Genetic variation associated with preterm birth: a HuGE review

Crider, Krista S.; Whitehead, Nedra; Buus, Rebecca M.

doi:10.1097/01.gim.0000187223.69947.db

Cited by 190Preterm Birth and ChorioamnionitisInfant Development and Preterm CareGenetic Associations and Epidemiology

Genetic variation associated with preterm birth: a HuGE review

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Crider, Krista S., Whitehead, Nedra, Buus, Rebecca M.·2005·Genetics in Medicine

DOI 10.1097/01.gim.0000187223.69947.db

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Abstract

Preterm birth (PTB) is a major public health concern because of its high prevalence, associated mortality and morbidity, and expense from both short-term hospitalization and long-term disability. In 2002, 11.9% of U.S. births occurred before 37 weeks gestation. Epidemiologic studies have identified many demographic, behavioral, and medical characteristics associated with PTB risk. In addition, recent evidence indicates a role for genetic susceptibility. We reviewed 18 studies published before June 1, 2004, that examined associations between polymorphisms in the maternal or fetal genome and PTB risk. Studies of a polymorphism in tumor necrosis factor-alpha, a proinflammatory cytokine, showed the most consistent increase in the risk of PTB. Environmental factors such as infection, stress, and obesity, which activate inflammatory pathways, have been associated with PTB, suggesting that environmental and genetic risk factors might operate and interact through related pathways. This review highlights maternal and fetal genetic susceptibilities to PTB, the potential relationships with environmental risk factors, and the need for additional well-designed studies of this critical public health problem.

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Fetal and maternal genotypes modify the risk of preterm delivery.
“The fetal and maternal genotypes modify the risk of preterm delivery.135”
From Epidemiology and causes of preterm birth (2008) · cites this paper as [135]
Genetic association studies have identified single-nucleotide polymorphisms in several genes associated with preterm labour and PPROM.
“Genetic association studies have been used to identify single-nucleotide polymorphisms in several genes associated with preterm labour and PPROM.133, 134, 135”
From Epidemiology and causes of preterm birth (2008) · cites this paper as [135]

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Authors: Crider, K. S., Whitehead, N., & Buus, R. M.
Affiliations: Centers for Disease Control and Prevention (US)
ORCID: Crider, Krista S.
Whitehead, Nedra
Venue: Genetics in Medicine
Publisher: Elsevier BV
Published: 2005-11
Volume: 7
Issue: 9
Pages: 593-604
ISSN: 1098-3600 (ISSN-L)
DOI: 10.1097/01.gim.0000187223.69947.db
OpenAlex: W2063627864
Cited by: 190
References: 121
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 8 · 2015: 6 · 2014: 13 · 2013: 13 · 2012: 13
FWCI: 2.27
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5923 d)
Locations: Genetics in Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: preterm birth, genetic susceptibility, TNF-α, TNF-alpha polymorphism, genetic polymorphism, maternal genetic risk, inflammation, infection, stress, obesity, environmental risk factors, gene-environment interaction
MeSH terms: Environmental Exposure, Female, Fetal Proteins, Humans, Interleukins, Pregnancy, Risk Factors, Tumor Necrosis Factor-alpha, Genetic Variation, Receptors, Adrenergic, beta-2, Genetic Predisposition to Disease, Matrix Metalloproteinases, Vascular Endothelial Growth Factor A, Methylenetetrahydrofolate Reductase (NADPH2), Premature Birth, Toll-Like Receptor 4

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Genetic variation associated with preterm birth: a HuGE review

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