S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt

Carvalho-Filho, Marco A.; Ueno, Mirian; Hirabara, Sandro M.; Seabra, Amedea B.; Carvalheira, José B.C.; de Oliveira, Marcelo G.; Velloso, Lício A.; Curi, Rui; Saad, Mario J.A.

doi:10.2337/diabetes.54.4.959

Cited by 277Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressMetabolism, Diabetes, and Cancer

S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt

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Carvalho-Filho, Marco A., Ueno, Mirian, Hirabara, Sandro M., Seabra, Amedea B., Carvalheira, José B.C., de Oliveira, Marcelo G., Velloso, Lício A., Curi, Rui +1 more·2005·Diabetes

DOI 10.2337/diabetes.54.4.959

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Abstract

Evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible nitric oxide synthase (iNOS) can induce insulin resistance in muscle. Here, we investigated whether this insulin resistance could be mediated by S-nitrosation of proteins involved in early steps of the insulin signal transduction pathway. Exogenous NO donated by S-nitrosoglutathione (GSNO) induced in vitro and in vivo S-nitrosation of the insulin receptor beta subunit (IRbeta) and protein kinase B/Akt (Akt) and reduced their kinase activity in muscle. Insulin receptor substrate (IRS)-1 was also rapidly S-nitrosated, and its expression was reduced after chronic GSNO treatment. In two distinct models of insulin resistance associated with enhanced iNOS expression-diet-induced obesity and the ob/ob diabetic mice-we observed enhanced S-nitrosation of IRbeta/IRS-1 and Akt in muscle. Reversal of S-nitrosation of these proteins by reducing iNOS expression yielded an improvement in insulin action in both animal models. Thus, S-nitrosation of proteins involved in insulin signal transduction is a novel molecular mechanism of iNOS-induced insulin resistance.

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Ablation of the NOS2 gene has no effect on weight gain but improves glucose tolerance, normalizes insulin sensitivity, and prevents derangements in PI3K/Akt signaling in high fat-fed mice.
“Although ablation of the NOS2 gene has no effect on weight gain, its absence was shown to improve glucose tolerance, normalize insulin sensitivity, and prevent derangements in PI3K/Akt signaling in high fat-fed mice [346].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [346]

