The DOI matches its Crossref record.
Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.
Abstract
Leptin has been shown to improve insulin sensitivity and glucose metabolism in normoinsulinemic healthy or obese rodents. It has not been determined whether leptin may act independently of insulin in regulating energy metabolism in vivo. The present study was designed to examine the effects of leptin treatment alone on glucose metabolism in insulin-deficient streptozotocin (STZ)-induced diabetic rats. Four groups of STZ-induced diabetic rats were studied: 1) rats treated with recombinant methionine murine leptin subcutaneous infusion with osmotic pumps for 12-14 days (LEP; 4 mg x kg(-1) x day(-1), n = 10); 2) control rats infused with vehicle (phosphate-buffered saline) for 12-14 days (VEH; n = 10); 3) pair-fed control rats given a daily food ration matching that of LEP rats for 12-14 days (PF; n = 8); and 4) rats treated with subcutaneous phloridzin for 4 days (PLZ; 0.4 g/kg twice daily, n = 10). Phloridzin treatment normalizes blood glucose without insulin and was used as a control for the effect of leptin in correcting hyperglycemia. All animals were then studied with a hyperinsulinemic-euglycemic clamp (6 mU x kg(-1) x min(-1). Our study demonstrates that leptin treatment in the insulin-deficient diabetic rats restored euglycemia, minimized body weight loss due to food restriction, substantially improved glucose metabolic rates during the postabsorptive state, and restored insulin sensitivities at the levels of the liver and the peripheral tissues during the glucose clamp. The effects on glucose turnover are largely independent of food restriction and changes in blood glucose concentration, as evidenced by the minimal improvement of insulin action and glucose turnover parameters in the PF and PLZ groups. Our results suggest that the antidiabetic effects of leptin are achieved through both an insulin-independent and an insulin-sensitizing mechanism.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“hyperleptinemia induced by either pharmacological leptin administration (34) or with adenoviral gene therapy (210) fully ameliorates hyperglycemia in STZ-induced diabetic rats, even in the face of extremely low plasma insulin levels.”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [34]
In the citing paper
“recent evidence suggests that pharmacological administration of leptin systemically (3,4) can also normalize blood glucose levels in rodent models of uncontrolled diabetes mellitus (uDM).”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [3]
Citations
Cited by
Sorted by citations
Items 101–197 of 197
Jun, J. Y., Ma, Z., Pyla, R., & Segar, L. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.10.031 · Cited by 33
“Studies using pharmacologic doses or overexpression of leptin in T1D animal models demonstrate beneficial effects of leptin on glucose metabolism [6, 7] and lipid metabolism [7].”
BackgroundHypothalamic Control of Hepatic Glucose Production and Its Potential Role in Insulin Resistance
Buettner, C., & Camacho, R. C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.09.001 · Cited by 31
Effects of leptin on oxidative stress in healthy and Streptozotocin-induced diabetic rats
Gülen, Ş., & Dinçer, S. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9426-5 · Cited by 31
“demonstrated that leptin administration can normalize blood glucose levels when just pharmacologic doses [25] used in STZ-diabetic rats while we used leptin in physiologic dose [47].”
BackgroundMethodCNS Regulation of Glucose Homeostasis: Role of the Leptin-Melanocortin System
da Silva, A. A., do Carmo, J. M., & Hall, J. E. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01311-1 · Cited by 30
The role of leptin in the regulation of carbohydrate metabolism.
