Aging and insulin secretion
Abstract
Glucose tolerance progressively declines with age, and there is a high prevalence of type 2 diabetes and postchallenge hyperglycemia in the older population. Age-related glucose intolerance in humans is often accompanied by insulin resistance, but circulating insulin levels are similar to those of younger people. Under some conditions of hyperglycemic challenge, insulin levels are lower in older people, suggesting β-cell dysfunction. When insulin sensitivity is controlled for, insulin secretory defects have been consistently demonstrated in aging humans. In addition, β-cell sensitivity to incretin hormones may be decreased with advancing age. Impaired β-cell compensation to age-related insulin resistance may predispose older people to develop postchallenge hyperglycemia and type 2 diabetes. An improved understanding of the metabolic alterations associated with aging is essential for the development of preventive and therapeutic interventions in this population at high risk for glucose intolerance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Age-related declines of pancreatic islet function and of islet proliferative capacity have been described.
“However, age-related declines of pancreatic islet function4, 14 and of islet proliferative capacity15, 16; have been described.”
From Diabetes in Older Adults: A Consensus Report (2012) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405 · see citing works
Harris, M. I., Hadden, W. C., Knowler, W. C., & Bennett, P. H. (1987) · Diabetes · doi:10.2337/diab.36.4.523 · Cited by 1,096 · see citing works
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G. B., Styrkarsdottir, U., Gretarsdottir, S., Emilsson, V., Ghosh, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2043 · Cited by 1,072 · see citing works
Bmi1, stem cells, and senescence regulation
Park, I.-K., Morrison, S. J., & Clarke, M. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420800 · Cited by 495 · see citing works
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance
Basu, R., Breda, E., Oberg, A. L., Powell, C. C., Dalla Man, C., Basu, A., Vittone, J. L., Klee, G. G., Arora, P., Jensen, M. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1738 · Cited by 440 · see citing works
DeFronzo, R. A. (1981) · Diabetes Care · doi:10.2337/diacare.4.4.493 · Cited by 389 · see citing works
Barrett-Connor, E., & Ferrara, A. (1998) · Diabetes Care · doi:10.2337/diacare.21.8.1236 · Cited by 369 · cited 6× · see citing works
“Individuals with type 2 diabetes (including IPH) or IGT have associated increased morbidity and mortality (5, 6, 43).”
BackgroundInfluentialbeta-cell turnover: its assessment and implications.
Bonner-Weir, S. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s20 · Cited by 230 · see citing works
Montanya, E., Nacher, V, Biarnés, M., & Soler, J. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1341 · Cited by 220 · see citing works
Elahi, D., Andersen, D. K., Muller, D. C., Tobin, J. D., Brown, J. C., & Andres, R. (1984) · Diabetes · doi:10.2337/diab.33.10.950 · Cited by 87 · cited 2× · see citing works
“GIP and GLP-1 levels in response to oral glucose have been found to be normal (25, 26) or increased in nonobese (16, 39) and obese healthy old people (28) compared with young controls.”
