Cited by 404Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

Open access

Belfort, Renata, Mandarino, Lawrence, Kashyap, Sangeeta, Wirfel, Kelly, Pratipanawatr, Thongchai, Berria, Rachele, DeFronzo, Ralph A., Cusi, Kenneth·2005·Diabetes

DOI 10.2337/diabetes.54.6.1640

Open this paper in CoChat — free account Open PDF

Abstract

The dose-response relationship between elevated plasma free fatty acid (FFA) levels and impaired insulin-mediated glucose disposal and insulin signaling was examined in 21 lean, healthy, normal glucose-tolerant subjects. Following a 4-h saline or Liposyn infusion at 30 (n = 9), 60 (n = 6), and 90 (n = 6) ml/h, subjects received a 2-h euglycemic insulin (40 mU · m−2 · min−1) clamp. Basal plasma FFA concentration (∼440 μmol/l) was increased to 695, 1,251, and 1,688 μmol/l after 4 h of Liposyn infusion and resulted in a dose-dependent reduction in insulin-stimulated glucose disposal (Rd) by 22, 30, and 34%, respectively (all P < 0.05 vs. saline control). At the lowest lipid infusion rate (30 ml/h), insulin receptor and insulin receptor substrate (IRS)-1 tyrosine phosphorylation, phosphatidylinositol (PI) 3-kinase activity associated with IRS-1, and Akt serine phosphorylation were all significantly impaired (P < 0.05–0.01). The highest lipid infusion rate (90 ml/h) caused a further significant reduction in all insulin signaling events compared with the low-dose lipid infusion (P < 0.05–0.01) whereas the 60-ml/h lipid infusion caused an intermediate reduction in insulin signaling. However, about two-thirds of the maximal inhibition of insulin-stimulated glucose disposal already occurred at the rather modest increase in plasma FFA induced by the low-dose (30-ml/h) lipid infusion. Insulin-stimulated glucose disposal was inversely correlated with both the plasma FFA concentration after 4 h of lipid infusion (r = −0.50, P = 0.001) and the plasma FFA level during the last 30 min of the insulin clamp (r = −0.54, P < 0.001). PI 3-kinase activity associated with IRS-1 correlated with insulin-stimulated glucose disposal (r = 0.45, P < 0.01) and inversely with both the plasma FFA concentration after 4 h of lipid infusion (r = −0.39, P = 0.01) and during the last 30 min of the insulin clamp (r = −0.43, P < 0.01). In summary, in skeletal muscle of lean, healthy subjects, a progressive increase in plasma FFA causes a dose-dependent inhibition of insulin-stimulated glucose disposal and insulin signaling. The inhibitory effect of plasma FFA was already significant following a rather modest increase in plasma FFA and develops at concentrations that are well within the physiological range (i.e., at plasma FFA levels observed in obesity and type 2 diabetes).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2337/diabetes.54.6.1640

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Self-citation
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770
Self-citation
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of pima indians
Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508
Banting Lecture 2001
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435

Show all 74 references

Sorted by citations

Items 201–300 of 404

Comparison of mechanisms underlying changes in glucose utilization in fasted rats anesthetized with propofol or sevoflurane: Hyperinsulinemia is exaggerated by propofol with concomitant insulin resistance induced by an acute lipid load
Li, X., Kitamura, T., Kawamura, G., Mori, Y., Sato, K., Araki, Y., Sato, R., & Yamada, Y. (2014) · BioScience Trends · doi:10.5582/bst.2014.01060 · Cited by 21
Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment
DeFronzo, R. A., Triplitt, & Cersosimo (2010) · Vascular Health and Risk Management · doi:10.2147/vhrm.s4852 · Cited by 23
Self-citation
Effects of prednisolone on energy and fat metabolism in patients with rheumatoid arthritis: tissue‐specific insulin resistance with commonly used prednisolone doses
Radhakutty, A., Mangelsdorf, B. L., Drake, S. M., Samocha‐Bonet, D., Heilbronn, L. K., Smith, M., Thompson, C. H., & Burt, M. G. (2016) · Clinical Endocrinology · doi:10.1111/cen.13138 · Cited by 22
Dietary bioactive compounds for type 2 diabetes: A comprehensive review of molecular interactions and mechanistic insights
Aguerd, O., Elhrech, H., Fessikh, M. E., Goh, K. W., Omari, N. E., Aanniz, T., & Bouyahya, A. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106705 · Cited by 24
From Obesity to Muscle Insulin Resistance: The Mediating Roles of Intramyocellular Lipids, Inflammation, and Oxidative Stress
Razi, O., de Moraes, C., Zamani, N., Saeidi, A., Hadjicharalambous, M., Hackney, A. C., Coso, J. D., Laher, I., & Zouhal, H. (2025) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.70094 · Cited by 24
Sphingolipid regulators of cellular dysfunction in Type 2 diabetes mellitus: a systems overview
Ross, J. S., Russo, S. B., Chavis, G. C., & Cowart, L. A. (2014) · Clinical Lipidology · doi:10.2217/clp.14.37 · Cited by 20
Experimental Hyperlipidemia Dramatically Reduces Access of Insulin to Canine Skeletal Muscle
Chiu, J. D., Kolka, C. M., Richey, J. M., Harrison, L. N., Zuniga, E. A., Kirkman, E. L., & Bergman, R. N. (2009) · Obesity · doi:10.1038/oby.2009.165 · Cited by 20
Long-term moderate ethanol consumption restores insulin sensitivity in high-fat-fed rats by increasing SLC2A4 (GLUT4) in the adipose tissue by AMP-activated protein kinase activation
Li, F., Gao, L., Guan, Q., Hou, X., Wan, Q., Wang, X., & Zhao, J. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0026 · Cited by 20
Cardiovascular Disease and Diabetes
Mangiapane, H. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5441-0_17 · Cited by 20
A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual
Sarkar, J., Dwivedi, G., Chen, Q., Sheu, I. E., Paich, M., Chelini, C. M., D'Alessandro, P. M., & Burns, S. P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192472 · Cited by 21
Insulin Resistance in Type 2 Diabetes
Roden, M., Petersen, K. F., & Shulman, G. I. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch13 · Cited by 20
Short-term increase of plasma free fatty acids does not interfere with intrinsic mitochondrial function in healthy young men
Brands, M., Hoeks, J., Sauerwein, H. P., Ackermans, M. T., Ouwens, M., Lammers, N. M., van der Plas, M. N., Schrauwen, P., Groen, A. K., & Serlie, M. J. (2011) · Metabolism · doi:10.1016/j.metabol.2011.02.006 · Cited by 19
Potential biomarker in serum for predicting susceptibility to type 2 diabetes mellitus: Free fatty acid 22:6
Ma, Y., Xiong, J., Zhang, X., Qiu, T., Pang, H., Li, X., Zhu, J., Wang, J., Pan, C., Yang, X., et al. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13443 · Cited by 21
Time-course effects of physiological free fatty acid surges on insulin sensitivity in humans
Gormsen, L. C., Nielsen, C., Jessen, N., Jørgensen, J. O. L., & Møller, N. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02181.x · Cited by 19
Lifestyle Interventions for Weight Control Modified by Genetic Variation: A Review of the Evidence
Tan, P. Y., Mitra, S. R., & Amini, F. (2018) · Public Health Genomics · doi:10.1159/000499854 · Cited by 19
Lipid-induced insulin resistance does not impair insulin access to skeletal muscle
