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Cited by 444Diabetes, Cardiovascular Risks, and LipoproteinsSex and Gender in HealthcareCardiovascular Function and Risk Factors

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Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies

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Lee, W L, Cheung, A M, Cape, D, Zinman, B·2000·Diabetes Care
DOI 10.2337/diacare.23.7.962
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Abstract

OBJECTIVE: Women are at a much lower risk of coronary disease mortality than men are. It is widely believed that diabetes "erases" this female advantage, increasing the risk of heart disease much more in women than in men. In reality, the extent of this increased risk is controversial, with studies showing conflicting results and wide confidence intervals. Clarification of this issue has implications for the pathogenesis of coronary disease, and for public health efforts to reduce coronary disease in women. RESEARCH DESIGN AND METHODS: We performed a meta-analysis to calculate a summary estimate of the relative risk of coronary death among women with diabetes as compared to those without. For comparison, we also calculated the analogous risk among men. All prospective cohort studies containing both men and women, and both patients with and without diabetes, were examined. Sixteen studies were identified; 10 had sufficient data for statistical analysis. RESULTS: After combining studies that adjusted for other cardiac risk factors, the relative risk of coronary death from diabetes was 2.58 (95% CI 2.05-3.26) for women and 1.85 (1.47-2.33) for men. This difference is statistically significant (P = 0.045). Other sensitivity analyses did not change these estimates appreciably. CONCLUSIONS: The impact of diabetes on the risk of coronary death is significantly greater for women than men. Further research is required to explain this clinically meaningful difference between the sexes.

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Research works printed but not linked: 2

  1. Kalin MF, Zumoff B: Sex hormones and coronary disease: a review of the clinical studies. Steroids 55:330-352, 1990
  2. Greenland S: Quantitative methods in the review of epidemiologic literature. Epi- demiol Rev 9:1-30, 1987

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Metadata

Authors
Lee, W. L., Cheung, A. M., Cape, D., & Zinman, B.
Affiliations
University of Toronto (CA)
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2000-07-01
Volume
23
Issue
7
Pages
962-968
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.23.7.962
OpenAlex
W1992229080
Cited by
442
References
0
Citations by year
2026: 1 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 9 · 2020: 11 · 2019: 14 · 2018: 23 · 2017: 12 · 2016: 15 · 2015: 29 · 2014: 31 · 2013: 31 · 2012: 26
FWCI
1.84
Type
journal article
Language
en
Open access
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Canadian Institutes of Health Research (44917)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
diabetes mellitus, coronary artery disease, coronary heart disease mortality, sex differences, women, men, cardiovascular risk, relative risk
MeSH terms
Coronary Disease, Diabetic Angiopathies, Female, Humans, Male, Risk, Risk Factors, Sex Characteristics

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