The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Skeletal Muscle Triglyceride
Abstract
Recent evidence derived from four independent methods indicates that an excess triglyceride storage within skeletal muscle is linked to insulin resistance. Potential mechanisms for this association include apparent defects in fatty acid metabolism that are centered at the mitochondria in obesity and in type 2 diabetes. Specifically, defects in the pathways for fatty acid oxidation during postabsorptive conditions are prominent, leading to diminished use of fatty acids and increased esterification and storage of lipid within skeletal muscle. These impairments in fatty acid metabolism during fasting conditions may be related to a metabolic inflexibility in insulin resistance that is not limited to defects in glucose metabolism during insulin-stimulated conditions. Thus, there is substantial evidence implicating perturbations in fatty acid metabolism during accumulation of skeletal muscle triglyceride and in the pathogenesis of insulin resistance. Weight loss by caloric restriction improves insulin sensitivity, but the effects on fatty acid metabolism are less conspicuous. Nevertheless, weight loss decreases the content of triglyceride within skeletal muscle, perhaps contributing to the improvement in insulin action with weight loss. Alterations in skeletal muscle substrate metabolism provide insight into the link between skeletal muscle triglyceride accumulation and insulin resistance, and they may lead to more appropriate therapies to improve glucose and fatty acid metabolism in obesity and in type 2 diabetes.
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The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
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“The muscle isoform of CPT I is highly sensitive to allosteric inhibition by malonyl CoA, the precursor of fatty acid synthesis (63).”
BackgroundMechanism of free fatty acid-induced insulin resistance in humans.
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Skeletal muscle triglyceride levels are inversely related to insulin action
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Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
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Goodpaster, B. H., Thaete, F. L., & Kelley, D. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.885 · Cited by 707 · cited 3×
“Furthermore, the crosssectional area of thigh muscle decreased, which was entirely due to the decrease in the area of low-density muscle, because the area of normal-density muscle did not change (12).”
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Effects of weight loss on regional fat distribution and insulin sensitivity in obesity.
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Self-citation
Cited by
Insulin resistance: a metabolic pathway to chronic liver disease
Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005) · Hepatology · doi:10.1002/hep.20920 · Cited by 900
Skeletal muscle inflammation and insulin resistance in obesity
Wu, H., & Ballantyne, C. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88880 · Cited by 695
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., & Nair, K. S. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1888 · Cited by 631
Correa-de-Araujo, R., Addison, O., Miljkovic, I., Goodpaster, B. H., Bergman, B. C., Clark, R. V., Elena, J. W., Esser, K. A., Ferrucci, L., Harris-Love, M. O., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00963 · Cited by 468
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Metadata
- Authors
- Kelley, D. E., & Goodpaster, B. H.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2001-05-01
- Volume
- 24
- Issue
- 5
- Pages
- 933-941
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2050277889
- Cited by
- 406
- References
- 30
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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