Metabolic inflammation in heart failure with preserved ejection fraction
Open accessAbstract
One in 10 persons in the world aged 40 years and older will develop the syndrome of HFpEF (heart failure with preserved ejection fraction), the most common form of chronic cardiovascular disease for which no effective therapies are currently available. Metabolic disturbance and inflammatory burden contribute importantly to HFpEF pathogenesis. The interplay within these two biological processes is complex; indeed, it is now becoming clear that the notion of metabolic inflammation-metainflammation-must be considered central to HFpEF pathophysiology. Inflammation and metabolism interact over the course of syndrome progression, and likely impact HFpEF treatment and prevention. Here, we discuss evidence in support of a causal, mechanistic role of metainflammation in shaping HFpEF, proposing a framework in which metabolic comorbidities profoundly impact cardiac metabolism and inflammatory pathways in the syndrome.
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Obesity indirectly promotes insulin resistance and hyperglycemia and has additional direct deleterious effect via a systemic proinflammatory state.
“Obesity indirectly promotes insulin resistance and hyperglycemia and has additional direct deleterious effect, given that adipose tissue is highly metabolically active and involved in promoting a systemic proinflammatory state.”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [63]
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Heart Failure With Preserved Ejection Fraction
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- Authors
- Schiattarella, G. G., Rodolico, D., & Hill, J. A.
- Affiliations
- University of Naples Federico II (IT)
- Università Cattolica del Sacro Cuore (IT)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Schiattarella, Gabriele G
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-07-14
- Volume
- 117
- Issue
- 2
- Pages
- 423-434
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- PMC
- PMC8599724
- OpenAlex
- W3043246921
- Cited by
- 284
- References
- 177
- Citations by year
- 2026: 60 · 2025: 63 · 2024: 59 · 2023: 54 · 2022: 27 · 2021: 18 · 2020: 3
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- American Heart Association
- Theodore and Beulah Beasley Foundation (18POST34060230)
- National Institutes of Health (HL-120732, HL-128215, HL-126012, HL-147933)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- heart failure with preserved ejection fraction, meta-inflammation, metabolic inflammation, metabolic comorbidities, myocardial metabolism, inflammation, HFpEF pathophysiology, inflammatory signaling
- MeSH terms
- Adult, Anti-Inflammatory Agents, Energy Metabolism, Female, Heart Failure, Humans, Inflammation, Male, Myocardium, Obesity, Stroke Volume, Signal Transduction, Comorbidity, Ventricular Function, Left, Inflammation Mediators
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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