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Cited by 333Retinal Diseases and TreatmentsAntioxidant Activity and Oxidative StressChronic Kidney Disease and Diabetes

The DOI matches its Crossref record.

High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.

Bursell, S E, Clermont, A C, Aiello, L P, Aiello, L M, Schlossman, D K, Feener, E P, Laffel, L, King, G L·1999·Diabetes Care
DOI 10.2337/diacare.22.8.1245
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Abstract

OBJECTIVE: To determine the effectiveness of vitamin E treatment in normalizing retinal blood flow and renal function in patients with <10 years of type 1 diabetes. RESEARCH DESIGN AND METHODS: An 8-month randomized double-masked placebo-controlled crossover trial evaluated 36 type 1 diabetic and 9 nondiabetic subjects. Subjects were randomly assigned to either 1,800 IU vitamin E/day or placebo for 4 months and followed, after treatment crossover, for a further 4 months. Retinal blood flow was measured using video fluorescein angiography, and renal function was assessed using normalized creatinine clearance from timed urine collections. RESULTS: After vitamin E treatment, serum levels of vitamin E were significantly elevated (P<0.01) in both type 1 diabetic and control patients. Hemoglobin A1c was not affected by vitamin E treatment. Diabetic patient baseline retinal blood flow (29.1+/-7.5 pixel2/s) was significantly (P = 0.030) decreased compared with that of nondiabetic subjects (35.2+/-7.2 pixel2/s). After vitamin E treatment, diabetic patient retinal blood flow (34.5+/-7.8 pixel2/s) was significantly increased (P<0.001) and was comparable with that of nondiabetic subjects. Additionally, vitamin E treatment significantly (P = 0.039) normalized elevated baseline creatinine clearance in diabetic patients. CONCLUSIONS: Oral vitamin E treatment appears to be effective in normalizing retinal hemodynamic abnormalities and improving renal function in type 1 diabetic patients of short disease duration without inducing a significant change in glycemic control. This suggests that vitamin E supplementation may provide an additional benefit in reducing the risks for developing diabetic retinopathy or nephropathy.

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Metadata

Authors
Bursell, S. E., Clermont, A. C., Aiello, L. P., Aiello, L. M., Schlossman, D. K., Feener, E. P., Laffel, L., & King, G. L.
Affiliations
Joslin Diabetes Center (US)
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1999-08-01
Volume
22
Issue
8
Pages
1245-1251
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.22.8.1245
OpenAlex
W2027478328
Cited by
333
References
0
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 3 · 2020: 11 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 14 · 2013: 11 · 2012: 16
FWCI
20.09
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords
vitamin E supplementation, type 1 diabetes, retinal blood flow, retinal hemodynamics, creatinine clearance, renal function, diabetic nephropathy, diabetic retinopathy, glycemic control, HbA1c
MeSH terms
Adolescent, Adult, Analysis of Variance, Creatinine, Diabetes Mellitus, Type 1, Diabetic Retinopathy, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Metabolic Clearance Rate, Middle Aged, Regional Blood Flow, Retinal Vessels, Vitamin E, Treatment Outcome, Plasminogen Activator Inhibitor 1, Cross-Over Studies, Dietary Supplements

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