Glucose-induced changes in cytosolic ATP content in pancreatic islets
Abstract
The cytosolic and mitochondrial contents in ATP, ADP and AMP were measured in islets incubated for 45 min at increasing concentrations of D-glucose and then exposed for 20 s to digitonin. The latter treatment failed to affect the total islet ATP/ADP ratio and adenylate charge. D-Glucose caused a much greater increase in cytosolic than mitochondrial ATP/ADP ratio. In the cytosol, a sigmoidal pattern characterized the changes in ATP/ADP ratio at increasing concentrations of D-glucose. These findings are compatible with the view that cytosolic ATP participates in the coupling of metabolic to ionic events in the process of nutrient-induced insulin release.
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As intracellular ATP levels never fall below 1 mM in β-cells, even in the absence of glucose, KATP channels are largely closed even at resting glucose concentrations.
“As intracellular ATP levels never fall below 1 mM in β-cells, even in the absence of glucose (143, 422), KATP channels are largely closed, even at resting glucose concentrations.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [422]
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Ketone bodies and islet function: 45Ca handling, insulin synthesis, and release
Malaisse, W. J., Lebrun, P., Yaylali, B., Cámara, J., Valverde, I., & Sener, A. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.1.e117 · Cited by 22 · see citing works
Self-citationAdenylate Kinase Activity in ABC Transporters
Randak, C. O., & Welsh, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.r500009200 · Cited by 22 · see citing works
Hexose metabolism in pancreatic islets: Regulation of mitochondrial hexokinase binding
MALAISSE-LAGAE, F., & Malaisse, W. J. (1988) · Biochemical Medicine and Metabolic Biology · doi:10.1016/0885-4505(88)90061-8 · Cited by 22 · see citing works
Self-citationHexose metabolism in pancreatic islets. Feedback control of d-glucose oxidation by functional events
Malaisse, W. J., & Sener, A. (1988) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(88)80038-0 · Cited by 22 · see citing works
Self-citationHexose metabolism in pancreatic islets
Sener, A., & Malaisse, W. J. (1988) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(88)90099-9 · Cited by 20 · see citing works
Self-citationVitamin D and pancreatic islet function II. Dynamics of insulin release and cationic fluxes
Billaudel, B. J. L., Labriji-Mestaghanmi, H., Sutter, B. C. J., & Malaisse, W. J. (1988) · Journal of Endocrinological Investigation · doi:10.1007/bf03350186 · Cited by 20 · see citing works
Self-citationNilsson, T., Arkhammar, P. O. G., & Berggren, P. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81325-1 · Cited by 20 · see citing works
Remote control of glucose-sensing neurons to analyze glucose metabolism
Alvarsson, A., & Stanley, S. A. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00469.2017 · Cited by 20 · see citing works
“Increasing glucose concentrations increase glucose metabolism and the intracellular ATPto-ADP ratio (97), which, in some GE neurons, leads to closure of the KATP channel, resulting in depolarization and activation (2).”
BackgroundSjöholm, Å. (1998) · Endocrine · doi:10.1385/endo:9:1:1 · Cited by 19 · see citing works
Rasschaert, J., & Malaisse, W. J. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90040-b · Cited by 18 · see citing works
Self-citationKetone bodies and islet function: 86Rb handling and metabolic data
Malaisse, W. J., Lebrun, P., Rasschaert, J., Blachier, F., Yilmaz, T., & Sener, A. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.1.e123 · Cited by 17 · see citing works
Self-citationTsuura, Y., Fujimoto, S., Kajikawa, M., Ishida, H., & Seino, Y. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1052 · Cited by 17 · see citing works
Ammon, H. P. T., Bacher, M., Brändle, W. F., Waheed, A., Roenfeldt, M., el-Sayed, M. E., Ahmed, A. A. E., & Wahl, M. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560583 · Cited by 17 · see citing works
“Glucose-induced insulin secretion is closely related to the metabolism of glucose through the formation of critical metabolic products including ATP (Cook & Hales 1984, Malaisse & Sener 1987) and reduced pyridine nucleotides (Ammon & Wahl 1994).”
