Insulin resistance: a metabolic pathway to chronic liver disease
Open accessAbstract
Insulin resistance (IR) is the pathophysiological hallmark of nonalcoholic fatty liver disease (NAFLD), one of the most common causes of chronic liver disease in Western countries. We review the definition of IR, the methods for the quantitative assessment of insulin action, the pathophysiology of IR, and the role of IR in the pathogenesis of chronic liver disease. Increased free fatty acid flux from adipose tissue to nonadipose organs, a result of abnormal fat metabolism, leads to hepatic triglyceride accumulation and contributes to impaired glucose metabolism and insulin sensitivity in muscle and in the liver. Several factors secreted or expressed in the adipocyte contribute to the onset of a proinflammatory state, which may be limited to the liver or more extensively expressed throughout the body. IR is the common characteristic of the metabolic syndrome and its related features. It is a systemic disease affecting the nervous system, muscles, pancreas, kidney, heart, and immune system, in addition to the liver. A complex interaction between genes and the environment favors or enhances IR and the phenotypic expression of NAFLD in individual patients. Advanced fibrotic liver disease is associated with multiple features of the metabolic syndrome, and the risk of progressive liver disease should not be underestimated in individuals with metabolic disorders. Finally, the ability of insulin-sensitizing, pharmacological agents to treat NAFLD by reducing IR in the liver (metformin) and in the periphery (thiazolidinediones) are discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Insulin resistance is one of the most relevant pathogenetic features of MASLD and the driver for progression of liver inflammation.
“While insulin resistance has been considered one of the most relevant pathogenetic feature of MASLD and the driver for the progression of liver inflammation (11), reduced metabolic flexibility remains a less explored mechanism (12).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [11]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285 · see citing works
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,831 · see citing works
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664 · see citing works
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604 · see citing works
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345 · see citing works
Self-citationCellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works
Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome
Marchesini, G., Bugianesi, E., Forlani, G., Cerrelli, F., Lenzi, M., Manini, R., Natale, S., Vanni, E., Villanova, N., Melchionda, N., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50161 · Cited by 2,676 · see citing works
Self-citationHotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works
Nonalcoholic Fatty Liver Disease
Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G., & Melchionda, N. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1844 · Cited by 2,581 · see citing works
Self-citationBonora, E., Targher, G., Alberiche, M., Bonadonna, R. C., Saggiani, F., Zenere, M. B., Monauni, T., & Muggeo, M. (2000) · Diabetes Care · doi:10.2337/diacare.23.1.57 · Cited by 2,456 · see citing works
Insulin Resistance in Essential Hypertension
Ferrannini, E., Buzzigoli, G., Bonadonna, R., Giorico, M. A., Oleggini, M., Graziadei, L., Pedrinelli, R., Brandi, L., & Bevilacqua, S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170605 · Cited by 2,344 · see citing works
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,086 · see citing works
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078 · see citing works
Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7231 · Cited by 1,940 · see citing works
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works
Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., L'Italien, G. J., Pio, J. R., & Williams, G. R. (2004) · Circulation · doi:10.1161/01.cir.0000140677.20606.0e · Cited by 1,845 · see citing works
Comment on the provisional report from the WHO consultation
(1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00059.x · Cited by 1,820 · see citing works
Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
Angulo, P., Keach, J. C., Batts, K., & Lindor, K. (1999) · Hepatology · doi:10.1002/hep.510300604 · Cited by 1,708 · see citing works
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640 · see citing works
Association of nonalcoholic fatty liver disease with insulin resistance
