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Cited by 153Advanced Glycation End Products researchWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and Management

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice

Peppa, Melpomeni, Brem, Harold, Ehrlich, Paul, Zhang, Jian-Gang, Cai, Weijing, Li, Zhu, Croitoru, Anca, Thung, Swan, Vlassara, Helen·2003·Diabetes
DOI 10.2337/diabetes.52.11.2805
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Abstract

Advanced glycoxidation end products (AGEs) are implicated in delayed diabetic wound healing. To test the role of diet-derived AGE on the rate of wound healing, we placed female db/db (+/+) (n = 55, 12 weeks old) and age-matched control db/db (+/-) mice (n = 45) on two diets that differed only in AGE content (high [H-AGE] versus low [L-AGE] ratio, 5:1) for 3 months. Full-thickness skin wounds (1 cm) were examined histologically and for wound closure. Serum 24-h urine and skin samples were monitored for N(epsilon)-carboxymethyl-lysine and methylglyoxal derivatives by enzyme-linked immunosorbent assays. L-AGE-fed mice displayed more rapid wound closure at days 7 and 14 (P < 0.005) and were closed completely by day 21 compared with H-AGE nonhealed wounds. Serum AGE levels increased by 53% in H-AGE mice and decreased by 7.8% in L-AGE mice (P < 0.04) from baseline. L-AGE mice wounds exhibited lower skin AGE deposits, increased epithelialization, angiogenesis, inflammation, granulation tissue deposition, and enhanced collagen organization up to day 21, compared with H-AGE mice. Reepithelialization was the dominant mode of wound closure in H-AGE mice compared with wound contraction that prevailed in L-AGE mice. Thus, increased diet-derived AGE intake may be a significant retardant of wound closure in diabetic mice; dietary AGE restriction may improve impaired diabetic wound healing.

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Metadata

Authors
Peppa, M., Brem, H., Ehrlich, P., Zhang, J.-G., Cai, W., Li, Z., Croitoru, A., Thung, S., & Vlassara, H.
Affiliations
  • Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York
  • Icahn School of Medicine at Mount Sinai (US)
  • Penn State Milton S. Hershey Medical Center (US)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2003-11-01
Volume
52
Issue
11
Pages
2805-2813
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.52.11.2805
OpenAlex
W2153488117
Cited by
153
References
50
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 8 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 14 · 2014: 6 · 2013: 12 · 2012: 12
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (60214, 59424)
  • National Institute of Diabetes and Digestive and Kidney Diseases
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Keywords
dietary AGEs, diabetic wound healing, db/db mice, carboxymethyllysine, methylglyoxal, wound closure, re-epithelialization, angiogenesis, collagen organization, age limits
MeSH terms
Administration, Oral, Animals, Blood Glucose, Diabetes Mellitus, Diet, Mice, Mutant Strains, Skin, Wound Healing, Glycation End Products, Advanced, Mice

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