Prevention of Type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise The 6-year Malm� feasibility study
Open accessAbstract
From a previously reported 5-year screening programme of 6,956 47-49-year-old Malmö males, a series of 41 subjects with early-stage Type 2 (non-insulin-dependent) diabetes mellitus and 181 subjects with impaired glucose tolerance were selected for prospective study and to test the feasibility aspect of long-term intervention with an emphasis on life-style changes. A 5-year protocol, including an initial 6-months (randomised) pilot study, consisting of dietary treatment and/or increase of physical activity or training with annual check-ups, was completed by 90% of subjects. Body weight was reduced by 2.3-3.7% among participants, whereas values increased by 0.5-1.7% in non-intervened subjects with impaired glucose tolerance and in normal control subjects (p less than 0.0001); maximal oxygen uptake (ml.min-1.kg-1) was increased by 10-14% vs decreased by 5-9%, respectively (p less than 0.0001). Glucose tolerance was normalized in greater than 50% of subjects with impaired glucose tolerance, the accumulated incidence of diabetes was 10.6%, and more than 50% of the diabetic patients were in remission after a mean follow-up of 6 years. Blood pressure, lipids, and hyperinsulinaemia were reduced and early insulin responsiveness to glucose loading preserved. Improvement in glucose tolerance was correlated to weight reduction (r = 0.19, p less than 0.02) and increased fitness (r = 0.22, p less than 0.02). Treatment was safe, and mortality was low (in fact 33% lower than in the remainder of the cohort).(ABSTRACT TRUNCATED AT 250 WORDS)
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Physical training can play a significant role in the prevention of insulin resistance and type 2 diabetes.
“In addition, physical training can play a significant role in the prevention of insulin resistance and type 2 diabetes [22–25].”
From Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle (2007) · cites this paper as [24]
Experimental — accuracy not yet measuredResults from previous studies in Sweden and China also provide evidence that changes in lifestyle are effective in preventing diabetes, and the magnitude of the benefit in these studies was similar to that in this study.
“The results from previous studies in Sweden 17 and China 18 also provide evidence that changes in lifestyle are effective in preventing diabetes, and the magnitude of the benefit in these studies was similar to that in our study.”
From Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance (2001) · cites this paper as [17]
A lifestyle intervention, typically comprising diet and exercise, reduced the risk of progression from IGT to Type 2 diabetes.
“In this context, a lifestyle intervention, typically comprising a combination of diet and exercise, reduced the risk of progression from IGT to Type 2 diabetes. This effect was first shown in a feasibility study in Malmö, Sweden [157].”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [157]
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- Authors
- Eriksson, K. F., & Lindg�rde, F.
- Affiliations
- Lund University (SE)
- Venue
- Diabetologia
- Published
- 1991-12
- Volume
- 34
- Issue
- 12
- Pages
- 891-898
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2008699478
- Semantic Scholar
- 497d07fadc0f360f3a154e193184ccf2d3d099de
- Cited by
- 1,092
- References
- 46
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 22 · 2023: 15 · 2022: 18 · 2021: 14 · 2020: 24 · 2019: 22 · 2018: 18 · 2017: 30 · 2016: 32 · 2015: 34 · 2014: 49 · 2013: 50 · 2012: 39
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes prevention, impaired glucose tolerance, lifestyle intervention, dietary therapy, physical activity, weight loss, VO2max, glucose tolerance, diabetes remission, hyperinsulinemia, insulin sensitivity, blood pressure, lipids, feasibility
- MeSH terms
- Blood Glucose, Blood Pressure, Diabetes Mellitus, Type 2, Diet, Diabetic, Feasibility Studies, Follow-Up Studies, Glucose Tolerance Test, Humans, Hyperglycemia, Insulin, Lipids, Male, Middle Aged, Prediabetic State, Prospective Studies, Sweden, Exercise
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