Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

Mammalian MAP kinase signalling cascades

Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Harding, H. P., Zhang, Y., & Ron, D. (1999) · Nature · doi:10.1038/16729 · Cited by 3,310 · see citing works

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188 · see citing works

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Urano, F., Wang, X.-Z., Bertolotti, A., Zhang, Y., Chung, P., Harding, H. P., & Ron, D. (2000) · Science · doi:10.1126/science.287.5453.664 · Cited by 2,997 · see citing works

Cellular uptake of the tat protein from human immunodeficiency virus

Frankel, A. D., & Pabo, C. O. (1988) · Cell · doi:10.1016/0092-8674(88)90263-2 · Cited by 2,782 · see citing works

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441 · see citing works

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

Schwarze, S. R., Ho, A. L., Vocero-Akbani, A. M., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,418 · see citing works

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886 · see citing works

Insulin-promoter-factor 1 is required for pancreas development in mice

Jonsson, J., Carlsson, L., Edlund, T., & Edlund, H. (1994) · Nature · doi:10.1038/371606a0 · Cited by 1,879 · see citing works

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. M., & Wright, C. V. E. (1996) · Development · doi:10.1242/dev.122.3.983 · Cited by 1,514 · see citing works

The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307

Aguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487 · see citing works

Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

Harding, H. P., Zeng, H., Zhang, Y., Jungries, R., Chung, P., Plesken, H., Sabatini, D. D., & Ron, D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00264-7 · Cited by 1,217 · see citing works

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

Tiedge, M., Lortz, S., Drinkgern, J., & Lenzen, S. (1997) · Diabetes · doi:10.2337/diab.46.11.1733 · Cited by 1,211 · see citing works

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues

Lenzen, S., Drinkgern, J., & Tiedge, M. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)02051-5 · Cited by 1,167 · see citing works

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

Stoffers, D. A., Zinkin, N. T., Stanojevic, V., Clarke, W. L., & Habener, J. F. (1997) · Nature Genetics · doi:10.1038/ng0197-106 · Cited by 1,103 · see citing works

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

Robertson, R. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400019200 · Cited by 1,078 · see citing works

In vitro cultivation of human islets from expanded ductal tissue

Bonner‐Weir, S., Taneja, M., Weir, G. C., Tatarkiewicz, K., Song, K., Sharma, A., & O’Neil, J. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7999 · Cited by 978 · see citing works

Intercellular Trafficking and Protein Delivery by a Herpesvirus Structural Protein

Elliott, G., & O’Hare, P. (1997) · Cell · doi:10.1016/s0092-8674(00)81843-7 · Cited by 975 · see citing works

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

Nagahara, H., Vocero-Akbani, A. M., Snyder, E. L., Ho, A. L., Latham, D. G., Lissy, N. A., Becker‐Hapak, M., Ezhevsky, S. A., & Dowdy, S. F. (1998) · Nature Medicine · doi:10.1038/4042 · Cited by 928 · see citing works

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsPreprint

Tirasophon, W., Welihinda, A. A., & Kaufman, R. J. (1998) · Genes & Development · doi:10.1101/gad.12.12.1812 · Cited by 921 · see citing works

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetesPreprint

Ahlgren, U., Jönsson, J., Jönsson, L., Simu, K., & Edlund, H. (1998) · Genes & Development · doi:10.1101/gad.12.12.1763 · Cited by 918 · see citing works

Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

Robertson, R. P., Harmon, J., Tran, P. O., Tanaka, Y., & Takahashi, H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.581 · Cited by 897 · see citing works

IPF1, a homeodomain‐containing transactivator of the insulin gene.

Ohlsson, H., Karlsson, K., & Edlund, H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06109.x · Cited by 893 · see citing works

Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1

Staffers, D. A., Ferrer, J. P., Clarke, W. L., & Habener, J. F. (1997) · Nature Genetics · doi:10.1038/ng1097-138 · Cited by 880 · see citing works

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., & Mori, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14550 · Cited by 858 · see citing works

Oxidative damage to DNA in diabetes mellitus

Dandona, P., Thusu, K., Cook, S., Snyder, B., Makowski, J., Armstrong, D., & Nicotera, T. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90013-6 · Cited by 788 · see citing works

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

Wang, X., Harding, H. P., Zhang, Y., Jolicoeur, E. M., Kuroda, M., & Ron, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5708 · Cited by 787 · see citing works

Translational control in the endoplasmic reticulum stress response

Ron, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16784 · Cited by 778 · see citing works

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

Shi, Y., Vattem, K. M., Sood, R., An, J., Liang, J., Stramm, L. E., & Wek, R. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7499 · Cited by 776 · see citing works

Targeted disruption of the chop gene delays endoplasmic reticulum stress-mediated diabetes

Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., & Mori, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214550 · Cited by 752 · see citing works

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

Ferber, S., Halkin, A., Cohen, H., Ber, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N., et al. (2000) · Nature Medicine · doi:10.1038/75050 · Cited by 745 · see citing works

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

Inoue, H., Tanizawa, Y., Wasson, J., Behn, P., Kalidas, K., Bernal‐Mizrachi, E., Mueckler, M. M., Marshall, H., Donis-Keller, H., Crock, P., et al. (1998) · Nature Genetics · doi:10.1038/2441 · Cited by 744 · see citing works

Minireview: Secondary β-Cell Failure in Type 2 Diabetes—A Convergence of Glucotoxicity and Lipotoxicity

Poitout, V., & Robertson, R. P. (2002) · Endocrinology · doi:10.1210/endo.143.2.8623 · Cited by 743 · see citing works

Translational control in the endoplasmic reticulum stress response

Ron, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216784 · Cited by 728 · see citing works

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., Hanafusa, T., Matsuzawa, Y., Yamasaki, Y., & Hori, M. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2398 · Cited by 713 · see citing works

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., & Davis, R. J. (1997) · Science · doi:10.1126/science.277.5326.693 · Cited by 675 · see citing works

