The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells
Abstract
Glucagon-like peptide-1 (GLP-1) is released from intestinal L-cells in response to carbohydrate and fat in the diet. Despite the interest in GLP-1 as an antidiabetic agent, very little is known about the mechanism of stimulus-secretion coupling in L-cells. We investigated the electrophysiological events underlying glucose-induced GLP-1 release in the GLP-1-secreting cell line, GLUTag. Cells were studied using perforated-patch and standard whole-cell patch clamp recordings. GLUTag cells were largely quiescent and hyperpolarized in the absence of glucose. Increasing the glucose concentration between 0 and 20 mmol/l decreased the membrane conductance, caused membrane depolarization, and triggered the generation of action potentials. Action potentials were also triggered by tolbutamide (500 μmol/l) and were suppressed by diazoxide (340 μmol/l) or the metabolic inhibitor azide (3 mmol/l), suggesting an involvement of KATP channels. Large tolbutamide-sensitive washout currents developed in standard whole-cell recordings, confirming the presence of KATP channels. RT-PCR detected the KATP channel subunits Kir6.2 and SUR1 and glucokinase. GLP-1 secretion was also stimulated by glucose over the concentration range 0–25 mmol/l and by tolbutamide. Our results suggest that glucose triggers GLP-1 release through closure of KATP channels and action potential generation.
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Cited by
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
Self-citationGastrointestinal regulation of food intake
Cummings, D. E., & Overduin, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30227 · Cited by 1,216
T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1
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Metadata
- Authors
- Reimann, F., & Gribble, F. M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-09-01
- Volume
- 51
- Issue
- 9
- Pages
- 2757-2763
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1996669620
- Cited by
- 292
- References
- 46
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
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