Tucholski, K., & Otto-Buczkowska, E. (2011) · PubMed · Cited by 29
D’Elia, L., Strazzullo, P., Iacone, R., Russo, O., & Galletti, F. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.10.003 · Cited by 29
Effect of leptin in proliferating and differentiated HC11 mouse mammary cells
Baratta, M., Grolli, S., & Tamanini, C. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00006-5 · Cited by 29
Calorigenic actions of leptin are additive to, but not dependent on, those of thyroid hormones
Wang, J., Chinookoswong, N., Yin, S., & Shi, Z. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.6.e1278 · Cited by 28
Self-citationKostalova, L., Leskova, L., Kapellerová, A., & Štrbák, V. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450053 · Cited by 27
Therapeutic use of recombinant methionyl human leptin
Vatier, C., Gautier, J., & Vigouroux, C. (2012) · Biochimie · doi:10.1016/j.biochi.2012.03.013 · Cited by 29
Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol
Denroche, H. C., Kwon, M., Quong, W. L., Neumann, U. H., Kulpa, J. E., Karunakaran, S., Clee, S. M., Brownsey, R. W., Covey, S. D., & Kieffer, T. J. (2015) · Diabetologia · doi:10.1007/s00125-015-3529-4 · Cited by 25
“Leptin depletes hepatic energy-yielding stores in STZ-diabetic mice Several studies have shown that leptin reduces endogenous glucose production in rodent models of type 1 diabetes [1, 6, 11], suggesting that this may drive the glucose-lowering effect of leptin.”
BackgroundResultInfluentialKim, G. H., Szabo, A., King, E. M., Ayala, J., Ayala, J. E., & Altarejos, J. Y. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.12.006 · Cited by 24
“Lastly, both the glucoregulatory and thermogenic effects of leptin are independent of leptin’s anorexigenic actions [1,2,6,19,47].”
BackgroundLiving without insulin: the role of leptin signaling in the hypothalamus
Fujikawa, T., & Coppari, R. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00108 · Cited by 24
“Chinookoswong and colleagues demonstrated that systemic leptin administration restores normoglycemia in otherwise hyperglycemic rats with low circulating insulin levels (∼70 pg/mL) (Chinookoswong et al., 1999).”
BackgroundLeptin and the regulation of bodyweight.
Somogyi, J. C. (2000) · Cited by 23
Leptin downregulates ghrelin levels in streptozotocin-induced diabetic mice
Tsubone, T., Masaki, T., Katsuragi, I., Tanaka, K., Kakuma, T., & Yoshimatsu, H. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00773.2004 · Cited by 24
Leptin therapy in type 2 diabetes
Cummings, B. P. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12048 · Cited by 24
Akirav, E. M., Chan, O. T. M., Inouye, K., Riddell, M. C., Matthews, S. G., & Vranić, M. (2004) · Metabolism · doi:10.1016/j.metabol.2004.06.024 · Cited by 23
Meek, T. H., Matsen, M. E., Damian, V. M., Cubelo, A., Chua, S. C., & Morton, G. J. (2014) · Endocrinology · doi:10.1210/en.2014-1169 · Cited by 22
Xu, Y., Chang, J. T., Myers, M. G., Xu, Y., & Tong, Q. (2016) · Diabetes · doi:10.2337/db15-1160 · Cited by 21
Leptin modulates the daily rhythmicity of blood glucose
Grosbellet, E., Dumont, S., Schuster, C., Lemaître, B. J., Pévet, P., Criscuolo, F., & Challet, É. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1035440 · Cited by 20
“In peripheral organs, leptin also participates in lipid and glucose metabolism (Chinookoswong et al., 1999; Schwartz et al., 1996; Wang et al., 1999, 2010).”
BackgroundFatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice
Chen, H. C., & Farese, R. V. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200207000-00002 · Cited by 22
Oztay, F., Kandil, A., Gurel, E., Ustunova, S., Kapucu, A., Balcı, H., Akgun-Dar, K., & Demirci, C. (2008) · Cell Biochemistry and Function · doi:10.1002/cbf.1418 · Cited by 20
Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice
Denroche, H. C., Quong, W. L., Bruin, J. E., Tudurí, E., Asadi, A., Glavas, M. M., Fox, J. K., & Kieffer, T. J. (2013) · Diabetes · doi:10.2337/db12-1684 · Cited by 17
“Alternatively, leptin therapy has been shown to enhance insulin sensitivity in diabetic rodents (4,8,25,34).”