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

Rothbard, J. B., Garlington, S., Lin, Q., Kirschberg, T. A., Kreider, E., McGrane, P. L., Wender, P. A., & Khavari, P. A. (2000) · Nature Medicine · doi:10.1038/81359 · Cited by 632 · see citing works

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

Oyadomari, S., Takeda, K., Takiguchi, M., Gotoh, T., Matsumoto, M., Wada, I., Akira, S., Araki, E., & Mori, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191207498 · Cited by 599 · see citing works

Cell-Permeable Peptide Inhibitors of JNK

Bonny, C., Oberson, A., Negri, S., Sauser, C., & Schorderet, D. F. (2001) · Diabetes · doi:10.2337/diabetes.50.1.77 · Cited by 571 · see citing works

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

Jonas, J., Sharma, A., Hasenkamp, W. M., ILKOVA, H. M., Patanè, G., Laybutt, D. R., Bonner‐Weir, S., & Weir, G. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14112 · Cited by 559 · see citing works

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

Ahlgren, U., Jonsson, J., & Edlund, H. (1996) · Development · doi:10.1242/dev.122.5.1409 · Cited by 547 · see citing works

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

井上, 寛. (2000) · Medical Entomology and Zoology · doi:10.11501/3171821 · Cited by 534 · see citing works

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

Ihara, Y., Toyokuni, S., Uchida, K., Odaka, H., Tanaka, T., Ikeda, H., Hiai, H., Seino, Y., & Yamada, Y. (1999) · Diabetes · doi:10.2337/diabetes.48.4.927 · Cited by 506 · see citing works

Endoplasmic Reticulum Stress and the Development of Diabetes

Harding, H. P., & Ron, D. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s455 · Cited by 465 · see citing works

Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes

Nakatani, Y., Kaneto, H., Kawamori, D., Yoshiuchi, K., Hatazaki, M., Matsuoka, T., Ozawa, K., Ogawa, S., Hori, M., Yamasaki, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411860200 · Cited by 462 · see citing works

Beta-cell adaptation and decompensation during the progression of diabetes

Weir, G. C., Laybutt, D. R., Kaneto, H., Bonner-Weir, S., & Sharma, A. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s154 · Cited by 462 · see citing works

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

Tanaka, Y., Gleason, C. E., Tran, P. O. T., Harmon, J. S., & Robertson, R. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10857 · Cited by 460 · see citing works

IDX‐1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

Miller, C. P., McGehee, R. E., & Habener, J. F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06363.x · Cited by 420 · see citing works

In Vivo and In Vitro Characterization of Insulin-Producing Cells Obtained From Murine Bone Marrow

Tang, D., Cao, L.-Z., Burkhardt, B. R., Xia, C.-Q., Litherland, S. A., Atkinson, M. A., & Yang, L.-J. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1721 · Cited by 388 · see citing works

Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion

Briššová, M., Shiota, M., Nicholson, W. E., GANNON, M. A., Knobel, S. M., Piston, D. W., Wright, C. V. E., & Powers, A. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111272200 · Cited by 376 · see citing works

Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.

Matsuoka, T., Kajimoto, Y., Watada, H., Kaneto, H., Kishimoto, M., Umayahara, Y., Fujitani, Y., Kamada, T., Kawamori, R., & Yamasaki, Y. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119126 · Cited by 360 · see citing works

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

Leonard, J. N., Peers, B., Johnson, T. W., Ferreri, K., Lee, S. Y., & Montminy, M. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.10.7505393 · Cited by 360 · see citing works

Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells

Maechler, P., Jornot, L., & Wollheim, C. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27905 · Cited by 359 · see citing works

Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression

Kaneto, H., Xu, G., FUJII, N. L., Kim, S., Bonner‐Weir, S., & Weir, G. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202066200 · Cited by 349 · see citing works

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

Waeber, G., Thompson, N. A., NICOD, P. H., & Bonny, C. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.11.8923459 · Cited by 348 · see citing works

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

Kaneto, H., Fujii, J., Seo, H. G., Suzuki, K., Matsuko, T.-A., Masahiro, N., Tatsumi, H., Yamasaki, Y., Kamada, T., & Taniguchi, N. (1995) · Diabetes · doi:10.2337/diab.44.7.733 · Cited by 342 · see citing works

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y., & Hori, M. (2004) · Nature Medicine · doi:10.1038/nm1111 · Cited by 337 · see citing works

Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress

Kaneto, H., Xu, G., Song, K., Suzuma, K., Bonner‐Weir, S., Sharma, A., & Weir, G. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104115200 · Cited by 327 · see citing works

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells

Sakai, K., Matsumoto, K., Nishikawa, T., Suefuji, M., Nakamaru, K., Hirashima, Y., Kawashima, J., Shirotani, T., Ichinose, K., Brownlee, M., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02832-2 · Cited by 323 · see citing works

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.

Eizirik, D. L., Sandler, S., Welsh, N., Ćetković-Cvrlje, M., Nieman, A., Geller, D. A., PIPELEERS, D. G., Bendtzen, K., & Hellerström, C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117188 · Cited by 317 · see citing works

A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity

Tanaka, Y., Tran, P. O. T., Harmon, J. S., & Robertson, R. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192445199 · Cited by 316 · see citing works

The β cell transcription factors and development of the pancreas

Sander, M., & German, M. (1997) · Journal of molecular medicine · doi:10.1007/s001090050118 · Cited by 307 · see citing works

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.

