The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue
Abstract
Sympathetic stimulation activates glucose utilization in parallel with fatty acid oxidation and thermogenesis in brown adipose tissue (BAT) through the β-adrenergic receptors. To clarify the roles of the principal thermogenic molecule mitochondrial uncoupling protein 1 (UCP1) in the sympathetically stimulated glucose utilization, we investigated the uptake of 2-deoxyglucose (2-DG) into BAT and some other tissues of UCP1-knockout (KO) mice in vivo. In wild-type (WT) mice, administration of norepinephrine (NE) accelerated the disappearance of plasma 2-DG and increased 2-DG uptake into BAT and heart without any rise of plasma insulin level. In UCP1-KO mice, the stimulatory effect of NE on 2-DG uptake into BAT, but not into heart, disappeared completely. Insulin administration increased 2-DG uptake into BAT and also heart similarly in WT and UCP1-KO mice. NE also increased the activity of AMP-activated protein kinase (AMP kinase) in BAT of WT but not UCP1-KO mice. Our results, together with reports that the activation of AMP kinase increases glucose transport in myocytes, suggest that the sympathetically stimulated glucose utilization in BAT is due to the serial activation of UCP1 and AMP kinase.
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Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379
Self-citationMinireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
Hardie, D. G. (2003) · Endocrinology · doi:10.1210/en.2003-0982 · Cited by 994
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
Li, B., Nolte, L. A., Ju, J.-S., Ho Han, D., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2000) · Nature Medicine · doi:10.1038/80450 · Cited by 291
Han, D.-H., Nolte, L. A., Ju, J.-S., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00434.2003 · Cited by 49
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High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848
Self-citationUnexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824
Recruited brown adipose tissue as an antiobesity agent in humans
Yoneshiro, T., Aita, S., Matsushita, M., Kayahara, T., Kameya, T., Kawai, Y., Iwanaga, T., & Saito, M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67803 · Cited by 957
Self-citationMitochondrial uncoupling, ROS generation and cardioprotection
Cadenas, S. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.05.019 · Cited by 591
Yoneshiro, T., Aita, S., Matsushita, M., Okamatsu‐Ogura, Y., Kameya, T., Kawai, Y., Miyagawa, M., Tsujisaki, M., & Saito, M. (2011) · Obesity · doi:10.1038/oby.2011.125 · Cited by 502
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Metadata
- Authors
- Inokuma, K.-I., Ogura-Okamatsu, Y., Toda, C., Kimura, K., Yamashita, H., & Saito, M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-05-01
- Volume
- 54
- Issue
- 5
- Pages
- 1385-1391
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2057683888
- Cited by
- 173
- References
- 5
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Inokuma, K.-I., Ogura-Okamatsu, Y., Toda, C., Kimura, K., Yamashita, H., & Saito, M. (2005). Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue. Diabetes. https://doi.org/10.2337/diabetes.54.5.1385
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