The Common Single Nucleotide Polymorphism E23K in KIR6.2 Sensitizes Pancreatic β-Cell ATP-Sensitive Potassium Channels Toward Activation Through Nucleoside Diphosphates

Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance

Polonsky, K. S., Sturis, J., & Bell, G. I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341207 · Cited by 590 · see citing works

ATP-sensitive K+ channels and insulin secretion: their role in health and disease

Ashcroft, F., & Gribble, F. (1999) · Diabetologia · doi:10.1007/s001250051247 · Cited by 435 · see citing works

Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria.

Kennedy, H., Pouli, A. E., Ainscow, E., Jouaville, L. S., Rizzuto, R., & Rutter, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13281 · Cited by 319 · see citing works

Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

Koster, J. C., Marshall, B. A., Ensor, N. J., Corbett, J. A., & Nichols, C. G. (2000) · Cell · doi:10.1016/s0092-8674(00)80701-1 · Cited by 287 · see citing works

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR ): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

Hani, E., Boutin, P., Durand, E., Inoue, H., Permutt, M., Velho, G., & Froguel, P. (1998) · Diabetologia · doi:10.1007/s001250051098 · Cited by 282 · see citing works

A Novel Method for Measurement of Submembrane ATP Concentration

Gribble, F. M., Loussouarn, G., Tucker, S. J., Zhao, C., Nichols, C. G., & Ashcroft, F. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001010200 · Cited by 280 · see citing works

KIR6.2 Polymorphism Predisposes to Type 2 Diabetes by Inducing Overactivity of Pancreatic β-Cell ATP-Sensitive K+ Channels

Schwanstecher, C., Meyer, U., & Schwanstecher, M. (2002) · Diabetes · doi:10.2337/diabetes.51.3.875 · Cited by 243 · see citing works

The ATP‐sensitivity of K⁺ channels in rat pancreatic B‐cells is modulated by ADP

Kakei, M., Kelly, R. P., Ashcroft, S. J. H., & Ashcroft, F. M. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)81533-2 · Cited by 241 · see citing works

The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.

Enkvetchakul, D., Loussouarn, G., Makhina, E., Shyng, S., & Nichols, C. G. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76779-8 · Cited by 172 · see citing works

Association studies of variants in promoter and coding regions of beta‐cell ATP‐sensitive K‐channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)

Gloyn, A. L., Hashim, Y., Ashcroft, S. J. H., Ashfield, R., Wiltshire, S., & Turner, R. C. (2001) · Diabetic Medicine · doi:10.1046/j.1464-5491.2001.00449.x · Cited by 170 · see citing works

The Changes in Adenine Nucleotides Measured in Glucose-stimulated Rodent Islets Occur in β Cells but Not in α Cells and Are Also Observed in Human Islets

Detimary, P., Dejonghe, S., Ling, Z., Pipeleers, D., Schuit, F., & Henquin, J.-C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33905 · Cited by 159 · see citing works

Concentration Dependence and Time Course of the Effects of Glucose on Adenine and Guanine Nucleotides in Mouse Pancreatic Islets*

de Timary, P., van den Berghe, G., & Henquin, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20559 · Cited by 144 · see citing works

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in white caucasian subjects or evidence of abnormal function when expressed in vitro

Sakura, H., Wat, N., Horton, V., Millns, H., Turner, R. C., & Ashcroft, F. M. (1996) · Diabetologia · doi:10.1007/bf02658512 · Cited by 122 · see citing works

Glucose-induced changes in cytosolic ATP content in pancreatic islets

Malaisse, W. J., & Sener, A. (1987) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(87)90134-0 · Cited by 116 · see citing works

ATP inhibition of KATP channels: control of nucleotide sensitivity by the N‐terminal domain of the Kir6.2 subunit

Koster, J., Sha, Q., Shyng, S., & Nichols, C. (1999) · Journal of Physiology · doi:10.1111/j.1469-7793.1999.019ad.x · Cited by 100 · see citing works

Evidence for a Unique Long Chain Acyl-CoA Ester Binding Site on the ATP-regulated Potassium Channel in Mouse Pancreatic Beta Cells

Bränström, R., Corkey, B. E., Berggren, P., & Larsson, O. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17390 · Cited by 83 · see citing works

The gating of nucleotide-sensitive K+ channels in insulin-secreting cells can be modulated by changes in the ratio ATP4−/ADP3− and by nonhydrolyzable derivatives of both ATP and ADP

Dunne, M. J., West-Jordan, J. A., Abraham, R. J., Edwards, R. H. T., & Petersen, O. H. (1988) · The Journal of Membrane Biology · doi:10.1007/bf01870928 · Cited by 82 · see citing works

ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites.

Markworth, E., Schwanstecher, C., & Schwanstecher, M. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1413 · Cited by 76 · see citing works

The N-terminus of KIR6.2 limits spontaneous bursting and modulates the ATP-inhibition of KATP channels.

Babenko, A. P., Gonzalez, G., & Bryan, J. (1999) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.1999.0172 · Cited by 74 · see citing works

Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits

Trapp, S., Tucker, S. J., & Ashcroft, F. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8872 · Cited by 66 · see citing works

Phosphate and thiophosphate group donating adenine and guanine nucleotides inhibit glibenclamide binding to membranes from pancreatic islets

Schwanstecher, M., L�ser, S. V., Rietze, I., & Panten, U. (1991) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00180681 · Cited by 59 · see citing works

ATP Interaction with the Open State of the KATP Channel

Enkvetchakul, D., Loussouarn, G., Makhina, E., & Nichols, C. G. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76051-1 · Cited by 56 · see citing works

Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM

Inoue, H., Ferrer, J. P., Warren-Perry, M., ZHANG, Y., Millns, H., Turner, R. C., Elbein, S. C., Hampe, C. L., Suarez, B. K., Inagaki, N., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.3.502 · Cited by 33 · see citing works

Interaction of tolbutamide and cytosolic nucleotides in controlling the ATP‐sensitive K+ channel in mouse β‐cells

Schwanstecher, C., Dickel, C., & Panten, U. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14060.x · Cited by 26 · see citing works

Tolbutamide-sensitivity of the adenosine 5?-triphosphate-dependent K+ channel in mouse pancreatic B-cells

Panten, U., Heipel, C., Rosenberger, F., Scheffer, K., Ziinkler, B. J., & Schwanstecher, C. (1990) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169047 · Cited by 26 · see citing works

Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM

Hansen, L., Echwald, S. M., Hansen, T. F., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.3.508 · Cited by 24 · see citing works

Characterization of Nucleoside Diphosphokinase Activity in Human and Rodent Pancreatic .beta. Cells: Evidence for Its Role in the Formation of Guanosine Triphosphate, a Permissive Factor for Nutrient-Induced Insulin Secretion

Kowluru, A., & Metz, S. A. (1994) · Biochemistry · doi:10.1021/bi00207a017

The binding properties of the solubilized sulfonylurea receptor from a pancreatic B-cell line are modulated by the Mg(++)-complex of ATP.

Schwanstecher, M., Behrends, S., Brandt, C., & Panten, U. (1992) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10785-4

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works