Corbett, J. A., Wang, J., Sweetland, M. A., Lancaster, J. R., & McDaniel, M. L. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116129 · Cited by 287 · see citing works

Quantitative Assessment of Gene Targeting in Vitroand in Vivo by the Pancreatic Transcription Factor, Pdx1

Chakrabarti, S. K., James, J. C., & Mirmira, R. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111857200 · Cited by 287 · see citing works

Integration of endoplasmic reticulum signaling in health and disease

Aridor, M., & Balch, W. E. (1999) · Nature Medicine · doi:10.1038/10466 · Cited by 281 · see citing works

A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

Noguchi, H., Matsushita, M., Okitsu, T., Moriwaki, A., Tomizawa, K., Kang, S., Li, S., Kobayashi, N., Matsumoto, S., Tanaka, K., et al. (2004) · Nature Medicine · doi:10.1038/nm994 · Cited by 266 · see citing works

Functional, Persistent, and Extended Liver to Pancreas Transdifferentiation

Ber, I., Keren Shternhall-ron, A., Perl, S., Ohanuna, Z., Goldberg, I., Barshack, I., Benvenisti-Zarum, L., Meivar‐Levy, I., & Ferber, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303127200 · Cited by 264 · see citing works

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

Kulkarni, R., Jhala, U. S., Winnay, J. N., Krajewski, S., Montminy, M., & Kahn, C. R. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21845 · Cited by 263 · see citing works

beta-cell apoptosis: stimuli and signaling.

Mandrup-Poulsen, T. R. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s58 · Cited by 253 · see citing works

Reducing sugars trigger oxidative modification and apoptosis in pancreatic β-cells by provoking oxidative stress through the glycation reaction

Kaneto, H., Fujii, J., Myint, T., Miyazawa, N., Islam, K. N., Kawasaki, Y., Suzuki, K., Nakamura, M., Tatsumi, H., Yamasaki, Y., et al. (1996) · Biochemical Journal · doi:10.1042/bj3200855 · Cited by 252 · see citing works

Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem Cells

Miyazaki, S., Yamato, E., & Miyazaki, J. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1030 · Cited by 245 · see citing works

Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status

Nakatani, Y., Kaneto, H., Kawamori, D., Hatazaki, M., Miyatsuka, T., Matsuoka, T., Kajimoto, Y., Matsuhisa, M., Yamasaki, Y., & Hori, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406963200 · Cited by 230 · see citing works

Experimental control of pancreatic development and maintenance

Holland, A. M., Hale, M. A., Kagami, H., Hammer, R. E., & MacDonald, R. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192255099 · Cited by 230 · see citing works

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1

Peers, B., Leonard, J. N., Sharma, S., Teitelman, G., & Montminy, M. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.12.7708065 · Cited by 223 · see citing works

The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells

Watada, H., Kajimoto, Y., Umayahara, Y., Matsuoka, T., Kaneto, H., Fujitani, Y., Kamada, T., Kawamori, R., & Yamasaki, Y. (1996) · Diabetes · doi:10.2337/diab.45.11.1478 · Cited by 221 · see citing works

PDX-1 Protein Containing Its Own Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct and Islet Cells

Noguchi, H., Kaneto, H., Weir, G. C., & Bonner‐Weir, S. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1732 · Cited by 216 · see citing works

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.

Ammendrup, A., Maillard, A., Nielsen, K., Andersen, N. A., Serup, P., Madsen, O. D., Mandrup-Poulsen, T. R., & Bonny, C. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1468 · Cited by 212 · see citing works

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

Petersen, H. V., Serup, P., Leonard, J. N., Michelsen, B. K., & Madsen, O. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10465 · Cited by 207 · see citing works

ORP150 protects against hypoxia/ischemia-induced neuronal death

Tamatani, M., Matsuyama, T., Yamaguchi, A., Mitsuda, N., Tsukamoto, Y., Taniguchi, M., Ho, Y., Ozawa, K., Hori, O., Nishimura, H., et al. (2001) · Nature Medicine · doi:10.1038/85463 · Cited by 197 · see citing works

Purification and Characterization of a Novel Stress Protein, the 150-kDa Oxygen-regulated Protein (ORP150), from Cultured Rat Astrocytes and Its Expression in Ischemic Mouse Brain

Kuwabara, K., Matsumoto, M., Ikeda, J., Hori, O., Ogawa, S., Maeda, Y., Kitagawa, K., Imuta, N., Kinoshita, T., Stern, D. M., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.5025 · Cited by 195 · see citing works

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH2-terminal Kinase

Kawamori, D., Kajimoto, Y., Kaneto, H., Umayahara, Y., Fujitani, Y., Miyatsuka, T., Watada, H., Leibiger, I., Yamasaki, Y., & Hori, M. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2896 · Cited by 189 · see citing works

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

Waeber, G., Delplanque, J., Bonny, C., Mooser, V., Steinmann, M., Widmann, C., Maillard, A. M., Judith Miklossy, A., Christian Dina, C., Hani, E. H., et al. (2000) · Nature Genetics · doi:10.1038/73523 · Cited by 182 · see citing works

Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation*

Wang, H.-Y., Maechler, P., Ritz-Laser, B., Hagenfeldt, K., Ishihara, H., Philippe, J., & Wollheim, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101233200 · Cited by 175 · see citing works

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

Sharma, A. K., Olson, L. K., Robertson, R. P., & Stein, R. W. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.9.7491105 · Cited by 164 · see citing works

Regulatory factor linked to late-onset diabetes?

Dutta, S., Bonner‐Weir, S., Montminy, M., & Wright, C. V. E. (1998) · Nature · doi:10.1038/33311 · Cited by 155 · see citing works

Analysis of Insulin-Producing Cells During In Vitro Differentiation From Feeder-Free Embryonic Stem Cells

Moritoh, Y., Yamato, E., Yasui, Y., Miyazaki, S., & Miyazaki, J. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1163 · Cited by 152 · see citing works

Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin

Kojima, H., Nakamura, T., Fujita, Y., Kishi, A., Fujimiya, M., Yamada, S., Kudo, M., Nishio, Y., Maegawa, H., Haneda, M., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1398 · Cited by 145 · see citing works

IB1, a JIP-1-related Nuclear Protein Present in Insulin-secreting Cells

Bonny, C., NICOD, P. H., & Waeber, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1843 · Cited by 139 · see citing works

Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15.

