Diabetes mellitus and free radicals

Wolff, S P

doi:10.1093/oxfordjournals.bmb.a072637

Cited by 660Advanced Glycation End Products researchAntioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

Diabetes mellitus and free radicals

Wolff, S P·1993·British Medical Bulletin

DOI 10.1093/oxfordjournals.bmb.a072637

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Abstract

Diabetes mellitus is a syndrome initially characterized by a loss of glucose homeostasis. The disease is progressive and is associated with high risk of atherosclerosis, kidney and nerve damage as well as blindness. Abnormalities in the regulation of peroxide and transition metal metabolism are postulated to result in establishment of the disease as well as its longer term complications. Diabetes mellitus is associated with oxidative reactions, particularly those which are catalyzed by decompartmentalized transition metals, but their causative significance in diabetic tissue damage remains to be established.

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Iron excess is a known feature of gestational diabetes and a clear risk factor for diabetes even in normal populations; diabetes is a classical consequence of iron overloading in hereditary haemochromatosis.
“Iron 'excess' is also a known feature of gestational diabetes [591-593], and is a clear risk factor for the disease even in 'normal' populations [594-603], and indeed diabetes is a classical consequence of iron overloading as seen in hereditary haemochromatosis [604].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [595]

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Authors: Wolff, S. P.
Affiliations: University College London (GB)
Corresponding author: Wolff, S P
Venue: British Medical Bulletin
Publisher: Oxford University Press (OUP)
Published: 1993
Volume: 49
Issue: 3
Pages: 642-652
ISSN: 0007-1420 (ISSN-L)
1471-8391
DOI: 10.1093/oxfordjournals.bmb.a072637
OpenAlex: W1953115230
Cited by: 660
References: 0
Citations by year: 2026: 2 · 2025: 9 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 17 · 2018: 11 · 2017: 15 · 2016: 22 · 2015: 32 · 2014: 35 · 2013: 29 · 2012: 31
FWCI: 7.19
Type: journal article
Language: en
Open access: closed
Locations: British Medical Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: diabetes mellitus, free radicals, oxidative stress, glucose homeostasis, peroxide metabolism, atherosclerosis, diabetes complications, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy
MeSH terms: Alloxan, Animals, Arginine, Diabetes Mellitus, Free Radicals, Glucose, Humans, Lysine, Metals, Oxidation-Reduction, Oxygen Consumption, Streptozocin, Lipid Peroxidation, Reactive Oxygen Species, Diabetes Complications, Rats

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