The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes
Open accessAbstract
Vascular endothelial growth factor (VEGF), a major mediator of vascular permeability and angiogenesis, may play a pivotal role in mediating the development and progression of diabetic retinopathy. In the present study, we examined the genetic variations of the VEGF gene to assess its possible relation to diabetic retinopathy in type 2 diabetic patients. Among seven common polymorphisms in the promoter region, 5′-untranslated region (UTR) and 3′UTR of the VEGF gene, genotype distribution of the C(−634)G polymorphism differed significantly (P = 0.011) between patients with (n = 150) and without (n = 118) retinopathy, and the C allele was significantly increased in patients with retinopathy compared with those without retinopathy (P = 0.0037). The odds ratio (OR) for the CC genotype of C(−634)G to the GG genotype was 3.20 (95% CI 1.45–7.05, P = 0.0046). The −634C allele was significantly increased in patients with nonproliferative diabetic retinopathy (non-PDR) (P = 0.0026) and was insignificantly increased in patients with proliferative diabetic retinopathy (PDR) (P = 0.081) compared with patients without retinopathy, although frequencies of the allele did not differ significantly between the non-PDR and PDR groups. Logistic regression analysis revealed that the C(−634)G polymorphism was strongly associated with an increased risk of retinopathy (P = 0.0018). Furthermore, VEGF serum levels were significantly higher in healthy subjects with the CC genotype of the C(−634)G polymorphism than in those with the other genotypes. These data suggest that the C(−634)G polymorphism in the 5′UTR of the VEGF gene is a novel genetic risk factor for diabetic retinopathy.
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Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,338
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220
The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,330
Aiello, L. P., Avery, R. L., Arrigg, P. G., Keyt, B. A., Jampel, H. D., Shah, S. T., Pasquale, L. R., Thieme, H., Iwamoto, M. A., Park, J. E., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199412013312203 · Cited by 3,793
Quandt, K., Frech, K., Karas, H., Wingender, E., & Werner, T. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.23.4878 · Cited by 2,588
Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J. C., & Abraham, J. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99049-6 · Cited by 1,476
Adamis, A. P., Miller, J. W., Bernal, M.-T., D'Amico, D. J., Folkman, J., Yeo, T.-K., & Yeo, K.-T. (1994) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)75794-0 · Cited by 1,296
Watson, C. J., Webb, N. J. A., Bottomley, M. J., & Brenchley, P. E. C. (2000) · Cytokine · doi:10.1006/cyto.2000.0692 · Cited by 735
Renner, W., Kotschan, S., Hoffmann, C., Obermayer-Pietsch, B., & Pilger, E. (2000) · Journal of Vascular Research · doi:10.1159/000054076 · Cited by 545
Tolentino, M. J., Miller, J. W., Gragoudas, E. S., Jakobiec, F. A., Flynn, E., Chatzstefanou, K., Ferrara, N., & Adamis, A. P. (1996) · Ophthalmology · doi:10.1016/s0161-6420(96)30420-x · Cited by 518
Cited by
VEGF: A modifier of the del22q11 (DiGeorge) syndrome?
Stalmans, I., Lambrechts, D., De smet, F., Jansen, S., Wang, J., Maity, S., Kneer, P., von der Ohe, M., Swillen, A., Maes, C., et al. (2003) · Nature Medicine · doi:10.1038/nm819 · Cited by 310
Genetic variation associated with preterm birth: a HuGE review
Crider, K. S., Whitehead, N., & Buus, R. M. (2005) · Genetics in Medicine · doi:10.1097/01.gim.0000187223.69947.db · Cited by 190
Banerjee, S., Bhandary, P., Woodhouse, M., Sen, T. Z., Wise, R. P., & Andorf, C. M. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04120-9 · Cited by 35
Metadata
- Authors
- Awata, T., Inoue, K., Kurihara, S., Ohkubo, T., Watanabe, M., Inukai, K., Inoue, I., & Katayama, S.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-05-01
- Volume
- 51
- Issue
- 5
- Pages
- 1635-1639
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2140694423
- Cited by
- 567
- References
- 19
- FWCI
- 18.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Awata, T., Inoue, K., Kurihara, S., Ohkubo, T., Watanabe, M., Inukai, K., Inoue, I., & Katayama, S. (2002). A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes. Diabetes. https://doi.org/10.2337/diabetes.51.5.1635
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