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works
Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene
Elchebly, M., Payette, P., Michaliszyn, E., Cromlish, W., Collins, S., Loy, A. L., Normandin, D., Cheng, A., Himms-Hagen, J., Chan, C.-C., et al. (1999) · Science · doi:10.1126/science.283.5407.1544 · Cited by 2,210 · see citing works
S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.
Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T. M., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.444 · Cited by 1,471 · see citing works
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,344 · see citing works
Lipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265 · see citing works
Untitled work
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261 · see citing works
Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice
Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y.-B., Sharpe, A. H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5479-5489.2000 · Cited by 1,235 · see citing works
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
Shimabukuro, M., Zhou, Y.-T., Levi, M., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2498 · Cited by 1,142 · see citing works
Nitric Oxide: Pathophysiological Mechanisms
Gross, S. S., & Wolin, M. S. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003513 · Cited by 888 · see citing works
The Biotin Switch Method for the Detection of S -Nitrosylated Proteins
Jaffrey, S. R., & Snyder, S. H. (2001) · Science s STKE · doi:10.1126/stke.2001.86.pl1 · Cited by 805 · see citing works
S -Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function
Chung, K. K. K., Thomas, B., Li, X., Pletniková, O., Troncoso, J. C., Marsh, L., Dawson, V. L., & Dawson, T. M. (2004) · Science · doi:10.1126/science.1093891 · Cited by 765 · see citing works
(S)NO Signals: Translocation, Regulation, and a Consensus Motif
Stamler, J. S., Toone, E. J., Lipton, S. A., & Sucher, N. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80310-4 · Cited by 674 · see citing works
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
Perreault, M., & Marette, A. (2001) · Nature Medicine · doi:10.1038/nm1001-1138 · Cited by 540 · see citing works
Estimates ofIn VivoInsulin Action in Man: Comparison of Insulin Tolerance Tests with Euglycemic and Hyperglycemic Glucose Clamp Studies*
Bonora, E., Moghetti, P., Zancanaro, C., CIGOLINI, M., Querena, M., Cacciatori, V., Corgnati, A., & Muggeo, M. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-2-374 · Cited by 525 · see citing works
Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro
Leighton, B., & Cooper, G. J. S. (1988) · Nature · doi:10.1038/335632a0 · Cited by 473 · see citing works
Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats
Storlien, L. H., James, D. E., Burleigh, K. M., Chisholm, D. J., & Kraegen, E. W. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.251.5.e576 · Cited by 458 · see citing works
Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor
Matsushita, K., Morrell, C. N., Cambien, B., Yang, S.-X., Yamakuchi, M., Bao, C., Hara, M. R., Quick, R. A., Cao, W., O'Rourke, B. P., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00803-1 · Cited by 446 · see citing works
Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase
Peraldi, P., Hotamisligil, G. S., Buurman, W. A., White, M. F., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13018 · Cited by 412 · see citing works
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.
Vedia, L. M. Y., McDonald, B. R., Reep, B. R., Brüne, B., Silvio, M. D., Billiar, T. R., & Lapetina, E. G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)73985-4 · Cited by 390 · see citing works
Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of the Inducible Nitric Oxide Synthase Gene
Li, M., Pascual, G., & Glass, C. K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4699-4707.2000 · Cited by 377 · see citing works
Nitric oxide-stimulated guanine nucleotide exchange on p21ras
Lander, H. M., Ogiste, J. S., Pearce, S. F. A., Levi, R., & Novogrodsky, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7017 · Cited by 364 · see citing works
Tumor necrosis factor alpha: a key component of the obesity-diabetes link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diabetes.43.11.1271 · Cited by 354 · see citing works
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
Saad, M. J., Folli, F., Kahn, J. A., & Kahn, C. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116803 · Cited by 349 · see citing works
Self-citation
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.
Saad, M. J. A., Araki, E., Miralpeix, M., Rothenberg, P., White, M. F., & Kahn, C. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116060 · Cited by 323 · see citing works
Self-citation
Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites
Crettaz, M., Prentki, M., Zaninetti, D., & Jeanrenaud, B. (1980) · Biochemical Journal · doi:10.1042/bj1860525 · Cited by 311 · see citing works
Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase
De Fea, K., & Roth, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31400 · Cited by 298 · see citing works
Basal and Stimulated Protein S-Nitrosylation in Multiple Cell Types and Tissues
Gow, A. J., Chen, Q., Hess, D. T., Day, B. J., Ischiropoulos, H., & Stamler, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100746200 · Cited by 294 · see citing works
Role of nitric oxide in obesity-induced beta cell disease.
Shimabukuro, M., Ohneda, M., Lee, Y., & Unger, R. H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119534 · Cited by 282 · see citing works
Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action.
Kapur, S., Bédard, S., Marcotte, B., Côté, C. H., & Marette, A. (1997) · Diabetes · doi:10.2337/diab.46.11.1691 · Cited by 225 · cited 3× · see citing works
“It is well established that proinflammatory cytokines (tumor necrosis factor- and interleukin-6) and endotoxins synergistically increase NO production via increased expression of iNOS in rat skeletal muscle and cultured myocytes and adipocytes (8,17,18).”
Background
Direct and indirect effects of nitric oxide in chemical reactions relevant to biology
Wink, D. A., Grisham, M. B., Mitchell, J. B., & Ford, P. C. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68006-9 · Cited by 182 · see citing works
Determination of nitric oxide using fluorescence spectroscopy
Miles, A. M., Wink, D. A., Cook, J. C., & Grisham, M. B. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68013-6 · Cited by 176 · see citing works
The Biotin Switch Method for the Detection of S-Nitrosylated Proteins
Jaffrey, S. R., & Snyder, S. H. (2001) · Science Signaling · doi:10.1126/scisignal.862001pl1 · Cited by 176 · see citing works
Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase
BÉDARD, S., Marcotte, B., & Marette, A. (1997) · Biochemical Journal · doi:10.1042/bj3250487 · Cited by 175 · see citing works
Direct Activation of the Olfactory Cyclic Nucleotide–Gated Channel through Modification of Sulfhydryl Groups by NO Compounds
Broillet, M.-C., & Firestein, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80055-0 · Cited by 158 · see citing works
Thermal Stability of Primary S-Nitrosothiols: Roles of Autocatalysis and Structural Effects on the Rate of Nitric Oxide Release
de Oliveira, M. G., Shishido, S. M., Seabra, A. B., & Morgon, N. H. (2002) · The Journal of Physical Chemistry A · doi:10.1021/jp025756u · Cited by 138 · see citing works
Self-citation
Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: evidence for an effect of leptin on glucose uptake and decarboxylation
Ceddia, R. B., William, W., & Curi, R. A. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800762 · Cited by 132 · see citing works
Self-citation
Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance
Sugita, H., Kaneki, M., Tokunaga, E., Sugita, M., Koike, C., Yasuhara, S., Tompkins, R. G., & Martyn, J. A. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00087.2001 · Cited by 130 · see citing works
Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.
Maggi, L. B., Sadeghi, H., Weigand, C. M., Scarim, A. L., Heitmeier, M. R., & Corbett, J. A. (2000) · Diabetes · doi:10.2337/diabetes.49.3.346 · Cited by 128 · see citing works
Regulation of β cell glucokinase by S-nitrosylation and association with nitric oxide synthase
Rizzo, M. A., & Piston, D. W. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301063 · Cited by 124 · see citing works
Detection and proteomic identification of S-nitrosylated proteins in endothelial cells
Martı́nez-Ruiz, A., & Lamas, S. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.006 · Cited by 120 · see citing works
Selenite Inhibits the c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) through a Thiol Redox Mechanism
Park, H.-S., Park, E., Kim, M.-S., Ahn, K., Kim, I. Y., & Choi, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2527 · Cited by 119 · see citing works
Insulin Induces Tyrosine Phosphorylation of JAK2 in Insulin-sensitive Tissues of the Intact Rat
Saad, M. J. A., Carvalho, C. R. D. O., Thirone, A. C. P., & Velloso, L. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22100 · Cited by 112 · see citing works
Self-citation
Cell signaling by nitric oxide.
Lane, P. B., & Gross, S. S. (1999) · PubMed · Cited by 103 · see citing works
Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols
Li, S., & Whorton, A. R. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00696-3 · Cited by 99 · see citing works
Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.
Chin, J. E., Liu, F., & Roth, R. A. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.1.7512195 · Cited by 85 · see citing works
Tumor Necrosis Factor α-induced Pancreatic β-Cell Insulin Resistance Is Mediated by Nitric Oxide and Prevented by 15-Deoxy-Δ12,14-prostaglandin J2 and Aminoguanidine
Kwon, G., Xu, G. H., Marshall, C. A., & McDaniel, M. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18702 · Cited by 80 · see citing works
Mechanism of adipose tissue iNOS induction in endotoxemia
Kapur, S., Marcotte, B., & Marette, A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e635 · Cited by 78 · see citing works
Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance—the obese middle-aged and the spontaneously hypertensive rats
Zecchin, H. G., Bezerra, R. M. N., Carvalheira, J. B. C., Carvalho-Filho, M. A., Metze, K., Franchini, K. G., & Saad, M. J. A. (2003) · Diabetologia · doi:10.1007/s00125-003-1073-0 · Cited by 65 · see citing works
Self-citation
Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action
Kapur, S., Bedard, S., Marcotte, B., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.11.1691 · Cited by 56 · see citing works
Complementation Mapping in Microcell Hybrids: Localization of XRCC4 to 5q15–q21
Athwal, R. S., & Kaur, G. P. (1996) · Methods · doi:10.1006/meth.1996.0003 · Cited by 29 · see citing works

