Cited by 22Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.

Hansen, L, Reneland, R, Berglund, L, Rasmussen, S K, Hansen, T, Lithell, H, Pedersen, O·2000·Diabetes

Abstract

A polymorphism (PP1ARE) in the 3'-untranslated region of the gene encoding the glycogen-associated regulatory subunit of type 1 protein phosphatase PPP1R3 is associated with insulin resistance in Pima Indians. The aim of this study was to investigate whether two common variants in the PPP1R3 gene, Asp905Tyr and PP1ARE, are associated with reduced insulin sensitivity or can predict the development of impaired glucose tolerance (IGT) or type 2 diabetes during a 20-year follow-up period in 696 50-year-old Caucasian men. The allelic frequency of Tyr905 was 0.11 (95% CI 0.09-0.13) and of PP1ARE 0.34 (0.31-0.37) and the two polymorphisms were in linkage disequilibrium (chi2 = 46, P < 0.0001, Fisher's exact test). None of the polymorphisms was associated with the development of IGT or type 2 diabetes, but the PP1ARE polymorphism was weakly correlated to whole-body insulin sensitivity (r = -0.08, P = 0.04). In conclusion, we found no evidence in Swedish men that the PP1ARE or the Asp905Tyr variants over a 20-year period predict the development of IGT or type 2 diabetes, but the PP1ARE polymorphism could have a higher penetrance in other populations.

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Crossref · 10.2337/diabetes.49.2.298

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Authors
Hansen, L., Reneland, R., Berglund, L., Rasmussen, S. K., Hansen, T., Lithell, H., & Pedersen, O.
Affiliations
Steno Diabetes Center Copenhagen (DK)
Venue
Diabetes
Published
2000-02-01
Volume
49
Issue
2
Pages
298-301
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2051127607
Cited by
22
References
11
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2020: 1 · 2018: 2
FWCI
1.75
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
3' untranslated region, insulin sensitivity, insulin resistance, impaired glucose tolerance, type 2 diabetes, genetic susceptibility, linkage disequilibrium, Pima Indians, Swedish men
MeSH terms
Alleles, Diabetes Mellitus, Type 2, Follow-Up Studies, Gene Frequency, Humans, Insulin Resistance, Genetic Linkage, Longitudinal Studies, Male, Middle Aged, Phosphoprotein Phosphatases, Polymorphism, Genetic, Glucose Intolerance, White People

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