The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes
Open accessAbstract
Recently, a role for uncoupling protein-3 (UCP3) in carbohydrate metabolism and in type 2 diabetes has been suggested. Mice overexpressing UCP3 in skeletal muscle showed reduced fasting plasma glucose levels, improved glucose tolerance after an oral glucose load, and reduced fasting plasma insulin levels. However, data regarding the expression of UCP3 in patients with type 2 diabetes is inconsistent, and so far, there have been no reports of UCP3 protein content. Here we compared, for the first time, the protein levels of UCP3 in vastus lateralis muscle in 14 male type 2 diabetic patients (age 49.8 +/- 2.1 years; BMI 27.2 +/- 1.2 kg/m(2); mean +/- SE) with 16 male control subjects (age 48.0 +/- 1.9 years; BMI 23.4 +/- 0.6 kg/m(2)). We found that UCP3 protein levels were twice as low in patients with type 2 diabetes compared with control subjects (117 +/- 16 vs. 58 +/- 12 AU; P = 0.007). There was no correlation between UCP3 content and BMI. In conclusion, UCP3 content is lower in type 2 diabetic patients compared with healthy control subjects. These results are consistent with a role for UCP3 in glucose homeostasis and suggest a role for UCP3 in type 2 diabetes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Diet, muscle glycogen and physical performance.
Bergström, J., Hermansen, L., Hultman, E., & Saltin, B. (1967) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1967.tb03720.x · Cited by 1,740
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604
Thiazolidinediones: a new class of antidiabetic drugs
Day, C. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00023.x · Cited by 440
Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM
Mårin, P., Andersson, B., Krotkiewski, M., & Björntorp, P. A. (1994) · Diabetes Care · doi:10.2337/diacare.17.5.382 · Cited by 342
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
Li, B., Nolte, L. A., Ju, J.-S., Ho Han, D., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2000) · Nature Medicine · doi:10.1038/80450 · Cited by 291
Tsuboyama-Kasaoka, N., Tsunoda, N., Maruyama, K., Takahashi, M. M., Kim, H., Ikemoto, S., & Ezaki, O. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8818 · Cited by 131
Schrauwen, P., Xia, J., Walder, K. R., Snitker, S., & Ravussin, É. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801057 · Cited by 117
Self-citationUncoupling protein 3 is reduced in skeletal muscle of NIDDM patients.
Krook, A., Digby, J., O’Rahilly, S., Zierath, J. R., & Wallberg‐Henriksson, H. (1998) · Diabetes · doi:10.2337/diabetes.47.9.1528 · Cited by 106
Bashan, N., Burdett, E., Gumà, A., Sargeant, R., Tumiati, L., Liu, Z., & Klip, A. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.2.c430 · Cited by 99
Bao, S., Kennedy, A., Wojciechowski, B., Wallace, P., Ganaway, E., & Garvey, W. T. (1998) · Diabetes · doi:10.2337/diabetes.47.12.1935 · Cited by 96
Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers
Hesselink, M. K. C., KEIZER, H. A., Borghouts, L. B., Schaart, G., Kornips, C. F. P., Slieker, L. J., Sloop, K. W., Saris, W. H. M., & Schrauwen, P. (2001) · The FASEB Journal · doi:10.1096/fj.00-0517fje · Cited by 89
Self-citationHuman Uncoupling Proteins and Obesity
Schrauwen, P., Walder, K. R., & Ravussin, É. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00396.x · Cited by 89
Self-citationHuppertz, C., Fischer, B., Kim, Y., Kotani, K., Vidal‐Puig, A., Slieker, L. J., Sloop, K. W., Lowell, B. B., & Kahn, B. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011708200 · Cited by 86
Meirhaeghe, A., Amouyel, P., Helbecque, N., Cottel, D., Otabe, S., Froguel, P., & Vasseur, F. (2000) · Diabetologia · doi:10.1007/s001250051549 · Cited by 76
Bidirectional regulation of uncoupling protein-3 and GLUT-4 mRNA in skeletal muscle by cold
Lin, B.-Z., Coughlin, S., & Pilch, P. F. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.3.e386 · Cited by 59
Emilsson, V., O’Dowd, J. F., Wang, S., Liu, Y.-L., Sennitt, M. V., Heyman, R. A., & Cawthorne, M. A. (2000) · Metabolism · doi:10.1053/meta.2000.18692 · Cited by 50
Schrauwen, P., Schaart, G., Saris, W. H. M., Slieker, L. J., Glatz, J. F. C., Vidal, H., & Blaak, E. E. (2000) · Diabetologia · doi:10.1007/s001250051547 · Cited by 47
Self-citationOverexpression of GLUT4 in Mice Causes Up-Regulation of UCP3 mRNA in Skeletal Muscle
Tsuboyama-Kasaoka, N., Tsunoda, N., Maruyama, K., Takahashi, M. M., Kim, H., Cooke, D. W., Lane, M. D., & Ezaki, O. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0617 · Cited by 27
Vidal, H., Langin, D., Andréelli, F., Millet, L., Larrouy, D., & Laville, M. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.5.e830 · Cited by 27
Oberkofler, H., Neschen, S., Esterbauer, H., Waldhäusl, W. K., Patsch, W., & Fürnsinn, C. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00270-0 · Cited by 7
Cited by
Sorted by citations
Mitochondrial electron transport chain, ROS generation and uncoupling (Review)
Zhao, R., Jiang, S., Zhang, L., & Yu, Z. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4188 · Cited by 1,511
Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
Rolo, A. P., & Palmeira, C. M. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.01.003 · Cited by 1,007
Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742
Mitochondrial uncoupling, ROS generation and cardioprotection
Cadenas, S. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.05.019 · Cited by 591
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542
Metadata
- Authors
- Schrauwen, P., Hesselink, M. K. C., Blaak, E. E., Borghouts, L. B., Schaart, G., Saris, W. H. M., & Keizer, H. A.
- Affiliations
- Maastricht University (NL)
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2001-12-01
- Volume
- 50
- Issue
- 12
- Pages
- 2870-2873
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2100804159
- Cited by
- 112
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 7 · 2012: 5
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- UCP3, type 2 diabetes, skeletal muscle, vastus lateralis, glucose homeostasis, carbohydrate metabolism, insulin resistance, body mass index
- MeSH terms
- Uncoupling Protein 3, Blood Glucose, Carrier Proteins, Diabetes Mellitus, Type 2, Fluorescent Antibody Technique, Homeostasis, Humans, Insulin, Ion Channels, Male, Middle Aged, RNA, Messenger, Thiazoles, Body Mass Index, Muscle, Skeletal, Mitochondrial Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
