The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Endothelial Progenitor Cell Dysfunction
Abstract
Type 1 diabetes is associated with reduced vascular repair, as indicated by impaired wound healing and reduced collateral formation in ischemia. Recently, endothelial progenitor cells (EPCs) have been identified as important regulators of these processes. We therefore explored the concept that EPCs are dysfunctional in diabetes. The number of EPCs obtained from type 1 diabetic patients in culture was 44% lower compared with age- and sex-matched control subjects (P < 0.001). This reduction was inversely related to levels of HbA1c (R = −0.68, P = 0.01). In addition, we demonstrated that patient EPCs were also impaired in function using an in vitro angiogenesis assay. Conditioned media from patient EPCs were significantly reduced in their capacity to support endothelial tube formation in comparison to control EPCs. Therefore, despite culturing the EPCs under normoglycemic conditions, functional differences between patient and control EPCs were maintained. Our findings demonstrate that adverse metabolic stress factors in type 1 diabetes are associated with reduced EPC numbers and angiogenicity. We hypothesize that EPC dysfunction contributes to the pathogenesis of vascular complications in type 1 diabetes.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
Hill, J. M., Zalos, G., Halcox, J. P. J., Schenke, W. H., Waclawiw, M. A., Quyyumi, A. A., & Finkel, T. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022287 · Cited by 3,423
Cited by
Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Urbich, C., & Dimmeler, S. (2004) · Circulation Research · doi:10.1161/01.res.0000137877.89448.78 · Cited by 2,369
Endothelial progenitor cells in cardiovascular disorders
Shantsila, E., Watson, T., & Lip, G. Y. H. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.050 · Cited by 413
Aging and disease as modifiers of efficacy of cell therapy
Dimmeler, S., & Leri, A. (2008) · Circulation Research · doi:10.1161/circresaha.108.175943 · Cited by 379
Huang, P., Li, S., Han, M., Xiao, Z., Yang, R., & Han, Z. C. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2155 · Cited by 351
Xiao-Yun, X., Zhao-Hui, M., Ke, C., Hong-Hui, H., & Yan-Hong, X. (2011) · Medical Science Monitor · doi:10.12659/msm.881383 · Cited by 88
Metadata
- Authors
- Loomans, C. J. M., de Koning, E. J. P., Staal, F. J. T., Rookmaaker, M. B., Verseyden, C., de Boer, H. C., Verhaar, M. C., Braam, B., Rabelink, T. J., & van Zonneveld, A.-J.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-01-01
- Volume
- 53
- Issue
- 1
- Pages
- 195-199
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2142041241
- Cited by
- 839
- References
- 2
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Loomans, C. J. M., de Koning, E. J. P., Staal, F. J. T., Rookmaaker, M. B., Verseyden, C., de Boer, H. C., Verhaar, M. C., Braam, B., Rabelink, T. J., & van Zonneveld, A.-J. (2004). Endothelial Progenitor Cell Dysfunction. Diabetes. https://doi.org/10.2337/diabetes.53.1.195
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