Cited by 99Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityDiabetes, Cardiovascular Risks, and Lipoproteins

Mild suppression of hyperinsulinemia to treat obesity and insulin resistance

Open access
Page, Melissa M., Johnson, James D.·2018·Trends in Endocrinology & Metabolism

Abstract

Insulin plays roles in lipid uptake, lipolysis, and lipogenesis, in addition to controlling blood glucose levels. Excessive circulating insulin is associated with adipose tissue expansion and obesity, yet a causal role for hyperinsulinemia in the development of mammalian obesity has proven controversial, with many researchers suggesting it as a consequence of insulin resistance. Recently, evidence that specifically reducing hyperinsulinemia can prevent and reverse obesity in animal models has been presented. Our experiments, and others in this field, question the current dogma that hyperinsulinemia is a response to obesity and/or insulin resistance. In this review, we discuss preclinical evidence in the context of the broader literature and speculate on the possibility of clinical translation of alternative approaches for treating obesity.

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Crossref · 10.1016/j.tem.2018.03.018

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108 of 108 references verified0 citation errors · 0 not checkable

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Authors
Page, M. M., & Johnson, J. D.
Affiliations
University of British Columbia (CA)
Corresponding author
Johnson, James D.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2018-06
Volume
29
Issue
6
Pages
389-399
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2796621520
Cited by
99
References
108
Citations by year
2026: 3 · 2025: 6 · 2024: 11 · 2023: 16 · 2022: 15 · 2021: 17 · 2020: 21 · 2019: 7 · 2018: 3
FWCI
1.71
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
hyperinsulinemia, obesity, insulin resistance, insulin signaling, adipose tissue expansion, lipolysis, lipogenesis, lipid uptake, obesity treatment, animal models of obesity
MeSH terms
Animals, Glucose, Homeostasis, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Obesity

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