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Rosiglitazone Treatment in Zucker Diabetic Fatty Rats Is Associated With Ameliorated Cardiac Insulin Resistance and Protection From Ischemia/Reperfusion-Induced Myocardial Injury
Open accessAbstract
The mechanism responsible for the enhanced myocardial susceptibility to ischemic insult in patients with type 2 diabetes is not clear. The present study examines the effect of rosiglitazone treatment on cardiac insulin sensitization and its association with cardioprotection from ischemia/reperfusion injury in an animal model of diabetes. Male Zucker diabetic fatty (ZDF) rats were treated with rosiglitazone (3 mg · kg−1 · day−1 orally) or vehicle for 8 days before undergoing 30 min of coronary artery ligation, followed by reperfusion for 4 h (apoptosis) or 24 h (infarction). Rosiglitazone reduced the blood levels of glucose, triglycerides, and free fatty acids; enhanced cardiac glucose oxidation; and increased Akt phosphorylation (Akt-pS473) 2.1-fold and Akt kinase activity 1.8-fold in the ischemic myocardium. The phosphorylation of two downstream targets of Akt, glycogen synthase kinase-3β and FKHR (forkhead transcription factor), was also enhanced by 2- and 2.9-fold, respectively. In rosiglitazone-treated rats, the number of apoptotic cardiomyocytes and the myocardial infarct size were decreased by 58 and 46%, respectively, and the myocardial contractile dysfunction was improved. Blockade of the insulin-Akt signaling pathway by wortmannin in the 8-day rosiglitazone-treated ZDF rats resulted in a markedly diminished cardioprotective effect of rosiglitazone. In addition, 8-day rosiglitazone treatment in Zucker lean rats or 2-day rosiglitazone treatment in ZDF rats, both of which showed no change in whole-body insulin sensitivity, resulted in a significant reduction in cardiac infarct size, but to a lesser degree when compared with that observed in 8-day rosiglitazone–treated ZDF rats. These results suggest that chronic treatment with rosiglitazone protects the heart against ischemia/reperfusion injury in ZDF rats, and that the enhanced cardiac protection observed after rosiglitazone treatment might be attributable in part to an improvement in cardiac insulin sensitivity.
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“In contrast, studies in older Zucker rats demonstrated reduced recovery from ischemia, which could be prevented by treating these animals with a TZD (159, 322, 389).”
From Cardiac remodeling in obesity (2008) · cites this paper as [389]
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Citations
Cites
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860
Cohen, P., & Frame, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096075 · Cited by 1,493
Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation
Hoeflich, K. P., Luo, J., Rubie, E. A., Tsao, M., Jin, O., & Woodgett, J. R. (2000) · Nature · doi:10.1038/35017574 · Cited by 1,401
Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway
Pap, M., & Cooper, G. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.19929 · Cited by 1,046
Myocardial Cell Death in Human Diabetes
Frustaci, A., Kajstura, J., Chimenti, C., Jakoniuk, I., Leri, A., Maseri, A., Nadal-Ginard, B., & Anversa, P. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1123 · Cited by 796
Garofalo, R. S., Orena, S. J., Rafidi, K., Torchia, A. J., Stock, J. L., Hildebrandt, A. L., Coskran, T., Black, S. C., Brees, D. J., Wicks, J. R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16885 · Cited by 726
Impact of Diabetes on Mortality After the First Myocardial Infarction
Miettinen, H., Lehto, S., Salomaa, V., Mähönen, M., Niemelä, M., Haffner, S. M., Pyörälä, K., Tuomilehto, J., & The FINMONICA Myocardial Infarction Register Study Group (1998) · Diabetes Care · doi:10.2337/diacare.21.1.69 · Cited by 665
A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in AKT2