Marchesini, G., Brizi, M., Morselli‐Labate, A. M., Bianchi, G. P., Bugianesi, E., McCullough, A. J., Forlani, G., & Melchionda, N. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00271-5 · Cited by 1,564 · see citing works
Self-citationFried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,528 · see citing works
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435 · see citing works
The Metabolic Syndrome and Chronic Kidney Disease in U.S. Adults
Chen, J., Muntner, P., Hamm, L. L., Jones, D. W., Batuman, V., Fonseca, V. A., Whelton, P. K., & He, J. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-3-200402030-00007 · Cited by 1,354 · see citing works
Xu, A., Wang, Y., Keshaw, H., Xu, L. Y., Lam, K. S. L., & Cooper, G. J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17797 · Cited by 1,298 · see citing works
Xu, A., Wang, Y., Keshaw, H., Xu, L. Y., Lam, K. S. L., & Cooper, G. J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317797 · Cited by 1,298 · see citing works
Yokota, T., Oritani, K., Takahashi, I., Ishikawa, J., Matsuyama, A., Ouchi, N., Kihara, S., Funahashi, T., Tenner, A. J., Tomiyama, Y., et al. (2000) · Blood · doi:10.1182/blood.v96.5.1723 · Cited by 1,294 · see citing works
Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264 · see citing works
Prevalence of and Risk Factors for Hepatic Steatosis in Northern Italy
Bellentani, S., Saccoccio, G., Masutti, F., Crocè, L. S., Brandi, G., Sasso, F., Cristanini, G., & Tiribelli, C. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-2-200001180-00004 · Cited by 1,261 · see citing works
Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
Rajala, M. W., & Scherer, P. E. (2003) · Endocrinology · doi:10.1210/en.2003-0580 · Cited by 1,190 · see citing works
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works
Fried, S. K. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.847 · Cited by 1,146 · see citing works
Hu, G. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1066 · Cited by 1,135 · see citing works
Chitturi, S., Abeygunasekera, S., Farrell, G. C., Holmes-Walker, J., Hui, J. M., Fung, C., Karim, R., Lin, R., Samarasinghe, D., Liddle, C., et al. (2002) · Hepatology · doi:10.1053/jhep.2002.30692 · Cited by 1,122 · see citing works
Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications
Unger, R. H. (1995) · Diabetes · doi:10.2337/diab.44.8.863 · Cited by 1,100 · see citing works
American College of Endocrinology Position Statement on the Insulin Resistance Syndrome
Einhorn, D. (2003) · Endocrine Practice · doi:10.4158/ep.9.s2.5 · Cited by 1,066 · see citing works
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.
Stümvoll, M., Mitrakou, A., Pimenta, W. P., Jenssen, T. G., Yki-Järvinen, H., van Haeften, T. W., Renn, W., & Gerich, J. E. (2000) · Diabetes Care · doi:10.2337/diacare.23.3.295 · Cited by 1,040 · see citing works
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
Ashrafi, K., Chang, F., Watts, J. L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature · doi:10.1038/nature01279 · Cited by 972 · see citing works
Cytokines in Alcoholic and Nonalcoholic Steatohepatitis
Tilg, H., & Diehl, A. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011163432007 · Cited by 945 · see citing works
Beyond insulin resistance in NASH: TNF-α or adiponectin?
Hui, J. M., Hodge, A., Farrell, G. C., Kench, J. G., Kriketos, A., & George, J. (2004) · Hepatology · doi:10.1002/hep.20280 · Cited by 942 · see citing works
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 935 · see citing works
Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P. A., Moser, A. B., Desimone, C., Song, X.-Y., & Diehl, A. M. (2003) · Hepatology · doi:10.1053/jhep.2003.50048 · Cited by 930 · see citing works
Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
Fernández-Real, J. M., & Ricart, W. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0010 · Cited by 886 · see citing works
Interleukin-6 induces cellular insulin resistance in hepatocytes.
Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3391 · Cited by 883 · see citing works
Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1600 · Cited by 877 · see citing works
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works
Zimmet, P., Alberti, K. G. M. M., & Serrano Ríos, M. (2005) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(06)60742-1 · Cited by 864 · see citing works
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854 · see citing works
A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test
Mari, A., Pacini, G., Murphy, E., Ludvik, B. H., & Nolan, J. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.539 · Cited by 805 · see citing works
Is obesity an inflammatory condition?
