The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.
Abstract
We hypothesized that diabetic sensory neuropathy is associated with activation of apoptosis and concomitant mitochondrial dysfunction. Studies were performed in excised intact and acutely dissociated dorsal root ganglion (DRG) neurons from control and streptozotocin-induced diabetic rats with decreased peripheral nerve conduction velocities (NCV). Apoptosis was increased in acutely dissociated DRG neurons from 3- to 6-week-old diabetic rats. Basal mitochondrial membrane potential (deltapsi) was significantly more positive in DRG neurons from diabetic rats. Depolarization with glutamate resulted in significantly more positive deltapsi and delayed recovery of deltapsi in neurons from diabetic rats. Restoration of euglycemia for 2 weeks with insulin implants normalized NCV, deltapsi, and apoptosis. Intact and acutely dissociated neurons from diabetic rats demonstrated decreased Bcl-2 levels and translocation of cytochrome C from the mitochondria to the cytoplasm. Neither levels of Bax nor levels of Bcl-XL were altered in diabetic neuropathy. Apoptosis associated with mitochondrial dysfunction may contribute to the pathogenesis of diabetic sensory neuropathy.
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Cites
Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884
Cited by
Pharmacological and Clinical Aspects of Heme Oxygenase
Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115
Schmeichel, A. M., Schmelzer, J. D., & Low, P. A. (2003) · Diabetes · doi:10.2337/diabetes.52.1.165 · Cited by 367
Diabetic neuropathy and oxidative stress
Pop-Busui, R., Sima, A., & Stevens, M. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.625 · Cited by 286
Self-citationDiabetes and the enteric nervous system
Chandrasekharan, B., & Srinivasan, S. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.01023.x · Cited by 243
Self-citationChowdhury, S. K. R., Dobrowsky, R. T., & Fernyhough, P. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.06.007 · Cited by 82
Metadata
- Authors
- Srinivasan, S., Stevens, M., & Wiley, J. W.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2000-11-01
- Volume
- 49
- Issue
- 11
- Pages
- 1932-1938
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2156935910
- Cited by
- 267
- References
- 1
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