George, S., Rochford, J. J., Wolfrum, C., Gray, S. L., Schinner, S., Wilson, J. C., Soos, M. A., Murgatroyd, P. R., Williams, R. M., Acerini, C. L., et al. (2004) · Science · doi:10.1126/science.1096706 · Cited by 562
Adaptation and Maladaptation of the Heart in Diabetes: Part I
Taegtmeyer, H., McNulty, P. H., & Young, M. E. (2002) · Circulation · doi:10.1161/01.cir.0000012466.50373.e8 · Cited by 520
Fatty acid homeostasis in the normoxic and ischemic heart
Vusse, G. J., Glatz, J. F. C., Stam, H. C., & Reneman, R. S. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.4.881 · Cited by 516
Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial Ischemia-Reperfusion
Gao, F., Gao, E., Yue, T.-L., Ohlstein, E. H., Lopez, B. L., Christopher, T. A., & Ma, X. (2002) · Circulation · doi:10.1161/01.cir.0000012529.00367.0f · Cited by 469
Self-citationTong, H., Imahashi, K., Steenbergen, C., & Murphy, E. (2002) · Circulation Research · doi:10.1161/01.res.0000012567.95445.55 · Cited by 377
Wayman, N. S., Hattori, Y., McDonald, M. C., Mota‐Filipe, H., Cuzzocrea, S., PISANO, B., Chatterjee, P. K., & Thiemermann, C. (2002) · The FASEB Journal · doi:10.1096/fj.01-0793com · Cited by 359
Yue, T.-L., Chen, J., Bao, W., Narayanan, P. K., Bril, A., Jiang, W., Lysko, P. G., Gu, J.-L., Boyce, R., Zimmerman, D. M., et al. (2001) · Circulation · doi:10.1161/hc4601.099403 · Cited by 295
Self-citationWoodfield, S. L., Lundergan, C. F., Reiner, J. S., Greenhouse, S. W., Thompson, M. A., Rohrbeck, S. C., Deychak, Y. A., Simoons, M. L., Califf, R. M., Topol, E. J., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00397-x · Cited by 280
Yue, T.-L., Ma, X.-L., Wang, X., Romanic, A. M., Gao-lin, L., Louden, C. S., Gu, J.-L., Kumar, S., Poste, G. H., Ruffolo, R. R., Jr., et al. (1998) · Circulation Research · doi:10.1161/01.res.82.2.166 · Cited by 234
Self-citationMalhotra, R., & Brosius, F. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12567 · Cited by 232
Aikawa, R., Nawano, M., Gu, Y., Katagiri, H., Asano, T., Zhu, W., Nagai, R., & Komuro, I. (2000) · Circulation · doi:10.1161/01.cir.102.23.2873 · Cited by 228
The effect of diabetes on outcomes of patients with advanced heart failure in the BEST trial
Domanski, M., Krause-Steinrauf, H., Deedwania, P., Follmann, D., Ghali, J. K., Gilbert, E., Haffner, S., Katz, R., Lindenfeld, J., Lowes, B. D., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00856-8 · Cited by 215
Khandoudi, N., Delerive, P., Berrebi-Bertrand, I., Buckingham, R. E., Staels, B., & Bril, A. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1507 · Cited by 174
The diabetic heart is more sensitive to ischemic injury
Paulson, D. J. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00018-7 · Cited by 170
Sidell, R. J., Cole, M. A., Draper, N. J., Desrois, M., Buckingham, R. E., & Clarke, K. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1110 · Cited by 165
Paternostro, G., Camici, P. G., Lammertsma, A. A., Marinho, N. V. S., Baliga, R. R., Kooner, J. S., Radda, G. K., & Ferrannini, E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119015 · Cited by 150
Feuvray, D. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00037-0 · Cited by 134
Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM
Utriainen, T., Takala, T., Luotolahti, M., Rönnemaa, T., Laine, H. K., Ruotsalainen, U., Haaparanta‐Solin, M., Nuutila, P., & Yki‐Järvinen, H. (1998) · Diabetologia · doi:10.1007/s001250050946 · Cited by 129
Ohtake, T., Yokoyama, I., Watanabe, T., Momose, T., Serezawa, T., Nishikawa, J., & Sasaki, Y. (1995) · PubMed · Cited by 106
Ito, H., Nakano, A., Kinoshita, M., & Matsumori, A. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000106724.29121.da · Cited by 104
O’Connor, C. M., Hathaway, W. R., Bates, E., Leimberger, J. D., Sigmon, K. N., Kereiakes, D. J., George, B. S., Samaha, J. K., Abbottsmith, C. W., Candela, R. J., et al. (1997) · American Heart Journal · doi:10.1016/s0002-8703(97)70168-6 · Cited by 104