Das, U. N. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00672-4 · Cited by 799 · see citing works
Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction
Kahn, C. R. (1978) · Metabolism · doi:10.1016/s0026-0495(78)80007-9 · Cited by 793 · see citing works
Bugianesi, E., Gastaldelli, A., Vanni, E., Gambino, R., Cassader, M., Baldi, S., Ponti, V., Pagano, G., Ferrannini, E., & Rizzetto, M. (2005) · Diabetologia · doi:10.1007/s00125-005-1682-x · Cited by 770 · see citing works
Self-citationPagano, G., Pacini, G., Musso, G., Gambino, R., Mecca, F., Depetris, N., Cassader, M., David, E., Cavallo‐Perin, P., & Rizzetto, M. (2002) · Hepatology · doi:10.1053/jhep.2002.30690 · Cited by 754 · see citing works
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753 · see citing works
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
Gainsford, T., Willson, T. A., Metcalf, D., Handman, E., McFarlane, C., Ng, A. P., Nicola, N. A., Alexander, W. S., & Hilton, D. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14564 · Cited by 750 · see citing works
Neuschwander‐Tetri, B. A., Brunt, E. M., Wehmeier, K. R., Oliver, D., & Bacon, B. R. (2003) · Hepatology · doi:10.1053/jhep.2003.50420 · Cited by 749 · see citing works
How good a marker is insulin level for insulin resistance?
Laakso, M. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116768 · Cited by 726 · see citing works
A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
Promrat, K., Lutchman, G., Uwaifo, G. I., Freedman, R. J., Soza, A., Heller, T., Doo, E., Ghany, M., Premkumar, A., Park, Y., et al. (2004) · Hepatology · doi:10.1002/hep.20012 · Cited by 726 · see citing works
Vozarova, B., Stefan, N., Lindsay, R. S., Saremi, A., Pratley, R. E., Bogardus, C., & Tataranni, P. A. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1889 · Cited by 717 · see citing works
Bugianesi, E., Gentilcore, E., Manini, R., Natale, S., Vanni, E., Villanova, N., David, E., Rizzetto, M., & Marchesini, G. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41583.x · Cited by 683 · see citing works
Self-citationMetformin in non-alcoholic steatohepatitis.
Marchesini, G., Bianchi, G., Tomassetti, S., Zoli, M., & Melchionda, N. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06042-1 · Cited by 682 · see citing works
Self-citationClinical Features and Natural History of Nonalcoholic Steatosis Syndromes
Falck-Ytter, Y. T., Younossi, Z. M., Marchesini, G., & McCullough, A. J. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-12926 · Cited by 668 · see citing works
Self-citationBays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664 · see citing works
Shapiro, L. S., & Scherer, P. E. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70133-2 · Cited by 652 · see citing works
Liver Pathology and the Metabolic Syndrome X in Severe Obesity
Marceau, P., Biron, S., Hould, F. S., Marceau, S., Simard, S., Thung, S. N., & Kral, J. G. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5661 · Cited by 633 · see citing works
Havel, P. J. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s143 · Cited by 625 · see citing works
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
Petersen (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215001 · Cited by 622 · see citing works
Fernandez-Real, J.-M., Vayreda, M., Richart, C., Gutierrez, C., Broch, M., Vendrell, J., & Ricart, W. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7305 · Cited by 567 · see citing works
Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes
Pickup, J. C., Chusney, G. D., Thomas, S. M., & Burt, D. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00622-6 · Cited by 566 · see citing works
Rajala, M. W., Obici, S., Scherer, P. E., & Rossetti, L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16521 · Cited by 525 · see citing works
Tiikkainen, M., Häkkinen, A.-M., Korsheninnikova, E., Nyman, T., Mäkimattila, S., & Yki-Järvinen, H. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2169 · Cited by 524 · see citing works
Mitochondrial abnormalities in non-alcoholic steatohepatitis
Caldwell, S. H., Swerdlow, R. H., Khan, E. M., Iezzoni, J. C., Hespenheide, E. E., Parks, J. K., & Parker, W. D. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80033-6 · Cited by 495 · see citing works
Failure of adipocyte differentiation causes type II diabetes mellitus?
