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Cited by 399Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

The DOI matches its Crossref record, with a small difference in title or year; 46 of the 46 references it cites were found in a registry or an index.

The Diabetes Prevention Program: baseline characteristics of the randomized cohort. The Diabetes Prevention Program Research Group.

Open access
·2000·Diabetes Care
DOI 10.2337/diacare.23.11.1619PMC PMC1360735
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Abstract

OBJECTIVE: The Diabetes Prevention Program (DPP) is a 27-center randomized clinical trial designed to evaluate the safety and efficacy of interventions that may delay or prevent development of diabetes in people at increased risk for type 2 diabetes. RESEARCH DESIGN AND METHODS: Eligibility requirements were age > or = 25 years, BMI > or = 24 kg/m2 (> or = 22 kg/m2 for Asian-Americans), and impaired glucose tolerance plus a fasting plasma glucose of 5.3-6.9 mmol/l (or < or = 6.9 mmol for American Indians). Randomization of participants into the DPP over 2.7 years ended in June 1999. Baseline data for the three treatment groups--intensive lifestyle modification, standard care plus metformin, and standard care plus placebo--are presented for the 3,234 participants who have been randomized. RESULTS: Of all participants, 55% were Caucasian, 20% were African-American, 16% were Hispanic, 5% were American Indian, and 4% were Asian-American. Their average age at entry was 51 +/- 10.7 years (mean +/- SD), and 67.7% were women. Moreover, 16% were < 40 years of age, and 20% were > or = 60 years of age. Of the women, 48% were postmenopausal. Men and women had similar frequencies of history of hypercholesterolemia (37 and 33%, respectively) or hypertension (29 and 26%, respectively). On the basis of fasting lipid determinations, 54% of men and 40% of women fit National Cholesterol Education Program criteria for abnormal lipid profiles. More men than women were current or former cigarette smokers or had a history of coronary heart disease. Furthermore, 66% of men and 71% of women had a first-degree relative with diabetes. Overall, BMI averaged 34.0 +/- 6.7 kg/m2 at baseline with 57% of the men and 73% of women having a BMI > or = 30 kg/m2. Average fasting plasma glucose (6.0 +/- 0.5 mmol/l) and HbA1c (5.9 +/- 0.5%) in men were comparable with values in women (5.9 +/- 0.4 mmol/l and 5.9 +/- 0.5%, respectively). CONCLUSIONS: The DPP has successfully randomized a large cohort of participants with a wide distribution of age, obesity, and ethnic and racial backgrounds who are at high risk for developing type 2 diabetes. The study will examine the effects of interventions on the development of diabetes.

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  1. [32]32. Hainline A Jr, Karon J, Lippel K (Eds.): Manual of Laboratory Operations. 2nd ed. Lipid Research Clinics Program, Lipid and Lipoprotein Analysis, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health (updated 1983)

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Metadata

Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2000-11-01
Volume
23
Issue
11
Pages
1619-1629
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.23.11.1619
PMC
PMC1360735
OpenAlex
W1935237410
Cited by
399
References
44
Citations by year
2026: 11 · 2025: 9 · 2024: 19 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 18 · 2016: 16 · 2015: 16 · 2014: 17 · 2013: 17 · 2012: 22
FWCI
12.13
Type
journal article
Language
en
Open access
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Diabetes Association
  • Bristol-Myers Squibb
  • National Institutes of Health
  • Centers for Disease Control and Prevention
  • National Institute on Aging
  • National Institute of Diabetes and Digestive and Kidney Diseases (U01DK048489)
  • National Institute of Child Health and Human Development
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 2 diabetes prevention, impaired glucose tolerance, prediabetes, metformin, lifestyle modification, baseline characteristics, sex differences, racial and ethnic differences, body mass index, fasting blood glucose, HbA1c, hypercholesterolemia, hypertension, smoking, coronary artery disease, Diabetes Prevention Program
MeSH terms
Adult, Asian, Black or African American, Blood Glucose, Blood Pressure, Cholesterol, Coronary Disease, Diabetes Mellitus, Type 2, Female, Hispanic or Latino, Humans, Hypercholesterolemia, Indians, North American, Lipids, Male, Middle Aged, Patient Education as Topic, Risk Factors, Sex Factors, Smoking, Socioeconomic Factors, United States, Cohort Studies, Body Mass Index, Glucose Intolerance, White People, Racial Groups

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