Cited by 319Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension

Rahmouni, Kamal, Morgan, Donald A., Morgan, Gina M., Mark, Allyn L., Haynes, William G.·2005·Diabetes

DOI 10.2337/diabetes.54.7.2012

Open this paper in CoChat — free account

Abstract

Leptin is an adipocyte-derived hormone that plays a key role in the regulation of body weight through its actions on appetite and metabolism. Leptin also increases sympathetic nerve activity (SNA) and blood pressure. We tested the hypothesis that diet-induced obesity is associated with resistance to the metabolic actions of leptin but preservation of its renal SNA and arterial pressure effects, leading to hypertension. Mice were fed a high-fat diet for 10 weeks to induce moderate obesity. The decrease in food intake and body weight induced by intraperitoneal or intracerebroventricular leptin was significantly attenuated in the obese mice. Regional SNA responses to leptin were differentially altered in diet-induced obese mice. Renal SNA response to leptin was preserved, whereas lumbar and brown adipose tissue SNA responses were attenuated in obese mice. Radiotelemetric arterial pressure was ∼10 mmHg higher in obese mice. Furthermore, the increase in arterial pressure in response to long-term (12 days) leptin treatment was preserved in obese mice. Thus, mice with diet-induced obesity exhibit circulating hyperleptinemia and resistance to the metabolic actions of leptin. However, there is preservation of the renal sympathetic and arterial pressure responses to leptin, which represent a potential mechanism for the adverse cardiovascular consequences of obesity.

Integrity signals

Registry

Crossref · 10.2337/diabetes.54.7.2012

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
Caro, J. F., Kolaczynski, J. W., Nyce, M. R., Ohannesian, J. P., Opentanova, I., Goldman, W. H., Lynn, R. B., Zhang, P.-L., Sinha, M. K., & Considine, R. V. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03173-x · Cited by 1,175
Receptor-mediated regional sympathetic nerve activation by leptin.
Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979
Self-citation
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887
The Kidney, Hypertension, and Obesity
Hall, J. E. (2003) · Hypertension · doi:10.1161/01.hyp.0000052314.95497.78 · Cited by 868
Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737
Chronic Leptin Infusion Increases Arterial Pressure
Shek, E. W., Brands, M. W., & Hall, J. E. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.409 · Cited by 686
Sympathetic Neural Activation in Visceral Obesity
Alvarez, G. E., Beske, S. D., Ballard, T. P., & Davy, K. P. (2002) · Circulation · doi:10.1161/01.cir.0000041244.79165.25 · Cited by 557