Danforth, E. (2000) · Nature Genetics · doi:10.1038/79111 · Cited by 487 · see citing works
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin
Kamada, Y., Tamura, S., Kiso, S., Matsumoto, H., Saji, Y., Yoshida, Y., Fukui, K., Maeda, N., Nishizawa, H., Nagaretani, H., et al. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.029 · Cited by 480 · see citing works
Yokohama, S., Yoneda, M., Haneda, M., Okamoto, S., Okada, M., Aso, K., Hasegawa, T., Tokusashi, Y., Miyokawa, N., & Nakamura, K. (2004) · Hepatology · doi:10.1002/hep.20420 · Cited by 458 · see citing works
Sanyal, A. J., MOFRAD, P., Contos, M. J., Sargeant, C., Luketic, V. A., Sterling, R. K., Stravitz, R. T., Shiffman, M. L., Clore, J. N., & Mills, A. S. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00457-4 · Cited by 436 · see citing works
Bugianesi, E., Manzini, P. M., D’Antico, S., Vanni, E., Longo, F., Leone, N., Massarenti, P., Piga, A. G., Marchesini, G., & Rizzetto, M. (2004) · Hepatology · doi:10.1002/hep.20023 · Cited by 436 · see citing works
Self-citationNonalcoholic Fatty Liver Disease
Clark, J. M., & Diehl, A. M. (2003) · JAMA · doi:10.1001/jama.289.22.3000 · Cited by 431 · see citing works
Kelley, D. E., McKolanis, T. M., Hegazi, R. A. F., Kuller, L. H., & Kalhan, S. C. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00117.2003 · Cited by 426 · see citing works
Willner, I. R., Waters, B., Patil, S. R., Reuben, A., Morelli, J., & Riely, C. A. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04667.x · Cited by 419 · see citing works
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., Nakakuki, M., Nagai, R., Ishibashi, S., Osuga, J.-I., Yamada, N., & Shimano, H. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.028 · Cited by 415 · see citing works
Adiponectin and its receptors in non-alcoholic steatohepatitis
Kaser, S., Moschen, A. R., Cayon, A., Kaser, A., Crespo, J., Pons-Romero, F., Ebenbichler, C. F., Patsch, J. R., & Tilg, H. (2004) · Gut · doi:10.1136/gut.2003.037010 · Cited by 412 · see citing works
Bugianesi, E., Pagotto, U., Manini, R., Vanni, E., Gastaldelli, A., IASIO, R. D., Gentilcore, E., Natale, S., Cassader, M., Rizzetto, M., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2240 · Cited by 409 · see citing works
Self-citationLeptin is essential for the hepatic fibrogenic response to chronic liver injury
Leclercq, I. A., Farrell, G. C., Schriemer, R., & Robertson, G. R. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00102-2 · Cited by 407 · see citing works
Kelley, D. E., & Goodpaster, B. H. (2001) · Diabetes Care · doi:10.2337/diacare.24.5.933 · Cited by 406 · see citing works
Metformin in the treatment of patients with non‐alcoholic steatohepatitis
Uygun, A., Kadayıfçı, A., Işık, A. T., Ozgurtas, T., Deveci, S., Tüzün, A., Yeşilova, Z., Gülşen, M., & Dağalp, K. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01888.x · Cited by 404 · see citing works
Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling
Belfort, R., Mandarino, L., Kashyap, S., Wirfel, K., Pratipanawatr, T., Berria, R., DeFronzo, R. A., & Cusi, K. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1640 · Cited by 404 · see citing works
Adiponectin protects LPS-induced liver injury through modulation of TNF-α in KK-Ay obese mice
Masaki, T., Chiba, S., Tatsukawa, H., Yasuda, T., Noguchi, H., Seike, M., & Yoshimatsu, H. (2004) · Hepatology · doi:10.1002/hep.20282 · Cited by 402 · see citing works
A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis.