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Sodium‐Calcium Exchange in the Pancreatic B Cella
Herchuelz, A., & Plasman, P.-O. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb17361.x · Cited by 16 · see citing works
Malaisse, W. J., Rasschaert, J., Conget, I., & Sener, A. (1991) · International Journal of Biochemistry · doi:10.1016/0020-711x(91)90085-2 · Cited by 16 · see citing works
Self-citationGomis, R., Novials, A., Coves, M. J., Casamitjana, R., & Malaisse, W. J. (1989) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(89)90029-6 · Cited by 15 · see citing works
Self-citationLeclerc, I., Xavier, G. D. S., & Rutter, G. A. (2002) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(02)71041-6 · Cited by 15 · see citing works
Opposite effects of d-fructose on total versus cytosolic ATP/ADP ratio in pancreatic islet cells
Giroix, M.-H., Ağaşçioğlu, E., Oguzhan, B., Louchami, K., Zhang, Y., Courtois, P., Malaisse, W. J., & Sener, A. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.003 · Cited by 14 · see citing works
Self-citationReale, V., Hales, C. N., & Ashford, M. L. J. (1994) · The Journal of Membrane Biology · doi:10.1007/bf00233437 · Cited by 14 · see citing works
4 Nutrients as regulators of endocrine and neuroendocrine secretion
Best, L. C., & McLaughlin, J. T. (2004) · Topics in current genetics · doi:10.1007/978-3-540-39898-1_5 · Cited by 13 · see citing works
Hexose metabolism in pancreatic islets: pyruvate carboxylase activity
Curi, R., Carpinelli, Â. R., & Malaisse, W. J. (1991) · Biochimie · doi:10.1016/0300-9084(91)90026-w · Cited by 13 · see citing works
Self-citationCamargo, R. L., Torrezan, R., de Oliveira, J. C., Branco, R. C. S., Barella, L. F., Grassiolli, S., Gravena, C., & Mathias, P. C. D. F. (2013) · Neurological Research · doi:10.1179/1743132812y.0000000112 · Cited by 12 · see citing works
Hexose metabolism in pancreatic islets
Malaisse, W. J., & Sener, A. (1991) · Molecular and Cellular Biochemistry · doi:10.1007/bf00225512 · Cited by 12 · see citing works
“It favours those reactions yielding the major fraction of ATP generated in the islet cells, and ATP is currently considered as the key coupling factor between metabolic and cationic events in the secretory sequence [23].”
BackgroundSelf-citationRegulation of Na+/Ca2+ exchange in the rat pancreatic B cell
Plasman, P. O., & Herchuelz, A. (1992) · Biochemical Journal · doi:10.1042/bj2850123 · Cited by 11 · see citing works
Acute stimulation of pancreatic islets by inhibitors of lactic acid transport
Best, L. C., Trebilcock, R., & Tomlinson, S. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90537-f · Cited by 9 · see citing works
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alpha-Glycerophosphate shuttle in a clonal beta-cell line
Meglasson, M. D., Smith, K. M., NELSON, D. S., & Erecińska, M. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.1.e173 · Cited by 8 · see citing works
Hexamminecobalt(III) Chloride Inhibits Glucose-induced Insulin Secretion at the Exocytotic Process
Tsubamoto, Y., Eto, K., Noda, M., Daniel, S., Suga, S., Yamashita, S., Kasai, H., Wakui, M., Sharp, G. W. G., Kimura, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005816200 · Cited by 8 · see citing works
Role of CFTR’s intrinsic adenylate kinase activity in gating of the Cl− channel
Randak, C. O., & Welsh, M. J. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9119-5 · Cited by 7 · see citing works
Malaisse, W. J. (1990) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-74098-5_6 · Cited by 7 · see citing works
Self-citationHexose metabolism in pancreatic islets
Rasschaert, J., & Malaisse, W. J. (1992) · Biochemical Medicine and Metabolic Biology · doi:10.1016/0885-4505(92)90045-z · Cited by 7 · see citing works
Self-citationOuabain Suppresses ATP Elevation in Response to Fuel Secretagogues in Pancreatic Islets
Tsuura, Y., Ishida, H., Nishimura, M., Fujimoto, S., Kajikawa, M., & Seino, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9240 · Cited by 7 · see citing works
Blachier, F., Mourtada, A., Gomis, R., Sener, A., & Malaisse, W. J. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(91)90055-3 · Cited by 6 · see citing works
Self-citationHexose metabolism in pancreatic islets: Succinate dehydrogenase activity in islet homogenates
Rasschaert, J., & Malaisse, W. J. (1993) · Cell Biochemistry and Function · doi:10.1002/cbf.290110302 · Cited by 5 · see citing works
Self-citationStimulus-Secretion Coupling in the Pancreatic B Cell
Malaisse, W. J. (1988) · Current topics in neuroendocrinology · doi:10.1007/978-3-642-73495-3_8 · Cited by 5 · see citing works
Self-citationStimulation by d-glucose of the synthesis of polyphosphoinositides in pancreatic islets
Blachier, F., & Malaisse, W. J. (1990) · Biochimie · doi:10.1016/0300-9084(90)90001-w · Cited by 5 · see citing works
Self-citation
- Authors
- Malaisse, W. J., & Sener, A.
- Affiliations
- Université Libre de Bruxelles (BE)
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 1987-02
- Volume
- 927
- Issue
- 2
- Pages
- 190-195
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2037863419
- Cited by
- 116
- References
- 29
- Citations by year
- 2023: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2013: 1
- FWCI
- 19.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- Fondation pour la Recherche Médicale
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- glucose, pancreatic islets, cytosolic ATP, ATP/ADP ratio, mitochondrial ATP, digitonin, insulin secretion, energy metabolism
- MeSH terms
- Insulin Secretion, Adenosine Diphosphate, Adenosine Monophosphate, Adenosine Triphosphate, Animals, Cytosol, Digitonin, Glucose, Glutamate Dehydrogenase, Insulin, Ion Channels, Islets of Langerhans, L-Lactate Dehydrogenase, Mitochondria, Potassium, Rats
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