Flagged first, then by citations

Show all 31 references

Sorted by citations

Items 201–300 of 319

Modulation of P2Y11-related purinergic signaling in inflammation and cardio-metabolic diseases
Dănilă, M. D., Piollet, M., Aburel, O.-M., Angoulvant, D., Gabillard-Lefort, C., Chadet, S., Roger, S., Muntean, D. M., & Ivanés, F. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173060 · Cited by 16
Attenuation of Signaling and Nitric Oxide Production following Prolonged Leptin Exposure in Human Aortic Endothelial Cells
Blanquicett, C., Graves, A. S., Kleinhenz, D. J., & Hart, C. M. (2007) · Journal of Investigative Medicine · doi:10.2310/6650.2007.00017 · Cited by 16
The complex role of PPARγ in renal dysfunction in obesity: Managing a Janus-faced receptor
Dobrian, A. D. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.01.017 · Cited by 16
Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet
Tófolo, L. P., Ribeiro, T. A., Malta, A., Miranda, R. A., Gomes, R. M., de Oliveira, J. C., Abdennebi‐Najar, L., Almeida, D. L., Trombini, A. B., Franco, C. C. D. S., et al. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0816-7 · Cited by 16
CNS Targets of Adipokines
Beall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160045 · Cited by 16
Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology
Daniels, L. J., Macindoe, C., Koutsifeli, P., Annandale, M., James, S. L., Watson, L. E., Coffey, S., Raaijmakers, A. J. A., Weeks, K. L., Bell, J. R., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-39499-3 · Cited by 15
Abdominal Adipose Tissue was Associated with Glomerular Hyperfiltration among Non- Diabetic and Normotensive Adults with a Normal Body Mass Index
Lee, J., Kim, H. J., Cho, B., Park, J., Choi, H.-C., Lee, C. M., Oh, S., Kwon, H., & Heo, N. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141364 · Cited by 16
Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity
Kim, L. J., Shin, M., Pho, H., Otvos, L. J., Tufik, S., Andersen, M. L., Pham, L. V., & Polotsky, V. Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.688375 · Cited by 15
Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity
Balapattabi, K., Yavuz, Y., Jiang, J., Deng, G., Mathieu, N. M., Ritter, M. L., Opichka, M. A., Reho, J. J., McCorvy, J. D., Nakagawa, P., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112935 · Cited by 14
Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice
Tanner, J. M., Kearns, D., Kim, B., Sloan, C., Jia, Z., Yang, T., Abel, E. D., & Symons, J. D. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010171 · Cited by 14
Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase
Alé, A., Zhang, Y., Han, C., & Cai, D. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00337.2016 · Cited by 14
Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemia
Luo, W., Bodary, P. F., Shen, Y., Wickenheiser, K. J., Öhman, M. K., Guo, C., Bahrou, K. L., Myers, M. G., & Eitzman, D. T. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.10.009 · Cited by 14
Obesity and the renin– angiotensin–aldosterone system
Sharma, A. M., & Engeli, S. (2006) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.1.2.255 · Cited by 15
Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II–Induced Organ Damage
Nakagawa, P., Nair, A. R., Agbor, L. N., Gomez, J. A., Wu, J. F., Zhang, S. Y., Lu, K., Morgan, D. A., Rahmouni, K., Grobe, J. L., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14972 · Cited by 13
Self-citation
Plasma Leptin and Blood Pressure Progression in Blacks
Kazé, A. D., Musani, S. K., Bidulescu, A., Correa, A., Bertoni, A. G., Ahima, R. S., Golden, S. H., Abdalla, M., & Echouffo-Tcheugui, J. B. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16174 · Cited by 13
Complex Catabolic Effects of Central Alpha-MSH Infusion in Rats of Altered Nutritional States: Differences from Leptin
Soós, S., Pétervári, E., Székely, M., Jech-Mihálffy, A., & Balaskó, M. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9462-6 · Cited by 13
Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptin
Bełtowski, J., Wójcicka, G., Jamróz-Wiśniewska, A., & Borkowska, E. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2006.12.007 · Cited by 13
High Intakes of [6S]-5-Methyltetrahydrofolic Acid Compared with Folic Acid during Pregnancy Programs Central and Peripheral Mechanisms Favouring Increased Food Intake and Body Weight of Mature Female Offspring