Caldwell, S. H., Hespenheide, E. E., Redick, J. A., Iezzoni, J. C., Battle, E. H., & Sheppard, B. L. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03553.x · Cited by 394 · see citing works
Role of resistin in diet-induced hepatic insulin resistance
Muse, E. D., Obici, S., Bhanot, S., Monia, B. P., McKay, R. A., Rajala, M. W., Scherer, P. E., & Rossetti, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21270 · Cited by 371 · see citing works
Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial
Nair, S., Diehl, A. M., Wiseman, M., Farr, G. H., & Perrillo, R. P. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02025.x · Cited by 369 · see citing works
Weston, S. R., Leyden, W. A., Murphy, R., Bass, N. M., Bell, B. P., Manos, M. M., & Terrault, N. A. (2005) · Hepatology · doi:10.1002/hep.20554 · Cited by 361 · see citing works
Bajaj, M. S., Suraamornkul, S., Piper, P. K., Hardies, L. J., Glass, L. C., Cersósimo, E., Pratipanawatr, T., Miyazaki, Y., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031315 · Cited by 354 · see citing works
Westerbacka, J., Corn�r, A., Tiikkainen, M., Tamminen, M., Vehkavaara, S., H�kkinen, A.-M., Fredriksson, J., & Yki-J�rvinen, H. (2004) · Diabetologia · doi:10.1007/s00125-004-1460-1 · Cited by 338 · see citing works
Aytug, S., Reich, D. L., Sapiro, L. E., Bernstein, D., & Begum, N. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.012 · Cited by 336 · see citing works
Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds
Struben, V. M. D., Hespenheide, E. E., & Caldwell, S. H. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00315-0 · Cited by 295 · see citing works
Metabolic Effects of Visceral Fat Accumulation in Type 2 Diabetes
Gastaldelli, A., Miyazaki, Y., Pettiti, M., Matsuda, M., Mahankali, S., Santini, E., DeFronzo, R. A., & Ferrannini, E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020696 · Cited by 289 · see citing works
CLINICAL REVIEW 26 Insulin Resistance in Obese and Nonobese Man
CARO, J. F. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-4-691 · Cited by 279 · see citing works
Insulin release and peripheral sensitivity at the oral glucose tolerance test
Cederholm, J., & Wibell, L. (1990) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(90)90040-z · Cited by 264 · see citing works
Genetics of the metabolic syndrome
Groop, L. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000945 · Cited by 261 · see citing works
Clausen, J. O., Borch-Johnsen, K., Ibsen, H., Bergman, R. N., Hougaard, P., Winther, K., & Pedersen, O. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118903 · Cited by 259 · see citing works
Beard, J. C., Bergman, R. N., Ward, W. K., & Porte, D. (1986) · Diabetes · doi:10.2337/diab.35.3.362 · Cited by 247 · see citing works
Relation between iron stores and non-insulin dependent diabetes in men: case-control study
Salonen, J. T., Tuomainen, T.-P., Nyyssönen, K., Lakka, H.-M., & Punnonen, K. (1998) · BMJ · doi:10.1136/bmj.317.7160.727 · Cited by 242 · see citing works
Donati, G., Stagni, B., Piscaglia, F., Venturoli, N., Morselli‐Labate, A. M., Rasciti, L., & Bolondi, L. (2004) · Gut · doi:10.1136/gut.2003.027086 · Cited by 231 · see citing works
Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy†
Javor, E. D., Ghany, M. G., Cochran, E. K., Oral, E. A., DePaoli, A. M., Premkumar, A., Kleiner, D. E., & Gorden, P. (2005) · Hepatology · doi:10.1002/hep.20672 · Cited by 228 · see citing works
Campbell, P. J., Mandarino, L. J., & Gerich, J. E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90023-6 · Cited by 226 · see citing works
The Roles of Leptin and Adiponectin
Ding, X., Saxena, N. K., Lin, S., Xu, A., Srinivasan, S., & Anania, F. A. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62476-5 · Cited by 225 · see citing works
Ghanim, H., Garg, R., Aljada, A., Mohanty, P., Kumbkarni, Y., Assian, E., Hamouda, W., & Dandona, P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7309 · Cited by 218 · see citing works