Moran, A., Zhang, H. J., Olson, L. K., Harmon, J. S., Poitout, V., & Robertson, R. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119190 · Cited by 131 · see citing works

PDX-1 Induces Differentiation of Intestinal Epithelioid IEC-6 Into Insulin-Producing Cells

Yoshida, S., Kajimoto, Y., Yasuda, T., Watada, H., Fujitani, Y., Kosaka, H., Gotow, T., Miyatsuka, T., Umayahara, Y., Yamasaki, Y., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2505 · Cited by 127 · see citing works

Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter1

Stoffers, D. A., Heller, R. S., Miller, C. P., & Habener, J. F. (1999) · Endocrinology · doi:10.1210/endo.140.11.7122 · Cited by 125 · see citing works

IB1 Reduces Cytokine-induced Apoptosis of Insulin-secreting Cells

Bonny, C., Oberson, A., Steinmann, M., Schorderet, D. F., NICOD, P. H., & Waeber, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908297199 · Cited by 122 · see citing works

Probucol preserves pancreatic β-cell function through reduction of oxidative stress in type 2 diabetes

Gorogawa, S.-I., Kajimoto, Y., Umayahara, Y., Kaneto, H., Watada, H., Kuroda, A., Kawamori, D., Yasuda, T., Matsuhisa, M., Yamasaki, Y., et al. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(02)00005-0 · Cited by 115 · see citing works

β-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas

Taniguchi, H., Yamato, E., Tashiro, F., Ikegami, H., Ogihara, T., & Miyazaki, J. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301846 · Cited by 112 · see citing works

Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction

Kaneto, H., Kajimoto, Y., Fujitani, Y., Matsuoka, T., Sakamoto, K., Matsuhisa, M., Yamasaki, Y., & Hori, M. (1999) · Diabetologia · doi:10.1007/s001250051276 · Cited by 111 · see citing works

Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis.

Miyatsuka, T., Kaneto, H., Kajimoto, Y., Hirota, S., Arakawa, Y., Fujitani, Y., Umayahara, Y., Watada, H., Yamasaki, Y., Magnuson, M., et al. (2003) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2003.09.108 · Cited by 109 · see citing works

When Translation Meets Metabolism: Multiple Links to Diabetes

Shi, Y., Taylor, S. I., Tan, S., & Sonenberg, N. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0018 · Cited by 89 · see citing works

Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor during Pancreas Development

Kaneto, H., Miyagawa, J., Kajimoto, Y., Yamamoto, K., Watada, H., Umayahara, Y., Hanafusa, T., Matsuzawa, Y., Yamasaki, Y., Higashiyama, S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.46.29137 · Cited by 72 · see citing works

Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells

Kajimoto, Y., Matsuoka, T., Kaneto, H., Watada, H., Fujitani, Y., Kishimoto, M., Sakamoto, K., Matsuhisa, M., Kawamori, R., Yamasaki, Y., et al. (1999) · Diabetologia · doi:10.1007/s001250051313 · Cited by 65 · see citing works

Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?

Malhotra, J. D., & Kaufman, R. J. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1782 · Cited by 1,556 · see citing works

Beta Cell Dysfunction and Insulin Resistance

Cerf, M. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00037 · Cited by 964 · see citing works

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

Kaneto, H., Katakami, N., Matsuhisa, M., & Matsuoka, T. (2010) · Mediators of Inflammation · doi:10.1155/2010/453892 · Cited by 578 · see citing works

The crucial role and mechanism of insulin resistance in metabolic disease

Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149239 · Cited by 630 · see citing works

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

Borradaile, N. M., Han, X., Harp, J. D., Gale, S. E., Ory, D. S., & Schaffer, J. E. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600299-jlr200 · Cited by 564 · see citing works

GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress

Yusta, B., Baggio, L. L., Estall, J. L., Koehler, J. A., Holland, D. P., Li, H., Pipeleers, D., Ling, Z., & Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.001 · Cited by 444 · see citing works

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

Seimon, T. A., Li, Y., Yao, P. M., Stone, E. F., Wang, Y., Davis, R. J., Flavell, R. A., & Tabas, I. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502078 · Cited by 353 · see citing works

Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis

Piao, M. J., Ahn, M. J., Kang, K. A., Ryu, Y. S., Hyun, Y. J., Shilnikova, K., Zhen, A. X., Jeong, J. W., Choi, Y. H., Kang, H. K., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2197-9 · Cited by 339 · see citing works

The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes

Eguchi, N., Vaziri, N. D., Dafoe, D. C., & Ichii, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041509 · Cited by 354 · see citing works

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

Hoehn, K. L., Hohnen-Behrens, C., Cederberg, A., Wu, L. E., Turner, N. A., Yuasa, T., Ebina, Y., & James, D. E. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.005 · Cited by 321 · see citing works

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

Yuzefovych, L. V., Musiyenko, S. I., Wilson, G. L., & Rachek, L. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054059 · Cited by 302 · see citing works

Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link

Zhang, Y., Huang, N.-Q., Yan, F., Jin, H., Zhou, S.-Y., Shi, J.-S., & Jin, F. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.11.015 · Cited by 301 · see citing works

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

Zaplatić, E., Bule, M. H., Shah, S. Z. A., Uddin, M. S., & Niaz, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.055 · Cited by 298 · see citing works

Essential role of mitochondrial function in adiponectin synthesis in adipocytes

Koh, E. H., Park, J.-Y., Park, H.-S., Jeon, M. J., Ryu, J. W., Kim, M., Kim, S. Y., Kim, M.-S., Kim, S.-W., Park, I. S., et al. (2007) · Diabetes · doi:10.2337/db07-0510 · Cited by 275 · see citing works

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions

Han, S., Liang, C.-P., Seimon, T. A., Ranalletta, M., Welch, C. L., Collins-Fletcher, K., Accili, D., Tabas, I. A., & Tall, A. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.008 · Cited by 275 · see citing works