Flagged first, then by citations

Sorted by citations

Inflammation and insulin resistance
de Luca, C., & Olefsky, J. M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.057 · Cited by 1,161 · see citing works
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939 · see citing works
Molecular mechanisms of ROS production and oxidative stress in diabetes
Newsholme, P., Cruzat, V. F., Keane, K. N., Carlessi, R., & de Bittencourt, P. I. H. (2016) · Biochemical Journal · doi:10.1042/bcj20160503c · Cited by 878 · see citing works
Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., et al. (2007) · Diabetes · doi:10.2337/db06-1595 · Cited by 826 · see citing works
Self-citation
Retracted
Selenium biochemistry and its role for human health
Roman, M., Jitaru, P., & Barbante, C. (2014) · Metallomics · doi:10.1039/c3mt00185g · Cited by 823 · see citing works
Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance
Saad, M. J. A., Santos, A., & Prada, P. O. (2016) · Physiology · doi:10.1152/physiol.00041.2015 · Cited by 818 · see citing works
Self-citation
Protein S-nitrosylation in health and disease: a current perspective
Foster, M. W., Hess, D. T., & Stamler, J. S. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.007 · Cited by 752 · see citing works
Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.
Newsholme, P., Haber, E. P., Hirabara, S. M., Rebelato, E. L. O., Procopio, J., Morgan, D., Oliveira‐Emilio, H. C., Carpinelli, A. R., & Curi, R. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135871 · Cited by 684 · see citing works
Self-citation
Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease
Masarone, M., Rosato, V., Dallio, M., Gravina, A. G., Aglitti, A., Loguercio, C., Federico, A., & Persico, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9547613 · Cited by 648 · see citing works
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542 · see citing works
S -Nitrosylation in Cardiovascular Signaling
Lima, B., Forrester, M. T., Hess, D. T., & Stamler, J. S. (2010) · Circulation Research · doi:10.1161/circresaha.109.207381 · Cited by 490 · see citing works
Regulation by S-Nitrosylation of Protein Post-translational Modification
Hess, D. T., & Stamler, J. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.285742 · Cited by 385 · see citing works
S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities
Martı́nez-Ruiz, A., Villanueva, L., de Orduña, C. G., López‐Ferrer, D., Higueras, M. Á., Tarín, C., Rodríguez‐Crespo, I., Vázquez, J., & Lamas, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407294102 · Cited by 330 · see citing works
Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
Martins, A. R., Nachbar, R. T., Gorjão, R., Vinolo, M. A. R., Festuccia, W. T., Lambertucci, R. H., Cury‐Boaventura, M. F., Silveira, L. R., Curi, R., & Hirabara, S. M. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-30 · Cited by 288 · see citing works
Self-citation
Metabolic inflammation in heart failure with preserved ejection fraction
Schiattarella, G. G., Rodolico, D., & Hill, J. A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa217 · Cited by 284 · see citing works
Skeletal muscle insulin resistance: role of mitochondria and other ROS sources
Di Meo, S., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0598 · Cited by 282 · see citing works
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
“responsible for NOS2-induced insulin resistance [346,347].”
The Role of Gut Microbiota on Insulin Resistance
Caricilli, A. M., & Saad, M. A. (2013) · Nutrients · doi:10.3390/nu5030829 · Cited by 273 · see citing works
Self-citation
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Anand, P., & Stamler, J. S. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0878-z · Cited by 270 · see citing works
S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction
Yang, L., Calay, E. S., Fan, J., Arduini, A., Kunz, R. C., Gygi, S. P., Yalçın, A., Fu, S., & Hotamışlıgil, G. S. (2015) · Science · doi:10.1126/science.aaa0079 · Cited by 231 · see citing works
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Anavi, S., & Tirosh, O. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.10.411 · Cited by 226 · see citing works
Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights
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Petrakis, D., Vassilopoulou, L., Mamoulakis, C., Psycharakis, C., Anifantaki, A., Sifakis, S., Docea, A. O., Tsiaoussis, J., Makrigiannakis, A., & Tsatsakis, A. M. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14101282 · Cited by 194 · see citing works
Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions
Hirabara, S. M., Gorjão, R., Vinolo, M. A. R., Rodrigues, A. C., Nachbar, R. T., & Curi, R. (2012) · BioMed Research International · doi:10.1155/2012/379024 · Cited by 178 · see citing works
Self-citation
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Bielka, W., Przezak, A., & Pawlik, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010480 · Cited by 184 · see citing works
