Cited by 333Retinal Diseases and TreatmentsAntioxidant Activity and Oxidative StressChronic Kidney Disease and Diabetes

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High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.

Bursell, S E, Clermont, A C, Aiello, L P, Aiello, L M, Schlossman, D K, Feener, E P, Laffel, L, King, G L·1999·Diabetes Care

DOI 10.2337/diacare.22.8.1245

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Abstract

OBJECTIVE: To determine the effectiveness of vitamin E treatment in normalizing retinal blood flow and renal function in patients with <10 years of type 1 diabetes. RESEARCH DESIGN AND METHODS: An 8-month randomized double-masked placebo-controlled crossover trial evaluated 36 type 1 diabetic and 9 nondiabetic subjects. Subjects were randomly assigned to either 1,800 IU vitamin E/day or placebo for 4 months and followed, after treatment crossover, for a further 4 months. Retinal blood flow was measured using video fluorescein angiography, and renal function was assessed using normalized creatinine clearance from timed urine collections. RESULTS: After vitamin E treatment, serum levels of vitamin E were significantly elevated (P<0.01) in both type 1 diabetic and control patients. Hemoglobin A1c was not affected by vitamin E treatment. Diabetic patient baseline retinal blood flow (29.1+/-7.5 pixel2/s) was significantly (P = 0.030) decreased compared with that of nondiabetic subjects (35.2+/-7.2 pixel2/s). After vitamin E treatment, diabetic patient retinal blood flow (34.5+/-7.8 pixel2/s) was significantly increased (P<0.001) and was comparable with that of nondiabetic subjects. Additionally, vitamin E treatment significantly (P = 0.039) normalized elevated baseline creatinine clearance in diabetic patients. CONCLUSIONS: Oral vitamin E treatment appears to be effective in normalizing retinal hemodynamic abnormalities and improving renal function in type 1 diabetic patients of short disease duration without inducing a significant change in glycemic control. This suggests that vitamin E supplementation may provide an additional benefit in reducing the risks for developing diabetic retinopathy or nephropathy.

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Chistiakov, D. A. (2011) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2012.02.025 · Cited by 70
Vitamin E, Its Beneficial Role in Diabetes Mellitus (DM) and Its Complications
Jain, A. (2012) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2012/4791.2625 · Cited by 71
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Horio, N., Clermont, A. C., Abiko, A., Abiko, T., Shoelson, B., Bursell, S., & Feener, E. P. (2004) · Diabetologia · doi:10.1007/s00125-003-1262-x · Cited by 71
“Previous studies have shown that treatment of DM rats with an endothelin type A receptor antagonist (BQ123), a PKCβ inhibitor (LY333531), or vitamin E could also ameliorate RBF abnormalities [10, 27, 30, 31].”
BackgroundSelf-citation
Pharmacotherapy for diabetic retinopathy
Comer, G. M., & Ciulla, T. A. (2004) · Current Opinion in Ophthalmology · doi:10.1097/01.icu.0000143685.60479.3b · Cited by 71
Antioxidant activity of three extracts of Morus nigra
Naderi, G. A., Asgary, S., Sarrafzadegan, N., et al. (2004) · Phytotherapy Research · doi:10.1002/ptr.1400 · Cited by 70
“Antioxidant supplementation has also documented normalizing retinal haemodynamic abnormalities and improving renal function in type 1 diabetic patients of short disease duration (Bursell et al., 1999).”
Background
Update on the treatment of diabetic retinopathy.
Yam, J. C. S., & Kwok, A. K. (2007) · PubMed · Cited by 76
Delayed Treatment with Lithospermate B Attenuates Experimental Diabetic Renal Injury
Lee, G. T., Ha, H., Jung, M., Li, H., Hong, S. W., Soo, B., Lee, H. C., & Cho, A. Y. D. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000051660.82593.19 · Cited by 69
Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials
García‐Medina, J. J., Rubio-Velázquez, E., Foulquie-Moreno, E., Casaroli-Marano, R. P., Pinazo-Duran, M. D., Zanón‐Moreno, V., & del‐Río‐Vellosillo, M. (2020) · Antioxidants · doi:10.3390/antiox9060561 · Cited by 69
“The authors reported that diabetic patients showed a decreased retinal blood flow that improved after treatment, similarly to control cases [134].”
