Cited by 368Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementPhysical Activity and Health

Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland

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Eriksson, J., Lindström, J., Valle, T., Aunola, S., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M. +12 more·1999·Diabetologia

Abstract

Unlabelled AIMS/HYPOTHESIS; The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiovascular risk factors and to assess the determinants for the progression to diabetes in persons with impaired glucose tolerance.Methods A total of 523 overweight subjects with impaired glucose tolerance ascertained by two oral glucose tolerance tests were randomised to either a control or intervention group. The control subjects received general information at the start of the trial about the lifestyle changes necessary to prevent diabetes and about annual follow-up visits. The intervention subjects had seven sessions with a nutritionist during the first year and a visit every 3 months thereafter aimed at reducing weight, the intake of saturated fat and increasing the intake of dietary fibre. Intervention subjects were also guided individually to increase their physical activity.Results During the first year, weight loss in the first 212 study subjects was 4.7 +/- 5.5 vs 0.9 +/- 4.1 kg in the intervention and control group, respectively (p < 0.001). The plasma glucose concentrations (fasting: 5.9 +/- 0.7 vs 6.4 +/- 0.8 mmol/l, p < 0.001; and 2-h 7.8 +/- 1.8 vs 8.5 +/- 2.3 mmol/l, p < 0.05) were significantly lower in the intervention group after the first year of intervention. Favourable changes were also found in blood pressure, serum lipids and anthropometric indices in the intervention group.Conclusion/interpretation The interim results show the efficacy and feasibility of the lifestyle intervention programme.

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Crossref · 10.1007/s001250051229

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  • Lifestyle modification in the Finnish Diabetes Prevention Study and the U.S. Diabetes Prevention Program reduced incident diabetes by 58% and, in the DPP, had a greater effect than metformin (31%).

    “Lifestyle modification in both studies reduced incident diabetes by 58% and, in the DPP, had a greater effect than metformin (31%).”

    From Exercise and Type 2 Diabetes (2010) · cites this paper as [74]

    The Abstract describes a lifestyle intervention in the Finnish DPS and reports improved weight and glucose measures after one year. The Discussion says whether diabetes onset would be postponed remained to be seen. This interim report therefore does not support the claimed 58% reduction in incident diabetes or the DPP comparison with metformin (31%). (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • The changes in lifestyle in our study not only improved glucose tolerance but also reduced the magnitude of several other cardiovascular risk factors.

    “The changes in lifestyle in our study not only improved glucose tolerance but also reduced the magnitude of several other cardiovascular risk factors.13”

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Research works printed but not linked: 4

  1. [11]11. Tuomilehto J, Tuomilehto-Wolf E, Zimmet P, Alberti KGMM, Knowler WC (1997) Primary prevention of diabe- tes mellitus. In: Alberti KGMM, Zimmet P, DeFronzo RA, Keen H (eds) International Textbook of Diabetes Mellitus, 2nd edn. Wiley, Chichester New York Brisbane Toronto, pp 1799±1827
  2. [18]18. Valle T, Tuomilehto J, Eriksson J (1997) Epidemiology of NIDDM in Europids. In: Alberti KGMM, Zimmet P, De- Fronzo RA, Keen H (eds) International textbook of diabe- tes mellitus, 2nd edn. Wiley, Chichester New York Brisbane Toronto, pp 125±142
  3. [31]31. World Health Organization Expert Committee (1985) Dia- betes Mellitus. Technical Report Series No 742, WHO, Geneva 33. Norman GR, Streiner DL (1994) Biostatistics. The bare es- sentials. Mosby, St Louis Baltimore Boston Chicago Lon- don Madrid Philadelphia Sydney Toronto
  4. [34]34. Lakka T (1994) Leisure time physical activity, cardiorespi- ratory fitness, biological coronary risk factors and coronary heart disease: a population study in men in eastern Finland. Academic Doctoral Dissertation. Kuopio, Finland. Kuopio University Printing Office

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Authors
Eriksson, J., Lindström, J., Valle, T., Aunola, S., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Lauhkonen, M., Lehto, P., Lehtonen, A., Louheranta, A., Mannelin, M., Martikkala, V., Rastas, M., Sundvall, J., Turpeinen, A., Viljanen, T., Uusitupa, M., & Tuomilehto, J.
Affiliations
  • Social Insurance Institution (FI)
  • University of Oulu (FI)
  • University of Turku (FI)
  • University of Eastern Finland (FI)
  • Oulu Deaconess Institute (FI)
Venue
Diabetologia
Published
1999-06-21
Volume
42
Issue
7
Pages
793-801
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
OpenAlex
W170708439
Cited by
368
References
53
Citations by year
2026: 1 · 2025: 2 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 15 · 2014: 9 · 2013: 17 · 2012: 15
FWCI
8.06
Type
journal article
Language
en
Open access
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
  • Yrjö Jahnssonin Säätiö
  • Academy of Finland
  • Novo Nordisk
  • Diabetestutkimussäätiö
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
type 2 diabetes prevention, impaired glucose tolerance, lifestyle intervention, weight loss, dietary fiber, saturated fat intake, physical activity, cardiovascular risk factors, progression to diabetes, overweight
MeSH terms
Blood Glucose, Blood Pressure, Body Weights and Measures, Diabetes Mellitus, Type 2, Finland, Humans, Obesity, Triglycerides, Exercise, Treatment Outcome, Glucose Intolerance

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