Pannia, E., Hammoud, R., Kubant, R., Yup, J., Simonian, R., Wasek, B. L., Ashcraft, P., Bottiglieri, T., Pausová, Z., & Anderson, G. H. (2021) · Nutrients · doi:10.3390/nu13051477 · Cited by 12
Expression and function of nesfatin-1 are altered by stage of the estrous cycle
Pate, A. T., Schnell, A. L., Ennis, T. A., Samson, W. K., & Yosten, G. L. C. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00249.2018 · Cited by 12
Programming of rat adrenal medulla by neonatal hyperleptinemia: adrenal morphology, catecholamine secretion, and leptin signaling pathway
Trevenzoli, I. H., Pinheiro, C. R., da Conceição, E. P. S., Oliveira, E., Passos, M. C. F., Lisboa, P. C., & de Moura, E. G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00734.2009 · Cited by 13
Endospanin 1 Determines the Balance of Leptin-Regulated Hypothalamic Functions
Roujeau, C., Jockers, R., & Dam, J. (2018) · Neuroendocrinology · doi:10.1159/000494557 · Cited by 12
Effects of leptin on sympathetic nerve activity in conscious mice
Morgan, D. A., Despas, F., & Rahmouni, K. (2015) · Physiological Reports · doi:10.14814/phy2.12554 · Cited by 11
Self-citation
Differential hypothalamic leptin sensitivity in obese rat offspring exposed to maternal and postnatal intake of chocolate and soft drink
Kjaergaard, M., Nilsson, C., Secher, A., Kildegaard, J., Skovgaard, T., Nielsen, M., Grove, K., & Raun, K. (2017) · Nutrition & Diabetes · doi:10.1038/nutd.2016.53 · Cited by 11
Rimonabant: the evidence for its use in the treatment of obesity and the metabolic syndrome
Journal, C. (2007) · Core evidence · doi:10.2147/ce.s7428 · Cited by 10
Effects of central administration of resistin on renal sympathetic nerve activity in rats fed a high‐fat diet: a comparison with leptin
Habeeballah, H. H., Alsuhaymi, N., Stebbing, M. J., & Badoer, E. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12495 · Cited by 10
Increased Adiposity Appraised with CUN-BAE Is Highly Predictive of Incident Hypertension. The SUN Project
Dominguez, L. J., Sayón-Orea, C., Gea, A., Toledo, E., Barbagallo, M., & Martínez‐González, M. Á. (2021) · Nutrients · doi:10.3390/nu13103309 · Cited by 11
Endothelial leptin receptor is dispensable for leptin-induced sympatho-activation and hypertension in male mice
Atawia, R. T., Faulkner, J., Mehta, V., Austin, A., Jordan, C. R., Kennard, S., & de Chantemèle, E. J. B. (2022) · Vascular Pharmacology · doi:10.1016/j.vph.2022.107093 · Cited by 10
Leptin and Obesity
Bell, L. N., & Considine, R. V. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_3 · Cited by 10
Short-term physiological hyperleptinemia decreases arterial blood pressure
Knight, W. D., Seth, R., Boron, J., & Overton, J. M. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.02.001 · Cited by 10
DIFFERENTIAL CONTROL OF THE SYMPATHETIC NERVOUS SYSTEM BY LEPTIN: IMPLICATIONS FOR OBESITY
Rahmouni, K. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04760.x · Cited by 9
Self-citation
Leptin and Its Emerging Role in Children and Adolescents
Kelesidis, I., & Mantzoros, C. S. (2006) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.15.1 · Cited by 8
Resistant Hypertension in Diabetes Mellitus
Bayliss, G. P., Weinrauch, L. A., & D’Elia, J. A. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0516-y · Cited by 9
Central Administration of Insulin and Leptin Together Enhance Renal Sympathetic Nerve Activity and Fos Production in the Arcuate Nucleus
Habeeballah, H. H., Alsuhaymi, N., Stebbing, M. J., Jenkins, T. A., & Badoer, E. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2016.00672 · Cited by 9
Obese Male Mice Exposed to Early Life Stress Display Sympathetic Activation and Hypertension Independent of Circulating Angiotensin II
Dalmasso, C., Ahmed, N., Ghuneim, S., Cincinelli, C., Leachman, J. R., Giani, J. F., Cassis, L. A., & Loria, A. S. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.029511 · Cited by 9
Leptin, Obesity, and Leptin Resistance
Münzberg, H., & Heymsfield, S. B. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_6 · Cited by 11
Central leptin and resistin combined elicit enhanced central effects on renal sympathetic nerve activity
Habeeballah, H. H., Alsuhaymi, N., Stebbing, M. J., Jenkins, T. A., & Badoer, E. (2016) · Experimental Physiology · doi:10.1113/ep085723 · Cited by 8
High Fat Diet Decreases Neuronal Activation in the Brain Induced by Resistin and Leptin