Background
15 th Golgi lecture: from hyperglycaemia to the dysregulation of vascular remodelling in diabetes
Mario, U. D., & Pugliese, G. (2001) · Diabetologia · doi:10.1007/s001250051676 · Cited by 68
Free Radicals, Antioxidants and Diabetes: Embryopathy, Retinopathy, Neuropathy, Nephropathy and Cardiovascular Complications
Aruoma, O. I., Neergheen, V. S., Bahorun, T., & Jen, L. (2006) · Neuroembryology and Aging · doi:10.1159/000109344 · Cited by 67
“ROS has been involved in decreased retinal blood flow [”
Background
Protective effects of α-tocopherol against oxidative stress related to nephrotoxicity by monosodium glutamate in rats
Paul, M. V. S., Abhilash, M., Varghese, M. V., et al. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2012.714008 · Cited by 66
“α-tocopherol supplementation has improved renal function in type I diabetic patients and prevent oxidative stress related chronic renal failure in patients undergoing hemodialysis and nephropathy in rats (Bursell et al. 1999; Bhogade et al. 2008; Naziroglu et al. 2004).”
Blockade of Oxidative Stress by Vitamin C Ameliorates Albuminuria and Renal Sclerosis in Experimental Diabetic Rats
Lee, E. Y., Lee, E. Y., Hong, S. W., Chung, C. H., & Hong, S. Y. (2007) · Yonsei Medical Journal · doi:10.3349/ymj.2007.48.5.847 · Cited by 65
The role of protein kinase C in the development of the complications of diabetes
Ways, D. K., & Sheetz, M. J. (2000) · Vitamins and hormones · doi:10.1016/s0083-6729(00)60019-5 · Cited by 65
Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials
Asbaghi, O., Nazarian, B., Yousefi, M., Anjom-Shoae, J., Rasekhi, H., & Sadeghi, O. (2023) · Nutrition Journal · doi:10.1186/s12937-023-00840-1 · Cited by 68
“In terms of types of diabetes, 7 studies included patients with type 1 diabetes [7, 46, 52, 53, 55, 56, 59], 3 studies recruited patients with diabetic nephropathy [14, 17, 29], one study perform the intervention on patients with diabetic neuropathy [15], and 26 studies enrolled type 2 diabetic patients.”
BackgroundInfluential
Validation of structural and functional lesions of diabetic retinopathy in mice.
Kern, T. S., Tang, J., & Berkowitz, B. A. (2010) · PubMed · Cited by 65
Biochemical Pathways for Microvascular Complications of Diabetes Mellitus
Setter, S. M., Campbell, R. K., & Cahoon, C. J. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1d002 · Cited by 66
Prevention and management of diabetic retinopathy in STZ diabetic rats by Tinospora cordifolia and its molecular mechanisms
Agrawal, S. S., Naqvi, S., Gupta, S. K., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.05.057 · Cited by 64
“Oxidative stress caused by formation of free radicals leads to retinal vasculature damage (Bursell and King, 1999; Bursell et al., 1999).”
Background
Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population
Valero-Velló, M., Peris‐Martínez, C., García‐Medina, J. J., Sanz-Gonzalez, S. M., Ramirez, A. I., Fernández‐Albarral, J. A., Galarreta, D., Zanón‐Moreno, V., Casaroli-Marano, R. P., & Pinazo-Duran, M. D. (2021) · Foods · doi:10.3390/foods10061231 · Cited by 68
“[164] investigated the supplementation with high-dose of α-tocopherol in a group of type-1 diabetes mellitus patients and found an increase of retinal blood flow that improved after 8-month supplementation.”
