Cited by 1,257Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGestational Diabetes Research and Management

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Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.

Ehrmann, D A, Barnes, R B, Rosenfield, R L, Cavaghan, M K, Imperial, J·1999·Diabetes Care

DOI 10.2337/diacare.22.1.141

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Abstract

OBJECTIVE: NIDDM occurs commonly among women with polycystic ovary syndrome (PCOS). The prevalence and natural history of its precursor, impaired glucose tolerance (IGT), is less well known. The objective of this study was to characterize the prevalence and incidence of glucose intolerance in a large cohort of women with well-characterized PCOS. RESEARCH DESIGN AND METHODS: A total of 122 women with clinical and hormonal evidence of PCOS were recruited from the Medicine, Endocrinology, Gynecology, and Pediatrics Clinics at the University of Chicago. All women had a standard oral glucose tolerance test (OGTT) with measurement of glucose and insulin levels. A subset of 25 women were subsequently restudied with the aim of characterizing the natural history of glucose tolerance in PCOS. RESULTS: Glucose tolerance was abnormal in 55 (45%) of the 122 women: 43 (35%) had IGT and 12 (10%) had NIDDM at the time of initial study. The women with NIDDM differed from those with normal glucose tolerance in that they had a 2.6-fold higher prevalence of first-degree relatives with NIDDM (83 vs. 31%, P < 0.01 by chi 2) and were significantly more obese (BMI 41.0 +/- 2.4 vs. 33.4 +/- 1.1 kg/m2, P < 0.01). For the entire cohort of 122 women, there was a significant correlation between fasting and 2-h glucose concentrations (r = 0.76, P < 0.0001); among the subset with IGT, the fasting glucose concentration was poorly predictive of the 2-h level (r = 0.25, NS). After a mean follow-up of 2.4 +/- 0.3 years (range 0.5-6.3), 25 women had a second OGTT. The glucose concentration at 2 h during the second glucose tolerance test was significantly higher than the 2-h concentration during the first study (161 +/- 9 vs. 139 +/- 6 mg/dl, P < 0.02). CONCLUSIONS: The prevalence of IGT and NIDDM in women with PCOS is substantially higher than expected when compared with age- and weight-matched populations of women without PCOS. The conversion from IGT to NIDDM is accelerated in PCOS. The fasting glucose concentration does not reliably predict the glucose concentration at 2 h after an oral glucose challenge, particularly among those with IGT, the subgroup at highest risk for subsequent development of NIDDM. We conclude that women with PCOS should periodically have an OGTT and must be closely monitored for deterioration in glucose tolerance.

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“Previous investigations performed over the last few decades have confirmed that PCOS is often linked with an increased risk of type 2 diabetes mellitus and the PCOS patients with mild hyperandrogenism but normal ovulation have the risk of developing this chronic disorder in future [8, 9].”
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Assessment of central corneal thickness, intraocular pressure and retinal nerve fiber layer thickness at women with polycystic ovary syndrome
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Aziz, K. (2018) · Diabetes & Obesity International Journal · doi:10.23880/doij-16000173 · Cited by 5
Comparison of 2-Hour Oral Glucose Tolerance Test and Hemoglobin A1C in the Identification of Pre-Diabetes in Women with Infertility and Recurrent Pregnancy Loss
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“As an endocrinological disorder, polycystic ovary syndrome is often accompanied by insulin resistance, obesity, and various metabolic alterations,(4) and more than 40% of patients with polycystic ovary syndrome experience type 2 diabetes mellitus or glucose intolerance during their lives.(5,6) As a systemic disease, p…”
Background
Serum metabolomics probes the molecular mechanism of action of acupuncture on metabolic pathways related to glucose metabolism in patients with polycystic ovary syndrome–related obesity
Yang, N., Ma, K., Liu, W., Zhang, N., Shi, Z., Ren, J. M., Xu, W., Li, Y., Su, R., Liang, Y., et al. (2023) · Biomedical Chromatography · doi:10.1002/bmc.5710 · Cited by 5
Interlukin-22 improves ovarian function in polycystic ovary syndrome independent of metabolic regulation: a mouse-based experimental study
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Polycystic ovarian syndrome and insulin resistance: a North Indian study
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Conservative Management of Gynecologic Diseases
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“In addition, women with PCOS may also have other metabolic abnormalities such as insulin resistance [6,7], glucose intolerance, type 2 diabetes [4,8,9] and an increased prevalence of lipid-related abnormalities [10,11].”
Background
Current procedures for managing polycystic ovary syndrome
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Is there a link between polycystic ovary syndrome and non-thyroidal illness syndrome?
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“It is associated with an increased risk of type 2 diabetes mellitus (T2DM) (1-3).”
Background
Impaired glucose tolerance is associated with changes in clinical and biochemical parameters in women with polycystic ovary syndrome
Walch, K., Grimm, C., Nagele, F., Huber, J. C., Wölfler, M. M., Vytiska‐Binstorfer, E., Unfried, G., & Hefler, L. (2006) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340500342938 · Cited by 5
“Recently, large prospective studies recognized a varying degree of IGT as a significant finding in up to 40% of affected women (4,5).”
Background
A Paradox: The Roles of Inositolphosphoglycans in mediating insulin sensitivity and Hyperandrogenism in the Polycystic Ovary Syndrome
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Authors: Ehrmann, D. A., Barnes, R. B., Rosenfield, R. L., Cavaghan, M. K., & Imperial, J.
Affiliations: University of Chicago (US)
ORCID: Rosenfield, R L
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1999-01-01
Volume: 22
Issue: 1
Pages: 141-146
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.22.1.141
OpenAlex: W2007816906
Cited by: 1,257
References: 0
Citations by year: 2026: 10 · 2025: 13 · 2024: 22 · 2023: 18 · 2022: 39 · 2021: 45 · 2020: 32 · 2019: 39 · 2018: 40 · 2017: 45 · 2016: 37 · 2015: 63 · 2014: 63 · 2013: 55 · 2012: 75
FWCI: 31.87
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08dk002315-02)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-31842, DK 20595, DK-02315)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords: polycystic ovary syndrome, impaired glucose tolerance, type 2 diabetes, prevalence, incidence, natural history (disease), oral glucose tolerance test, fasting blood glucose, obesity, family history of diabetes, women's health
MeSH terms: Adult, Analysis of Variance, Blood Glucose, Chicago, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Glucose Tolerance Test, Humans, Insulin, Polycystic Ovary Syndrome, Regression Analysis, Testosterone, Prevalence, Glucose Intolerance

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Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.

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