The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Autologous Transplantation of Granulocyte Colony–Stimulating Factor–Mobilized Peripheral Blood Mononuclear Cells Improves Critical Limb Ischemia in Diabetes
Open accessAbstract
OBJECTIVE— To assess the application of autologous transplantation of granulocyte colony–stimulating factor (G-CSF)–mobilized peripheral blood mononuclear cells (PBMNCs) in the treatment of critical limb ischemia (CLI) of diabetic patients and to evaluate the safety, efficacy, and feasibility of this novel therapeutic approach. RESEARCH DESIGN AND METHODS—Twenty-eight diabetic patients with CLI were enrolled and randomized to either the transplant group or the control group. In the transplant group, the patients received subcutaneous injections of recombinant human G-CSF (600 μg/day) for 5 days to mobilize stem/progenitor cells, and their PBMNCs were collected and transplanted by multiple intramuscular injections into ischemic limbs. All of the patients were followed up after at least 3 months. RESULTS—At the end of the 3-month follow-up, the main manifestations, including lower limb pain and ulcers, were significantly improved in the patients of the transplant group. Their laser Doppler blood perfusion of lower limbs increased from 0.44 ± 0.11 to 0.57 ± 0.14 perfusion units (P < 0.001). Mean ankle-brachial pressure index increased from 0.50 ± 0.21 to 0.63 ± 0.25 (P < 0.001). A total of 14 of 18 limb ulcers (77.8%) of transplanted patients were completely healed after cell transplantation, whereas only 38.9% of limb ulcers (7 of 18) were healed in the control patients (P = 0.016 vs. the transplant group). No adverse effects specifically due to cell transplantation were observed, and no lower limb amputation occurred in the transplanted patients. In contrast, five control patients had to receive a lower limb amputation (P = 0.007, transplant vs. control group). Angiographic scores were significantly improved in the transplant group when compared with the control group (P = 0.003). CONCLUSIONS—These results provide pilot evidence indicating that the autologous transplantation of G-CSF–mobilized PBMNCs represents a simple, safe, effective, and novel therapeutic approach for diabetic CLI.
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1 retracted
Angiogenesis by Implantation of Peripheral Blood Mononuclear Cells and Platelets Into Ischemic Limbs
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Endothelial Progenitor Cell Dysfunction
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Cited by
Lipsky, B. A., Berendt, A. R., Cornia, P. B., Pile, J. C., Peters, E. J. G., Armstrong, D. G., Deery, H. G., Embil, J. M., Joseph, W. S., Karchmer, A. W., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis346 · Cited by 1,766
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A systematic review and meta-analysis of tests to predict wound healing in diabetic foot.
Wang, Z., Hasan, R., Firwana, B., Elraiyah, T., Tsapas, A., Prokop, L., Mills, J. L., & Murad, M. H. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2015.10.004 · Cited by 173
Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation
Keighron, C., Lyons, C. J., Creane, M., O'Brien, T., & Liew, A. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00354 · Cited by 74
Metadata
- Authors
- Huang, P., Li, S., Han, M., Xiao, Z., Yang, R., & Han, Z. C.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2005-09-01
- Volume
- 28
- Issue
- 9
- Pages
- 2155-2160
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2022248346
- Cited by
- 351
- References
- 26
- FWCI
- 17.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huang, P., Li, S., Han, M., Xiao, Z., Yang, R., & Han, Z. C. (2005). Autologous Transplantation of Granulocyte Colony–Stimulating Factor–Mobilized Peripheral Blood Mononuclear Cells Improves Critical Limb Ischemia in Diabetes. Diabetes Care. https://doi.org/10.2337/diacare.28.9.2155
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