Cited by 369Metabolism, Diabetes, and CancerCardiovascular and exercise physiologyMuscle metabolism and nutrition

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Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans

Chen, Zhi-Ping, Stephens, Terry J., Murthy, Sid, Canny, Benedict J., Hargreaves, Mark, Witters, Lee A., Kemp, Bruce E., McConell, Glenn K.·2003·Diabetes

DOI 10.2337/diabetes.52.9.2205

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Abstract

The effect of exercise intensity on skeletal muscle AMP-activated protein kinase (AMPK) signaling and substrate metabolism was examined in eight men cycling for 20 min at each of three sequential intensities: low (40 ± 2% Vo2 peak), medium (59 ± 1% Vo2 peak), and high (79 ± 1% Vo2 peak). Muscle free AMP/ATP ratio only increased at the two higher exercise intensities (P < 0.05). AMPK α1 (1.5-fold) and AMPK α2 (5-fold) activities increased from low to medium intensity, with AMPK α2 activity increasing further from medium to high intensity. The upstream AMPK kinase activity was substantial at rest and only increased 50% with exercise, indicating that, initially, signaling through AMPK did not require AMPK kinase posttranslational modification. Acetyl-CoA carboxylase (ACC)-β phosphorylation was sensitive to exercise, increasing threefold from rest to low intensity, whereas neuronal NO synthase (nNOS)μ phosphorylation was only observed at the higher exercise intensities. Glucose disappearance (tracer) did not increase from rest to low intensity, but increased sequentially from low to medium to high intensity. Calculated fat oxidation increased from rest to low intensity in parallel with ACCβ phosphorylation, then declined during high intensity. These results indicate that ACCβ phosphorylation is especially sensitive to exercise and tightly coupled to AMPK signaling and that AMPK activation does not depend on AMPK kinase activation during exercise.

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Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
A Flexible System of Enzymatic Analysis
Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050
Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration
Romijn, J. A., Coyle, E. F., Sidossis, L. S., Gastaldelli, A., Horowitz, J. F., Endert, E., & Wolfe, R. R. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.3.e380 · Cited by 1,747
Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase
Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264
5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232
Table of nonprotein respiratory quotient: an update.
Péronnet, F., & Massicotte, D. (1991) · PubMed · Cited by 1,209
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
Merrill, G. F., Kurth, E. J., Hardie, D. G., & Winder, W. W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1107 · Cited by 1,048
The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways
Fryer, L. G. D., Patel, A. P., & Carling, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202489200 · Cited by 1,035
Glycogen, Glycolytic Intermediates and High-Energy Phosphates Determined in Biopsy Samples of Musculus Quadriceps Femoris of Man at Rest. Methods and Variance of Values
Harris, R. C., Hultman, E., & Nordesjö, L. ‐. (1974) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517409082477 · Cited by 948
The effects of increasing exercise intensity on muscle fuel utilisation in humans
van Loon, L. J. C., Greenhaff, P. L., Constantin‐Teodosiu, D., Saris, W. H. M., & Wagenmakers, A. J. M. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00295.x · Cited by 897

