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Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane
Abstract
We describe a new technique for microencapsulation with high–mannuronic acid (high-M) alginate crosslinked with BaCl2 without a traditional permselective component, which allows the production of biocompatible capsules that allow prolonged survival of syngeneic and allogeneic transplanted islets in diabetic BALB/c and NOD mice for >350 days. The normalization of the glycemia in the transplanted mice was associated with normal glucose profiles in response to intravenous glucose tolerance tests. After explantation of the capsules, all mice became hyperglycemic, demonstrating the efficacy of the encapsulated islets. The retrieved capsules were free of cellular overgrowth and islets responded to glucose stimulation with a 5- to 10-fold increase of insulin secretion. Transfer of splenocytes isolated from transplanted NOD mice to NOD/SCID mice adoptively transferred diabetes, indicating that NOD recipients maintained islet-specific autoimmunity. In conclusion, we have developed a simple technique for microencapsulation that prolongs islet survival without immunosuppression, providing complete protection against allorejection and the recurrence of autoimmune diabetes.
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Cited by
Vegas, A. J., Veiseh, O., Doloff, J. C., Ma, M., Tam, H. H., Bratlie, K., Li, J., Bader, A. R., Langan, E., Olejnik, K., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3462 · Cited by 551
Self-citationAdvances in islet encapsulation technologies
Desai, T., & Shea, L. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.232 · Cited by 427
Bochenek, M. A., Veiseh, O., Vegas, A. J., McGarrigle, J. J., Qi, M., Marchese, E., Omami, M., Doloff, J. C., Mendoza-Elias, J., Nourmohammadzadeh, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0275-1 · Cited by 367
Self-citationBiocompatibility of alginate–poly-l-lysine microcapsules for cell therapy
Orive, G., Tam, S. K., Pedraz, J. L., & Hallé, J.-P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.048 · Cited by 337
Scharp, D. W., & Marchetti, P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.018 · Cited by 314
Metadata
- Authors
- Duvivier-Kali, V. F., Omer, A., Parent, R. J., O’Neil, J. J., & Weir, G. C.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2001-08-01
- Volume
- 50
- Issue
- 8
- Pages
- 1698-1705
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2110753158
- Cited by
- 291
- References
- 0
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Duvivier-Kali, V. F., Omer, A., Parent, R. J., O’Neil, J. J., & Weir, G. C. (2001). Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane. Diabetes. https://doi.org/10.2337/diabetes.50.8.1698
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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