Cited by 21Adipose Tissue and MetabolismMuscle Physiology and DisordersMitochondrial Function and Pathology

Targeting skeletal muscle mitochondrial health in obesity

Open access
Pileggi, Chantal A., Hooks, Breana G., McPherson, Ruth, Dent, Robert R.M., Harper, Mary-Ellen·2022·Clinical Science

Abstract

Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch between fatty acid and glucose substrates) are altered in obesity, with some changes proceeding and some following the development of the disease. Nonetheless, there are marked interindividual differences in skeletal muscle composition and metabolism in obesity, some of which have been associated with obesity risk and weight loss capacity. In this review, we discuss related molecular mechanisms and how current and novel treatment strategies may enhance weight loss capacity, particularly in diet-resistant obesity.

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Crossref · 10.1042/cs20210506

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  • Mitochondrial dysfunction, characterized by reduced mitochondrial size and activity, is prevalent in individuals with obesity and T2DM.

    “Mitochondrial dysfunction, characterized by reduced mitochondrial size and activity, is prevalent in individuals with obesity and T2DM and is a known contributor to muscle wasting in ageing and some chronic diseases.”

    From The Effects of Glucagon-Like Peptide-1 Receptor Agonists on Mitochondrial Function Within Skeletal Muscle: A Systematic Review (2025) · cites this paper as [30]

    The review’s Skeletal muscle and mitochondrial bioenergetics section reports reduced mitochondrial content and impaired mitochondrial function in obesity; its Aerobic exercise section says mitochondria appear smaller in skeletal muscle from people with obesity. The passages do not establish that reduced mitochondrial size and activity are also prevalent in people with T2DM. (LLM, conf=0.82)

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3 of the 395 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [69]Goldberg G.R., Black A.E., Prentice A.M. and Coward W. (1991) No evidence of lower energy expenditure in post-obese women. Proc. Nutr. Soc. 50, 109A, [Abstract]

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Authors
Pileggi, C. A., Hooks, B. G., McPherson, R., Dent, R. R. M., & Harper, M.-E.
Affiliations
  • University of Ottawa (CA)
  • Ottawa Heart Institute (CA)
Corresponding author
Harper, Mary-Ellen
Venue
Clinical Science
Published
2022-07
Volume
136
Issue
14
Pages
1081-1110
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
OpenAlex
W4288046809
Cited by
21
References
395
Citations by year
2026: 5 · 2025: 8 · 2024: 4 · 2023: 3 · 2022: 1
FWCI
0.55
Type
journal article
Language
en
Open access
Locations
  • Clinical Science (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research (143278_1)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
skeletal muscle, mitochondrial function, obesity, mitochondrial biogenesis, muscle fiber type, substrate metabolism, fatty acid oxidation, glucose utilization, interindividual variability, obesity risk, obesity treatment strategies
MeSH terms
Fatty Acids, Humans, Mitochondria, Mitochondria, Muscle, Obesity, Weight Loss, Muscle, Skeletal

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