Kolka, C. M., Richey, J. M., Castro, A. V., Broussard, J. L., Ionut, V., & Bergman, R. N. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2015 · Cited by 20
Metformin treatment affects adipocytokine secretion and lipid composition in adipose tissues of diet-induced insulin-resistant rats
Grycel, S., Markowski, A. R., Hady, H. R., Zabielski, P., Kojta, I., Imierska, M., Górski, J., & Błachnio-Zabielska, A. U. (2019) · Nutrition · doi:10.1016/j.nut.2019.01.019 · Cited by 18
Isosteviol Has Beneficial Effects on Palmitate-Induced α-Cell Dysfunction and Gene Expression
Chen, X., Hermansen, K., Xiao, J., Bystrup, S., O’Driscoll, L., & Jeppesen, P. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034361 · Cited by 18
Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA
Newens, K. J., Thompson, A. K., Jackson, K. G., Wright, J., & Williams, C. M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510004976 · Cited by 19
Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells
Feng, X., Duan, H., & Li, S. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3070 · Cited by 18
In Vitro Effects of Cyanidin‐3‐O‐Glucoside on Inflammatory and Insulin‐Sensitizing Genes in Human Adipocytes Exposed to Palmitic Acid
Molonia, M. S., Quesada‐López, T., Speciale, A., Muscarà, C., Saija, A., Villarroya, F., & Cimino, F. (2021) · Chemistry & Biodiversity · doi:10.1002/cbdv.202100607 · Cited by 17
Oleic Acid
López, S., Bermúdez, B., Pacheco, Y. M., Ortega‐Gómez, A., Varela, L. M., Abia, R., & Muriana, F. J. G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374420-3.00154-6 · Cited by 17
The Second Meal Effect and Its Influence on Glycemia
Fletcher, J. A. (2012) · Journal of Nutritional Disorders & Therapy · doi:10.4172/2161-0509.1000108 · Cited by 17
A data-driven computational model for obesity-driven diabetes onset and remission through weight loss
Yildirim, V., Sheraton, V. M., Brands, R., Crielaard, L., Quax, R., van Riel, N. A. W., Stronks, K., Nicolaou, M., & Sloot, P. M. A. (2023) · iScience · doi:10.1016/j.isci.2023.108324 · Cited by 18
Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action
Friedrichsen, M. H., Poulsen, P., Richter, E. A., Hansen, B. F., Birk, J. B., Ribel‐Madsen, R., Stender-Petersen, K. L., Nilsson, E., Beck‐Nielsen, H., Vaag, A. A., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1795-8 · Cited by 16
Metabolic effects of muraglitazar in type 2 diabetic subjects
Fernandez, M., Gastaldelli, A., Triplitt, C. L., Hardies, J., Casolaro, A., Petz, R., Tantiwong, P., Musi, N., Cersósimo, E., Ferrannini, E., et al. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01429.x · Cited by 16
Self-citation
Oat Polar Lipids Improve Cardiometabolic-Related Markers after Breakfast and a Subsequent Standardized Lunch: A Randomized Crossover Study in Healthy Young Adults
Hossain, M. M., Tovar, J., Cloetens, L., Soria-Florido, M. T., Petersson, K., Prothon, F., & Nilsson, A. C. (2021) · Nutrients · doi:10.3390/nu13030988 · Cited by 16
Prevalence of Type 2 Diabetes and Its Association with Added Sugar Intake in Citizens and Refugees Aged 40 or Older in the Gaza Strip, Palestine
Jebril, M., Liu, X., Shi, Z., Mazidi, M., Altaher, A., & Wang, Y. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17228594 · Cited by 16
The Epidemic of Type 2 Diabetes Mellitus: Its Links to Obesity, Insulin Resistance, and Lipotoxicity
Cusi, K. J. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-260-1_1 · Cited by 15
Self-citation
Pronounced expression of the lipolytic inhibitor G0/G1 Switch Gene 2 (G0S2) in adipose tissue from brown bears ( Ursus arctos ) prior to hibernation