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Merry, T. L., Dywer, R. M., Bradley, E., Rattigan, S., & McConell, G. K. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01335.2009 · Cited by 21
Self-citation
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Champ, C. E., Francis, L. K., Klement, R. J., Dickerman, R., & Smith, R. P. (2016) · Prostate Cancer · doi:10.1155/2016/9462975 · Cited by 22
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Promoter-specific regulation of PPARGC1A gene expression in human skeletal muscle
Popov, D. V., Lysenko, E. A., Vepkhvadze, T. F., Kurochkina, N. S., Makhnovskii, P. A., & Виноградова, О. Л. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0150 · Cited by 22
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Self-citation
[AMPK as a cellular energy sensor and its function in the organism].
Miranda, N., Tovar, A. R., Palacios, B., & Torres, N. (2007) · PubMed · Cited by 21
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McConell, G. K., Manimmanakorn, A., Lee, R. S., Kemp, B. E., Linden, K. C., & Wadley, G. D. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01371.2007 · Cited by 22
Self-citation
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Self-citation
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A review of the signaling pathways of aerobic and anaerobic exercise on atherosclerosis
Liu, S., Liu, Y., Liu, Z., Hu, Y., & Jiang, M. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.30989 · Cited by 18
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Morishima, T., Iemitsu, M., & Ochi, E. (2019) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13434 · Cited by 17
Glucose Uptake After Resistance Training of Different Intensities but of Equal Work Volume
Luebbers, P. E., Potteiger, J. A., Warren, B. J., Clore, J. N., Jennings, C., & Bond, D. S. (2008) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31816d456f · Cited by 17
AMPK/mTOR balance during exercise: implications for insulin resistance in aging muscle
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Maughan, R. (2006) · Routledge eBooks · doi:10.4324/9780203967430 · Cited by 21
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Diao, Y., Nie, J., Tan, P., Zhao, Y., Zhao, T., Tu, J., Ji, H., Cao, Y., Wu, Z., Liang, H., et al. (2020) · Aging · doi:10.18632/aging.103401 · Cited by 14
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Cook, N., Fraser, S. A., Katerelos, M., Katsis, F., Gleich, K., Mount, P. F., Steinberg, G. R., Levidiotis, V., Kemp, B. E., & Power, D. A. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90372.2008 · Cited by 13
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de Carvalho, C. D., Valentim, R. R., Navegantes, L. C. C., & Papoti, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-22958-8 · Cited by 6
Phosphatidylinositol 3-kinase p110α mediates phosphorylation of AMP-activated protein kinase in myoblasts.
Matheny, R. W., Geddis, A., Abdalla, M. N., & Leandry, L. A. (2016) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2015.12.118 · Cited by 6
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Su, R., Luo, Y., BoHui, W., Hou, Y., Zhao, L., Su, L. C., Yao, D., Qian, Y., & Jin, Y. (2019) · Small Ruminant Research · doi:10.1016/j.smallrumres.2019.106023 · Cited by 5
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Persinger, A., Butawan, M. B., Faietti, M., Pryke, A., Rose, K., van der Merwe, M., Bloomer, R. J., & Puppa, M. (2021) · Nutrients · doi:10.3390/nu13051717 · Cited by 5
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A Combination of Soy Isoflavone and L-Carnitine Improves Running Endurance in Mice
Lee, J. R., Joh, Y., Choi, C., Kim, K., & Lee, Y. (2023) · Nutrients · doi:10.3390/nu15173678 · Cited by 4
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Spagnolo, A., Klug, S., Schenkl, C., & Schwarzer, M. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00283.x · Cited by 4
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Li, X., Gao, M. Y., & Hua, J. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-04745-1 · Cited by 4
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Afzalpour, M. E., Yousefi, M. R., Eivari, S., & Ilbeigi, S. (2016) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2016.60911 · Cited by 4
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Nutritional interventions to promote post-exercise muscle protein synthesis
Koopman, R. (2006) · Research Publications (Maastricht University) · doi:10.26481/dis.20060622rk · Cited by 4
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El-Mesallamy, A. M. D., Mahmoud, S. A., Elazab, K. M., Hussein, S. A. M., & Hussein, A. M. (2018) · Acta Scientiarum Polonorum Technologia Alimentaria · doi:10.17306/j.afs.2018.0567 · Cited by 3
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Scott, J. W. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6382-6_9 · Cited by 2
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Günaydın, G., & Gedik, M. E. (2018) · Bozok Tıp Dergisi · doi:10.16919/bozoktip.434074 · Cited by 2

Authors: Chen, Z.-P., Stephens, T. J., Murthy, S., Canny, B. J., Hargreaves, M., Witters, L. A., Kemp, B. E., & McConell, G. K.
Affiliations: St. Vincent’s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
Monash University (AU)
The University of Melbourne (AU)
Deakin University (AU)
Dartmouth College (US)
ORCID: Hargreaves, Mark
Kemp, Bruce E.
McConell, Glenn K.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2003-09-01
Volume: 52
Issue: 9
Pages: 2205-2212
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.52.9.2205
OpenAlex: W2142716760
Cited by: 369
References: 55
Citations by year: 2026: 9 · 2025: 13 · 2024: 10 · 2023: 11 · 2022: 18 · 2021: 12 · 2020: 26 · 2019: 16 · 2018: 16 · 2017: 15 · 2016: 17 · 2015: 18 · 2014: 20 · 2013: 20 · 2012: 14
FWCI: 5.64
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
National Institutes of Health
National Health and Medical Research Council
National Medical Research Council
National Institute of Diabetes and Digestive and Kidney Diseases (DK-35712, R01DK035712)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: exercise intensity, AMPK, skeletal muscle, neuronal nitric oxide synthase, glucose disappearance, fat oxidation, substrate metabolism
MeSH terms: AMP-Activated Protein Kinase Kinases, Adult, Physical Exertion, Fatty Acids, Nonesterified, Glucose, Humans, Male, Nitric Oxide, Oxygen Consumption, Phosphorylation, Protein Kinases, Rest, Signal Transduction, Muscle, Skeletal, Nitric Oxide Synthase, Nitric Oxide Synthase Type I

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Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans

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