Kim, S. P., Ellmerer, M., Citters, G. W. V., & Bergman, R. N. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2453 · Cited by 195 · see citing works
Molecular basis of insulin action
Combettes-Souverain, M., & Issad, T. (1986) · International Journal of Biochemistry · doi:10.1016/0020-711x(86)90171-0 · Cited by 191 · see citing works
Hepatic Gene Expression in Histologically Progressive Nonalcoholic Steatohepatitis
Raghavakaimal, S., Rosado, B., Rasmussen, D. L., & Charlton, M. (2003) · Hepatology · doi:10.1053/jhep.2003.50290 · Cited by 184 · see citing works
Sutinen, J., Häkkinen, A.-M., Westerbacka, J., Seppälä-Lindroos, A., Vehkavaara, S., Halavaara, J., Järvinen, A., Ristola, M., & Yki-Järvinen, H. (2002) · AIDS · doi:10.1097/00002030-200211080-00011 · Cited by 184 · see citing works
Increased levels of acute-phase serum proteins in diabetes
McMillan, D. E. (1989) · Metabolism · doi:10.1016/0026-0495(89)90038-3 · Cited by 176 · see citing works
Seppala-Lindroos, A. (2002) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.7.3023 · Cited by 168 · see citing works
Anderwald, C. H., Bernroider, E., Krššák, M., Stingl, H., Brehm, A., Bischof, M. G., Nowotny, P., Roden, M., & Waldhäusl, W. K. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3025 · Cited by 168 · see citing works
Liver‐Fat Accumulation and Insulin Resistance in Obese Women with Previous Gestational Diabetes
Tiikkainen, M., Tamminen, M., Häkkinen, A., Bergholm, R., Vehkavaara, S., Halavaara, J. T., Teramo, K., Rissanen, A., & Yki‐Järvinen, H. (2002) · Obesity Research · doi:10.1038/oby.2002.118 · Cited by 161 · see citing works
Marchesini, G., Forlani, G., Cerrelli, F., Manini, R., Natale, S., Baraldi, L., Ermini, G., Savorani, G., Zocchi, D., & Melchionda, N. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01115.x · Cited by 152 · see citing works
Self-citationDoes Leptin Play A Role in The Pathogenesis of Human Nonalcoholic Steatohepatitis?
Chalasani, N., Crabb, D. W., Cummings, O. W., Kwo, P. Y., Asghar, A., Pandya, P., & Considine, R. V. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.08767.x · Cited by 148 · see citing works
Tumor necrosis factor α and insulin resistance in obese type 2 diabetic patients
Miyazaki, Y., Pipek, R., Mandarino, L. J., & DeFronzo, R. A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802187 · Cited by 148 · see citing works
Tietge, U. J. F., Böker, K. H. W., Manns, M. P., & Bahr, M. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00494.2003 · Cited by 148 · see citing works
Wanless, I. R., Bargman, J. M., Oreopoulos, D. G., & Vas, S. I. (1989) · PubMed · Cited by 146 · see citing works
Scheen, A. J., & Luyckx, F. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0225 · Cited by 146 · see citing works
Goto, T., Onuma, T., Takebe, K., & Kral, J. G. (1995) · PubMed · Cited by 145 · see citing works
Antiinflammatory and Antiarteriosclerotic Effects of Pioglitazone
Ishibashi, M., Egashira, K., Hiasa, K., Inoue, S., Ni, W., Zhao, Q. D., Usui, M., Kitamoto, S., Ichiki, T., & Takeshita, A. (2002) · Hypertension · doi:10.1161/01.hyp.0000036396.64769.c2 · Cited by 141 · see citing works
Sykiotis, G. P., & Papavassiliou, A. G. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.11.0725 · Cited by 132 · see citing works
Metabolic and molecular basis of insulin resistance
Bajaj, M., & DeFronzo, R. A. (2003) · Journal of Nuclear Cardiology · doi:10.1016/s1071-3581(03)00520-8 · Cited by 131 · see citing works
Systemic and regional free fatty acid metabolism in type 2 diabetes
Basu, A., Basu, R., Shah, P., Vella, A., Rizza, R. A., & Jensen, M. D. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.6.e1000 · Cited by 123 · see citing works
Neuschwander‐Tetri, B. A., Brunt, E. M., Wehmeier, K. R., Sponseller, C. A., Hampton, K., & Bacon, B. R. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00027-8 · Cited by 119 · see citing works