Jessen, N., Nielsen, T. S., Vendelbo, M. H., Viggers, R., Støen, O., Evans, A. L., & Fröbert, O. (2016) · Physiological Reports · doi:10.14814/phy2.12781 · Cited by 15
Nonalcoholic Fatty Liver Disease
Puri, P., & Sanyal, A. J. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0881-3.00053-x · Cited by 16
CerS1 but Not CerS5 Gene Silencing, Improves Insulin Sensitivity and Glucose Uptake in Skeletal Muscle
Błachnio-Zabielska, A. U., Roszczyc-Owsiejczuk, K., Imierska, M., Pogodzińska, K., Rogalski, P., Daniluk, J., & Zabielski, P. (2022) · Cells · doi:10.3390/cells11020206 · Cited by 15
Effects of Pollen Typhae total flavone on glucose and lipid metabolism in 3T3-L1 adipocytes
He, Y. (2006) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20060610 · Cited by 15
Sarcopenia in a type 2 diabetic state: Reviewing literature on the pathological consequences of oxidative stress and inflammation beyond the neutralizing effect of intracellular antioxidants
Muvhulawa, N., Mazibuko-Mbeje, S. E., Ndwandwe, D. E., Silvestri, S., Ziqubu, K., Moetlediwa, M. T., Mthembu, S. X. H., Marnewick, J. L., van der Westhuizen, F. H., Nkambule, B. B., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122125 · Cited by 16
GPAT Gene Silencing in Muscle Reduces Diacylglycerols Content and Improves Insulin Action in Diet-Induced Insulin Resistance
Kojta, I., Zabielski, P., Roszczyc-Owsiejczuk, K., Imierska, M., Sokołowska, E., & Błachnio-Zabielska, A. U. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197369 · Cited by 14
Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance
Frangos, S. M., Bishop, D. J., & Holloway, G. P. (2021) · Biochemical Journal · doi:10.1042/bcj20210145 · Cited by 14
Acute insulin resistance stimulates and insulin sensitization attenuates vascular smooth muscle cell migration and proliferation
Cersósimo, E., Xu, X., Upala, S., Triplitt, C. L., & Musi, N. (2014) · Physiological Reports · doi:10.14814/phy2.12123 · Cited by 14
Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-45015-5_8 · Cited by 14
Self-citation
Oleic acid—the main component of olive oil on postprandial metabolic processes
López, S., Bermúdez, B., la Paz, S. M., Pacheco, Y. M., Ortega‐Gómez, A., Varela, L. M., Lemus‐Conejo, A., Millán-Linares, M. C., Rosillo, M. Á., Abia, R., et al. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819528-4.00034-1 · Cited by 14
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch25 · Cited by 17
Self-citation
Triglycerides, Glucose Metabolism, and Type 2 Diabetes
Wang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209910 · Cited by 20
10-Day Hyperlipidemic Clamp in Cats: Effects on Insulin Sensitivity, Inflammation, and Glucose Metabolism-related Genes
Zini, E., Osto, M., Konrad, D., Franchini, M., Sieber‐Ruckstuhl, N. S., Kaufmann, K., Guscetti, F., Ackermann, M., Lutz, T. A., & Reusch, C. E. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1248251 · Cited by 13
Acute Free Fatty Acid Elevation Eliminates Endurance Training Effect on Insulin Sensitivity
Chow, L. S., Seaquist, E. R., Eberly, L. E., Mashek, M. T., Schimke, J. M., Nair, K. S., & Mashek, D. G. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1515 · Cited by 13
Endothelial function and insulin sensitivity during acute non-esterified fatty acid elevation: Effects of fat composition and gender
Newens, K. J., Thompson, A. K., Jackson, K. G., & Williams, C. M. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.03.004 · Cited by 13
Choice of Lipid Emulsion Determines Inflammation of the Gut‐Liver Axis, Incretin Profile, and Insulin Signaling in a Murine Model of Total Parenteral Nutrition