BackgroundLewitt, M., & Brismar, K. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802135 · Cited by 19
Central regulation of glucose metabolism in an insulin‐dependent and ‐independent manner
Fujikawa, T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12941 · Cited by 21
Leveraging leptin for type I diabetes?
Kraus, D., Herman, M. A., & Kahn, B. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000736107 · Cited by 18
Shen, J., & Gundlach, A. L. (2004) · Neuroendocrinology · doi:10.1159/000079752 · Cited by 18
“These findings suggest that hyperphagia together with NPY overexpression and reduced GALP expression are not directly caused by hypoinsulinemia in STZ-DM rodents, but are triggered by hypoleptinemia. Furthermore, in severely insulinopenic rats, leptin treatment alone was able to correct hyperglycemia and restore basal…”
BackgroundDenroche, H. C., Glavas, M. M., Tudurí, E., Karunakaran, S., Quong, W. L., Philippe, M., Britton, H. M., Clee, S. M., & Kieffer, T. J. (2016) · Endocrinology · doi:10.1210/en.2015-1998 · Cited by 19
Kalra, S. P. (2011) · Gene Therapy · doi:10.1038/gt.2010.164 · Cited by 16
The effects of sympathectomy and dexamethasone in rats ingesting sucrose
Franco-Colín, M., Villanueva, I., Piñón, M., & Racotta, R. (2006) · International Journal of Biological Sciences · doi:10.7150/ijbs.2.17 · Cited by 16
“Because this was the group that had lost weight and had supposedly also the highest leptin levels, two conditions that improve glucose tolerance [29, 30 ] such a result might be expected.”
Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1
Chen, H. C., Smith, S. J., Ladha, Z., Jensen, D. R., Ferreira, L. D., Pulawa, L. K., McGuire, J. G., Pitas, R. E., Eckel, R. H., & Farese, R. V. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200214672 · Cited by 16
Mota-Zamorano, S., Luna, E., García‐Pino, G., González, L. M., & Gervasini, G. (2019) · Annals of Medicine · doi:10.1080/07853890.2019.1614656 · Cited by 14
The effect of leptin on maturing porcine oocytes is dependent on glucose concentration
Silva, E., Paczkowski, M., & Krisher, R. L. (2012) · Molecular Reproduction and Development · doi:10.1002/mrd.22029 · Cited by 15
“Leptin reduces systemic glucose levels and regulates glucose utilization in a diabetic mouse model via an insulin independent pathway (Chinookoswong et al., 1999; Hidaka et al., 2002; Kojima et al., 2009).”
BackgroundLu, R., Zhou, Y., Yuan, X., Liang, X., Liu, F., Bai, X., Wang, M., & Zhao, Y. (2015) · Fish Physiology and Biochemistry · doi:10.1007/s10695-015-0063-8 · Cited by 14
“The normalization of blood glucose levels by leptin therapy in insulin-deficient rodents correlates with increased insulin sensitivity (Chinookoswong et al. 1999; Denroche et al. 2011; Lin et al. 2002).”
BackgroundDenroche, H. C., Kwon, M., Glavas, M. M., Tudurí, E., Philippe, M., Quong, W. L., & Kieffer, T. J. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.009 · Cited by 13
Borba‐Murad, G. R., Mário, É. G., Bassoli, B. K., Bazotte, R. B., & de Souza, H. M. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1163 · Cited by 13
Brain Insulin and Leptin Signaling in Metabolic Control
Scherer, T., Lehnert, H., & Hallschmid, M. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.002 · Cited by 11
How does leptin restore euglycemia in insulin-deficient diabetes?
Oberlin, D. J., & Buettner, C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci91880 · Cited by 12
Benefits of leptin therapy in HIV patients
Sinha, U., Sinharay, K., Sengupta, N., & Mukhopadhyay, P. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105583 · Cited by 12
Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?
