Cited by 220Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

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Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy.

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Montanya, E, Nacher, V, Biarnés, M, Soler, J·2000·Diabetes

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Abstract

We determined the beta-cell replicative rate, beta-cell apoptosis, cross-sectional beta-cell area, and pancreatic beta-cell mass throughout the entire postweaning lifespan (months 1, 3, 7, 10, 15, and 20) of Lewis rats. Beta-cell replication was progressively reduced in the initial months of life but remained stable after month 7 (month 1, 0.99 +/- 0.10%; month 3, 0.24 +/- 0.04%; month 7, 0.12 +/- 0.02%; month 10, 0.14 +/- 0.02%; month 15, 0.10 +/- 0.03%; month 20, 0.13 +/- 0.03%; analysis of variance [ANOVA], P < 0.001). Beta-cell apoptosis was low and did not change significantly from month 1 to 20 of life. Cross-sectional area of individual beta-cells increased progressively in the initial months, remained stable from month 7 to 15, and increased again on month 20. The estimated number of beta-cells per pancreas, calculated as the ratio of total beta-cell mass to individual beta-cell mass, tripled from month 1 to 7 but did not change significantly thereafter. Beta-cell mass increased approximately 8 times from month 1 to 20 (month 1, 2.04 +/- 0.28 mg; month 20, 15.5 +/- 2.32 mg; ANOVA, P < 0.001) and showed a strong and significant linear correlation with body weight (r = 0.98, P < 0.001). In summary, we have shown that beta-cell replication was maintained throughout the lifespan in normal rats, clearly establishing that the beta-cell birth rate does not fall to 0, even in very old rats. Beta-cell mass increased throughout the lifespan, closely matching the increment in total body weight at any time point. This increment was selective for beta-cells, since the growth of the endocrine non-beta-cell mass was limited to the initial months of life. Both beta-cell hypertrophy and hyperplasia contributed to increased beta-cell mass in young animals, but only beta-cell hypertrophy was responsible for the increased beta-cell mass found in old animals. This study provides a global perspective for understanding the dynamics of beta-cell mass in young, adult, and aged animals.

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Authors: Montanya, E., Nacher, V, Biarnés, M., & Soler, J.
Affiliations: Bellvitge University Hospital (ES)
ORCID: Montanya, E
Nacher, V
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2000-08-01
Volume: 49
Issue: 8
Pages: 1341-1346
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.49.8.1341
OpenAlex: W2097735638
Cited by: 220
References: 34
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 13 · 2014: 6 · 2013: 7 · 2012: 14
FWCI: 9.00
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion, other-oa)
Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by-nc-nd)
Funders: Ministerio de Sanidad, Consumo y Bienestar Social
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: beta-cell mass, beta-cell hyperplasia, beta-cell hypertrophy, beta-cell proliferation, beta-cell apoptosis, body weight, lifespan, aging, pancreatic beta cells, Lewis rats
MeSH terms: Aging, Animals, Blood Glucose, Body Weight, Cell Division, Hyperplasia, Hypertrophy, Islets of Langerhans, Male, Organ Size, Rats, Inbred Lew, Apoptosis, Rats

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Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy.

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