Voipio‐Pulkki, L., Nuutila, P., Knuuti, J. M., Ruotsalainen, U., Haaparanta‐Solin, M., Teräs, M., Wegelius, U., & Koivisto, V. A. (1993) · PubMed · Cited by 104
Jagasia, D. H., Whiting, J. M., Concato, J., Pfau, S. E., & McNulty, P. H. (2001) · Circulation · doi:10.1161/01.cir.103.13.1734 · Cited by 92
Troglitazone Improves Recovery of Left Ventricular Function After Regional Ischemia in Pigs
Zhu, P., Li, L., Xu, Y., & Schwartz, G. G. (2000) · Circulation · doi:10.1161/01.cir.101.10.1165 · Cited by 90
Wang, P., & Chatham, J. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00295.2003 · Cited by 81
Jucker, B. M., Rennings, A. J. M., Cline, G. W., & Shulman, G. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10464 · Cited by 77
Self-citationResidual Left Ventricular Pump Function After Acute Myocardial Infarction in NIDDM Patients
Iwasaka, T., Takahashi, N., Nakamura, S., Sugiura, T., Tarumi, N., Kimura, Y., Okubo, N., Taniguchi, H., Matsui, Y., & Inada, M. (1992) · Diabetes Care · doi:10.2337/diacare.15.11.1522 · Cited by 58
Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats
Lopaschuk, G. D., Saddik, M., Barr, R. L., Huang, L., Barker, C. C., & MUZYKA, R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2006.263.6.e1046 · Cited by 48
Left Ventricular Regional Function After Acute Anterior Myocardial Infarction in Diabetic Patients
Takahashi, N., Iwasaka, T., Sugiura, T., Hasegawa, T., Tarumi, N., Kimura, Y., Kurihara, S., Onoyama, H., & Inada, M. (1989) · Diabetes Care · doi:10.2337/diacare.12.9.630 · Cited by 26
Zaninetti, D., Greco-Perotto, R., Assimacopoulos‐Jeannet, F., & Jeanrenaud, B. (1989) · Diabetologia · doi:10.1007/bf00265405 · Cited by 24
Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats
Lopaschuk, G. D., Saddik, M., Barr, R. L., Huang, L., Barker, C. C., & MUZYKA, R. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.6.e1046 · Cited by 24
van Rooyen, J., McCarthy, J., & OPIE, L. (2002) · PubMed · Cited by 15
Lack of both oxygen and glucose contributes to I/R-induced changes in cardiac SR function
Temsah, R. M., Netticadan, T., Kawabata, K., & Dhalla, N. S. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00138.2002 · Cited by 7
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Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543
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Jope, R. S., Yuskaitis, C. J., & Beurel, E. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9128-5 · Cited by 774
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Metadata
- Authors
- Yue, T.-L., Bao, W., Gu, J.-L., Cui, J., Tao, L., Ma, X.-L., Ohlstein, E. H., & Jucker, B. M.
- Affiliations
- From the Department of Investigative and Cardiac Biology, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania
- GlaxoSmithKline (United States) (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-02-01
- Volume
- 54
- Issue
- 2
- Pages
- 554-562
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2154626866
- Cited by
- 170
- References
- 41
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 10 · 2012: 14
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- rosiglitazone, cardiac insulin resistance, insulin sensitization, myocardial ischemia-reperfusion injury, type 2 diabetes, Zucker diabetic fatty rats, Akt signaling, glycogen synthase kinase-3β, forkhead transcription factor, cardiomyocyte apoptosis, myocardial infarct size, myocardial contractile dysfunction, wortmannin, PPARγ agonists
- MeSH terms
- Rosiglitazone, Administration, Oral, Animals, Blood Glucose, Coronary Vessels, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Heart, Hypoglycemic Agents, Insulin Resistance, Male, Myocardial Infarction, Myocardium, Rats, Zucker, Triglycerides, Myocardial Reperfusion Injury, Thiazolidinediones, Rats
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