Adiponectin, hepatocellular dysfunction and insulin sensitivity
López‐Bermejo, A., Botas, P., Funahashi, T., Delgado, E., Kihara, S., Ricart, W., & Fernández‐Real, J. M. (2004) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2004.01977.x · Cited by 117 · see citing works
Diabetes Mellitus and the Liver
Stone, B. G., & Thiel, D. V. (1985) · Seminars in Liver Disease · doi:10.1055/s-2008-1041754 · Cited by 116 · see citing works
Targher, G., Bertolini, L., Scala, L., Poli, F., Zenari, L., & Falezza, G. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02151.x · Cited by 109 · see citing works
Pioglitazone Prevents Early-Phase Hepatic Fibrogenesis Caused by Carbon Tetrachloride
Kon, K., Ikejima, K., Hirose, M., Yoshikawa, M., Enomoto, N., Kitamura, T., Takei, Y., & Sato, N. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6385 · Cited by 105 · see citing works
Mari, A., Pacini, G., Brazzale, A. R., & Ahr�n, B. (2005) · Diabetologia · doi:10.1007/s00125-005-1683-9 · Cited by 105 · see citing works
Leptin and liver fibrosis: A matter of fat
Marra, F. (2002) · Gastroenterology · doi:10.1053/gast.2002.33369 · Cited by 91 · see citing works
Qian, H., Hausman, G., Compton, M. M., Azain, M. J., Hartzell, D. L., & Baile, C. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8680 · Cited by 84 · see citing works
Expression of Leptin and Leptin Receptor During the Development of Liver Fibrosis and Cirrhosis
Otte, C., Otte, J. ‐., Strodthoff, D., Bornstein, S. R., Fölsch, U. R., Mönig, H., & Kloehn, S. (2004) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2004-815720 · Cited by 62 · see citing works
Effect of Losartan, an Angiotensin II Antagonist, on Hepatic Fibrosis Induced by CCl4 in Rats
Wei, Y. H., Li, J., & Qiang, C. J. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000043369.88701.5b · Cited by 55 · see citing works
Shadid, S., & Jensen, M. D. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1053/s1542-3565(03)00198-8 · Cited by 54 · see citing works
Determinants of postabsorptive endogenous glucose output in non-diabetic subjects
Natali, A., Toschi, E., Camastra, S., Gastaldelli, A., Groop, L., & Ferrannini, E. (2000) · Diabetologia · doi:10.1007/s001250051522 · Cited by 50 · see citing works
Diabetes, Insulin Secretion, and the Pancreatic Beta-Cell Mitochondrion
Langin, D. (2001) · New England Journal of Medicine · doi:10.1056/nejm200112133452412 · Cited by 46 · see citing works
Insulin resistance in non-alcoholic steatohepatitis
Cömert, B., Mas, M. R., Erdem, H., Dinç, A., Saǧlamkaya, U., Ciğerim, M., Kuzhan, O., Unal, T., & Kocabalkan, F. (2001) · Digestive and Liver Disease · doi:10.1016/s1590-8658(01)80091-8 · Cited by 44 · see citing works
Angiotensinogen, adipocyte differentiation and fat mass enlargement
Ailhaud, G. P., Teboul, M., & Massiéra, F. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200207000-00006 · Cited by 44 · see citing works
Challenges and Strategies for Investigating the Genetic Complexity of Common Human Diseases
Rich, S. S., & CONCANNON, P. J. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s288 · Cited by 36 · see citing works
Kanauchi, M., Tsujimoto, N., & Hashimoto, T. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00313-8 · Cited by 30 · see citing works
A Novel View of Metabolic Syndrome
Dandona, P., Phil., D., Aljada, A., Chaudhuri, A., Mohanty, P., & Garg, R. (2004) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2004.2.2 · Cited by 22 · see citing works
Negative trials in nonalcoholic steatohepatitis: Why they happen and what they teach us
Clark, J. M., & Brancati, F. L. (2004) · Hepatology · doi:10.1002/hep.20121 · Cited by 22 · see citing works
Intermittent disconjugate gaze
Al‐Osaimi, A. M. S., Berg, C. L., & Caldwell, S. H. (2005) · Hepatology · doi:10.1002/hep.20675 · Cited by 19 · see citing works
