Endothelial progenitor cells in cardiovascular disorders

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725 · see citing works

Bone marrow cells regenerate infarcted myocardium

Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J. M., McKay, R. D. G., Nadal‐Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,149 · see citing works

Circulating endothelial progenitor cells, vascular function, and cardiovascular risk

Hill, J. M., Zalos, G., Halcox, J. P. J., Schenke, W. H., Waclawiw, M. A., Quyyumi, A. A., & Finkel, T. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022287 · Cited by 3,423 · see citing works

Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization

Asahara, T., Masuda, H., Takahashi, T., Kalka, C., Pastore, C., Silver, M., Kearne, M., Magner, M., & Isner, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.3.221 · Cited by 3,249 · see citing works

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

Krause, D. S., Theise, N. D., Collector, M. I., Henegariu, O., Hwang, S., Gardner, R. L., Neutzel, S., & Sharkis, S. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00328-2 · Cited by 2,661 · see citing works

Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

Kocher, A. A., Schuster, M., Szabolcs, M., Takuma, S., Burkhoff, D., Wang, J., Homma, S., Edwards, N. M., & Itescu, S. (2001) · Nature Medicine · doi:10.1038/86498 · Cited by 2,537 · see citing works

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization

Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J. M., & Asahara, T. (1999) · Nature Medicine · doi:10.1038/7434 · Cited by 2,421 · see citing works

Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease

Vasa‐Nicotera, M., Fichtlscherer, S., Aicher, A., Adler, K., Urbich, C., Martin, H., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh1301.093953 · Cited by 2,328 · see citing works

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

Aßmus, B., Schächinger, V., Teupe, C., Britten, M. B., Lehmann, R., Döbert, N., Grünwald, F., Aicher, A., Urbich, C., Martin, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000043246.74879.cd · Cited by 2,199 · see citing works

Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial

Wollert, K. C., Meyer, G. P., Lotz, J., Ringes‐Lichtenberg, S., Lippolt, P., Breidenbach, C., Fichtner, S., Korte, T., Hornig, B., Messinger, D., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16626-9 · Cited by 2,188 · see citing works

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

Murry, C. E., Soonpaa, M. H., Reinecke, H., Nakajima, H., Nakajima, H. O., Rubart, M., Pasumarthi, K. B. S., Virag, J. A. I., Bartelmez, S. H., Poppa, V., et al. (2004) · Nature · doi:10.1038/nature02446 · Cited by 2,154 · see citing works

Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans

Strauer, B. E., Brehm, M. U., Zeus, T., Köstering, M., Hernandez, A., Sorg, R. V., Kögler, G., & Wernet, P. (2002) · Circulation · doi:10.1161/01.cir.0000034046.87607.1c · Cited by 2,065 · see citing works

Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization

Kalka, C., Masuda, H., Takahashi, T., Kalka-Moll, W. M., Silver, M., Kearney, M., Li, T., Isner, J. M., & Asahara, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3422 · Cited by 1,862 · see citing works

VEGF contributes to postnatal neovascularization by mobilizing bone marrow‐derived endothelial progenitor cells

Asahara, T., Takahashi, T., Masuda, H., Kalka, C., Chen, D., Iwaguro, H., Inai, Y., Silver, M., & Isner, J. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3964 · Cited by 1,856 · see citing works

Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial

Tateishi-Yuyama, E., Matsubara, H., Murohara, T., Ikeda, U., Shintani, S., Masaki, H., Amano, K., Kishimoto, Y., Yoshimoto, K., Akashi, H., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09670-8 · Cited by 1,734 · see citing works

Peripheral Blood “Endothelial Progenitor Cells” Are Derived From Monocyte/Macrophages and Secrete Angiogenic Growth Factors

Rehman, J., Li, J., Orschell, C. M., & March, K. L. (2003) · Circulation · doi:10.1161/01.cir.0000058702.69484.a0 · Cited by 1,682 · see citing works

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

Rafii, S., & Lyden, D. C. (2003) · Nature Medicine · doi:10.1038/nm0603-702 · Cited by 1,572 · see citing works

Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures

Tepper, O. M., Galiano, R. D., Capla, J. M., Kalka, C., Gagne, P. J., Jacobowitz, G. R., Levine, J. P., & Gurtner, G. C. (2002) · Circulation · doi:10.1161/01.cir.0000039526.42991.93 · Cited by 1,447 · see citing works

Autologous bone-marrow stem-cell transplantation for myocardial regeneration

Stamm, C., Westphal, B., Kleine, H., Petzsch, M., Kittner, C., Klinge, H., Schümichen, C., Nienaber, C. A., Freund, M., & Steinhoff, G. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12110-1 · Cited by 1,354 · see citing works

Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease

Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420702 · Cited by 1,340 · see citing works

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

Aicher, A., Heeschen, C., Mildner-Rihm, C., Urbich, C., Ihling, C. H., Technau‐Ihling, K., Zeiher, A. M., & Dimmeler, S. (2003) · Nature Medicine · doi:10.1038/nm948 · Cited by 1,297 · see citing works

Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial

Janssens, S. P., Dubois, C., Bogaert, J. G., Theunissen, K., Deroose, C. M., Desmet, W. J., Kalantzi, M. V., Herbots, L., Sinnaeve, P., Dens, J. A., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67861-0 · Cited by 1,293 · see citing works

Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure

Perin, E. C., Dohmann, H. F. R., Borojević, R., Silva, S. A., Sousa, A., Mesquita, C. T., Rossi, M. I. D., de Carvalho, A. C. C., Dutra, H. S., Dohmann, H. J. F., et al. (2003) · Circulation · doi:10.1161/01.cir.0000070596.30552.8b · Cited by 1,288 · see citing works

Vascular Endothelial Growth Factor

Ferrara, N. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179663 · Cited by 1,283 · see citing works

Current Perspectives on Statins

Maron, D. J., Fazio, S., & Linton, M. F. (2000) · Circulation · doi:10.1161/01.cir.101.2.207 · Cited by 1,217 · see citing works

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

Dimmeler, S., Aicher, A., Vasa‐Nicotera, M., Mildner-Rihm, C., Adler, K., Tiemann, M., Rütten, H., Fichtlscherer, S., Martin, H., & Zeiher, A. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13152 · Cited by 1,206 · see citing works

Endothelial Dysfunction

Endemann, D. H., & Schiffrin, E. L. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000132474.50966.da · Cited by 1,198 · see citing works

Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction

Shintani, S., Murohara, T., Ikeda, H., Ueno, T., Honma, T., Katoh, A., Sasaki, K., Shimada, T., Oike, Y., & Imaizumi, T. (2001) · Circulation · doi:10.1161/hc2301.092122 · Cited by 1,185 · see citing works

Stromal Cell–Derived Factor-1 Effects on Ex Vivo Expanded Endothelial Progenitor Cell Recruitment for Ischemic Neovascularization

Yamaguchi, J.-I., Kusano, K. F., Masuo, O., Kawamoto, A., Silver, M., Murasawa, S., Bosch‐Marcé, M., Masuda, H., Losordo, D. W., Isner, J. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000055313.77510.22 · Cited by 1,149 · see citing works

Myoblast transplantation for heart failure

Menasché, P., Hagège, A. A., Scorsin, M., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03617-5 · Cited by 1,128 · see citing works

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction

Schächinger, V., Aßmus, B., Britten, M. B., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.08.014 · Cited by 1,092 · see citing works

Bone marrow–derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation

Nygren, J., Jovinge, S. V., Breitbach, M., Säwén, P., Roell, W., Hescheler, J., Taneera, J., Fleischmann, B. K., & Jacobsen, S. E. W. (2004) · Nature Medicine · doi:10.1038/nm1040 · Cited by 1,036 · see citing works

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

Dimmeler, S., Aicher, A., Vasa‐Nicotera, M., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113152 · Cited by 1,025 · see citing works

Increase in Circulating Endothelial Progenitor Cells by Statin Therapy in Patients With Stable Coronary Artery Disease

Vasa‐Nicotera, M., Fichtlscherer, S., Adler, K., Aicher, A., Martin, H., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation · doi:10.1161/hc2401.092816 · Cited by 1,007 · see citing works

Regular Physical Exercise Corrects Endothelial Dysfunction and Improves Exercise Capacity in Patients With Chronic Heart Failure

Hambrecht, R., Fiehn, E., Weigl, C., Gielen, S., Hamann, C., Kaiser, R., Yu, J., Adams, V., Niebauer, J., & Schuler, G. C. (1998) · Circulation · doi:10.1161/01.cir.98.24.2709 · Cited by 963 · see citing works

Implantation of Bone Marrow Mononuclear Cells Into Ischemic Myocardium Enhances Collateral Perfusion and Regional Function via Side Supply of Angioblasts, Angiogenic Ligands, and Cytokines

Kamihata, H., Matsubara, H., Nishiue, T., Fujiyama, S., Tsutsumi, Y., Ozono, R., Masaki, H., Mori, Y., Iba, O., Tateishi, E., et al. (2001) · Circulation · doi:10.1161/hc3501.093817 · Cited by 948 · see citing works

Statin Therapy Accelerates Reendothelialization

Walter, D. H., Rittig, K., Bahlmann, F. H., Kirchmair, R., Silver, M., Murayama, T., Nishimura, H., Losordo, D. W., Asahara, T., & Isner, J. M. (2002) · Circulation · doi:10.1161/01.cir.0000018166.84319.55 · Cited by 918 · see citing works

Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon

Eto, T., & Takahashi, H. (1999) · Nature Medicine · doi:10.1038/8462 · Cited by 914 · see citing works

Physical Training Increases Endothelial Progenitor Cells, Inhibits Neointima Formation, and Enhances Angiogenesis

Laufs, U., Werner, N., Link, A., Endres, M., Waßmann, S., Jürgens, K., Miche, E., Böhm, M., & Nickenig, G. (2003) · Circulation · doi:10.1161/01.cir.0000109141.48980.37 · Cited by 858 · see citing works

Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation

Tse, H., Kwong, Y., Chan, J. K., Lo, G. G., Ho, C.-L., & Lau, C. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12111-3 · Cited by 848 · see citing works

Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo

Kaushal, S., Amiel, G. E., Guleserian, K. J., Shapira, O. M., Perry, T. E., Sutherland, F. W. H., Aikawa, E. R., Moran, A. M., Schöen, F. J., Atala, A., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1035 · Cited by 841 · see citing works

Endothelial Progenitor Cell Dysfunction

Loomans, C. J. M., de Koning, E. J. P., Staal, F. J. T., Rookmaaker, M. B., Verseijden, C., de Boer, H. C., Verhaar, M. C., Braam, B. G., Rabelink, T. J., & van Zonneveld, A. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.195 · Cited by 841 · see citing works

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

Heeschen, C., Aicher, A., Lehmann, R., Fichtlscherer, S., Vasa‐Nicotera, M., Urbich, C., Mildner-Rihm, C., Martin, H., Zeiher, A. M., & Dimmeler, S. (2003) · Blood · doi:10.1182/blood-2003-01-0223 · Cited by 840 · see citing works

Vascular Trauma Induces Rapid but Transient Mobilization of VEGFR2 + AC133 + Endothelial Precursor Cells

Gill, M., Dias, S., Hattori, K., Rivera, M., Hicklin, D. J., Witte, L., Girardi, L. N., Yurt, R. W., Himel, H. N., & Rafii, S. (2001) · Circulation Research · doi:10.1161/01.res.88.2.167 · Cited by 797 · see citing works

Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells

Urbich, C., Aicher, A., Heeschen, C., Dernbach, E., HOFMANN, W., Zeiher, A. M., & Dimmeler, S. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.07.003 · Cited by 740 · see citing works

HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells

Llevadot, J., Murasawa, S., Kureishi, Y., Uchida, S., Masuda, H., Kawamoto, A., Walsh, K., Isner, J. M., & Asahara, T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13131 · Cited by 701 · see citing works

Intravenous Transfusion of Endothelial Progenitor Cells Reduces Neointima Formation After Vascular Injury

Werner, N., Junk, S., Laufs, U., Link, A., Walenta, K. L. H., Böhm, M., & Nickenig, G. (2003) · Circulation Research · doi:10.1161/01.res.0000083812.30141.74 · Cited by 693 · see citing works

Aging, Progenitor Cell Exhaustion, and Atherosclerosis

Rauscher, F. M., Goldschmidt‐Clermont, P. J., Davis, B. H., Wang, T., Gregg, D., Ramaswami, P., Pippen, A. M., Annex, B. H., Dong, C., & Taylor, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000082924.75945.48 · Cited by 674 · see citing works

Physical Training Improves Endothelial Function in Patients With Chronic Heart Failure

Hornig, B., Maier, V., & Drexler, H. (1996) · Circulation · doi:10.1161/01.cir.93.2.210 · Cited by 628 · see citing works

Effect of Diabetes Mellitus on Formation of Coronary Collateral Vessels

Abacı, A., Oğuzhan, A., Kahraman, S., Eryol, N. K., Ünal, S., Arınç, H., & Ergin, A. (1999) · Circulation · doi:10.1161/01.cir.99.17.2239 · Cited by 626 · see citing works

Profoundly Reduced Neovascularization Capacity of Bone Marrow Mononuclear Cells Derived From Patients With Chronic Ischemic Heart Disease

Heeschen, C., Lehmann, R., Honold, J., Aßmus, B., Aicher, A., Walter, D. H., Martin, H., Zeiher, A. M., & Dimmeler, S. (2004) · Circulation · doi:10.1161/01.cir.0000124476.32871.e3 · Cited by 617 · see citing works

HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells

Llevadot, J., Murasawa, S., Kureishi, Y., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113131 · Cited by 611 · see citing works

Bone Marrow-Derived Cells Do Not Incorporate Into the Adult Growing Vasculature

Ziegelhoeffer, T., Fernández, B., Sawa Kostin, D., Heil, M., Voswinckel, R., Helisch, A., & Schaper, W. K. A. (2003) · Circulation Research · doi:10.1161/01.res.0000110419.50982.1c · Cited by 604 · see citing works

Exercise training for claudication.

Stewart, K., Hiatt, W., Regensteiner, J., & Hirsch, A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021135 · Cited by 591 · see citing works

Endothelial Progenitor Cell Vascular Endothelial Growth Factor Gene Transfer for Vascular Regeneration

Iwaguro, H., Yamaguchi, J.-I., Kalka, C., Murasawa, S., Masuda, H., Hayashi, S.-I., Silver, M., Li, T., Isner, J. M., & Asahara, T. (2002) · Circulation · doi:10.1161/hc0602.103673 · Cited by 587 · see citing works

Vascular Endothelial Growth Factor 165 Gene Transfer Augments Circulating Endothelial Progenitor Cells in Human Subjects

Kalka, C., Masuda, H., Takahashi, T., Gordon, R., Tepper, O. M., Gravereaux, E. C., Pieczek, A., Iwaguro, H., Hayashi, S.-I., Isner, J. M., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1198 · Cited by 564 · see citing works

Infarct Remodeling After Intracoronary Progenitor Cell Treatment in Patients With Acute Myocardial Infarction (TOPCARE-AMI)

Britten, M. B., Abolmaali, N., Aßmus, B., Lehmann, R., Honold, J., Schmitt, J., Vogl, T. J., Martin, H., Schächinger, V., Dimmeler, S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000095788.78169.af · Cited by 553 · see citing works

C-Reactive Protein Attenuates Endothelial Progenitor Cell Survival, Differentiation, and Function

Verma, S., Kuliszewski, M. A., Li, S.-H., Szmitko, P. E., Zucco, L., Wang, C., Badiwala, M. V., Mickle, D. A. G., Weisel, R. D., Fedak, P. W. M., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127577.63323.24 · Cited by 523 · see citing works

Endothelial Cells of Hematopoietic Origin Make a Significant Contribution to Adult Blood Vessel Formation

Crosby, J. R., Kaminski, W. E., Schatteman, G. C., Martin, P. J., Raines, E. W., Seifert, R. A., & Bowen‐Pope, D. F. (2000) · Circulation Research · doi:10.1161/01.res.87.9.728 · Cited by 519 · see citing works

Erythropoietin regulates endothelial progenitor cells

Bahlmann, F. H., de Groot, K., Spandau, J.-M., Landry, A. L., Hertel, B., Duckert, T., Boehm, S. M., Menne, J., Haller, H. G., & Fliser, D. (2003) · Blood · doi:10.1182/blood-2003-04-1284 · Cited by 503 · see citing works

Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction

Massa, M., Rosti, V., Ferrario, M., Campanelli, R., Ramajoli, I., Rosso, R., Ferrari, G. M. D., Ferlini, M., Goffredo, L., Bertoletti, A., et al. (2004) · Blood · doi:10.1182/blood-2004-05-1831 · Cited by 482 · see citing works

Endothelial Dysfunction in Human Disease

Drexler, H., & Hornig, B. (1999) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1998.0843 · Cited by 471 · cited 1× · see citing works

Experimental and Clinical Regenerative Capability of Human Bone Marrow Cells After Myocardial Infarction

Fernández‐Avilés, F., Román, J. A. S., García‐Frade, J., Fernández‐Santos, M. E., Peñarrubia, M. J., de la Fuente, L., Gómez-Bueno, M. F., Cantalapiedra, A. M. T., Fernández, J., Gutiérrez, O., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000144798.54040.ed · Cited by 467 · see citing works

Smoking Cessation Rapidly Increases Circulating Progenitor Cells in Peripheral Blood in Chronic Smokers

Kondo, T., Hayashi, M., Takeshita, K., Numaguchi, Y., Kobayashi, K., Iino, S., Inden, Y., & Murohara, T. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000135655.52088.c5 · Cited by 456 · see citing works

Estrogen Increases Bone Marrow–Derived Endothelial Progenitor Cell Production and Diminishes Neointima Formation

Strehlow, K., Werner, N., Berweiler, J., Link, A., Dirnagl, U., Priller, J., Laufs, K., Ghaeni, L., Milošević, M., Böhm, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000077911.81151.30 · Cited by 454 · see citing works

Bone Marrow-Derived Endothelial Progenitor Cells Participate in Cerebral Neovascularization After Focal Cerebral Ischemia in the Adult Mouse

Zhang, Z. G., Zhang, L., Jiang, Q., & Chopp, M. (2002) · Circulation Research · doi:10.1161/hh0302.104460 · Cited by 453 · see citing works

Simvastatin Versus Ezetimibe

Landmesser, U., Bahlmann, F. H., Mueller, M. F., Spiekermann, S., Kirchhoff, N., Schulz, S., Manes, C., Fischer, D., de Groot, K., Fliser, D., et al. (2005) · Circulation · doi:10.1161/01.cir.0000164260.82417.3f · Cited by 425 · see citing works

Estrogen-Mediated, Endothelial Nitric Oxide Synthase–Dependent Mobilization of Bone Marrow–Derived Endothelial Progenitor Cells Contributes to Reendothelialization After Arterial Injury

Iwakura, A., Luedemann, C., Shastry, S., Hanley, A., Kearney, M., Aikawa, R., Isner, J. M., Asahara, T., & Losordo, D. W. (2003) · Circulation · doi:10.1161/01.cir.0000106906.56972.83 · Cited by 414 · see citing works

HMG-CoA Reductase Inhibitors Reduce Senescence and Increase Proliferation of Endothelial Progenitor Cells via Regulation of Cell Cycle Regulatory Genes

Aßmus, B., Urbich, C., Aicher, A., Hofmann, W. K., Haendeler, J., Rössig, L., Spyridopoulos, I., Zeiher, A. M., & Dimmeler, S. (2003) · Circulation Research · doi:10.1161/01.res.0000070067.64040.7c · Cited by 392 · see citing works

Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta

Caplan, B. A., & Schwartz, C. J. (1973) · Atherosclerosis · doi:10.1016/0021-9150(73)90031-2 · Cited by 380 · see citing works

Asymmetric Dimethylarginine and the Risk of Cardiovascular Events and Death in Patients With Coronary Artery Disease

Schnabel, R. B., Blankenberg, S., Lubos, E., Lackner, K. J., Rupprecht, H. J., Espinola–Klein, C., Jachmann, N., Post, F., Peetz, D., Bickel, C., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000181286.44222.61 · Cited by 378 · see citing works

CD34 + and Endothelial Progenitor Cells in Patients With Various Degrees of Congestive Heart Failure

Valgimigli, M., Rigolin, G. M., Fucili, A., Porta, M. G. D., Soukhomovskaia, O., Malagutti, P., Bugli, A. M., Bragotti, L. Z., Francolini, G., Mauro, E., et al. (2004) · Circulation · doi:10.1161/01.cir.0000136813.89036.21 · Cited by 372 · see citing works

Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli

Hoffmann, J., Haendeler, J., Aicher, A., Rössig, L., Vasa‐Nicotera, M., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh2001.097796 · Cited by 355 · see citing works

Local Implantation of Autologous Bone Marrow Cells for Therapeutic Angiogenesis in Patients With Ischemic Heart Disease. Clinical Trial and Preliminary Results.

Hamano, K., Nishida, M., Hirata, K., et al. (2001) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.65.845 · Cited by 348 · see citing works

Age-dependent depression in circulating endothelial progenitor cells inpatients undergoing coronary artery bypass grafting

Scheubel, R. J., Zorn, H., Silber, R., Kuß, O., Morawietz, H., Holtz, J., & Simm, A. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.025 · Cited by 345 · see citing works

Exercise training intervention after coronary angioplasty: the ETICA trial

Belardinelli, R., Paolini, I., Cianci, G., Piva, R., Georgiou, D., & Purcaro, A. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01236-0 · Cited by 342 · see citing works

Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells

Rehman, J., Li, J., Parvathaneni, L., Karlsson, G., Panchal, V. R., Temm, C. J., Mahenthiran, J., & March, K. L. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.02.049 · Cited by 322 · see citing works

Young Adult Bone Marrow–Derived Endothelial Precursor Cells Restore Aging-Impaired Cardiac Angiogenic Function

Edelberg, J. M., Tang, L., Hattori, K., Lyden, D. C., & Rafii, S. (2002) · Circulation Research · doi:10.1161/01.res.0000020861.20064.7e · Cited by 320 · see citing works

Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications

Waltenberger, J. L. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00228-5 · Cited by 310 · see citing works

Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity

Rivard, A., Berthou-Soulié, L., Principe, N., Kearney, M., Curry, C., Branellec, D., Semenza, G. L., & Isner, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001029200 · Cited by 305 · see citing works

Constitutive Human Telomerase Reverse Transcriptase Expression Enhances Regenerative Properties of Endothelial Progenitor Cells

Murasawa, S., Llevadot, J., Silver, M., Isner, J. M., Losordo, D. W., & Asahara, T. (2002) · Circulation · doi:10.1161/01.cir.0000027584.85865.b4 · Cited by 303 · see citing works

Nitric Oxide and Angiogenesis

Cooke, J. P., & Losordo, D. W. (2002) · Circulation · doi:10.1161/01.cir.0000014928.45119.73 · Cited by 302 · see citing works

Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?

Dimmeler, S., & Zeiher, A. M. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0580-x · Cited by 294 · see citing works

Effects of Exercise and Ischemia on Mobilization and Functional Activation of Blood-Derived Progenitor Cells in Patients With Ischemic Syndromes

Sandri, M., Adams, V., Gielen, S., Linke, A., Lenk, K., Kränkel, N., Lenz, D., Erbs, S., Scheinert, D., Mohr, F. W., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.527135 · Cited by 280 · see citing works

Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress

Imanishi, T., Hano, T., & Nishio, I. (2005) · Journal of Hypertension · doi:10.1097/00004872-200501000-00018 · Cited by 269 · see citing works

Bone Marrow as a Source of Endothelial Cells and NeuN-Expressing Cells After Stroke

Hess, D. C., Hill, W., Martin-Studdard, A., Carroll, J. E., Brailer, J., & Carothers, J. (2002) · Stroke · doi:10.1161/01.str.0000014925.09415.c3 · Cited by 269 · see citing works

Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery.

Tschudi, M. R., Barton, M., Bersinger, N. A., Moreau, P. R., Cosentino, F., Noll, G., Maliñski, T., & Lüscher, T. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118872 · Cited by 260 · see citing works

Stimulation of Endothelial Progenitor Cells

Bahlmann, F. H., de Groot, K., Mueller, O., Hertel, B., Haller, H. G., & Fliser, D. (2005) · Hypertension · doi:10.1161/01.hyp.0000159191.98140.89 · Cited by 259 · see citing works

Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin Rapid Communication

Bahlmann, F. H., deGroot, K., Duckert, T., Niemczyk, E., Bahlmann, E., Boehm, S. M., Haller, H. G., & Fliser, D. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00279.x · Cited by 237 · see citing works

Restoration of Cardiac Progenitor Cells After Myocardial Infarction by Self-Proliferation and Selective Homing of Bone Marrow–Derived Stem Cells

Mouquet, F., Pfister, O., Jain, M., Oikonomopoulos, A., Ngoy, S., Summer, R. S., Fine, A., & Liao, R. (2005) · Circulation Research · doi:10.1161/01.res.0000194330.66545.f5 · Cited by 234 · see citing works

Suppression of Endothelial Progenitor Cells in Human Coronary Artery Disease by the Endogenous Nitric Oxide Synthase Inhibitor Asymmetric Dimethylarginine

Thum, T., Tsikas, D., Stein, S., Schultheiß, M., Eigenthaler, M., Anker, S. D., Poole-Wilson, P. A., Ertl, G., & Bauersachs, J. K. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.066 · Cited by 231 · see citing works

Hyperglycemia Reduces Survival and Impairs Function of Circulating Blood-Derived Progenitor Cells

Kränkel, N., Adams, V., Linke, A., Gielen, S., Erbs, S., Lenk, K., Schuler, G. C., & Hambrecht, R. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000156401.04325.8f · Cited by 230 · see citing works

Statins Enhance Migratory Capacity by Upregulation of the Telomere Repeat-Binding Factor TRF2 in Endothelial Progenitor Cells

Spyridopoulos, I., Haendeler, J., Urbich, C., Brümmendorf, T. H., Oh, H., Schneider, M. D., Zeiher, A. M., & Dimmeler, S. (2004) · Circulation · doi:10.1161/01.cir.0000142866.50300.eb · Cited by 230 · see citing works

Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation

George, J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.03.026 · Cited by 227 · see citing works

OXIDIZED LOW‐DENSITY LIPOPROTEIN INDUCES ENDOTHELIAL PROGENITOR CELL SENESCENCE, LEADING TO CELLULAR DYSFUNCTION

Imanishi, T., Hano, T., Sawamura, T., & Nishio, I. (2004) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2004.04022.x · Cited by 221 · see citing works

Endothelial Progenitor Cells During Cerebrovascular Disease

Ghani, U., Shuaib, A. M., Salam, A., Nasir, A., Shuaib, U., Jeerakathil, T., Sher, F., O’Rourke, F., Nasser, A. M., Schwindt, B., et al. (2004) · Stroke · doi:10.1161/01.str.0000149944.15406.16 · Cited by 209 · see citing works

Stem Cell Plasticity in Muscle and Bone Marrow

Goodell, M. A., Jackson, K. A., Majka, S. M., Mi, T., Wang, H., Pocius, J. S., Hartley, C. J., Majesky, M. W., Entman, M. L., Michael, L. H., et al. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03591.x · Cited by 199 · see citing works

Statin Trials and Goals of Cholesterol-Lowering Therapy

Grundy, S. M. (1998) · Circulation · doi:10.1161/01.cir.97.15.1436 · Cited by 197 · see citing works

Circulating CD34-Positive Cells Provide an Index of Cerebrovascular Function

Taguchi, A., Matsuyama, T., Moriwaki, H., Hayashi, T., Hayashida, K., Nagatsuka, K., Todo, K., Mori, K., Stern, D. M., Soma, T., et al. (2004) · Circulation · doi:10.1161/01.cir.0000133311.25587.de · Cited by 189 · see citing works

Autologous Culture-Modified Mononuclear Cells Confer Vascular Protection After Arterial Injury

Gulati, R., Jevremović, D., Peterson, T. E., Witt, T. A., Kleppe, L. S., Mueske, C. S., Lerman, A., Vile, R. G., & Simari, R. D. (2003) · Circulation · doi:10.1161/01.cir.0000089084.48655.49 · Cited by 177 · see citing works

Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease

Brendle, D. C., Joseph, L., Corretti, M. C., Gardner, A. W., & Katzel, L. I. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01367-9 · Cited by 166 · see citing works

PPARγ-agonist rosiglitazone increases number and migratory activity of cultured endothelial progenitor cells

Pistrosch, F., Herbrig, K., Oelschlaegel, U., RICHTER, S., Passauer, J., Fischer, S., & GROSS, P. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.039 · Cited by 157 · see citing works

Improvement in Endothelial Progenitor Cells from Peripheral Blood by Ramipril Therapy in Patients with Stable Coronary Artery Disease

Min, T. Q., Zhu, C. J., Xiang, W. X., Hui, Z., & Peng, S. Y. (2004) · Cardiovascular Drugs and Therapy · doi:10.1023/b:card.0000033641.33503.bd · Cited by 155 · see citing works

Endothelial Progenitor Cells Are Decreased in Blood of Cardiac Allograft Patients With Vasculopathy and Endothelial Cells of Noncardiac Origin Are Enriched in Transplant Atherosclerosis

Simper, D., Wang, S., Deb, A., Holmes, D. R., McGregor, C. G. A., Frantz, R. P., Kushwaha, S. S., & Caplice, N. M. (2003) · Circulation · doi:10.1161/01.cir.0000081703.34526.5d · Cited by 153 · see citing works

Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels

Zentilin, L., Tafuro, S., Zacchigna, S., Arsic, N., Pattarini, L., Sinigaglia, M., & Giacca, M. (2006) · Blood · doi:10.1182/blood-2005-08-3215 · Cited by 149 · see citing works

Changes in circulating mesenchymal stem cells, stem cell homing factor, and vascular growth factors in patients with acute ST elevation myocardial infarction treated with primary percutaneous coronary intervention

Wang, Y., Johnsen, H. E., Mortensen, S., et al. (2005) · Heart · doi:10.1136/hrt.2005.069799 · Cited by 149 · see citing works

Number and Adhesive Properties of Circulating Endothelial Progenitor Cells in Patients With In-Stent Restenosis

George, J., Herz, I., Goldstein, E., Abashidze, S., Deutch, V., Finkelstein, A., Michowitz, Y., Miller, H. I., & Keren, G. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000107029.65274.db · Cited by 149 · see citing works

Improvement of Collateral Perfusion and Regional Function by Implantation of Peripheral Blood Mononuclear Cells Into Ischemic Hibernating Myocardium

Kamihata, H., Matsubara, H., Nishiue, T., et al. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000039168.95670.b9 · Cited by 148 · see citing works

Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury

Li, R., Mickle, D. A. G., Weisel, R. D., et al. (2001) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(01)03216-7 · Cited by 137 · see citing works

Angiotensin II Potentiates Vascular Endothelial Growth Factor-Induced Proliferation and Network Formation of Endothelial Progenitor Cells

Imanishi, T., Hano, T., & Nishio, I. (2004) · Hypertension Research · doi:10.1291/hypres.27.101 · Cited by 120 · see citing works

Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells

Thum, T., Fraccarollo, D., Galuppo, P., Tsikas, D., Frantz, S., Ertl, G., & Bauersachs, J. K. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.002 · Cited by 113 · see citing works

CD117+ stem cells play a key role in therapeutic angiogenesis induced by bone marrow cell implantation

Li, T., Hamano, K., Nishida, M., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01146.2002 · Cited by 111 · see citing works

Circulating endothelial progenitor cells in subjects with erectile dysfunction

Foresta, C., Caretta, N., Lana, A., et al. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901311 · Cited by 102 · see citing works

Effects of homocysteine on number and activity of endothelial progenitor cells from peripheral blood

Chen, J. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2003.10.005 · Cited by 101 · see citing works

Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro

Butzal, M., Loges, S., Schweizer, M., Fischer, U., Gehling, U. M., HOSSFELD, D. K., & Fiedler, W. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.07.002 · Cited by 96 · see citing works

Oxidized low‐density lipoprotein inhibits vascular endothelial growth factor‐induced endothelial progenitor cell differentiation

Imanishi, T., Hano, T., Matsuo, Y., & Nishio, I. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03894.x · Cited by 90 · see citing works

Effects of Nicotine on the Number and Activity of Circulating Endothelial Progenitor Cells

Wang, X., Zhu, J., Chen, J.-Z., & Shang, Y. (2004) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004267593 · Cited by 78 · see citing works

PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans

Foresta, C., Lana, A., Cabrelle, A., et al. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901325 · Cited by 59 · see citing works

Effects of Ox‐LDL on Number and Activity of Circulating Endothelial Progenitor Cells

Wang, X., Chen, J.-Z., Tao, Q.-M., Zhu, J., & Shang, Y. (2004) · Drug and Chemical Toxicology · doi:10.1081/dct-120037505 · Cited by 56 · see citing works

Modulation of the vascular response to injury by autologous blood-derived outgrowth endothelial cells

Gulati, R., Jevremović, D., Witt, T. A., et al. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00063.2004 · Cited by 55 · see citing works

Moral Problems in the Use of Coercion in Dealing with Nonadherence in the Diagnosis and Treatment of Tuberculosis

Doyal, L. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb11379.x · Cited by 48 · see citing works

Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood.

Zhu, J., Wang, X., Chen, J.-Z., et al. (2004) · PubMed · Cited by 47 · see citing works

In vitro isolation of circulating endothelial progenitor cells is related to the high density lipoprotein plasma levels

Pellegatta, F., Bragheri, M., Grigore, L., et al. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.17.2.203 · Cited by 37 · see citing works

Effects of Ginkgo Biloba Extract on Number and Activity of Endothelial Progenitor Cells from Peripheral Blood

Chen, J.-Z., Wang, X., Zhu, J., et al. (2004) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200403000-00004 · Cited by 33 · see citing works

Therapeutic angiogenesis for patients with limb ischemia by autologous transplantation of bone-marrow cells : a pilot study and a randomised controlled trial.

Allaire, É. (2008) · Cited by 14 · see citing works

Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology

van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works

Heartache and heartbreak—the link between depression and cardiovascular disease

Nemeroff, C. B., & Goldschmidt-Clermont, P. J. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.91 · Cited by 424 · see citing works

Evolving Concepts of Cardiac Valve Dynamics: The Continuum of Development, Functional Structure, Pathobiology, and Tissue Engineering

Schoen, F. J. (2008) · Circulation · doi:10.1161/circulationaha.108.805911 · Cited by 421 · see citing works

Age Decreases Endothelial Progenitor Cell Recruitment Through Decreases in Hypoxia-Inducible Factor 1α Stabilization During Ischemia

Chang, E. I., Loh, S. A., Ceradini, D. J., Chang, E. I., Lin, S.-E., Bastidas, N., Aarabi, S., Chan, D. A., Freedman, M. L., Giaccia, A. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.715847 · Cited by 206 · see citing works

Improvement of Endothelial Function With Dietary Flavanols Is Associated With Mobilization of Circulating Angiogenic Cells in Patients With Coronary Artery Disease

Heiss, C., Jahn, S., Taylor, M., Real, W. M., Angeli, F. S., Wong, M. L., Amabile, N., Prasad, M., Rassaf, T., Ottaviani, J. I., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.039 · Cited by 202 · see citing works

Vascular aging: implications for cardiovascular disease and therapy

Ghebre, Y. T., Yakubov, E., Wong, W. T., & Krishnamurthy, P. (2016) · Translational Medicine · doi:10.4172/2161-1025.1000183 · Cited by 87 · see citing works

Endothelial Dysfunction and Hypertension

Konukoğlu, D., & Uzun, H. (2016) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_90 · Cited by 605 · see citing works

Endothelial Dysfunction in Hypercholesterolemia: Mechanisms, Pathophysiological Importance, and Therapeutic Interventions

Landmesser, U., Hornig, B., & Drexler, H. (2000) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2000-13209 · Cited by 135 · see citing works

Endothelial Dysfunction in Experimental Models of Arterial Hypertension: Cause or Consequence?

Bernátová, I. (2014) · BioMed Research International · doi:10.1155/2014/598271 · Cited by 118 · see citing works

Vascular endothelial dysfunction

DEMEYER, G., & HERMAN, A. (1997) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(97)80031-x · Cited by 180 · see citing works

Nitric Oxide and Vascular Endothelial Dysfunction

Meyer, G. R. Y. D., & Herman, A. G. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50035-6 · Cited by 14 · see citing works