Lou, P., Lucchinetti, E., Wawrzyniak, P., Morsy, Y., Wawrzyniak, M., Scharl, M. M., Krämer, S. D., Rogler, G., Hersberger, M., & Zaugg, M. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000412 · Cited by 13
Association of circulating long-chain free fatty acids and incident diabetes risk among normoglycemic Chinese adults: a prospective nested case–control study
Wang, S., Hu, C., Lin, H., Jia, X., Hu, R., Zheng, R., Li, M., Xu, Y., Xu, M., Zheng, J., et al. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.05.003 · Cited by 12
Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans
Karki, S., Farb, M. G., Myers, S. J., Apovian, C. M., Hess, D. T., & Gokce, N. (2015) · Mediators of Inflammation · doi:10.1155/2015/106237 · Cited by 12
Insulin Resistance in Type 2 Diabetes
Roden, M., Petersen, K. F., & Shulman, G. I. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch17 · Cited by 14
Emerging Insights into Brown Adipose Tissue Crosstalk With Pancreatic β-Cells in Metabolic Regulation
Yan, C., Burley, G., Gao, H., & Shi, Y. (2025) · Endocrinology · doi:10.1210/endocr/bqaf118 · Cited by 12
Incretin-based therapy: a new horizon in diabetes management
Zarei, M., Vaighan, N. S., Farjoo, M. H., Talebi, S., & Zarei, M. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01479-3 · Cited by 12
Relationship between trajectory of Chinese visceral adiposity index and risk of type 2 diabetes mellitus: Evidence from the China ‐ PAR project
Fu, X., Zhao, Y., Wu, Y., Wen, L., Huo, W., Zhang, D., Zhang, Y., Li, J., Lu, X., Hu, F., et al. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16074 · Cited by 11
Molecular Insights into Appetite Control and Neuroendocrine Disease as Risk Factors for Chronic Diseases in Western Countries
Martins, I. J., Creegan, R., Lim, W. L. F., & Martins, R. N. (2013) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2013.35a002 · Cited by 12
Anti-inflammatory and anti-proliferative action of adiponectin mediated by insulin signaling cascade in human vascular smooth muscle cells
Cersósimo, E., Xu, X., Terasawa, T., & Dong, L. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05707-w · Cited by 12
Brain Dopamine–Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Diabetes Subjects
Cincotta, A. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713255 · Cited by 11
The 6th Annual World Congress on the Insulin Resistance Syndrome
Bloomgarden, Z. T. (2009) · Diabetes Care · doi:10.2337/dc09-zb09 · Cited by 11
Short-term oral exposure to white wine transiently lowers serum free fatty acids
Joosten, M. M., de Graaf, C., Rietman, A., Witkamp, R. F., & Hendriks, H. (2010) · Appetite · doi:10.1016/j.appet.2010.04.217 · Cited by 11
Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-27317-4_8-1 · Cited by 11
Self-citation
Targeting Type 2 Diabetes
Schwanstecher, C., & Schwanstecher, M. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_1 · Cited by 11
Association of obesity with serum free fatty acid levels in individuals at different stages of prediabetes
Sasaki, N., Maeda, R., Ozono, R., Nakano, Y., & Higashi, Y. (2021) · Clinical Obesity · doi:10.1111/cob.12496 · Cited by 10
Early-Phase Changes in Serum Free Fatty Acid Levels After Glucose Intake Are Associated With Type 2 Diabetes Incidence: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases
Sasaki, N., Maeda, R., Ozono, R., Yoshimura, K., Nakano, Y., & Higashi, Y. (2022) · Diabetes Care · doi:10.2337/dc21-2554 · Cited by 11
The beneficial impact of curcumin on cardiac lipotoxicity