The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation‐Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management
Krause, M. D. S., Heck, T. G., Bittencourt, A., Scomazzon, S. P., Newsholme, P., Curi, R., & de Bittencourt, P. I. H. (2015) · Mediators of Inflammation · doi:10.1155/2015/249205 · Cited by 175 · see citing works
Self-citation
Redox regulation of protein kinases
Truong, T. H., & Carroll, K. S. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.790873 · Cited by 172 · see citing works
The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy
Barnett, S. D., & Buxton, I. L. O. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1304353 · Cited by 174 · see citing works
Gut microbiota and probiotics: Focus on diabetes mellitus
Tonucci, L. B., dos Santos, K. M. O., Ferreira, C. L. D. L. F., Ribeiro, S. M. R., de Oliveira, L. L., & Martino, H. S. D. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.934438 · Cited by 166 · see citing works
Influence of Gut Microbiota on Subclinical Inflammation and Insulin Resistance
Carvalho, B. M., & Saad, M. J. A. (2013) · Mediators of Inflammation · doi:10.1155/2013/986734 · Cited by 162 · see citing works
Self-citation
Role of Nitric Oxide in Insulin Secretion and Glucose Metabolism
Bahadoran, Z., Mirmiran, P., & Ghasemi, A. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.10.001 · Cited by 162 · see citing works
Thioredoxin and Thioredoxin Reductase in Relation to Reversible S -Nitrosylation
Sengupta, R., & Holmgren, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4716 · Cited by 156 · see citing works
Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure
Šoškić, S., Dobutović, B. D., Sudar-Milovanovic, E. M., Obradovic, M. M., Nikolić, D., Djordjevic, J. D., Radak, D. J., Mikhailidis, D. P., & Isenović, E. R. (2011) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401105010153 · Cited by 156 · see citing works
Increase in Glucose-6-Phosphate Dehydrogenase in Adipocytes Stimulates Oxidative Stress and Inflammatory Signals
Park, J., Choe, S. S., Choi, A. H., Kim, K. H., Yoon, M. J., Suganami, T., Ogawa, Y., & Kim, J. B. (2006) · Diabetes · doi:10.2337/db05-1570 · Cited by 155 · see citing works
The Lipid Peroxidation By-Product 4-Hydroxy-2-Nonenal (4-HNE) Induces Insulin Resistance in Skeletal Muscle through Both Carbonyl and Oxidative Stress
Pillon, N. J., Croze, M. L., Vella, R., Soulère, L., Lagarde, M., & Soulage, C. O. (2012) · Endocrinology · doi:10.1210/en.2011-1957 · Cited by 154 · see citing works
The Redox Regulation of PI 3-Kinase–Dependent Signaling
Leslie, N. R. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1765 · Cited by 148 · see citing works
Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet
Caricilli, A. M., Nascimento, P. H., Pauli, J. R., Tsukumo, D. M. L., Velloso, L. A., Carvalheira, J. B. C., & Saad, M. J. A. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0354 · Cited by 141 · see citing works
Self-citation
Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats
Oliveira, A. G., Carvalho, B. M., Tobar, N., Ropelle, E. R., Pauli, J. R., Bagarolli, R. A., Guadagnini, D., Carvalheira, J. B. C., & Saad, M. J. A. (2011) · Diabetes · doi:10.2337/db09-1907 · Cited by 134 · see citing works
Self-citation
Retracted
Nitrosative Stress and Pathogenesis of Insulin Resistance
Kaneki, M., Shimizu, N., Yamada, D., & Chang, K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1464 · Cited by 133 · see citing works
Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats
Picardi, P. K., Calegari, V. C., Prada, P. O., Moraes, J. C., ARAUJO, E. P. D., Gomes‐Marcondes, M. C. C., Ueno, M., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2008) · Endocrinology · doi:10.1210/en.2007-1506 · Cited by 127 · see citing works
Self-citation
Insulin Resistance Postburn: Underlying Mechanisms and Current Therapeutic Strategies
Gauglitz, G. G., Herndon, D. N., & Jeschke, M. G. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31818481ce · Cited by 120 · see citing works
Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice
Charbonneau, A., & Marette, A. (2010) · Diabetes · doi:10.2337/db09-1238 · Cited by 113 · see citing works
The role of thioredoxin in the regulation of cellular processes by S-nitrosylation
Sengupta, R., & Holmgren, A. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.012 · Cited by 110 · see citing works
The Role of Insulin Resistance in Fueling NAFLD Pathogenesis: From Molecular Mechanisms to Clinical Implications
Palma, R., Pronio, A., Romeo, M., Scognamiglio, F., Ventriglia, L., Ormando, V. M., Lamazza, A., Pontone, S., Federico, A., & Dallio, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133649 · Cited by 111 · see citing works
Thiol Signalling Network with an Eye to Diabetes
Matteucci, E., & Giampietro, O. (2010) · Molecules · doi:10.3390/molecules15128890 · Cited by 106 · see citing works
Muscle redox signalling pathways in exercise. Role of antioxidants
Mason, S. A., Morrison, D., McConell, G. K., & Wadley, G. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.022 · Cited by 103 · see citing works
Bifidobacterium species lower serum glucose, increase expressions of insulin signaling proteins, and improve adipokine profile in diabetic mice
Thi Kim Chung, L. E., Hosaka, T., Nguyen, T. T., Kassu, A., Thi Oanh, D. A. N. G., Hong Ba, T. R. A. N., Tran Phuong, P. H. A. M., Quang Binh, T. R. A. N., Thi Hong Hao, L. E., & Xuan Da, P. H. A. M. (2015) · Biomedical Research · doi:10.2220/biomedres.36.63 · Cited by 100 · see citing works
A Novel Pathway of Insulin Sensitivity in Chromogranin A Null Mice
Gayen, J. R., Saberi, M., Schenk, S., Biswas, N., Vaingankar, S. M., Cheung, W. W., Najjar, S. M., O’Connor, D. T., Bandyopadhyay, G. K., & Mahata, S. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020636 · Cited by 98 · see citing works
Acute physical exercise reverses S‐nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet‐induced obese Wistar rats
Pauli, J. R., Ropelle, E. R., Cintra, D. E., Carvalho‐Filho, M. A., Moraes, J. C., De Souza, C. T., Velloso, L. A., Carvalheira, J. B. C., & Saad, M. J. A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142414 · Cited by 97 · see citing works
Self-citation
Aging-Associated Dysfunction of Akt/Protein Kinase B: S-Nitrosylation and Acetaminophen Intervention
Wu, M., Katta, A., Gadde, M. K., Liu, H., Kakarla, S. K., Fannin, J. C., Paturi, S., Arvapalli, R. K., Rice, K. M., Wang, Y., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006430 · Cited by 97 · see citing works
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94 · see citing works
Microbiota, Obesity and NAFLD
Lau, L. H. S., & Wong, S. H. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-8684-7_9 · Cited by 91 · see citing works
Enhancement of Diabetic Wound Repair Using Biodegradable Nanofibrous Metformin-Eluting Membranes: in Vitro and in Vivo
Lee, C., Hsieh, M., Chang, S., Lin, Y.-H., Liu, S., Lin, T., Hung, K., Pang, J. S., & Juang, J. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am405329g · Cited by 90 · see citing works
The fat cell senescence hypothesis
Newsholme, P., & de Bittencourt, P. I. H. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000077 · Cited by 90 · see citing works
Inhibition of UCP2 expression reverses diet‐induced diabetes mellitus by effects on both insulin secretion and action
DeSouza, C. T., ARAUJO, E. P. D., Stoppiglia, L. F., Pauli, J. R., Ropelle, E. R., Rocco, S. A., Marin, R. M., Franchini, K. G., Carvalheira, J. B. C., Saad, M. J. A., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7148com · Cited by 90 · see citing works
Self-citation
Anti-obesity and anti-diabetic effects of nitrate and nitrite
Ghasemi, A., & Jeddi, S. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.08.003 · Cited by 89 · see citing works
Insulin resistance and liver microcirculation in a rat model of early NAFLD
Pasarín, M., Abraldeṣ, J. G., Rodrı́guez-Vilarrupla, A., Mura, V. L., García‐Pagán, J. C., & Bosch, J. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.01.053 · Cited by 87 · see citing works
Role of adipose tissue macrophages in obesity-related disorders
Chakarov, S., Blériot, C., & Ginhoux, F. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211948 · Cited by 86 · see citing works
Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRβ/IRS-1 and Akt and insulin resistance in muscle of mice
Carvalho-Filho, M. A., Ueno, M., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00422.2005 · Cited by 84 · see citing works
Self-citation
Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes
Anhê, G. F., Okamoto, M. M., Kinote, A. P. B. D. M., Sollon, C. S., Lellis‐Santos, C., Anhê, F. F., Lima, G. A., Hirabara, S. M., Velloso, L. A., Bordin, S. A., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.007 · Cited by 84 · see citing works
Self-citation
Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle
Boden, M. J., Brandon, A. E., Tid-Ang, J. D., Preston, E., Wilks, D. L., Stuart, E., Cleasby, M. E., Turner, N. A., Cooney, G. J., & Kraegen, E. W. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00577.2011 · Cited by 80 · see citing works
Insulin Resistance in HIV-Patients: Causes and Consequences
Pedro, M. N., Rocha, G. Z., Guadagnini, D., Santos, A., Magro, D. O., Assalin, H. B., Oliveira, A. G., Pedro, R. D. J., & Saad, M. J. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00514 · Cited by 80 · see citing works
Self-citation
Leishmanicidal activity of primary S-nitrosothiols against Leishmania major and Leishmania amazonensis: Implications for the treatment of cutaneous leishmaniasis
de Souza, G. F. P., Yokoyama-Yasunaka, J. K. U., Seabra, A. B., Miguel, D. C., de Oliveira, M. G., & Uliana, S. R. B. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.011 · Cited by 80 · see citing works
