The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Human Glomerular Podocyte Is a Novel Target for Insulin Action
Open accessAbstract
Microalbuminuria is significant both as the earliest stage of diabetic nephropathy and as an independent cardiovascular risk factor in nondiabetic subjects, in whom it is associated with insulin resistance. The link between disorders of cellular insulin metabolism and albuminuria has been elusive. Here, we report using novel conditionally immortalized human podocytes in vitro and human glomeruli ex vivo that the podocyte, the principal cell responsible for prevention of urinary protein loss, is insulin responsive and able to approximately double its glucose uptake within 15 min of insulin stimulation. Conditionally immortalized human glomerular endothelial cells do not respond to insulin, suggesting that insulin has a specific effect on the podocyte in the glomerular filtration barrier. The insulin response of the podocyte occurs via the facilitative glucose transporters GLUT1 and GLUT4, and this process is dependent on the filamentous actin cytoskeleton. Insulin responsiveness in this key structural component of the glomerular filtration barrier may have central relevance for understanding of diabetic nephropathy and for the association of albuminuria with states of insulin resistance.
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Cites
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
Boute, N., Gribouval, O., Roselli, S., Benessy, F., Lee, H., Fuchshuber, A., Dahan, K., Gubler, M.-C., Niaudet, P., & Antignac, C. (2000) · Nature Genetics · doi:10.1038/74166 · Cited by 1,444
Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus
Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295
Ryder, J. W., Yang, J., Galuska, D., Rincón, J., Björnholm, M., Krook, A., Lund, S., Pedersen, O., Wallberg-Henriksson, H., Zierath, J. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.4.647 · Cited by 216
Self-citation
Cited by
Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes
Forbes, J. M., Coughlan, M. T., & Cooper, M. E. (2008) · Diabetes · doi:10.2337/db08-0057 · Cited by 1,203
Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function
Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M., Maezawa, Y., Lennon, R., Pons, D. A., Owen, R. J., Satchell, S. C., Miles, M. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.015 · Cited by 462
Self-citationThe impact of insulin resistance on the kidney and vasculature
Artunc, F., Schleicher, E., Weigert, C., Fritsche, A., Stefan, N., & Häring, H.-U. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.145 · Cited by 462
Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms
Gnudi, L., Coward, R. J. M., & Long, D. A. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.07.002 · Cited by 332
Self-citationInsulin therapy in renal disease
Iglesias, P., & Díez, J. J. (2008) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00802.x · Cited by 110
Metadata
- Authors
- Coward, R. J. M., Welsh, G. I., Yang, J., Tasman, C., Lennon, R., Koziell, A., Satchell, S., Holman, G. D., Kerjaschki, D., Tavaré, J. M., Mathieson, P. W., & Saleem, M. A.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-11-01
- Volume
- 54
- Issue
- 11
- Pages
- 3095-3102
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2129648445
- Cited by
- 297
- References
- 4
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Coward, R. J. M., Welsh, G. I., Yang, J., Tasman, C., Lennon, R., Koziell, A., Satchell, S., Holman, G. D., Kerjaschki, D., Tavaré, J. M., Mathieson, P. W., & Saleem, M. A. (2005). The Human Glomerular Podocyte Is a Novel Target for Insulin Action. Diabetes. https://doi.org/10.2337/diabetes.54.11.3095
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