Abolfazli, S., Butler, A. E., Kesharwani, P., & Sahebkar, A. (2024) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgae102 · Cited by 10
Lipotoxicity in Obesity: Benefit of Olive Oil
Saad, E., Sbeit, W., Luai, A., Massad, B., & Assy, N. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_26 · Cited by 11
The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial
Samkani, A., Skytte, M. J., Anholm, C., Astrup, A. V., Deacon, C. F., Holst, J. J., Madsbad, S., Boston, R., Krarup, T., & Haugaard, S. B. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0953-8 · Cited by 11
Obesity: Molecular Mechanisms, Epidemiology, Complications and Pharmacotherapy
Jaberi, S. A., Cohen, A., Saeed, Z., Ojha, S. K., Singh, J., & Adeghate, E. A. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-84763-0_13 · Cited by 10
Metabolic Syndrome in Preeclampsia Women in Gorgan
Marjani, A., Rafeeinia, A., Tabandeh, A., & Khajeniazi, S. (2014) · The Open Biochemistry Journal · doi:10.2174/1874091x01408010094 · Cited by 10
Role of Mitochondrial Function in Insulin Resistance
Brands, M., Verhoeven, A. J., & Serlie, M. J. M. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_9 · Cited by 9
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
Glaesser, D., & Iwig, M. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.109888 · Cited by 9
Lipid‐Heparin Infusion Suppresses the IL‐10 Response to Trauma in Subcutaneous Adipose Tissue in Humans
Ikeoka, D., Pachler, C., Mader, J. K., Bock, G., Neves, A. L., Švehlíková, E., Feichtner, F., Koehler, G., Wrighton, C. J., Pieber, T. R., et al. (2010) · Obesity · doi:10.1038/oby.2010.227 · Cited by 9
Fatty acids may influence insulin dynamics through modulation of albumin‐Zn2+ interactions
Arya, S., Gourley, A. J., Penedo, J. C., Blindauer, C. A., & Stewart, A. J. (2021) · BioEssays · doi:10.1002/bies.202100172 · Cited by 9
Calpain-10 Gene and Protein Expression in Human Skeletal Muscle: Effect of Acute Lipid-Induced Insulin Resistance and Type 2 Diabetes
Norton, L., Parr, T., Chokkalingam, K., BARDSLEY, R. G., Ye, H. J., Bell, G. I., Pelsers, M. M. A. L., van Loon, L. J. C., & Tsintzas, K. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1981 · Cited by 9
Bariatric Surgery in Morbidly Obese Insulin Resistant Humans Normalises Insulin Signalling but Not Insulin-Stimulated Glucose Disposal
Chen, M. Z., Hudson, C. A., Vincent, E. E., de Berker, D. A. R., May, M., Hers, I., Dayan, C. M., Andrews, R. C., & Tavaré, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120084 · Cited by 9
Metabolische Nebenwirkungen von Antipsychotika der neuen Generation
Engl, J., Tschoner, A., Laimer, M. W., Rettenbacher, M. A., Fleischhacker, W. W., Patsch, J. R., & Ebenbichler, C. F. (2006) · Wiener klinische Wochenschrift · doi:10.1007/s00508-006-0584-3 · Cited by 10
Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients
Vestergaard, E. T., Hjelholt, A. J., Kuhre, R. E., Møller, N., Larraufie, P., Gribble, F. M., Reimann, F. M., Jessen, N., Holst, J. J., & Jørgensen, J. O. L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02503 · Cited by 9
Differential Roles of CD36 in Regulating Muscle Insulin Response Depend on Palmitic Acid Load
Sun, J.-Y., Su, Y.-J., Chen, J., Qin, D., Xu, Y., Chu, H., Lu, T.-F., Dong, J., Qin, L.-L., & Li, W.-D. (2023) · Biomedicines · doi:10.3390/biomedicines11030729 · Cited by 5
Palmitate exacerbates bisphenol A toxicity via induction of ER stress and mitochondrial dysfunction
Mondal, A., Burchat, N., & Sampath, H. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158816 · Cited by 8
Cardiac Metabolism in Health and Disease
