Cited by 97Diabetes, Cardiovascular Risks, and LipoproteinsParaoxonase enzyme and polymorphismsLipoproteins and Cardiovascular Health

In Vivo Evidence for Increased Oxidation of Circulating LDL in Impaired Glucose Tolerance

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Kopprasch, Steffi, Pietzsch, Jens, Kuhlisch, Eberhard, Fuecker, Katja, Temelkova-Kurktschiev, Theodora, Hanefeld, Markolf, Kühne, Helmut, Julius, Ulrich +1 more·2002·Diabetes

Abstract

Oxidized LDL (oxLDL) is a key mediator in atherogenesis and a marker of coronary artery disease (CAD). Type 2 diabetes is associated with excessive cardiovascular morbidity and mortality. Because atherogenesis starts before diabetes is diagnosed, we investigated whether circulating oxLDL levels are increased in impaired glucose tolerance (IGT). OxLDL levels were measured in 376 subjects with normal glucose tolerance (NGT), 113 patients with IGT, and 54 patients with newly diagnosed type 2 diabetes. After correction for age and BMI, serum levels of oxLDL were significantly increased in IGT versus NGT subjects (P = 0.002). OxLDL levels were not associated with the following parameters of the oxidative/antioxidative balance in the blood: total antioxidant capacity, urate-to-allantoin ratio, and circulating phagocyte oxygenation activity. In stepwise multivariate analysis, LDL cholesterol (P < 0.0005) and triglycerides (P < 0.0005) were the strongest predictors of circulating oxLDL levels, followed by HDL cholesterol (P = 0.003), 2-h postchallenge C-peptide (P = 0.011), fasting free fatty acids (P = 0.013), and serum paraoxonase activity (P = 0.035). The strong correlation of oxLDL with LDL cholesterol and triglycerides indicates that LDL oxidation in IGT is preferentially associated with dyslipidemia. OxLDL increase may explain the high atherogenic potency of dyslipidemia in the prediabetic state.

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Authors
Kopprasch, S., Pietzsch, J., Kuhlisch, E., Fuecker, K., Temelkova-Kurktschiev, T., Hanefeld, M., Kühne, H., Julius, U., & Graessler, J.
Affiliations
  • Technische Universität Dresden (DE)
  • Helmholtz-Zentrum Dresden-Rossendorf (DE)
  • GWT-TUD GmbH (Germany) (DE)
  • Centre for Clinical Studies GWT, Dresden, Germany
  • Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Dresden, Germany
Venue
Diabetes
Published
2002-10-01
Volume
51
Issue
10
Pages
3102-3106
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2129807678
Cited by
97
References
32
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 4
FWCI
3.80
Type
journal article
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
oxidized LDL, impaired glucose tolerance, type 2 diabetes, atherogenesis, dyslipidemia, LDL cholesterol, triglycerides, HDL cholesterol, paraoxonase activity, oxidative stress, prediabetes, coronary artery disease risk
MeSH terms
Adult, Aged, C-Peptide, Diabetes Mellitus, Type 2, Esterases, Fatty Acids, Nonesterified, Female, Glucose Tolerance Test, Humans, Hyperlipidemias, Insulin, Cholesterol, HDL, Lipoproteins, LDL, Cholesterol, LDL, Male, Middle Aged, Oxidation-Reduction, Proinsulin, Triglycerides, Linear Models, Aryldialkylphosphatase

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