Involvement of Oxidative Stress in the Pathogenesis of Diabetes

Kaneto, H., Katakami, N., Kawamori, D., Miyatsuka, T., Sakamoto, K., Matsuoka, T., Matsuhisa, M., & Yamasaki, Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1465 · Cited by 264 · see citing works

Ceramide- and Oxidant-Induced Insulin Resistance Involve Loss of Insulin-Dependent Rac-Activation and Actin Remodeling in Muscle Cells

JeBailey, L., Wanono, O., Niu, W., Roessler, J., Rudich, A., & Klip, A. (2007) · Diabetes · doi:10.2337/db06-0823 · Cited by 209 · see citing works

JNK Pathway Signaling: A Novel and Smarter Therapeutic Target for Various Biological Diseases

Kumar, A., Singh, U. K., Kini, S. G., Garg, V., Agrawal, S., Tomar, P. K., Pathak, P., Chaudhary, A., Gupta, P., & Malik, A. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.132 · Cited by 200 · see citing works

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

Giacca, A., Xiao, C., Oprescu, A. I., Carpentier, A. C., & Lewis, G. F. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2010 · Cited by 196 · see citing works

Journal of Pharmaceutical and Biomedical Sciences

(2016) · Journal of Pharmaceutical and Biomedical Sciences · doi:10.20936/jpbms · Cited by 193 · see citing works

Circulating microRNAs: novel biomarkers for cardiovascular diseases

Xu, J., Zhao, J., Evan, G., Xiao, C., Cheng, Y., & Xiao, J. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0840-5 · Cited by 187 · see citing works

Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

Sekiya, M., Hiraishi, A., Touyama, M., & Sakamoto, K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.068 · Cited by 175 · see citing works

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis

Deldicque, L., Cani, P. D., Philp, A., Raymackers, J.-M., Meakin, P. J., Ashford, M. L. J., Delzenne, N. M., Francaux, M., & Baar, K. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00038.2010 · Cited by 163 · see citing works

Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease

Liu, G., Sun, Y., Li, Z., Song, T., Wang, H., Zhang, Y., & Ge, Z. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.031 · Cited by 164 · see citing works

PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function

Kaneto, H., Miyatsuka, T., Kawamori, D., Yamamoto, K., Kato, K., Shiraiwa, T., Katakami, N., Yamasaki, Y., Matsuhisa, M., & Matsuoka, T. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-041 · Cited by 149 · see citing works

Genetic Basis of Lipodystrophies and Management of Metabolic Complications

Agarwal, A. K., & Garg, A. (2006) · Annual Review of Medicine · doi:10.1146/annurev.med.57.022605.114424 · Cited by 146 · see citing works

Lipotoxicity and β-Cell Failure in Type 2 Diabetes: Oxidative Stress Linked to NADPH Oxidase and ER Stress

Vilas‐Boas, E. A., de Almeida, D. C., Roma, L. P., Ortis, F., & Carpinelli, Â. R. (2021) · Cells · doi:10.3390/cells10123328 · Cited by 143 · see citing works

Reactive oxygen species-mediated pancreatic β-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases.

Hou, N., Torii, S., Saito, N., Hosaka, M., & Takeuchi, T. (2008) · Endocrinology · doi:10.1210/en.2007-0988 · Cited by 141 · see citing works

Autophagy and Non-Alcoholic Fatty Liver Disease

Lavallard, V., & Gual, P. (2014) · BioMed Research International · doi:10.1155/2014/120179 · Cited by 133 · see citing works

AKT Signaling in Physiology and Disease

Vasudevan, K. M., & Garraway, L. A. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_66 · Cited by 131 · see citing works

Mitogen-Activated Protein Kinases, Inhibitory-κB Kinase, and Insulin Signaling in Human Omental Versus Subcutaneous Adipose Tissue in Obesity

Bashan, N., Dorfman, K., Tarnovscki, T., Harman‐Boehm, I., Liberty, I. F., Blüher, M., Ovadia, S., Maymon-Zilberstein, T., Potashnik, R., Stümvoll, M., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1369 · Cited by 120 · see citing works

Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue

Li, Y., Zhang, H., Jiang, C., Xu, M., Pang, Y., Feng, J., Xiang, X., Kong, W., Xu, G., Li, Y., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.431627 · Cited by 116 · see citing works

Overnutrition and maternal obesity in sheep pregnancy alter the JNK‐IRS‐1 signaling cascades and cardiac function in the fetal heart

Wang, J., Ma, H., Tong, C., Zhang, H., Lawlis, G. B., Li, Y., Zang, M., Ren, J. T., Nijland, M. J., Ford, S. P., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-142315 · Cited by 105 · see citing works

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?

Rodrigues-Krause, J. D. C., Krause, M. D. S., O’Hagan, C., VITO, G. D., Boreham, C. A., Murphy, C., Newsholme, P., & Colleran, G. (2012) · Cell Stress and Chaperones · doi:10.1007/s12192-011-0319-x · Cited by 107 · see citing works

Algae as an Attractive Source for Cosmetics to Counter Environmental Stress

Aslam, A., Bahadar, A., Liaquat, R., Saleem, M., Waqas, A., & Zwawi, M. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144905 · Cited by 105 · see citing works

Nutritional regulation of insulin secretion: implications for diabetes.