Alsuhaymi, N., Habeeballah, H. H., Stebbing, M. J., & Badoer, E. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00867 · Cited by 8
Antihypertensive therapy in the obese hypertensive patient
Chrostowska, M., Szczęch, R., & Narkiewicz, K. (2006) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000242173.14082.dc · Cited by 8
Renal Sinus Adiposity and Hypertension
Mazairac, A. H. A., & Joles, J. A. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.158535 · Cited by 9
Leptin effects: focusing on the relationship between obesity and male infertility
Padula, D. L., Zavaglia, L., Hamad, T., Nocito, M. C., Aquila, S., Avena, P., & Rago, V. (2022) · Minerva Endocrinology · doi:10.23736/s2724-6507.22.03901-x · Cited by 7
Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function
Kim, Y. C., Fattah, H., Fu, Y., Nespoux, J., & Vallon, V. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00279.2022 · Cited by 9
Adenovirus‐Mediated Leptin Expression Normalises Hypertension Associated with Diet‐Induced Obesity
Zhang, W., Télémaque, S., Augustyniak, R. A., Anderson, P., Thomas, G. D., An, J., Wang, Z., Newgard, C. B., & Victor, R. G. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01953.x · Cited by 7
Crosstalk between leptin and interleukin-1 β abrogates negative inotropic effects in a model of chronic hyperleptinemia
Radin, M. J., Holycross, B. J., McCune, S. A., & Altschuld, R. A. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011144 · Cited by 6
Obesity-Associated Hypertension
Uwaifo, G. I. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-548-4_13 · Cited by 7
Effect of a long-term high-energy diet on cardiovascular parameters in Shetland pony mares
Fonseca, N. M. M. D., Beukers, M., Wijnberg, I. D., de Solís, C. N., de Ruijter‐Villani, M., van Doorn, D. A., Stout, T. A. E., & de Graaf‐Roelfsema, E. (2021) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.16229 · Cited by 6
Understanding cross-data dynamics of individual and social/environmental factors through a public health lens: explainable machine learning approaches
Jeong, S., Yun, S. B., Park, S. Y., & Mun, S. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1257861 · Cited by 5
Leptin-programmed rats respond to cold exposure changing hypothalamic leptin receptor and thyroid function differently from cold-exposed controls
Dutra, S. C. P., de Moura, E. G., Lisboa, P. C., Trevenzoli, I. H., & Passos, M. C. F. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.07.005 · Cited by 5
Visceral Fat and Hypertension: Sex Differences
Pausová, Z. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407869-7.00009-x · Cited by 5
Adipokine Production by Adipose Tissue: A Novel Target for Treating Metabolic Syndrome and its Sequelae
DeClercq, V., Defries, D. M., Hunt, R., Taylor, C. G., & Zahradka, P. C. (2011) · Wiley eBooks · doi:10.1002/9780470910016.ch4 · Cited by 5
Biomarkers and Mechanisms in the Early Assessment of Childhood Obesity from a Multidisciplinary Perspective—A Narrative Review
Mîndru, D. E., Bozomitu, L. I., Anton-Păduraru, D.-T., Țarcă, E., Curici, A., Elkan, E. M., Butnariu, L. I., Moraru, D. C., Diaconescu, C., & Luca, A.-C. (2025) · Medicina · doi:10.3390/medicina61040607 · Cited by 4
Brown adipose tissue, anthropometric traits, and metabolic profiles in women with normal weight obesity
Dojo, K., Ishida, K., Fuse-Hamaoka, S., Aoki, M., Tsunoda, M., Yamamoto, M., Ota, N., & Hamaoka, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-10583-0 · Cited by 5
Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture
Rahmouni, K. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.22066 · Cited by 4
Self-citation
Controversial culprit of leptin in obesity hypertension: clues from a case-control study with Chinese newly diagnosed adult early-onset obesity hypertensives
Wu, O., Leng, J. H., Zhang, X., Liu, W., Yang, F. F., Zhang, H., Li, J. J., Zhang, G. Z., & Lu, X. (2022) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2022.2071920 · Cited by 4
Hypertension in obese children and adolescents
Peco‐Antić, A. (2009) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh0902091p · Cited by 4
Placental Insufficiency: Programming of Leptin Secretion, Blood Pressure, and Postnatal Growth in Two Generations of Sprague-Dawley Rats
Anderson, C. M., Norby, F. L., Sandeen, A., & Johnson, L. K. (2008) · Biological Research For Nursing · doi:10.1177/1099800408324127 · Cited by 4
Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity?
Lingappan, K. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0199ed · Cited by 4
Sympathetic Tone in the Young
Rahmouni, K. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.140764 · Cited by 4
Self-citation
The conflicting effects of maternal nutrient restriction and early-life obesity on renal health
Fainberg, H. P., Budge, H., & Symonds, M. E. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110004921 · Cited by 3
Influences of maternal obesity on the health of the offspring: a review of animal models
Poston, L., Taylor, P. D., & Nathanielsz, P. W. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511782466.011 · Cited by 3
ЛЕПТИН И ПОЛОВЫЕ ОСОБЕННОСТИ МЕТАБОЛИЧЕСКИХ НАРУШЕНИЙПРИ ОЖИРЕНИИ
Хуссейн, Ю. Х. Х. (2022) · Juvenis scientia · doi:10.32415/jscientia_2022_8_1_19-31 · Cited by 3
Effect of Lauric vs. Oleic Acid-Enriched Diets on Leptin Autoparacrine Signalling in Male Mice
Fernández-Felipe, J., Plaza, A., Domı́nguez, G., Pérez‐Castells, J., Cano, V., Cioni, F., Olmo, N. D., Ruiz‐Gayo, M., & Merino, B. (2022) · Biomedicines · doi:10.3390/biomedicines10081864 · Cited by 3
Does selective leptin resistance cause obesity-related hypertension?
Correia, M., & Haynes, W. G. (2008) · Cited by 3
Self-citation
Hiperatividade simpática na obesidade
Carvalheira, J. B. C. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000100003 · Cited by 3
Chronic liquid nutrition feeding affects blood pressure, heart and kidney morphology, and serum lipid profile in Wistar rats
Mikuska, L., Vrabcová, M., Horváthová, Ľ., Osacká, J., Varga, I., & Mravec, B. (2016) · General Physiology and Biophysics · doi:10.4149/gpb_2015042 · Cited by 2
The Role of Perivascular Adipose Tissue in Microvascular Function and Coronary Atherosclerosis
Antonopoulos, A. S., Papanikolaou, P., & Tousoulis, D. (2019) · Springer eBooks · doi:10.1007/978-3-030-28199-1_6 · Cited by 2
ROLE OF ANGIOTENSIN CONVERTING ENZYME 2 (ACE2) IN OBESITY-ASSOCIATED HYPERTENSION
Gupte, M. (2011) · UKnowledge (University of Kentucky) · Cited by 2
PTP1B in Obesity-Related Cardiovascular Function
Ketsawatsomkron, P., Stepp, D. W., & de Chantemèle, E. J. B. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7855-3_7 · Cited by 2
Is hyperleptinemia a risk factor for hypertension?
Rafique, N., & Afzal, N. (2013) · Saudi Journal of Medicine and Medical Sciences · doi:10.4103/1658-631x.112930 · Cited by 2
Exercise training reverse autonomic dysfunction and hypertension in rats fed with high-fat diet
de Sordi, C. C., Lemos, M. D. P., Marocolo, M., Chriguer, R. S., Mendes, E. L., da Mota, G. R., & Neto, O. B. (2017) · Motriz Revista de Educação Física · doi:10.1590/s1980-6574201700040004 · Cited by 2
Alterations induced by juvenile obesity on the renal tissue of nutrient restricted offspring
Fainberg, H. P. (2010) · Nottingham ePrints (University of Nottingham) · Cited by 2
Leptina, obesidad e hipertensión arterial
Cortada, J. V., & Coca, A. (2006) · Medicina Clínica · doi:10.1157/13088783 · Cited by 2
Metabolisches Syndrom
Peters, A., & Lehnert, H. (2007) · Der Internist · doi:10.1007/s00108-006-1784-7 · Cited by 2
SerpinA3N in leptin-sensitive neurons is required for energy and glucose homeostasis and autonomic regulation
Guo, D., Luo, Z., Olson, A., Morgan, D. A., Newell, E. A., & Rahmouni, K. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156387 · Cited by 1
Self-citation
Niveles séricos de leptina y su relación con la excreción de sodio en niños y adolescentes obesos
Jensen, A., López, M. A., Mir, C. N., Martínez, M., Pianesi, M., & Erhard, M. (2011) · Revista Argentina de Endocrinología y Metabolismo · Cited by 1
Reward Capacity Predicts Leptin Dynamics During Laboratory‐Controlled Eating in Women as a Function of Body Mass Index
Holsen, L. M., & Jackson, B. M. (2017) · Obesity · doi:10.1002/oby.21930 · Cited by 1
Effects of adipocyte deficiency of angiotensin type 1a receptors in models of obesity and hypercholesterolemia
Putnam, K. (2012) · UKnowledge (University of Kentucky) · Cited by 1
Pediatric Obesity: It's Time for Prevention before Conception Can Maternal Obesity Program Pediatric Obesity?
Ferraro, Z., & Adamo, K. B. (2008) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s1099 · Cited by 1
Leptin, the Autonomic Nervous System, and Hypertension
