Sympathetic Neural Activation in Visceral Obesity
Abstract
Background— Muscle sympathetic nerve activity (MSNA) is elevated in obese humans. However, the potential role of abdominal visceral fat as an important adipose tissue depot linking obesity to elevated MSNA has not been explored. Accordingly, we tested the hypothesis that MSNA would be increased in men (age=18 to 40 years, body mass index ≤35 kg/m 2 ) with higher abdominal visceral fat (HAVF; n=13, abdominal visceral fat=118.1±15.8 cm 2 ) compared with their age- (28.7±2.4 versus 25.5±2.0 years, P >0.05), total fat mass-matched (20.6±2.1 versus 20.8±2.4 kg, P >0.05) and abdominal subcutaneous fat-matched (230.6±24.9 versus 261.4±34.8 cm 2 , P >0.05) peers with lower abdominal visceral fat levels (LAVF; n=13, visceral fat= 73.0±6.0 cm 2 ). Methods and Results— MSNA (microneurography), body composition (dual energy x-ray absorptiometry), and abdominal visceral and subcutaneous fat (computed tomography) were measured in 37 sedentary men across a wide range of adiposity. MSNA was ≈55% higher in men with HAVF compared with men with LAVF (33±4 versus 21±2 bursts/min, P <0.05). Furthermore, MSNA was more closely associated with the level of abdominal visceral fat ( r =0.65, P <0.05) than total fat mass ( r =0.323, P <0.05) or abdominal subcutaneous fat ( r =0.27, P =0.05). The relation between MSNA and abdominal visceral fat was independent of total body fat ( r =0.61, P <0.05). Conclusions— The results of our study indicate that MSNA is elevated in men with visceral obesity. Our observations are consistent with the idea that abdominal visceral fat is an important adipose tissue depot linking obesity with sympathetic neural activation in humans. Furthermore, these findings may have important implications for understanding the increased risk of developing cardiovascular diseases in individuals with visceral obesity.
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Sympathetic activation is associated with individual components of metabolic syndrome, including visceral obesity, insulinemia, essential hypertension, and type 2 diabetes.
“Sympathetic activation has already been associated with many of the individual components of the MS, such as visceral obesity, 5 insulinemia, 6 EHT, [1][2][3][4] and type 2 diabetes.7”
From Sympathetic Neural Activation in Nondiabetic Metabolic Syndrome and Its Further Augmentation by Hypertension (2004) · cites this paper as [5]
MS components such as visceral obesity, peripheral insulin resistance, and reactive hyperinsulinemia have been found to result in sympathetic hyperactivity.
“First, MS components such as visceral obesity, peripheral insulin resistance, and reactive hyperinsulinemia have been found to result in sympathetic hyperactivity.[5][6][7]”
From Sympathetic Neural Activation in Nondiabetic Metabolic Syndrome and Its Further Augmentation by Hypertension (2004) · cites this paper as [5]
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- Authors
- Alvarez, G. E., Beske, S. D., Ballard, T. P., & Davy, K. P.
- Affiliations
- University of Mississippi Medical Center (US)
- ORCID
- Davy, Kevin P.
- Venue
- Circulation
- Published
- 2002-11-12
- Volume
- 106
- Issue
- 20
- Pages
- 2533-2536
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2138900790
- Cited by
- 557
- References
- 21
- Citations by year
- 2026: 3 · 2025: 16 · 2024: 19 · 2023: 13 · 2022: 16 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 18 · 2017: 19 · 2016: 29 · 2015: 27 · 2014: 42 · 2013: 24 · 2012: 29
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL62283, K02HL067227, R01HL062283, HL67227)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- visceral obesity, visceral fat, muscle sympathetic nerve activity, sympathetic activation, adipose tissue depots, subcutaneous adipose tissue, body composition, cardiovascular risk
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Anthropometry, Body Composition, Humans, Male, Obesity, Sympathetic Nervous System, Baroreflex, Muscle, Skeletal, Abdominal Cavity
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