Background
The Antioxidant Vitamins C and E
Packer, L. (2003) · AOCS Publishing eBooks · doi:10.4324/9780429270710 · Cited by 59
Role of oxidative stress in hearing impairment in patients with type two diabetes mellitus
Aladağ, İ., Eyibilen, A., Güven, M., Atış, Ö., & ERKOKMAZ, Ü. (2009) · The Journal of Laryngology & Otology · doi:10.1017/s0022215109004502 · Cited by 59
Beyond AREDS: Is There a Place for Antioxidant Therapy in the Prevention/Treatment of Eye Disease?
Kowluru, R. A., & Zhong, Q. P. W. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6768 · Cited by 57
“Furthermore, oral vitamin E administration increases retinal blood flow and normalizes hemodynamic abnormalities in the retina of diabetic patients.(89) In contrast, others have found no significant associations between serum levels of major dietary antioxidants and retinopathy.”
Background
Activation of Phosphoinositide 3-kinase in Response to High Glucose Leads to Regulation of Reactive Oxygen Species-Related Nuclear Factor-κB Activation and Cyclooxygenase-2 Expression in Mesangial Cells
Sheu, M., Ho, F. M., Chao, K. F., Kuo, M. L., & Liu, S. (2004) · Molecular Pharmacology · doi:10.1124/mol.66.1.187 · Cited by 57
“…HG-induced extracellular matrix protein synthesis in mesangial cells (Trachtman, 1994) and in experimental diabetic animals (Koya et al., 1997), and that vitamin E normalized glomerular hyperfiltration in human diabetes (Bursell et al., 1999), revealed a pathogenic role of ROS in diabetes.”
Potential Therapeutic Effect of Antioxidants in Experimental Diabetic Retina: A Comparison between Chronic Taurine and Vitamin E Plus Selenium Supplementations
Leo, M. A. S. D., Ghirlanda, G., Silveri, N. G., et al. (2003) · Free Radical Research · doi:10.1080/1071576021000055271 · Cited by 57
Acceleration of Age-Related Changes in the Retina in α-Tocopherol Transfer Protein Null Mice Fed a Vitamin E–Deficient Diet
Tanito, M., Yoshida, Y., Kaidzu, S., Chen, Z., Cynshi, O., Jishage, K., Niki, E., & Ohira, A. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0872 · Cited by 57
Relations of Serum Ascorbic Acid and -Tocopherol to Diabetic Retinopathy in the Third National Health and Nutrition Examination Survey
Millen, A. E. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg116 · Cited by 56
Riboflavin Alleviates Cardiac Failure in Type I Diabetic Cardiomyopathy
Wang, G., Li, W., Lu, X., & Zhao, X. (2011) · Heart International · doi:10.4081/hi.2011.e21 · Cited by 54
Hypoxia and Dark Adaptation in Diabetic Retinopathy: Interactions, Consequences, and Therapy
Ramsey, D. J., & Arden, G. B. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0686-2 · Cited by 55
Zinc and Diabetic Retinopathy
Miao, X., Sun, W., Miao, L., Fu, Y., Wang, Y., Su, G., & Liu, Q. (2013) · Journal of Diabetes Research · doi:10.1155/2013/425854 · Cited by 59
Diabetic Retinopathy: Current Management and Experimental Therapeutic Targets
Ali, T. K., & El‐Remessy, A. B. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.2.182 · Cited by 53
Transition metals redox: reviving an old plot for diabetic vascular disease
Monnier, V. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12635 · Cited by 54
“In the diabetic human, conversely, while intra-arterial infusion of vitamin C improved endothelium-dependent vasodilation (1) and oral intake of vitamin E improved retinal blood flow and creatinine clearance (2), chronic treatment with vitamin E did not reduce cardiovascular risk (3).”
Background
The Use of Vitamin E in Type 2 Diabetes Mellitus
Fardoun, R. Z. (2007) · Clinical and Experimental Hypertension · doi:10.1080/10641960701361601 · Cited by 54
GISSI-Prevenzione trial
Jialal, I., Devaraj, S., Huet, B., & Traber, M. G. (1999) · The Lancet · doi:10.1016/s0140-6736(99)90191-5 · Cited by 53
Ineffectiveness of allopurinol in reduction of oxidative stress in diabetic patients; a randomized, double-blind placebo-controlled clinical trial
Afshari, M., Larijani, B. A., Rezaie, A. R., Mojtahedi, A., Zamani, M. J., Astanehi-Asghari, F., Mostafalou, S., Hossein‐Nezhad, A., Heshmat, R., & Abdollahi, M. R. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2004.09.012 · Cited by 49
Scientific Opinion on the substantiation of health claims related to vitamin E and protection of DNA, proteins and lipids from oxidative damage (ID 160, 162, 1947), maintenance of the normal function of the immune system (ID 161, 163), maintenance of norm
EFSA Panel on Dietetic Products, N. A. A. (. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1816 · Cited by 51
High Dose Vitamin E Attenuates Diabetic Nephropathy via Alleviation of Autophagic Stress
Zhao, Y., Zhang, W., Jia, Q., Feng, Z.-D., Guo, J., Han, X.-T., Liu, Y., Shang, H., Wang, Y.-X., & Liu, W.-J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01939 · Cited by 43
Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review
Lü, L., Jiang, Y., Jaganathan, R., & Hao, Y. (2018) · Journal of Ophthalmology · doi:10.1155/2018/1694187 · Cited by 53
Role of the angiotensin II type 1 receptor in the pathogenesis of diabetic retinopathy: effects of blood pressure control and beyond
Clermont, A. C., Bursell, S., & Feener, E. P. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000220410.69116.f8 · Cited by 49
Self-citation
Antioxidants and Diabetic Retinopathy
Williams, M. A., Hogg, R. E., & Chakravarthy, U. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0384-x · Cited by 49
Effects of inhibition of glycation and oxidative stress on the development of diabetic nephropathy in rats
Agardh, C., Stenram, U., Torffvit, O., et al. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00164-2 · Cited by 49
Antioxidants in the Prevention and Treatment of Diabetic Retinopathy – A Review
Baptista-Silva, S., da Costa, J. P. O., Pintado, M., Ferreira, D. D. C., & Sarmento, B. F. C. C. (2010) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000111 · Cited by 48
Calcium Dobesilate in the Treatment of Diabetic Retinopathy
Garay, R. P., Hannaert, P. A., & Chiavaroli, C. (2005) · Treatments in Endocrinology · doi:10.2165/00024677-200504040-00003 · Cited by 45
The Potential Use of Glutathionyl Hemoglobin as a Clinical Marker of Oxidative Stress
Bursell, S., & King, G. L. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.2.145 · Cited by 45
Self-citation
Diabetic macular edema: classification, medical and laser therapy
Bandello, F. M., Pognuz, D. R., Polito, A., et al. (2003) · Seminars in Ophthalmology · doi:10.1080/08820530390895262 · Cited by 44
Novel therapeutic approaches for diabetic nephropathy and retinopathy
Usuelli, V., & Rocca, E. L. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.10.003 · Cited by 44
Diabetic retinopathy: new therapeutic perspectives based on pathogenic mechanisms
Hernández, C., Simó-Servat, A., Bogdanov, P. M., & Simó, R. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0648-4 · Cited by 42
Molecular Mechanisms Underlying the Therapeutic Role of Vitamin E in Age-Related Macular Degeneration
Edwards, G., Olson, C. G., Euritt, C. P., & Koulen, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.890021 · Cited by 49
Effect of lipoic acid on expression of angiogenic factors in diabetic rat retina
Lee, S. G., Lee, C.-G., Yun, I. H., Hur, D. Y., Yang, J. W., & Kim, H. W. (2011) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2011.02695.x · Cited by 41
Role of Oral Antioxidant Supplementation in the Current Management of Diabetic Retinopathy
Alfonso-Muñoz, E. A., Matas, R. B.-S. D. L., Mataix, J., Martín, J. C. M., & Desco, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084020 · Cited by 40
“utilised fluorescein angiography to analyse the retinal blood flow in T1DM patients, and they observed a significant increase in the Vitamin E-supplemented group [157].”
BackgroundMethodInfluential
Adjuvant strategies for prevention of glomerulosclerosis
McCarty, M. F. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2004.11.048 · Cited by 38
Oxidative Stress As A Common Mediator for Apoptosis Induced-Cardiac Damage in Diabetic Rats
Dallak, M. A., Mikhailidis, D. P., Haidara, M. A., Bin‐Jaliah, I., Tork, O. M., Rateb, M., Yassin, H. Z., Al-refaie, Z. A., Ibrahim, I. M., Elawa, S. M., et al. (2008) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192400802010070 · Cited by 39
“On another level, antioxidant administration has been reported to show beneficial effects on parameters of oxidative stress and cardiovascular functions in experimental diabetes [17].”
Background
Diabetic retinopathy: a review
Chu, J., & Ali, Y. A. (2008) · Drug Development Research · doi:10.1002/ddr.20222 · Cited by 38
Functional involvement of scavenger receptor class B, type I, in the uptake of alpha-tocopherol using cultured rat retinal capillary endothelial cells.
Tachikawa, M., Okayasu, S., & Hosoya, K.-I. (2007) · PubMed · Cited by 37
Effects of high‐dose vitamin E supplementation on oxidative stress and microalbuminuria in young adult patients with childhood onset type 1 diabetes mellitus
Giannini, C., Lombardo, F., Currò, F., Pomilio, M., Bucciarelli, T., Chiarelli, F., & Mohn, A. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.717 · Cited by 36
“had a considerably shorter duration of diabetes compared to the patients in our study [26].”
BackgroundMethodResultInfluential
Beneficial and adverse effects of vitamin E on the kidney
Baltušnikienė, A., Stanevičienė, I., & Jansen, E. H. J. M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1145216 · Cited by 38
Role of dietary antioxidants in diabetes: An overview
Shafras, M., Sabaragamuwa, R., & Suwair, M. (2024) · Food Chemistry Advances · doi:10.1016/j.focha.2024.100666 · Cited by 46
Association between dietary antioxidants and risk for diabetic retinopathy in a Chinese population
She, C., Shang, F., Cui, M., Yang, X., & Liu, N. (2020) · Eye · doi:10.1038/s41433-020-01208-z · Cited by 34
Effects of Vitamin E Supplementation on Intracellular Antioxidant Enzyme Production in Adolescents with Type 1 Diabetes and Early Microangiopathy
Chiarelli, F., Santilli, F., Sabatino, G., Blasetti, A., Tumini, S., Cipollone, F., Mezzetti, A., & Verrotti, A. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000141990.12375.13 · Cited by 32
NO ASSOCIATION OF GLUTATHIONE S-TRANSFERASE M1 GENE POLYMORPHISM WITH DIABETIC NEPHROPATHY IN JAPANESE TYPE 2 DIABETIC PATIENTS
Fujita, H., Narita, T., Meguro, H., et al. (2000) · Renal Failure · doi:10.1081/jdi-100100889 · Cited by 32
Reduction of experimental diabetic vascular leakage and pericyte apoptosis in mice by delivery of αA-crystallin with a recombinant adenovirus
Kim, Y. H., Park, S. Y., Park, J., Kim, Y. S., Hwang, E., Park, J., Roh, G. S., Kim, H. J., Kang, S. S., Cho, G. J., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2625-y · Cited by 32
Nutrition for diabetic retinopathy: plummeting the inevitable threat of diabetic vision loss
Sharma, Y., Saxena, S., Mishra, A., Saxena, A., & Natu, S. M. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1406-2 · Cited by 32
Emerging drugs for diabetic retinopathy
Mohamed, Q. A., & Wong, T. Y. (2008) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210802584035 · Cited by 31
Natural products for the management of type 2 diabetes mellitus and comorbid conditions
Smith, J. D., & Clinard, V. B. (2014) · Journal of the American Pharmacists Association · doi:10.1331/japha.2014.14537 · Cited by 30
Nutrition and Retina
Schmidt-Erfurth, U. M. (2004) · KARGER eBooks · doi:10.1159/000082772 · Cited by 29
Superoxide dismutase overexpression and cellular oxidative damage in diabetes
Jain, S. K. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.017 · Cited by 28
Effect of Tempol on Diabetes-Induced Decreases in Retinal Blood Flow in the Mouse
Yadav, A. S., & Harris, N. R. (2011) · Current Eye Research · doi:10.3109/02713683.2011.556300 · Cited by 27
von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes.
Feng, D., Bursell, S., Clermont, A., et al. (2000) · Diabetes Care · doi:10.2337/diacare.23.11.1694 · Cited by 27
Self-citation
Effect of High Glucose on Superoxide in Human Mesangial Cells: Role of Angiotensin II
Leehey, D. J., Isreb, M. A., Marcic, S. M., Singh, A. K., & Singh, R. (2005) · Nephron Experimental Nephrology · doi:10.1159/000084348 · Cited by 25
Growth factors and protein kinase C inhibitors as novel therapies for the medical management diabetic retinopathy
Aiello, L. P., Cahill, M. T., & Cavallerano, J. D. (2004) · Eye · doi:10.1038/sj.eye.6700585 · Cited by 24
Self-citation
Changing Times for the Management of Diabetic Retinopathy
Fong, D. S. (2002) · Survey of Ophthalmology · doi:10.1016/s0039-6257(02)00389-2 · Cited by 23
The vascular endothelium in diabetes: a practical target fordrug treatment?
Andrews, K. L., Pannirselvam, M., Anderson, T. J., Jenkins, A. J., Triggle, C. R., & Hill, M. A. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.1.101 · Cited by 23
“Studies in human Type 1 diabetes (in young complication-free subjects) using surrogate end points of retinal blood flow [134] and flow-mediated dilation [125] and high-dose vitamin E have been positive.”
Background
Distribution of tocopherols and tocotrienols to rat ocular tissues after topical ophthalmic administration
Tanito, M., Itoh, N., Yoshida, Y., et al. (2004) · Lipids · doi:10.1007/s11745-004-1252-0 · Cited by 23
Extending Classification Algorithms to Case-Control Studies
Stanfill, B., Reehl, S., Bramer, L., Nakayasu, E. S., Rich, S. S., Metz, T., Rewers, M., Webb‐Robertson, B., & TEDDY Study Group (2019) · Biomedical Engineering and Computational Biology · doi:10.1177/1179597219858954 · Cited by 20
Antioxidants for adults with chronic kidney disease
Colombijn, J. M. T., Hooft, L., Jun, M., Webster, A. C., Bots, M. L., Verhaar, M. C., & Vernooij, R. W. M. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008176.pub3 · Cited by 23
Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy.
Beyazyıldız, E., Çankaya, A. B., Ergan, E., et al. (2013) · PubMed · doi:10.3980/j.issn.2222-3959.2013.04.23 · Cited by 22
OPHTHALMOLOGIC EMERGENCIES IN THE PATIENT WITH DIABETES
Wipf, J. E., & Paauw, D. S. (2000) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70166-3 · Cited by 22
Polymeric nanomicelles based on inulin D α-tocopherol succinate for the treatment of diabetic retinopathy
Rassu, G., Pavan, B., Mandracchia, D., Tripodo, G., Botti, G., Dalpiaz, A., Gavini, E., & Giunchedi, P. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102286 · Cited by 26
Do Nutrients and Nutraceuticals Play a Role in Diabetic Retinopathy? A Systematic Review
Milluzzo, A., Barchitta, M., Maugeri, A., Lio, R. M. S., Favara, G., Mazzone, M. G., Sciacca, L., & Agodi, A. (2022) · Nutrients · doi:10.3390/nu14204430 · Cited by 23
“, 1999 [33] USA T1D NDR (36) HC (9) Vitamin E 1800 IU 4 months treatment + 4 months placebo DM patient retinal blood flow increased and was comparable with that of HC subjects.”
BackgroundResultInfluential
rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice
Li, L., Wang, H., Pang, S., Wang, L., Fan, Z., Ma, C., Yang, S., Banda, J., Hui, Q., Lv, F., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105127 · Cited by 22
“DHE was used for the detection of ROS.”
BackgroundInfluential
Vascular Complications in Diabetes
Rosen, P., Tritschler, H., & Packer, L. (2001) · CRC Press eBooks · doi:10.1201/9780203904046.ch25 · Cited by 21
Vitamin E in renal therapeutic regimens
Thabet, M., & Chan, J. C. M. (2006) · Pediatric Nephrology · doi:10.1007/s00467-006-0211-6 · Cited by 21
“A placebocontrolled trial noted that high doses of VE (1,800 IU/d) normalized renal hyperfiltration and abnormalities of retinal blood flow in patients with <10 years duration of type I DM [112].”
Background
α-Glucosidase inhibitory activity and in vitro antioxidant activities of alcohol-water extract (AWE) of Ichnocarpus frutescens leaves
Chidambaram, K., & Mandal, S. C. (2007) · Medicinal Chemistry Research · doi:10.1007/s00044-007-9056-1 · Cited by 19
“However, antioxidant supplements or foods containing antioxidants may be used to help the human body reduce oxidative damage and decreases the occurrence of complications in diabetic animals (Bursell et al., 1999).”
Current and future pharmacological intervention for diabetic retinopathy
Comer, G. M., & Ciulla, T. A. (2005) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.10.2.441 · Cited by 19
Vitamin E and thetreatment and prevention of diabetes: a case for a controlled clinical trial.
Halliwell, B. B. (2002) · PubMed · Cited by 19
The effects of vitamin E on non-proliferative diabetic retinopathy in type 2 diabetes mellitus: Are they sustainable with 12 months of therapy
Ho, J.-I., Ng, E. Y., Chiew, Y., Koay, Y. Y., Chuar, P. F., Phang, S. C. W., Ahmad, B., & Kadir, K. A. (2022) · SAGE Open Medicine · doi:10.1177/20503121221095324 · Cited by 17
A Mediterranean Diet May Be Protective in the Development of Diabetic Retinopathy
Bryl, A., Mrugacz, M., Falkowski, M., & Zorena, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311145 · Cited by 23
“A Joslin Institute study demonstrated that in patients suffering from T1DM for less than 10 years, a dose of 1800 IU daily vitamin E improved retinal blood flow [98].”
Background
The Role of Complementary and Alternative Therapies in Pediatric Diabetes
Shapiro, S., & Rapaport, R. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.09.004 · Cited by 16
Diabetic Retinopathy
Zhang, K., Ferreyra, H. A., Grob, S., Bedell, M., & Zhang, J. J. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00046-1 · Cited by 16
The use of vitamin E in ocular health: Bridging omics approaches with Tocopherol and Tocotrienol in the management of glaucoma
Latib, F., Zafendi, M. A. I., & Lazaldin, M. A. M. (2024) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2024.100224 · Cited by 16
Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats.
Mori, F., King, G. L., Clermont, A. C., et al. (2000) · PubMed · Cited by 15
Self-citation
Medical Interventions for Diabetic Retinopathy
Richter, B., & KOHNER, E. M. (2005) · Evidence-Based Ophthalmology · doi:10.1002/9780470698709.ch42 · Cited by 16
MECHANISM OF DIABETIC NEPHROPATHY: ROLE OF PROTEIN KINASE-C ACTIVATION —
Ohshiro, Y., Lee, Y., & King, G. L. (2005) · Cited by 14
Self-citation
Therapeutic Targets of Type 2 Diabetes: an Overview
Banu, S., & Bhowmick, A. (2017) · MOJ Drug Design Development & Therapy · doi:10.15406/mojddt.2017.01.00011 · Cited by 15
Combination treatment of vitamin C and desferrioxamine suppresses glomerular superoxide and prostaglandin E 2 production in diabetic rats
Iino, K., Iwase, M., Sonoki, K., et al. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00371.x · Cited by 14
Sympathetic sudomotor disturbance in early type 1 diabetes mellitus is linked to lipid peroxidation
Hoeldtke, R. D., Bryner, K. D., Hoeldtke, M. E., Christie, I., Ganser, G. H., Hobbs, G. R., & Riggs, J. E. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.023 · Cited by 14
Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases
Rusciano, D., & Bagnoli, P. (2023) · Medicina · doi:10.3390/medicina59071334 · Cited by 14
Effect of the Mediterranean Diet (MeDi) on the Progression of Retinal Disease: A Narrative Review
Sbai, O., Torrisi, F., Fabrizio, F. P., Rabbeni, G., & Perrone, L. (2024) · Nutrients · doi:10.3390/nu16183169 · Cited by 13
“Oral vitamin E treatment (1800 IU daily vitamin E) was effective in normalizing retinal hemodynamic abnormalities and enhancing renal function in T1DM patients [126].”
Background
Effect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluation
Süleyman, H., Çinici, E., Ahiskali, I., Cetin, N., Süleyman, B., Kukula, O., Altuner, D., Çoban, T. A., Balta, H., & Kuzucu, M. (2016) · Indian Journal of Ophthalmology · doi:10.4103/0301-4738.187666 · Cited by 13
Novel triazine-based pyrimidines suppress glomerular mesangial cells proliferation and matrix protein accumulation through a ROS-dependent mechanism in the diabetic milieu
El-Harakeh, M. D., Njeim, R., Youssef, A. M., et al. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.04.052 · Cited by 12
Acceleration of Lipid Peroxidation in .ALPHA.-Tocopherol Transfer Protein-Knockout Mice Following the Consumption of Drinking Water Containing a Radical Initiator
Yoshida, Y., Hayakawa, M., Cynshi, O., et al. (2008) · Journal of Oleo Science · doi:10.5650/jos.57.577 · Cited by 12
Oxidative Stress in Diabetic Retinopathy
Caldwell, R. B., El‐Remessy, A. B., & Caldwell, R. W. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-563-3_9 · Cited by 12

Authors: Bursell, S. E., Clermont, A. C., Aiello, L. P., Aiello, L. M., Schlossman, D. K., Feener, E. P., Laffel, L., & King, G. L.
Affiliations: Joslin Diabetes Center (US)
ORCID: Bursell, S E
Clermont, A C
Aiello, L P
Schlossman, D K
Feener, E P
Laffel, L
King, G L
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1999-08-01
Volume: 22
Issue: 8
Pages: 1245-1251
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.22.8.1245
OpenAlex: W2027478328
Cited by: 333
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 3 · 2020: 11 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 14 · 2013: 11 · 2012: 16
FWCI: 20.09
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: vitamin E supplementation, type 1 diabetes, retinal blood flow, retinal hemodynamics, creatinine clearance, renal function, diabetic nephropathy, diabetic retinopathy, glycemic control, HbA1c
MeSH terms: Adolescent, Adult, Analysis of Variance, Creatinine, Diabetes Mellitus, Type 1, Diabetic Retinopathy, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Metabolic Clearance Rate, Middle Aged, Regional Blood Flow, Retinal Vessels, Vitamin E, Treatment Outcome, Plasminogen Activator Inhibitor 1, Cross-Over Studies, Dietary Supplements

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High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.

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