Cited by 333Retinal Diseases and TreatmentsAntioxidant Activity and Oxidative StressChronic Kidney Disease and Diabetes

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High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.

Bursell, S E, Clermont, A C, Aiello, L P, Aiello, L M, Schlossman, D K, Feener, E P, Laffel, L, King, G L·1999·Diabetes Care

DOI 10.2337/diacare.22.8.1245

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Abstract

OBJECTIVE: To determine the effectiveness of vitamin E treatment in normalizing retinal blood flow and renal function in patients with <10 years of type 1 diabetes. RESEARCH DESIGN AND METHODS: An 8-month randomized double-masked placebo-controlled crossover trial evaluated 36 type 1 diabetic and 9 nondiabetic subjects. Subjects were randomly assigned to either 1,800 IU vitamin E/day or placebo for 4 months and followed, after treatment crossover, for a further 4 months. Retinal blood flow was measured using video fluorescein angiography, and renal function was assessed using normalized creatinine clearance from timed urine collections. RESULTS: After vitamin E treatment, serum levels of vitamin E were significantly elevated (P<0.01) in both type 1 diabetic and control patients. Hemoglobin A1c was not affected by vitamin E treatment. Diabetic patient baseline retinal blood flow (29.1+/-7.5 pixel2/s) was significantly (P = 0.030) decreased compared with that of nondiabetic subjects (35.2+/-7.2 pixel2/s). After vitamin E treatment, diabetic patient retinal blood flow (34.5+/-7.8 pixel2/s) was significantly increased (P<0.001) and was comparable with that of nondiabetic subjects. Additionally, vitamin E treatment significantly (P = 0.039) normalized elevated baseline creatinine clearance in diabetic patients. CONCLUSIONS: Oral vitamin E treatment appears to be effective in normalizing retinal hemodynamic abnormalities and improving renal function in type 1 diabetic patients of short disease duration without inducing a significant change in glycemic control. This suggests that vitamin E supplementation may provide an additional benefit in reducing the risks for developing diabetic retinopathy or nephropathy.

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Authors: Bursell, S. E., Clermont, A. C., Aiello, L. P., Aiello, L. M., Schlossman, D. K., Feener, E. P., Laffel, L., & King, G. L.
Affiliations: Joslin Diabetes Center (US)
ORCID: Bursell, S E
Clermont, A C
Aiello, L P
Schlossman, D K
Feener, E P
Laffel, L
King, G L
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1999-08-01
Volume: 22
Issue: 8
Pages: 1245-1251
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.22.8.1245
OpenAlex: W2027478328
Cited by: 333
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 3 · 2020: 11 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 14 · 2013: 11 · 2012: 16
FWCI: 20.09
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: vitamin E supplementation, type 1 diabetes, retinal blood flow, retinal hemodynamics, creatinine clearance, renal function, diabetic nephropathy, diabetic retinopathy, glycemic control, HbA1c
MeSH terms: Adolescent, Adult, Analysis of Variance, Creatinine, Diabetes Mellitus, Type 1, Diabetic Retinopathy, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Metabolic Clearance Rate, Middle Aged, Regional Blood Flow, Retinal Vessels, Vitamin E, Treatment Outcome, Plasminogen Activator Inhibitor 1, Cross-Over Studies, Dietary Supplements

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High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.

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