Self-citation
Liver-specific Inducible Nitric-oxide Synthase Expression Is Sufficient to Cause Hepatic Insulin Resistance and Mild Hyperglycemia in Mice
Shinozaki, S., Choi, C. S., Shimizu, N., Yamada, M., Kim, M., Zhang, T., Shiota, G., Dong, H. H., Kim, Y.-B., & Kaneki, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187666 · Cited by 79 · see citing works
S‐Nitrosothiols as Platforms for Topical Nitric Oxide Delivery
de Oliveira, M. G. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12588 · Cited by 77 · see citing works
Endotoxin Mediated-iNOS Induction Causes Insulin Resistance via ONOO− Induced Tyrosine Nitration of IRS-1 in Skeletal Muscle
Pilon, G., Charbonneau, A., White, P. J., Dallaire, P., Perreault, M., Kapur, S., & Marette, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015912 · Cited by 74 · see citing works
EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice
Prada, P. O., Ropelle, E. R., Mourão, R. H. V., de Souza, C. T., Pauli, J. R., Cintra, D. E., Schenka, A. A., Rocco, S. A., Rittner, R., Franchini, K. G., et al. (2009) · Diabetes · doi:10.2337/db08-0506 · Cited by 73 · see citing works
Self-citation
Retracted
Angiotensin II Inhibits Insulin-Stimulated GLUT4 Translocation and Akt Activation through Tyrosine Nitration-Dependent Mechanisms
Csibi, A., Communi, D., Müller, N., & Bottari, S. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010070 · Cited by 73 · see citing works
Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice
Ropelle, E. R., Pauli, J. R., Cintra, D. E., da Silva, A. S. R., de Souza, C. T., Guadagnini, D., Carvalho, B. M., Caricilli, A. M., Katashima, C. K., Filho, C., et al. (2012) · Diabetes · doi:10.2337/db12-0339 · Cited by 73 · see citing works
Self-citation
Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry
Su, D. G. T., Shukla, A. K., Chen, B., Kim, J., Nakayasu, E. S., Qu, Y., Aryal, U. K., Weitz, K., Clauss, T. R., Monroe, M. E., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.12.010 · Cited by 69 · see citing works
Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics
Affourtit, C. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.07.008 · Cited by 67 · see citing works
Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity
do Nascimento, A. F., Luvizotto, R. D. A. M., Leopoldo, A. S., Lima‐Leopoldo, A. P., Seiva, F. R. F., Justulin, L. A., Dal‐Pai‐Silva, M., Okoshi, K., Wang, X., & Cicogna, A. C. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.03.015 · Cited by 66 · see citing works
Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet
Lalli, C. A., Pauli, J. R., Prada, P. O., Cintra, D. E., Ropelle, E. R., Velloso, L. A., & Saad, M. J. A. (2007) · Metabolism · doi:10.1016/j.metabol.2007.07.021 · Cited by 65 · see citing works
Self-citation
Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKAy mice
Ohtake, K., Nakano, G., Ehara, N., Sonoda, K., Ito, J., Uchida, H., & Kobayashi, J. (2015) · Nitric Oxide · doi:10.1016/j.niox.2014.11.009 · Cited by 63 · see citing works
Positive Aspects of Oxidative Stress at Different Levels of the Human Body: A Review
Jîtcă, G., Ősz, B. E., Tero-Vescan, A., Miklos, A., Rusz, C.-M., Bătrînu, M.-G., & Vari, C.-E. (2022) · Antioxidants · doi:10.3390/antiox11030572 · Cited by 64 · see citing works
Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes
Gheibi, S., Samsonov, A. P., Gheibi, S., Vazquez, A. B., & Kashfi, K. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113819 · Cited by 63 · see citing works
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
da Silva, A. S. R., Pauli, J. R., Ropelle, E. R., Oliveira, A. G., Cintra, D. E., de Souza, C. T., Velloso, L. A., Carvalheira, J. B. C., & Saad, M. J. A. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e45d08 · Cited by 60 · see citing works
Self-citation
Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt
Carvalho-Filho, M. A., Ropelle, E. R., Pauli, R. J., Cintra, D. E., Tsukumo, D. M. L., Silveira, L. R., Curi, R., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2009) · Diabetologia · doi:10.1007/s00125-009-1498-1 · Cited by 60 · see citing works
Self-citation
Diacerhein Improves Glucose Tolerance and Insulin Sensitivity in Mice on a High-Fat Diet
Tobar, N., Oliveira, A. G., Guadagnini, D., Bagarolli, R. A., Rocha, G. Z., Araújo, T. G., Santos-Silva, J. C., Zollner, R. D. L., Boechat, L. H. B., Carvalheira, J. B. C., et al. (2011) · Endocrinology · doi:10.1210/en.2011-0249 · Cited by 59 · see citing works
Self-citation
Acetaminophen: Beyond Pain and Fever-Relieving
Blough, E. R., & Wu, M. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00072 · Cited by 59 · see citing works
Akt/protein kinase B in skeletal muscle physiology and pathology
Wu, M., Falasca, M., & Blough, E. R. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22353 · Cited by 58 · see citing works
Type 1 diabetes: can exercise impair the autoimmune event? The L ‐arginine/glutamine coupling hypothesis
Krause, M. D. S., & de Bittencourt, P. I. H. (2008) · Cell Biochemistry and Function · doi:10.1002/cbf.1470 · Cited by 58 · see citing works
Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes
Bagarolli, R. A., Saad, M. J. A., & Saad, S. T. O. (2009) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2009.03.003 · Cited by 55 · see citing works
Self-citation
Increased Adipocyte S-Nitrosylation Targets Anti-lipolytic Action of Insulin
Ovadia, H., Haim, Y., Nov, O., Almog, O., Kovsan, J., Bashan, N., Benhar, M., & Rudich, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.235945 · Cited by 58 · see citing works
Dysfunction in the coagulation system and schizophrenia
Hoirisch-Clapauch, S., Amaral, O. B., Mezzasalma, M. A., Panizzutti, R., & Nardi, A. E. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.204 · Cited by 57 · see citing works
Phenolics and anthocyanins in berries of European cranberry and their antimicrobial activity
Česonienė, L., Jasutienė, I., & Šarkinas, A. (2024) · PubMed · doi:10.5281/zenodo.11174808 · Cited by 56 · see citing works
Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model
Crassous, P., Couloubaly, S., Huang, C., Zhou, Z., Baskaran, P., Kim, D. D., Papapetropoulos, A., Fioramonti, X., Durán, W. N., & Beuve, A. V. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00138.2012 · Cited by 53 · see citing works
Nelfinavir Induces Adipocyte Insulin Resistance through the Induction of Oxidative Stress: Differential Protective Effect of Antioxidant Agents
Ben-Romano, R., Rudich, A., Etzion, S., Potashnik, R., Kagan, E., Greenbaum, U., & Bashan, N. (2006) · Antiviral Therapy · doi:10.1177/135965350601100812 · Cited by 54 · see citing works
Insulin–Heart Axis: Bridging Physiology to Insulin Resistance
Caturano, A., Galiero, R., Vetrano, E., Sardu, C., Rinaldi, L., Russo, V., Monda, M., Marfella, R., & Sasso, F. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158369 · Cited by 56 · see citing works
Fish oil supplementation for two generations increases insulin sensitivity in rats
Hirabara, S. M., Folador, A., Fiamoncini, J., Lambertucci, R. H., Rodrigues, C., Rocha, M. S., Aikawa, J., Yamazaki, R. K., Martins, A. R., Rodrigues, A. C., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.08.014 · Cited by 51 · see citing works
Self-citation
Polynitrosated Polyesters: Preparation, Characterization, and Potential Use for Topical Nitric Oxide Release
Seabra, A. B., da Silva, R., & de Oliveira, M. G. (2005) · Biomacromolecules · doi:10.1021/bm050216z · Cited by 51 · see citing works
Self-citation
Diabetes and apoptosis: liver
Schattenberg, J. M., & Schuchmann, M. (2009) · APOPTOSIS · doi:10.1007/s10495-009-0366-2 · Cited by 49 · see citing works
Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation
Jagadapillai, R., Rane, M. J., Lin, X., Roberts, A. M., Hoyle, G. W., Cai, L., & Gozal, E. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111853 · Cited by 50 · see citing works
Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction
Pasarín, M., Abraldeṣ, J. G., Liguori, E., Kok, B., & Mura, V. L. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i37.6777 · Cited by 50 · see citing works
Sunflower Oil Supplementation Has Proinflammatory Effects and Does Not Reverse Insulin Resistance in Obesity Induced by High-Fat Diet in C57BL/6 Mice
Masi, L. N., Martins, A. R., Neto, J. C. R., do Amaral, C. L., Crisma, A. R., Vinolo, M. A. R., Júnior, E. A. D. L., Hirabara, S. M., & Curi, R. (2012) · BioMed Research International · doi:10.1155/2012/945131 · Cited by 47 · see citing works
Self-citation
Translational research into gut microbiota: new horizons on obesity treatment: updated 2014
Tsukumo, D. M. L., Carvalho, B. M., Filho, C., & Saad, M. J. A. (2015) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000029 · Cited by 46 · see citing works
Self-citation
Insulin-Dependent H2O2 Production Is Higher in Muscle Fibers of Mice Fed with a High-Fat Diet
Espinosa, A., Campos, C., Díaz‐Vegas, A., Galgani, J. E., Juretić, N., Osorio‐Fuentealba, C., Bucarey, J. L., Tapia, G., Valenzuela, R., Contreras‐Ferrat, A. E., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815740 · Cited by 45 · see citing works
Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice
de Farias, J., Maggi, R. M., Tromm, C. B., da Silva, L. A., Luciano, T. F., Marques, S. M. S., Lira, F. S., de Souza, C., & Pinho, R. A. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-134 · Cited by 45 · see citing works
Aging and Insulin Resistance: Just Say iNOS
Evans, J. L., & Goldfine, I. D. (2013) · Diabetes · doi:10.2337/db12-1239 · Cited by 45 · see citing works
[RETRACTION]Translational research into gut microbiota: new horizons in obesity treatment
Tsukumo, D. M. L., Carvalho, B. M., Filho, C., & Saad, M. J. A. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000200004 · Cited by 44 · see citing works
Self-citation
Retracted

S-nitrosação
Filho, C. (2005) · doi:10.47749/t/unicamp.2005.380971
Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRβ/IRS-1 and Akt and insulin resistance in muscle of mice
Carvalho-Filho, M. A., Ueno, M., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00422.2005 · Cited by 84 · see citing works
Self-citation
S-Nitrosylation-dependent Inactivation of Akt/Protein Kinase B in Insulin Resistance
Yasukawa, T., Tokunaga, E., Ota, H., Sugita, H., Martyn, J. A. J., & Kaneki, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411871200 · Cited by 262 · see citing works
Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRβ/IRS-1 and Akt
Zhou, J., & Huang, K. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.08.005 · Cited by 27 · see citing works
Nitrosative Stress and Pathogenesis of Insulin Resistance
Kaneki, M., Shimizu, N., Yamada, D., & Chang, K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1464 · Cited by 133 · see citing works

Authors: Carvalho-Filho, M. A., Ueno, M., Hirabara, S. M., Seabra, A. B., Carvalheira, J. B. C., de Oliveira, M. G., Velloso, L. A., Curi, R., & Saad, M. J. A.
Affiliations: Department of Internal Medicine, State University of Campinas, UNICAMP, Campinas, Brazil
Universidade Estadual de Campinas (UNICAMP) (BR)
Universidade de São Paulo (BR)
Chemistry Institute, State University of Campinas, UNICAMP, Campinas, Brazil
ORCID: Hirabara, Sandro M.
Seabra, Amedea B.
Curi, Rui
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2005-04-01
Volume: 54
Issue: 4
Pages: 959-967
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.54.4.959
OpenAlex: W2144153442
Cited by: 277
References: 53
Citations by year: 2026: 8 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 15 · 2021: 5 · 2020: 13 · 2019: 9 · 2018: 12 · 2017: 13 · 2016: 13 · 2015: 22 · 2014: 13 · 2013: 18 · 2012: 25
FWCI: 7.59
Type: journal article
Language: en
Update notices: expression_of_concern (2023-10-23)
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: S-nitrosylation, insulin resistance, insulin receptor beta-subunit, IRS-1, Akt/protein kinase B, nitric oxide, inducible nitric oxide synthase, S-nitrosoglutathione, insulin signaling, skeletal muscle, diet-induced obesity, ob/ob mice, kinase activity
MeSH terms: Rosiglitazone, Animals, Glutathione, Insulin, Insulin Resistance, Male, Nitric Oxide, Nitro Compounds, Obesity, Phosphoproteins, Protein Processing, Post-Translational, Proto-Oncogene Proteins, Receptor, Insulin, Nitrosation, Mice, Inbred NOD, Rats, Wistar, Protein Serine-Threonine Kinases, Muscle, Skeletal, Thiazolidinediones, Proto-Oncogene Proteins c-akt, Mice, Rats, Insulin Receptor Substrate Proteins

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S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt

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