The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes
Open accessAbstract
The aim of this work was to study the mechanism of free radical formation in type 1 diabetes and its possible prevention. We have found oxidation of blood glutathione and an increase in plasma lipoperoxide levels in both human type 1 diabetes and experimental diabetes. Peroxide production by mitochondria does not increase in diabetes. On the contrary, the activity of xanthine oxidase, a superoxide-generating enzyme, increases in liver and plasma of diabetic animals. The increase in plasma xanthine oxidase activity may be explained by the increase in the hepatic release of this enzyme, which is not due to nonspecific membrane damage: release of other hepatic enzymes, such as the amino transferases, does not increase in diabetes. Superoxide formation by aortic rings of rabbits increases significantly in diabetes. This is completely inhibited by allopurinol, an inhibitor of xanthine oxidase. Heparin, which releases xanthine oxidase from the vessel wall, also decreases superoxide formation by aortic rings of diabetic animals. Treatment with allopurinol decreases oxidative stress in type 1 diabetic patients: hemoglobin glycation, glutathione oxidation, and the increase in lipid peroxidation are prevented. These results may have clinical significance in the prevention of late-onset vascular complications of diabetes.
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Cites
Diabetes mellitus and free radicals
Wolff, S. P. (1993) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072637 · Cited by 660
White, C. R., Darley-Usmar, V, Berrington, W. R., McAdams, M., Gore, J. Z., Thompson, J. A., Parks, D. A., Tarpey, M. M., & Freeman, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8745 · Cited by 367
Cited by
Diabetes and Vascular Disease: Pathophysiology, Clinical Consequences, and Medical Therapy: Part I
Creager, M. A., Lüscher, T. F., of, P. W. T. A., Cosentino, F., & Beckman, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000091257.27563.32 · Cited by 1,650
Crans, D. C., Smee, J. J., Gaidamauskas, E., & Yang, L. (2004) · Chemical Reviews · doi:10.1021/cr020607t · Cited by 1,364
Incalza, M. A., D'Oria, R., Natalicchio, A., Perrini, S., Laviola, L., & Giorgino, F. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2017.05.005 · Cited by 1,356
Pacher, P., Nivorozhkin, A., & Szabó, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.6 · Cited by 1,218
A review on the role of antioxidants in the management of diabetes and its complications
Rahimi, R., Nikfar, S., Larijani, B., & Abdollahi, M. (2005) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2005.07.002 · Cited by 889
Metadata
- Authors
- Desco, M.-C., Asensi, M., Márquez, R., Martínez-Valls, J., Vento, M., Pallardó, F. V., Sastre, J., & Viña, J.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-04-01
- Volume
- 51
- Issue
- 4
- Pages
- 1118-1124
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2416837370
- Cited by
- 390
- References
- 2
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Desco, M.-C., Asensi, M., Márquez, R., Martínez-Valls, J., Vento, M., Pallardó, F. V., Sastre, J., & Viña, J. (2002). Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes. Diabetes. https://doi.org/10.2337/diabetes.51.4.1118
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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