Opie, L. H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405206-2.00002-8 · Cited by 8
Role of Dietary Macronutrients and Fatty Acids in Obesity and Metabolic Risk in Older Adults
Dooley, C., & Ryan, A. S. (2019) · International Journal of Obesity and Nutritional Science · doi:10.18689/ijons-1000102 · Cited by 7
Association of Ratio of Apolipoprotein B to Apolipoprotein A1 With Survival in Peritoneal Dialysis
Yu, J., Xia, X., Huang, N., Qiu, Y., Yang, X., Mao, H., Chen, W., & Huang, F. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.801979 · Cited by 7
Obesity and Type 2 Diabetes
(2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/978160805361211201010039 · Cited by 7
Regulation of Intermediatory Metabolism During Fasting and Feeding
DeFronzo, R. A., & Ferrannini, E. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00036-8 · Cited by 7
Self-citation
Diabetes and Obesity
Blüher, M., & Stümvoll, M. (2020) · Endocrinology · doi:10.1007/978-3-030-36694-0_1 · Cited by 10
Síndrome de Berardinelli-Seip: descrição genética e metabólica de cinco pacientes
Barra, C., Savoldelli, R. D., Manna, T. D., Kim, C. A., Magre, J., Porta, G., Setian, N., & Damiani, D. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000100007 · Cited by 7
Consequences of Dicarbonyl Stress on Skeletal Muscle Proteins in Type 2 Diabetes
Ahmad, K., Shaikh, S., Lee, E. J., Lee, Y., & Choi, I. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666191119100759 · Cited by 7
The Exocyst Is Required for CD36 Fatty Acid Translocase Trafficking and Free Fatty Acid Uptake in Skeletal Muscle Cells
Nakamura, N., Tokunaga, D. S., Ha, H. Y., & Polgár, N. (2022) · Cells · doi:10.3390/cells11152440 · Cited by 7
Obesity and Type 2 Diabetes
Zhyzhneuskaya, S. V., & Taylor, R. (2017) · Endocrinology · doi:10.1007/978-3-319-47685-8_21-1 · Cited by 8
Are there interindividual differences in the reactive hypoglycaemia response to breakfast? A replicate crossover trial
Gonzalez, J. T., Lolli, L., Veasey, R. C., Rumbold, P. L. S., Betts, J. A., Atkinson, G., & Stevenson, E. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03467-y · Cited by 8
Unsaturated Oral Fat Load Test Improves Glycemia, Insulinemia and Oxidative Stress Status in Nondiabetic Subjects with Abdominal Obesity
Martínez‐Hervás, S., Navarro, I., Real, J. T., Artero, A., Peiró, M., Navarro, H. G., Carmena, R., & Ascaso, J. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161400 · Cited by 6
Short‐term acipimox treatment is associated with decreased cardiac parasympathetic modulation
Vestergaard, E. T., Cichosz, S. L., Møller, N., Jørgensen, J. O. L., & Fleischer, J. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13384 · Cited by 6
Effects of Sustained Hyperglycemia on Skeletal Muscle Lipids in Healthy Subjects
Shannon, C. E., Merovci, A., Fourcaudot, M. J., Tripathy, D., Abdul‐Ghani, M. A., Wang, H., Han, X., Norton, L., & DeFronzo, R. A. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac306 · Cited by 7
Self-citation
Independent, but not co-supplementation, with nitrate and resveratrol improves glucose tolerance and reduces markers of cellular stress in high-fat-fed male mice
Handy, R. M., DesOrmeaux, G. J., Barbeau, P., Frangos, S. M., & Holloway, G. P. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00196.2022 · Cited by 6
The Mediterranean food pattern: a good recipe for patients with the metabolic syndrome
Amezaga, C. A. V.-D., Zulet, M. Á., Martí, A., Martínez‐González, M. Á., & Martínez, J. A. (2008) · Mediterranean Journal of Nutrition and Metabolism · doi:10.1007/s12349-008-0001-8 · Cited by 6
