Cited by 284Cardiovascular Function and Risk FactorsCardiac Fibrosis and RemodelingHeart Failure Treatment and Management

Metabolic inflammation in heart failure with preserved ejection fraction

Open access
Schiattarella, Gabriele G, Rodolico, Daniele, Hill, Joseph A·2021·Cardiovascular Research

Abstract

One in 10 persons in the world aged 40 years and older will develop the syndrome of HFpEF (heart failure with preserved ejection fraction), the most common form of chronic cardiovascular disease for which no effective therapies are currently available. Metabolic disturbance and inflammatory burden contribute importantly to HFpEF pathogenesis. The interplay within these two biological processes is complex; indeed, it is now becoming clear that the notion of metabolic inflammation-metainflammation-must be considered central to HFpEF pathophysiology. Inflammation and metabolism interact over the course of syndrome progression, and likely impact HFpEF treatment and prevention. Here, we discuss evidence in support of a causal, mechanistic role of metainflammation in shaping HFpEF, proposing a framework in which metabolic comorbidities profoundly impact cardiac metabolism and inflammatory pathways in the syndrome.

Integrity signals

Registry

Crossref · 10.1093/cvr/cvaa217

Cites

177 of 177 references verified0 citation errors · 0 not checkable

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  • Obesity indirectly promotes insulin resistance and hyperglycemia and has additional direct deleterious effect via a systemic proinflammatory state.

    “Obesity indirectly promotes insulin resistance and hyperglycemia and has additional direct deleterious effect, given that adipose tissue is highly metabolically active and involved in promoting a systemic proinflammatory state.”

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Authors
Schiattarella, G. G., Rodolico, D., & Hill, J. A.
Affiliations
  • University of Naples Federico II (IT)
  • Università Cattolica del Sacro Cuore (IT)
  • The University of Texas Southwestern Medical Center (US)
Corresponding author
Schiattarella, Gabriele G
Venue
Cardiovascular Research
Published
2020-07-14
Volume
117
Issue
2
Pages
423-434
ISSN
  • 0008-6363 (ISSN-L)
  • 1755-3245
OpenAlex
W3043246921
Cited by
284
References
177
Citations by year
2026: 60 · 2025: 63 · 2024: 59 · 2023: 54 · 2022: 27 · 2021: 18 · 2020: 3
FWCI
15.77
Type
journal article
Language
en
Open access
Locations
  • Cardiovascular Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Funders
  • American Heart Association
  • Theodore and Beulah Beasley Foundation (18POST34060230)
  • National Institutes of Health (HL-120732, HL-128215, HL-126012, HL-147933)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords
heart failure with preserved ejection fraction, meta-inflammation, metabolic inflammation, metabolic comorbidities, myocardial metabolism, inflammation, HFpEF pathophysiology, inflammatory signaling
MeSH terms
Adult, Anti-Inflammatory Agents, Energy Metabolism, Female, Heart Failure, Humans, Inflammation, Male, Myocardium, Obesity, Stroke Volume, Signal Transduction, Comorbidity, Ventricular Function, Left, Inflammation Mediators

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