da Silva, A. A., do Carmo, J. M., Wang, Z., & Hall, J. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_14 · Cited by 1
Sympathetic vascular tone in human obesity
Correia, M. (2007) · doi:10.17077/etd.v54kf0if · Cited by 1
ADIPOCYTE-DERIVED HORMONES AND CARDIOVASCULAR DISEASE
Eriksson, M. (2010) · DiVA at Umeå University (Umeå University) · Cited by 1
Multiple Roles of Leptin in Blood Pressure Regulation, From Central to Peripheral Mechanisms
Polak, J. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.285 · Cited by 1
Leptin and Cardiovascular Disease
(2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_10 · Cited by 1
Leptin Secretion and Action
Considine, R. V. (2010) · Wiley eBooks · doi:10.1002/9783527629527.ch10
Perinatal programming of appetite regulation and metabolic health
Dellschaft, N. S. (2012) · Nottingham ePrints (University of Nottingham)
Estudo morfológico e funcional dos efeitos da dieta hiperlipídica em rins de ratas Wistar
Pinhal, C. S. (2013) · doi:10.47749/t/unicamp.2013.902416
Neural mechanisms of sympathetic activation during hyperinsulinemia and obesity-induced hypertension
Bardgett, M. E. (2010) · UKnowledge (University of Kentucky)
Untersuchung des Einflusses von Leptin auf die Thrombozytenfunktion sowie Analyse der Leptin-vermittelten Signalkaskade in Thrombozyten
Rohm, I. (2015) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4929
The Outcome in Offspring of Obese Mothers: Clinical and Experimental Aspects
Poston, L. (2010) · Journal of Perinatal Medicine · doi:10.1515/jpm.2010.186
Does Genetic Variation in the Leptin Receptor Influence the Sympathetic Tone in Obesity?
Rahmouni, K. (2008) · Hypertension Research · doi:10.1291/hypres.31.1057
Self-citation
IMPACT OF OBESITY ON THE SUSCEPTIBILITY OF THE MYOCARDIUM TO HYPERTENSIVE AND ADRENERGIC-INDUCED APOPTOSIS
Vengethasamy, L. (2010) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
O tratamento com leptina por 7 e 28 dias altera a função e a morfologia renal de ratos.
Thieme, K. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2014.tde-18112014-161417
Role of leptin and obesity-related leptin resistance in the pathophysiology of metabolic syndrome
Rahmouni, K., & Correia, M. (2006)
Self-citation
Alterações renais e metabólicas induzidas pela dieta hiperlipídica e hipersódica em ratas ovariectomizadas
de Souza, S. I. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Factors associated with the severity of Apnoea Hypopnoea Index (AHI) in Obstructive Sleep Apnoea (OSA)
Earing, C. (2015) · Bangor University Research Portal (Bangor University)
PROGRAMA MULTICÊNTRICO DE PÓS-GRADUAÇÃO EM CIÊNCIAS FISIOLÓGICAS- SBFIS
Gusmão, D. D. O. (2012)
Артеријска хипертензија гојазне деце и адолесцената
Peco‐Antić, A. (2009)
Comparison of Hemodynamic Responses to Acute and Chronic Exercise in Obese and Lean Prehypertensive Men
Zeigler, Z. (2016)
THE SUBFORNICAL ORGAN AND AREA POSTREMA MEDIATE THE CENTRAL EFFECTS OF CIRCULATING LEPTIN
Smith, P. (2012) · QSpace (Queen's University Library)
Cardiovascular and Metabolic Responses to Peripheral Leptin Infusion in Rats
Knight, W. D. (2008)
Diabetes in Pregnancy
Starling, A. P., & Dabalea, D. (2017) · Wiley eBooks · doi:10.1002/9781119043805.ch28

Authors: Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L., & Haynes, W. G.
Affiliations: University of Iowa (US)
ORCID: Rahmouni, Kamal
Morgan, Donald A.
Morgan, Gina M.
Mark, Allyn L.
Haynes, William G.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2005-07-01
Volume: 54
Issue: 7
Pages: 2012-2018
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.54.7.2012
OpenAlex: W2012264731
Cited by: 319
References: 31
Citations by year: 2026: 7 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 19 · 2016: 14 · 2015: 16 · 2014: 16 · 2013: 25 · 2012: 19
FWCI: 9.32
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health (5p50hl044546-05)
National Heart, Lung, and Blood Institute (HL-14388, HL-44546, P01HL014388)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: leptin resistance, diet-induced obesity, hypertension, sympathetic activity, renal sympathetic nerve activity, arterial pressure, high-fat diet, hyperleptinemia, brown adipose tissue
MeSH terms: Animals, Blood Pressure, Adipose Tissue, Brown, Dietary Fats, Disease Models, Animal, Drug Resistance, Hypertension, Injections, Intraventricular, Male, Mice, Inbred C57BL, Obesity, Leptin, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks