., Judd, R. L., & White, B. D.
Affiliations: Department of Nutrition and Food Science, and
Auburn University (US)
ORCID: Lin, Chia-Yu
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2002-05-01
Volume: 282
Issue: 5
Pages: E1084-E1091
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00489.2001
OpenAlex: W2122422623
Cited by: 124
References: 43
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 8
FWCI: 2.11
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords: leptin, insulin sensitivity, insulin resistance, streptozotocin-induced diabetes, blood glucose, hyperglycemia, type 2 diabetes
MeSH terms: Animals, Blood Glucose, Body Weight, Brain Chemistry, Diabetes Mellitus, Experimental, Eating, Fasting, Hyperglycemia, Injections, Intraventricular, Insulin, Insulin Resistance, Male, Signal Transduction, Rats, Wistar, Leptin, Rats

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Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

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