CoChat
Sign Up
Cited by 153Advanced Glycation End Products researchWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and Management

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice

Peppa, Melpomeni, Brem, Harold, Ehrlich, Paul, Zhang, Jian-Gang, Cai, Weijing, Li, Zhu, Croitoru, Anca, Thung, Swan, Vlassara, Helen·2003·Diabetes
DOI 10.2337/diabetes.52.11.2805
Open this paper in CoChat — free account

Abstract

Advanced glycoxidation end products (AGEs) are implicated in delayed diabetic wound healing. To test the role of diet-derived AGE on the rate of wound healing, we placed female db/db (+/+) (n = 55, 12 weeks old) and age-matched control db/db (+/-) mice (n = 45) on two diets that differed only in AGE content (high [H-AGE] versus low [L-AGE] ratio, 5:1) for 3 months. Full-thickness skin wounds (1 cm) were examined histologically and for wound closure. Serum 24-h urine and skin samples were monitored for N(epsilon)-carboxymethyl-lysine and methylglyoxal derivatives by enzyme-linked immunosorbent assays. L-AGE-fed mice displayed more rapid wound closure at days 7 and 14 (P < 0.005) and were closed completely by day 21 compared with H-AGE nonhealed wounds. Serum AGE levels increased by 53% in H-AGE mice and decreased by 7.8% in L-AGE mice (P < 0.04) from baseline. L-AGE mice wounds exhibited lower skin AGE deposits, increased epithelialization, angiogenesis, inflammation, granulation tissue deposition, and enhanced collagen organization up to day 21, compared with H-AGE mice. Reepithelialization was the dominant mode of wound closure in H-AGE mice compared with wound contraction that prevailed in L-AGE mice. Thus, increased diet-derived AGE intake may be a significant retardant of wound closure in diabetic mice; dietary AGE restriction may improve impaired diabetic wound healing.

Overview

Integrity signals

Registry

Crossref · 10.2337/diabetes.52.11.2805

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 50 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Peppa, M., Brem, H., Ehrlich, P., Zhang, J.-G., Cai, W., Li, Z., Croitoru, A., Thung, S., & Vlassara, H.
Affiliations
  • Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York
  • Icahn School of Medicine at Mount Sinai (US)
  • Penn State Milton S. Hershey Medical Center (US)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2003-11-01
Volume
52
Issue
11
Pages
2805-2813
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.52.11.2805
OpenAlex
W2153488117
Cited by
153
References
50
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 8 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 14 · 2014: 6 · 2013: 12 · 2012: 12
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (60214, 59424)
  • National Institute of Diabetes and Digestive and Kidney Diseases
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Keywords
dietary AGEs, diabetic wound healing, db/db mice, carboxymethyllysine, methylglyoxal, wound closure, re-epithelialization, angiogenesis, collagen organization, age limits
MeSH terms
Administration, Oral, Animals, Blood Glucose, Diabetes Mellitus, Diet, Mice, Mutant Strains, Skin, Wound Healing, Glycation End Products, Advanced, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review