Barbetti, F., Colombo, C., Haataja, L., CRAS-MÉNEUR, C. M. H., Bernardini, S., & Arvan, P. (2016) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-016-0029-5 · Cited by 12
“Published results of others suggest that this approach may have promise for humans [31] as well as rodents [50, 51].”
ResultEffects of Selected Minerals on Leptin Secretion in Streptozotocin-lnduced Hyperglycemic Mice
Chen, M.-D., Yang, V. C., Alexander, P. S., Lin, P., & Song, Y.-M. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600905 · Cited by 10
Foskolos, A., Ehrhardt, R., Hileman, S. M., Gertler, A., & Boisclair, Y. R. (2015) · animal · doi:10.1017/s1751731115001159 · Cited by 11
“For example, a near total insulin deficiency not only leads to hyperglycemia, but also to a leptin deficit (Chinookoswong et al., 1999; Lin et al., 2002).”
BackgroundNutrient Sensing, Leptin and Insulin Action
Ukropec, J., ŠEBÖKOVÁ, E., & Klimeś, I. (2001) · Archives of Physiology and Biochemistry · doi:10.1076/apab.109.1.38.4284 · Cited by 9
“Leptin selectively decreases visceral adiposity and enhances the action of insulin (Barzilai et al., 1997; Chinookoswong et al., 1999).”
BackgroundRole of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering
Takanashi, M., Taira, Y., Okazaki, S., Takase, S., Kimura, T., Li, C. C., Xu, P., Noda, A., Sakata, I., Kumagai, H., et al. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.39552 · Cited by 9
Szilvássy, Z., Németh, J., Kovacs, P. L., Paragh, G., Sári, R. Z., Vı́gh, L., & Peitl, B. (2011) · Metabolism · doi:10.1016/j.metabol.2011.10.010 · Cited by 8
“This is strongly supported by the fact that an increase in leptin levels either by exogenous leptin [46] or by indirect maneuvers such as adenoviral gene therapy [47] decreases hypoglycemia despite persistent hypoinsulinemia in STZ diabetes.”
BackgroundWang, J., Wernette, C. M., Judd, R. L., Huggins, K. W., & White, B. D. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0135 · Cited by 8
“Chronic peripheral leptin administration (via subcutaneous osmotic pump) normalizes blood glucose concentrations in streptozotocin (STZ)-induced diabetic rats (Chinookoswong et al. 1999).”
BackgroundSelf-citationLeptin is a potent anti-diabetic in mice with lipodystrophy and insulin resistance
Berg, J. P. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1420114 · Cited by 8
Nuevas proyecciones fisiológicas, patológicas y terapéuticas de la leptina
Goldenberg, D., Santos, J. L., Hodgson, M. I., & Cortés, V. (2014) · Revista médica de Chile · doi:10.4067/s0034-98872014000600008 · Cited by 8
Xu, Y., & Tong, Q. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.09.027 · Cited by 7
Kapucu, A., & Akgün‐Dar, K. (2021) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2021_016 · Cited by 6
“Chinookoswong et al. (1999) reported that 4mg/kg leptin administration subcutaneously to STZ-induced diabetic rats restored euglycemia (18).”