BackgroundResultGlucose Metabolism in Older Adults: A Study Including Subjects More Than 80 Years of Age
Garcia, G. V., Freeman, R. V., Supiano, M. A., Smith, M. J., Galecki, A. T., & Halter, J. B. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb01507.x · Cited by 35 · see citing works
Self-citationEffects of epinephrine on insulin secretion and action in humans: interaction with aging
Morrow, L. A., Morganroth, G. S., Herman, W. H., Bergman, R. N., & Halter, J. B. (1993) · Diabetes · doi:10.2337/diab.42.2.307 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016 · see citing works
Hyperinsulinemia and risk of Alzheimer disease
Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140292.04932.87 · Cited by 683 · see citing works
Enge, M., Arda, H. E., Mignardi, M., Beausang, J., Bottino, R., Kim, S. K., & Quake, S. R. (2017) · Cell · doi:10.1016/j.cell.2017.09.004 · Cited by 568 · see citing works
Diabetes in Older Adults: A Consensus Report
Sue Kirkman, M., Briscoe, V. J., Clark, N., Florez, H., Haas, L. B., Halter, J. B., Huang, E. S., Korytkowski, M. T., Munshi, M. N., Odegard, P. S., et al. (2012) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12035 · Cited by 548 · see citing works
Self-citationFrom pre-diabetes to diabetes: diagnosis, treatments and translational research
Khan, R., Chua, Z., Tan, J., Yang, Y., Liao, Z., & Zhao, Y. (2019) · Medicina · doi:10.3390/medicina55090546 · Cited by 484 · see citing works
Effects of Age and Sex on Postprandial Glucose Metabolism
Basu, R., Dalla Man, C., Campioni, M., Basu, A., Klee, G., Toffolo, G., Cobelli, C., & Rizza, R. A. (2006) · Diabetes · doi:10.2337/db05-1692 · Cited by 334 · see citing works
Ramsey, K. M., Mills, K. F., Satoh, A., & Imai, S. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00355.x · Cited by 321 · see citing works
Polypharmacy in the Aging Patient: A Review of Glycemic Control in Older Adults With Type 2 Diabetes
Lipska, K. J., Krumholz, H., Soones, T., & Lee, S. J. (2016) · JAMA · doi:10.1001/jama.2016.0299 · Cited by 309 · see citing works
Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions
Halter, J. B., Musi, N., McFarland Horne, F., Crandall, J. P., Goldberg, A., Harkless, L., Hazzard, W. R., Huang, E. S., Kirkman, M. S., Plutzky, J., et al. (2014) · Diabetes · doi:10.2337/db14-0020 · Cited by 255 · see citing works
Self-citationHodes, R. J., Sierra, F., Austad, S. N., Epel, E., Neigh, G. N., Erlandson, K. M., Schafer, M. J., LeBrasseur, N. K., Wiley, C., Campisi, J., et al. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13299 · Cited by 132 · see citing works
Self-citationEffect of donor age on function of isolated human islets
Ihm, S.-H., Matsumoto, I., Sawada, T., Nakano, M., Zhang, H. J., Ansite, J. D., Sutherland, D. E. R., & Hering, B. J. (2006) · Diabetes · doi:10.2337/db05-1333 · Cited by 130 · see citing works
Caloric restriction, body fat and ageing in experimental models
Das, M., Gabriely, I., & Barzilai, N. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00115.x · Cited by 121 · see citing works
Masoro, E. J. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.s1.s218 · Cited by 81 · see citing works
Endocrine alterations in response to calorie restriction in humans
Redman, L. M., & Ravussin, E. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.014 · Cited by 54 · see citing works
Impact of carbohydrate-rich meals on plasma epinephrine levels: dysregulation with aging.
Penev, P., Spiegel, K., Marcinkowski, T., & Van Cauter, E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0415 · Cited by 39 · see citing works
Men Are from Mars, Women Are from Venus: Sex Differences in Insulin Action and Secretion
Basu, A., Dube, S., & Basu, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-70178-3_4 · Cited by 38 · see citing works
- Authors
- Chang, A. M., & Halter, J. B.
- Affiliations
- Divisions of Endocrinology and
- University of Michigan (US)
- ORCID
- Chang, Annette M.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2003-01-01
- Volume
- 284
- Issue
- 1
- Pages
- E7-E12
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2145317285
- Cited by
- 585
- References
- 14
- Citations by year
- 2026: 24 · 2025: 35 · 2024: 43 · 2023: 28 · 2022: 39 · 2021: 44 · 2020: 22 · 2019: 32 · 2018: 29 · 2017: 26 · 2016: 25 · 2015: 25 · 2014: 24 · 2013: 22 · 2012: 25
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- aging, insulin secretion, beta-cell dysfunction, impaired glucose tolerance, type 2 diabetes, insulin resistance, older adults
- MeSH terms
- Insulin Secretion, Adult, Aged, Aged, 80 and over, Aging, Diabetes Mellitus, Type 2, Glucagon-Like Peptides, Glucagon, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Middle Aged, Nutrition Surveys, Peptide Fragments, Glucose Intolerance, Glucagon-Like Peptide 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
