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The Glucagon-Like Peptides

Kieffer, Timothy James, Francis Habener, Joel·1999·Endocrine Reviews
DOI 10.1210/edrv.20.6.0385
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Abstract

I. Introduction II. History of the Incretin Concept: Discovery of Gastric Inhibitory Polypeptide III. Discovery of GLP-1 IV. Structures of GLPs and Family of Glucagon-Related Peptides V. Tissue Distribution of the Expression of GLPs A. Pancreatic α-cells B. Intestinal L cells C. Central nervous system VI. Proglucagon Biosynthesis A. Organization/structure of the proglucagon gene B. Regulation of glucagon gene expression C. Posttranslational processing of proglucagon VII. Regulation of GLP Secretion A. Overview B. Intracellular signals C. Carbohydrates D. Fats E. Proteins F. Endocrine G. Neural H. GLP-2 VIII. Metabolism of GLPs A. GLP-1 B. GLP-2 IX. Physiological Actions of GLPs A. Overview B. Pancreatic islets C. Counterregulatory actions of GLP-1 and leptin on β-cells D. Stomach E. Lung F. Brain G. Liver, skeletal muscle, and fat H. Pituitary, hypothalamus, and thyroid I. Cardiovascular system J. GLP-2 X. GLP Receptors A. Structure B. Signaling C. Distribution D. Regulation E. GLP-2 XI. Pathophysiology o...

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Metadata

Authors
Kieffer, T. J., & Francis Habener, J.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
1999-12-01
Volume
20
Issue
6
Pages
876-913
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv.20.6.0385
OpenAlex
W2017518223
Cited by
1,062
References
49
FWCI
21.28
Type
journal article
Language
en
Open access
closed

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