Reno, C. M., Ding, Y., & Sherwin, R. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2015 · Cited by 6
Bhattacharya, S. K., Madan, M., Mahajan, P., et al. (2008) · PubMed · Cited by 6
Regulation of Glucose Metabolism in the Liver
Newgard, C. B. (2004) · doi:10.1002/0470862092.d0303 · Cited by 6
The modulatory effect of leptin on the overall insulin production in ex-vivo normal rat pancreas
Haddad, N., Howland, R. J., Baroody, G. M., & Daher, C. F. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-006 · Cited by 6
Leptin and the Neural Circuit Regulating body Weight and Metabolism
Friedman, M. J. (2002) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-18999-9_2 · Cited by 5
Association between Leptin, Insulin, and Body Fat Distribution in 2‐Diabetes Mellitus
Gao, Y., Yang, Q., ZHOU, J., et al. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06513.x · Cited by 5
Leckström, A., Lew, P. S., Poritsanos, N. J., & Mizuno, T. M. (2011) · Neuropeptides · doi:10.1016/j.npep.2010.12.005 · Cited by 4
Contribution of Diabetes and Metabolic Syndrome in the Pathogenesis of Alzheimer’s Disease
Farooqui, A. A., & Farooqui, T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00019-5 · Cited by 4
Metabolic Syndrome as a Risk Factor for Alzheimer Disease
Farooqui, A. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7318-3_8 · Cited by 5
Leptin-Signaling Pathways as Therapeutic Targets in Cancer
Saxena, N. K., & Sharma, D. (2016) · Energy balance and cancer · doi:10.1007/978-3-319-41677-9_4 · Cited by 4
The Role of Brain in Glucose Metabolism
Obici, S., & Martins, P. J. F. (2009) · Springer eBooks · doi:10.1007/978-0-387-09841-8_6 · Cited by 5
Madhkhoor, S. R., & Ibrahim, I. R. (2016) · International Journal of Advanced Research · doi:10.21474/ijar01/102 · Cited by 3
La leptine, nouvelle perspective thérapeutique dans le traitement du diabète ?
Vatier, C., Capeau, J., & Vigouroux, C. (2010) · médecine/sciences · doi:10.1051/medsci/20102610803 · Cited by 3
“La première étude, publiée en 1999 [15], a pris pour modèle des rats traités par la streptozotocine, et a montré que l’infusion sous-cutanée de leptine, en l’absence d’insulinothérapie, pouvait normaliser les glycémies.”
Obstructive sleep apnea and glucose metabolism
Polak, J., Beamer, B. A., & Punjabi, N. M. (2011) · Informa Healthcare eBooks · doi:10.3109/9781420020885.014 · Cited by 2
Pleotropic Acute and Chronic Effects of Leptin to Reverse Type 1 Diabetes
Perry, R. J. (2017) · Postdoc Journal · doi:10.14304/surya.jpr.v5n1.2 · Cited by 2
“reductions in plasma and liver triglyceride content (11, 32-34).”
BackgroundInfluentialDuVall, M. A., Coulter, C. E., Gosey, J. L., Herrera, M. J., Hill, C. M., Jariwala, R. R., Maisano, L. E., Moldovan, L. A., Morrison, C. D., Nwabueze, N. V., et al. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102853 · Cited by 2
Clark, K. A., Shin, A. C., Sirivelu, M. P., Mohankumar, R., Maddineni, S. R., Ramachandran, R., MohanKumar, P. S., & MohanKumar, S. M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413197 · Cited by 2
“Another study used a higher dose of leptin (4 mg/kg BW/day) administered using minipumps and found that it was capable of restoring euglycemia in diabetic rats [24].”
BackgroundLusby, A. L. (2009) · Cited by 2
Leptin : a risk marker for cardiovascular disease
Söderberg, S. (1999) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 2
Pancreatic Islets as a Target of Adipokines
Reiterer, M., Gilani, A., & Lo, J. C. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210044 · Cited by 3
Leptin-Insulin Interrelationships
Thomas-Geevarghese, A., & Ratner, R. E. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_5 · Cited by 1
Effect of exogenous leptin on thrombotic and metabolic profiles of FVB/B6 lipodystrophic mice
Kadouh, H. C., Yang, S. J., IglayReger, H. B., & Bodary, P. F. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.1183.4 · Cited by 1
“Leptin reduces pancreatic B-cell production of insulin (23) and also enhances insulin action (24), which is thought to be controlled via a cascade of reactions (25).”
BackgroundPancreatic Islets as a Target of Adipokines
Reiterer, M., Gilani, A., & Lo, J. C. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00238.x · Cited by 1
Ozturk, A., Erdoğan, H. Ç., Ekici, F., Aydin, D. D. Y., & Sogut, E. (2016) · West Indian Medical Journal · doi:10.7727/wimj.2016.106 · Cited by 1
Platelet aggregation inhibitors in prevention and treatment of coronary thrombosis.