Microdialysis Monitoring of Glucose, Lactate, Glycerol, and Pyruvate in Patients with Diabetic Ketoacidosis
Ciechanowska, A., Ładyżyński, P., Wojcicki, J. M., Sabalińska, S., Krzymień, J., Pulawska, E., Karnafel, W., Foltyński, P., & Kawiak, J. (2013) · The International Journal of Artificial Organs · doi:10.5301/ijao.5000265 · Cited by 6
Insulin resistance in obese children and adolescents: from mechanisms to screening and exercise intervention
Cao, Y., Xu, R., & Zhang, J. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1679527 · Cited by 5
3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction
Celebi, L. E., & Zorlutuna, P. (2026) · Advanced Science · doi:10.1002/advs.202516114 · Cited by 5
Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes
Wismayer, D. S., LAURENTI, M. C., Song, Y., Egan, A. M., Welch, A. A., Bailey, K. R., Cobelli, C., Man, C. D., Jensen, M. D., & Vella, A. V. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2023 · Cited by 5
Basic Concepts in Insulin Resistance and Diabetes Treatment
Bril, F., & Cusi, K. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-72475-1_3 · Cited by 5
Self-citation
Postprandial triglyceridaemia is modulated by insulin resistance but not by grade of obesity in abdominal and morbid obese subjects
Moreno‐Pérez, B., Benito, E., Civera, M., Alabadí, B., Martínez‐Hervás, S., Peiró, M., Navarro, H. G., Piqueras, L., Sanz, M., Ascaso, J. F., et al. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13776 · Cited by 4
Pathophysiology and Management of Dyslipidemias Associated with Insulin-Resistant States
Maki, K. C., Benes, L. B., & Dicklin, M. R. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-56514-5_16 · Cited by 6
Pathogenesis of Insulin Resistance
Zaman, G. S. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92864 · Cited by 6
Effect of hyperlipidemia on 11β-hydroxysteroid-dehydrogenase, glucocorticoid receptor, and leptin expression in insulin-sensitive tissues of cats
Sieber‐Ruckstuhl, N. S., Zini, E., Osto, M., Franchini, M., Boretti, F. S., Meli, M. L., Sigrist, B., Lutz, T. A., & Reusch, C. E. (2010) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2010.06.003 · Cited by 5

Authors: Belfort, R., Mandarino, L., Kashyap, S., Wirfel, K., Pratipanawatr, T., Berria, R., DeFronzo, R. A., & Cusi, K.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
ORCID: Mandarino, Lawrence
Kashyap, Sangeeta
Pratipanawatr, Thongchai
DeFronzo, Ralph A.
Cusi, Kenneth
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2005-06-01
Volume: 54
Issue: 6
Pages: 1640-1648
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.54.6.1640
OpenAlex: W2115433418
Cited by: 404
References: 74
Citations by year: 2026: 9 · 2025: 10 · 2024: 22 · 2023: 10 · 2022: 18 · 2021: 21 · 2020: 24 · 2019: 15 · 2018: 14 · 2017: 20 · 2016: 15 · 2015: 23 · 2014: 28 · 2013: 26 · 2012: 15
FWCI: 11.03
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-24092, F32DK061189, R01DK024092)
National Center for Research Resources (M01RR01346, M01RR001346)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: plasma free fatty acids, insulin signaling, insulin resistance, insulin-stimulated glucose disposal, dose-response relationship, insulin receptor tyrosine phosphorylation, IRS-1, phosphatidylinositol 3-kinase, hyperinsulinemic-euglycemic clamp
MeSH terms: Adult, Dose-Response Relationship, Drug, Emulsions, Fat Emulsions, Intravenous, Fatty Acids, Nonesterified, Female, Glucose, Humans, Insulin, Male, Safflower Oil, Soybean Oil, Signal Transduction, Muscle, Skeletal, Lecithins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks