The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
In Vivo and In Vitro Characterization of Insulin-Producing Cells Obtained From Murine Bone Marrow
Open accessAbstract
Efforts toward routine islet cell transplantation as a means for reversing type 1 diabetes have been hampered by islet availability as well as allograft rejection. In vitro transdifferentiation of mouse bone marrow (BM)-derived stem (mBMDS) cells into insulin-producing cells could provide an abundant source of autologous cells for this procedure. For this study, we isolated and characterized single cell-derived stem cell lines obtained from mouse BM. In vitro differentiation of these mBMDS cells resulted in populations meeting a number of criteria set forth to define functional insulin-producing cells. Specifically, the mBMDS cells expressed multiple genes related to pancreatic β-cell development and function (insulin I and II, Glut2, glucose kinase, islet amyloid polypeptide, nestin, pancreatic duodenal homeobox-1 [PDX-1], and Pax6). Insulin and C-peptide production was identified by immunocytochemistry and confirmed by electron microscopy. In vitro studies involving glucose stimulation identified glucose-stimulated insulin release. Finally, these mBMDS cells transplanted into streptozotocin-induced diabetic mice imparted reversal of hyperglycemia and improved metabolic profiles in response to intraperitoneal glucose tolerance testing. These results indicate that mouse BM harbors cells capable of in vitro transdifferentiating into functional insulin-producing cells and support efforts to derive such cells in humans as a means to alleviate limitations surrounding islet cell transplantation.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
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Cell fusion is the principal source of bone-marrow-derived hepatocytes
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Self-citation
Cited by
Lee, R. H., Seo, M. J., Reger, R. L., Spees, J. L., Pulin, A. A., Olson, S. D., & Prockop, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608249103 · Cited by 710
Timper, K., Seboek, D., Eberhardt, M., Linscheid, P., Christ-Crain, M., Keller, U., Müller, B., & Zulewski, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.072 · Cited by 450
Kobolak, J., Dinnyes, A., Memic, A., Khademhosseini, A., & Mobasheri, A. (2016) · Methods · doi:10.1016/j.ymeth.2015.09.016 · Cited by 273
Therapeutic applications of mesenchymal stromal cells
Brooke, G., Cook, M., Blair, C., Han, R., Heazlewood, C., Jones, B., Kambouris, M., Kollar, K., McTaggart, S., Pelekanos, R., et al. (2007) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2007.09.012 · Cited by 259
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
Kaneto, H., Matsuoka, T.-A., Nakatani, Y., Kawamori, D., Miyatsuka, T., Matsuhisa, M., & Yamasaki, Y. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0640-x · Cited by 193
Metadata
- Authors
- Tang, D.-Q., Cao, L.-Z., Burkhardt, B. R., Xia, C.-Q., Litherland, S. A., Atkinson, M. A., & Yang, L.-J.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-07-01
- Volume
- 53
- Issue
- 7
- Pages
- 1721-1732
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2123158227
- Cited by
- 388
- References
- 39
- FWCI
- 25.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: In Vivo and In Vitro Characterization of Insulin-Producing Cells Obtained From Murine Bone Marrow. https://app.cochat.ai/papers/10.2337/diabetes.53.7.1721
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- Tang, D.-Q., Cao, L.-Z., Burkhardt, B. R., Xia, C.-Q., Litherland, S. A., Atkinson, M. A., & Yang, L.-J. (2004). In Vivo and In Vitro Characterization of Insulin-Producing Cells Obtained From Murine Bone Marrow. Diabetes. https://doi.org/10.2337/diabetes.53.7.1721
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