Newsholme, P., & Krause, M. D. S. (2012) · Europe PMC (PubMed Central) · Cited by 105 · see citing works

Caffeic Acid Phenethyl Ester (Propolis Extract) Ameliorates Insulin Resistance by Inhibiting JNK and NF-κB Inflammatory Pathways in Diabetic Mice and HepG2 Cell Models

Nie, J., Chang, Y., Li, Y., Zhou, Y., Qin, J., Sun, Z., & Li, H. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02880 · Cited by 104 · see citing works

METHYLGLYOXAL, DIABETES MELLITUS AND DIABETIC COMPLICATIONS

Jagt, D. L. V. (2008) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2008.23.1-2.93 · Cited by 104 · see citing works

Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

Panigrahy, S. K., Bhatt, R., & Kumar, A. (2017) · Journal of Drug Targeting · doi:10.1080/1061186x.2016.1207650 · Cited by 103 · see citing works

Alternatively Activated Macrophages in Types 1 and 2 Diabetes

Espinoza-Jiménez, A., Peón, A. N., & Terrazas, L. I. (2012) · Mediators of Inflammation · doi:10.1155/2012/815953 · Cited by 104 · see citing works

Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response

Qi, W., Mu, J., Luo, Z.-F., Zeng, W., Guo, Y., Pang, Q., Ye, Z.-L., Liu, L., Fa-huan, Y., & Feng, B. (2010) · Metabolism · doi:10.1016/j.metabol.2010.07.021 · Cited by 95 · see citing works

Diabetes‐ and angiotensin II‐induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection

Xu, J., Wang, G., Wang, Y., Liu, Q., Xu, W., Tan, Y., & Cai, L. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00833.x · Cited by 95 · see citing works

Inhibition of Endoplasmic Reticulum Stress Improves Mouse Embryo Development

Zhang, J. Y., Diao, Y. F., Kim, H. R., & Jin, D. I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040433 · Cited by 88 · see citing works

Microcystin-RR: Occurrence, content in water and food and toxicological studies. A review

Díez-Quijada, L., Puerto, M., Gutiérrez‐Praena, D., Llana‐Ruíz‐Cabello, M., Jos, A. M., & Cameán, A. M. (2018) · Environmental Research · doi:10.1016/j.envres.2018.07.019 · Cited by 83 · see citing works

Mitochondrial reactive oxygen species (ROS) inhibition ameliorates palmitate-induced INS-1 beta cell death

Lin, N., Chen, H., Zhang, H., Wan, X., & Su, Q. (2012) · Endocrine · doi:10.1007/s12020-012-9633-z · Cited by 83 · see citing works

Glucolipotoxicity in Pancreatic β-Cells

Kim, J.-W., & Yoon, K.-H. (2011) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2011.35.5.444 · Cited by 82 · see citing works

SPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response

Zhuang, M., Du, D., Pu, L., Song, H., Deng, M., Qian, L., Yin, X., Wang, Y., & Rao, L. (2019) · Small · doi:10.1002/smll.201903135 · Cited by 82 · see citing works

Probiotic Bacillus Attenuates Oxidative Stress- Induced Intestinal Injury via p38-Mediated Autophagy

Wu, Y., Wang, B., Xu, H., Tang, L., Li, Y., Gong, L., Wang, Y., & Li, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02185 · Cited by 80 · see citing works

Autophagy, signaling and obesity

Lavallard, V., Meijer, A. J., Codogno, P., & Gual, P. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.003 · Cited by 81 · see citing works

The Role of Leukocytes in Diabetic Cardiomyopathy

Bajpai, A., & Tilley, D. G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01547 · Cited by 78 · see citing works

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

LaFavers, K. A., Macedo, E. M., Garimella, P. S., Lima, C., Khan, S., Myslinski, J., McClintick, J. N., Witzmann, F. A., Winfree, S., Phillips, C. L., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw3639 · Cited by 77 · see citing works

Chronic Resveratrol Treatment Protects Pancreatic Islets against Oxidative Stress in db/db Mice

Lee, Y. E., Kim, J.-W., Lee, E. M., Ahn, Y., Song, K., Yoon, K., Kim, H.-W., Park, C.-W., Li, G., Liu, Z., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050412 · Cited by 78 · see citing works

cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets

Subramanian, S. L., Hull, R. L., Zraika, S., Aston‐Mourney, K., Udayasankar, J., & Kahn, S. E. (2011) · Diabetologia · doi:10.1007/s00125-011-2338-7 · Cited by 75 · see citing works

Resolvin D1 reduces ER stress-induced apoptosis and triglyceride accumulation through JNK pathway in HepG2 cells

Jung, T. W., Hwang, H., Hong, H. C., Choi, H. Y., Yoo, H. J., Baik, S. H., & Choi, K. M. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.04.012 · Cited by 71 · see citing works

Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR

Wei, Y., Weng, D., Li, F., Zou, X., Young, D. O., Ji, J., & Shen, P. (2008) · APOPTOSIS · doi:10.1007/s10495-008-0237-2 · Cited by 68 · see citing works

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells

Raciti, G. A., Iadicicco, C., Ulianich, L., Vind, B. F., Gaster, M., Andreozzi, F., Longo, M., Teperino, R., Ungaro, P., Jeso, B. D., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1676-1 · Cited by 67 · see citing works

Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway

Xu, J., Zhang, W., Lu, Z., Zhang, F., & Ding, W. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14070787 · Cited by 65 · see citing works

Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic β-cells

Joe, M. K., Lee, H., Suh, Y. H., Han, K. L., Lim, J. H., Song, J., Seong, J. K., & Jung, M. H. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.01.005 · Cited by 64 · see citing works

Role of Pancreatic Transcription Factors in Maintenance of Mature β-Cell Function

Kaneto, H., & Matsuoka, T. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16036281 · Cited by 64 · see citing works

Molecular mechanism by which pioglitazone preserves pancreatic β-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARγ agonist

Kanda, Y., Shimoda, M., Hamamoto, S., Tawaramoto, K., Kawasaki, F., Hashiramoto, M., Nakashima, K., Matsuki, M., & Kaku, K. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00388.2009 · Cited by 63 · see citing works

Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway

Jung, T. W., Lee, M. W., Lee, Y.-J., & Kim, S. M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.073 · Cited by 63 · see citing works

Comparison of the toxicity induced by microcystin-RR and microcystin-YR in differentiated and undifferentiated Caco-2 cells

Puerto, M., Pichardo, S., Jos, A. M., & Cameán, A. M. (2009) · Toxicon · doi:10.1016/j.toxicon.2009.03.030 · Cited by 62 · see citing works

Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes

Kimura, T., Kaneto, H., Shimoda, M., Hirukawa, H., Okauchi, S., Kohara, K., Hamamoto, S., Tawaramoto, K., Hashiramoto, M., & Kaku, K. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.018 · Cited by 60 · see citing works

Mitochondrial Dysfunction and Mitophagy in Type 2 Diabetes: Pathophysiology and Therapeutic Targets

Apostolova, N., Vezza, T., Muntané, J., Rocha, M., & Víctor, V. M. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0016 · Cited by 59 · see citing works

Mitochondrial DNA Damage via Augmented Oxidative Stress Regulates Endoplasmic Reticulum Stress and Autophagy: Crosstalk, Links and Signaling

Yuzefovych, L. V., LeDoux, S. P., Wilson, G. L., & Rachek, L. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083349 · Cited by 58 · see citing works

Singlet Oxygen Induced Products of Linoleates, 10- and 12-(Z,E)-Hydroxyoctadecadienoic Acids (HODE), Can Be Potential Biomarkers for Early Detection of Type 2 Diabetes

Umeno, A., Shichiri, M., Ishida, N., Hashimoto, Y. K., Abe, K., Kataoka, M., Yoshino, K., Hagihara, Y., Aki, N., Funaki, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063542 · Cited by 57 · see citing works

PDX-1 functions as a master factor in the pancreas.

Kaneto, H., Matsuoka, T., Miyatsuka, T., Kawamori, D., Katakami, N., Yamasaki, Y., & Matsuhisa, M. (2008) · Frontiers in Bioscience · doi:10.2741/3162 · Cited by 57 · see citing works

Stress, the Endoplasmic Reticulum, and Insulin Resistance

Tsiotra, P. C., & Tsigos, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.007 · Cited by 56 · see citing works

Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines

Das, S. K., Chu, W. S., Mondal, A. K., Sharma, N., Kern, P. A., Rasouli, N., & Elbein, S. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90355.2008 · Cited by 54 · see citing works

Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice

He, Y., Ruganzu, J. B., Lin, C., Ding, B., Zheng, Q., Wu, X., Ma, R., Liu, Q., Wang, Y., Jin, H. M., et al. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104610 · Cited by 54 · see citing works

Effects of triglyceride on ER stress and insulin resistance

Kim, D., Jeong, S., Kim, H., Kim, D. S., Chae, S., & Chae, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.151 · Cited by 54 · see citing works

Protective effects of the SGLT2 inhibitor luseogliflozin on pancreatic β‐cells in db/db mice: The earlier and longer, the better

Kimura, T., Obata, A., Shimoda, M., Okauchi, S., Kanda‐Kimura, Y., Nogami, Y., Moriuchi, S., Hirukawa, H., Kohara, K., Nakanishi, S., et al. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13400 · Cited by 52 · see citing works

Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic β-cell death

Kooptiwut, S., Mahawong, P., Hanchang, W., Semprasert, N., Kaewin, S., Limjindaporn, T., & Yenchitsomanus, P. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.09.018 · Cited by 51 · see citing works

Pioglitazone Reduces ER Stress in the Liver: Direct Monitoring of in vivo ER Stress Using ER Stress-activated Indicator Transgenic Mice

Yoshiuchi, K., Kaneto, H., Matsuoka, T., Kasami, R., Kohno, K., Iwawaki, T., Nakatani, Y., Yamasaki, Y., Shimomura, I., & Matsuhisa, M. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-140 · Cited by 51 · see citing works

Methylglyoxal Impairs Insulin Secretion of Pancreaticβ-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

Bo, J., Xie, S., Guo, Y., Zhang, C., Guan, Y., Li, C., Lü, J., & Meng, Q. H. (2015) · Journal of Diabetes Research · doi:10.1155/2016/2029854 · Cited by 50 · see citing works

Mark4 promotes adipogenesis and triggers apoptosis in 3T3‐L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways

Feng, M., Liang, T., Gan, L., Liu, Z., & Sun, C. (2014) · Biology of the Cell · doi:10.1111/boc.201400004 · Cited by 49 · see citing works

Exendin-4 Protects Oxidative Stress-Induced β-Cell Apoptosis through Reduced JNK and GSK3β Activity

Kim, J., Lim, D.-M., Moon, C. I., Jo, K.-J., Lee, S., Baik, H., Lee, K., Lee, K.-W., Park, K., & Kim, B.-J. (2010) · Journal of Korean Medical Science · doi:10.3346/jkms.2010.25.11.1626 · Cited by 48 · see citing works

Chronic insulin treatment causes insulin resistance in 3T3-L1 adipocytes through oxidative stress

Ge, X., Yu, Q., Qi, W., Shi, X., & Zhai, Q. (2008) · Free Radical Research · doi:10.1080/10715760802158448 · Cited by 47 · see citing works

Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets

Ihm, S., Moon, H. J., Kang, J. G., Park, C., Oh, K. W., Jeong, I., Oh, Y., & Park, S. W. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.01.049 · Cited by 46 · see citing works

Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve

Zhang, Q., Yu, J., Liu, B., Lv, Z., Xia, T., Xiao, F., Chen, S., & Guo, F. (2013) · Diabetes · doi:10.2337/db12-1050 · Cited by 46 · see citing works

Beta-Cell Dysfunction Induced by Tacrolimus: A Way to Explain Type 2 Diabetes?

Rodríguez‐Rodríguez, A. E., Porrini, E., & Torres, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910311 · Cited by 46 · see citing works

Adaptation and failure of pancreatic β cells in murine models with different degrees of metabolic syndrome

Medina‐Gómez, G., Yetukuri, L., Velagapudi, V., Campbell, M., Blount, M., Jimenez‐Liñan, M., Ros, M., Orešič, M., & Vidal‐Puig, A. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.003251 · Cited by 44 · see citing works

Jiaogulan tea ( Gpostemma pentaphyllum ) potentiates the antidiabetic effect of white tea via the AMPK and PI3K pathways in C57BL/6 mice

Xia, X., Xu, J., Wang, X., Wang, H., Lin, Z., Shao, K., Fang, L., Zhang, C., & Zhao, Y. (2020) · Food & Function · doi:10.1039/d0fo00395f · Cited by 44 · see citing works

Role of MafA in pancreatic β-cells

Kaneto, H., Matsuoka, T., Kawashima, S., Yamamoto, K., Kato, K., Miyatsuka, T., Katakami, N., & Matsuhisa, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.12.015 · Cited by 43 · see citing works

Effects of bitter melon (Momordica charantia L.) on the gut microbiota in high fat diet and low dose streptozocin-induced rats

Zhu, Y. G., Bai, J., Zhang, Y., Xiao, X., & Dong, Y. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1197185 · Cited by 42 · see citing works

Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice

Yamagishi, N., Ueda, T., Mori, A., Saito, Y., & Hatayama, T. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.118 · Cited by 42 · see citing works

Inducible Nitric Oxide Synthase-Nitric Oxide Plays an Important Role in Acute and Severe Hypoxic Injury to Pancreatic Beta Cells

Ko, S., Ryu, G. R., Kim, S., Ahn, Y., Yoon, K., Kaneto, H., Ha, H., Kim, Y. S., & Song, K. (2008) · Transplantation · doi:10.1097/tp.0b013e31816168f9 · Cited by 42 · see citing works

Oxidative stress plays a role in high glucose-induced activation of pancreatic stellate cells

Ryu, G. R., Lee, E., Chun, H., Yoon, K., Ko, S., Ahn, Y., & Song, K. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.046 · Cited by 42 · see citing works

Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice

Yoshiuchi, K., Kaneto, H., Matsuoka, T.-A., Kohno, K., Iwawaki, T., Nakatani, Y., Yamasaki, Y., Hori, M., & Matsuhisa, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.182 · Cited by 41 · see citing works

Endurance training in mice increases the unfolded protein response induced by a high-fat diet

Deldicque, L., Cani, P. D., Delzenne, N. M., Baar, K., & Francaux, M. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0204-9 · Cited by 41 · see citing works

WISP1 promotes non‐alcoholic fatty liver disease and skeletal muscle insulin resistance via TLR4/JNK signaling

Jung, T. W., Kang, C. M., Goh, J., Chae, S. I., Kim, H., Lee, T. J., El‐Aty, A. M. A., & Jeong, J. H. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26449 · Cited by 40 · see citing works

Stevioside Attenuates Insulin Resistance in Skeletal Muscle by Facilitating IR/IRS-1/Akt/GLUT 4 Signaling Pathways: An In Vivo and In Silico Approach

Deenadayalan, A., Subramanian, V., Paramasivan, V., Veeraraghavan, V. P., Rengasamy, G., Janaki, C. S., Rajagopal, P., & Jayaraman, S. (2021) · Molecules · doi:10.3390/molecules26247689 · Cited by 39 · see citing works

Heat Shock Proteins and Diabetes

Zilaee, M., & Shirali, S. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.05.016 · Cited by 39 · see citing works

Involvement of Oxidative Stress in Suppression of Insulin Biosynthesis under Diabetic Conditions

Kaneto, H., & Matsuoka, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131013680 · Cited by 31 · see citing works

Protective Unfolded Protein Response in Human Pancreatic Beta Cells Transplanted into Mice

Kennedy, J., Katsuta, H., Jung, M.-H., Marselli, L., Goldfine, A. B., Balis, U. J., Sgroi, D. C., Bonner‐Weir, S., & Weir, G. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011211 · Cited by 31 · see citing works

Targeted inhibition of endoplasmic reticulum stress: New hope for renal fibrosis

Ke, B., Zhu, N., Luo, F., Xu, Y., & Fang, X. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6762 · Cited by 31 · see citing works

Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice

Rodriguez, J., Gilson, H., Jamart, C., Naslain, D., Pierre, N., Deldicque, L., & Francaux, M. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0717-9 · Cited by 30 · see citing works

Human Protein Kinases and Obesity

Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_5 · Cited by 29 · see citing works

A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia

Matafome, P. N., Nunes, E., Louro, T. M., Amaral, C. P., Crisóstomo, J., Rodrigues, L., Moedas, A. R., Monteiro, P. F., Cipriano, A., & Seiça, R. M. F. (2008) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-008-0363-y · Cited by 29 · see citing works

Endoplasmic reticulum stress and the c-Jun N-terminal kinase pathway in insulin resistance

Kaneto, H., Nakatani, Y., Matsuhisa, M., & Yamasaki, Y. (2005) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2005.05.008

Involvement of Oxidative Stress and the JNK Pathway in Glucose Toxicity

Kaneto, H., Nakatani, Y., Kawamori, D., Miyatsuka, T., & Matsuoka, T. (2004) · The Review of Diabetic Studies · doi:10.1900/rds.2004.1.165 · Cited by 61 · see citing works

Oxidative Stress and the JNK Pathway in Diabetes

Kaneto, H., Matsuoka, T., Nakatani, Y., Kawamori, D., Matsuhisa, M., & Yamasaki, Y. (2005) · Current Diabetes Reviews · doi:10.2174/1573399052952613 · Cited by 100 · see citing works

The JNK pathway as a therapeutic target for diabetes

Kaneto, H. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.3.581 · Cited by 26 · see citing works

Oxidative Stress and the JNK Pathway are Involved in the Development of Type 1 and Type 2 Diabetes

Kaneto, H., Matsuoka, T., Katakami, N., Kawamori, D., Miyatsuka, T., Yoshiuchi, K., Yasuda, T., Sakamoto, K., Yamasaki, Y., & Matsuhisa, M. (2007) · Current Molecular Medicine · doi:10.2174/156652407782564408 · Cited by 104 · see citing works