Gomes, M. E. R., & Verheugt, F. W. A. (2003) · PubMed · Cited by 1
Leptin and Intermediary Metabolism: Focus on Glucoregulation and Lipids
Morgan, R. C., & Considine, R. V. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_7
Leptin: A Metabolic Perspective
Penn, D. M., Rooks, C. R., & Harris, R. B. S. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn070
Acquired Generalized Lipodystrophy with Severe Insulin Resistant Diabetes Mellitus
Lee, J. M., Sohn, T. S., & Son, H. S. (2006) · The Journal of Korean Diabetes Association · doi:10.4093/jkda.2006.30.6.487
INSULIN REGULATES PLASMA GHRELIN CONCENTRATIONS in STREPTOZOTOCIN-INDUCED DIABETIC RATS
Taşdemir, E., Obay, B. D., Bilgin, H. M., Şermet, A., Yildirim, Y., & Koçyiğit, Y. (2014)
LEPTIN— MUC HMOR ETHA N ASATIET YSIGNAL
Harris, S. S. (2000)
Gonçalves, C. G. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Modulação do metabolismo muscular da glicose pela ação hipotalâmica da leptina
Roman, E. A. D. F. R. (2011) · doi:10.47749/t/unicamp.2011.829153
Kamakshi Chaithri, P., Narne, P., Siraj, M., et al. (2012) · American Journal of Biochemistry and Molecular Biology · doi:10.3923/ajbmb.2013.159.166
The role of leptin in the regulation of glucose homeostasis
Levi, J. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0071042
“Utilizing the hyperinsulinemic-euglycemic clamp technique in streptozotocin (STZ) treated, insulin deficient rats, leptin was able to restore euglycemia, improve post-absorptive glucose metabolism, independently of food intake [112].”
Methodstreptozotocin-induced diabetic rats Central leptin increases insulin sensitivity in
Lin, C.-Y., Higginbotham, D. A., Judd, R. L., & White, B. D. (2016)
The metabolic effects of leptin therapy and glucagon suppression therapy in mouse models of diabetes
Neumann, U. H. (2017) · cIRcle (University of British Columbia) · doi:10.14288/1.0348695
“However, during pair feeding studies, despite consuming identical amounts of food as the leptin treated group, pair-fed STZ-rodents did not exhibit normalization of hyperglycemia [177, 233, 236, 237], basal glucose production rate, or plasma cholesterol, triglycerides, or free fatty acid levels, and only experienced a…”
BackgroundInfluentialLima, V. B. D. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.9.2017.tde-30012017-162842
The Role of Brain in Glucose Metabolism
Obici, S., & Martins, P. J. F. (2016) · Springer eBooks · doi:10.1007/978-3-319-20797-1_6-1
The Role of Brain in Glucose Metabolism
Obici, S., & Martins, P. J. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-18741-9_6
Kalra, S. P. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_20
Metadata
- Authors
- Chinookoswong, N., Wang, J. L., & Shi, Z. Q.
- Affiliations
- Amgen (United States) (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1999-07-01
- Volume
- 48
- Issue
- 7
- Pages
- 1487-1492
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2113808580
- Cited by
- 197
- References
- 0
- Citations by year
- 2022: 4 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 11 · 2016: 14 · 2015: 9 · 2014: 11 · 2013: 12 · 2012: 13
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- leptin, insulin-deficient diabetes, streptozotocin-induced diabetes, glucose turnover, normoglycemia, insulin sensitivity, hyperinsulinemic-euglycemic clamp, phloridzin, dietary restriction, weight loss, peripheral insulin action
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Drug Evaluation, Preclinical, Glucose, Insulin, Male, Obesity, Phlorhizin, Proteins, Glucose Clamp Technique, Rats, Sprague-Dawley, Leptin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