Molecular Basis of Insulin Action
Zick, Y. (2004) · Novartis Foundation symposium · doi:10.1002/0470869976.ch4 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of NAFLD development and therapeutic strategies
Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354 · see citing works
Adiels, M., Olofsson, S.-O., Taskinen, M.-R., & Borén, J. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.160192 · Cited by 820 · see citing works
Gastaldelli, A., Cusi, K., Pettiti, M., Hardies, J., Miyazaki, Y., Berria, R., Buzzigoli, E., Sironi, A. M., Cersosimo, E., Ferrannini, E., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.068 · Cited by 629 · see citing works
Glucocorticoids, metabolism and metabolic diseases
Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535 · see citing works
Metabolic syndrome and hepatocellular carcinoma: Two growing epidemics with a potential link
Siegel, A. B., & Zhu, A. X. (2009) · Cancer · doi:10.1002/cncr.24687 · Cited by 399 · see citing works
Roles of diacylglycerols and ceramides in hepatic insulin resistance
Petersen, M. C., & Shulman, G. I. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.04.004 · Cited by 373 · see citing works
Genetic Architecture of Insulin Resistance in the Mouse
Parks, B. W., Sallam, T., Mehrabian, M., Psychogios, N., Hui, S. T., Norheim, F., Castellani, L. W., Rau, C. D., Pan, C., Phun, J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.002 · Cited by 249 · see citing works
Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame
Ibrahim, S. H., Hirsova, P., Malhi, H., & Gores, G. J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3977-1 · Cited by 218 · see citing works
Prevalence of hypothyroidism in nonalcoholic fatty liver disease
Pagadala, M. R., Zein, C. O., Dasarathy, S., Yerian, L. M., Lopez, R., & McCullough, A. J. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-2006-2 · Cited by 178 · see citing works
Self-citationSerum Immunoglobulin Levels Predict Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease
McPherson, S., Henderson, E., Burt, A. D., Day, C. P., & Anstee, Q. M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.01.010 · Cited by 124 · see citing works
Gamas, L., Matafome, P., & Seiça, R. (2015) · Journal of Diabetes Research · doi:10.1155/2015/359159 · Cited by 114 · see citing works
Interactions between insulin and exercise
Richter, E. A., Sylow, L., & Hargreaves, M. (2021) · Biochemical Journal · doi:10.1042/bcj20210185 · Cited by 99 · see citing works
Huang, R.-C., Mori, T. A., Burke, V., Newnham, J., Stanley, F. J., Landau, L. I., Kendall, G. E., Oddy, W. H., & Beilin, L. J. (2009) · Diabetes Care · doi:10.2337/dc08-1917 · Cited by 93 · see citing works
“Furthermore, different associations of metabolic syndrome components with inflammatory markers suggest that the metabolic syndrome is likely to be a heterogeneous condition produced via different pathways, with implications for adult pathological conditions such as diabetes, NAFLD, and hypertension.”
BackgroundInfluentialDiabetes medications and risk of HCC
Plaz Torres, M. C., Jaffe, A., Perry, R., Marabotto, E., Strazzabosco, M., & Giannini, E. G. (2022) · Hepatology · doi:10.1002/hep.32439 · Cited by 86 · see citing works
Catta-Preta, M., Martins, M. A., Cunha Brunini, T. M., Mendes-Ribeiro, A. C., Mandarim-de-Lacerda, C. A., & Aguila, M. B. (2012) · Nutrition · doi:10.1016/j.nut.2011.05.011 · Cited by 83 · see citing works
Hyperinsulinemia: A unifying theory of chronic disease?
Crofts, C. A. P. (2015) · Diabesity · doi:10.15562/diabesity.2015.19 · Cited by 75 · see citing works
Mambrini, S. P., Grillo, A., Colosimo, S., Zarpellon, F., Pozzi, G., Furlan, D., Amodeo, G., & Bertoli, S. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1426551 · Cited by 70 · see citing works
Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus
Sim, A. Y., Barua, S., Kim, J. Y., Lee, Y.-H., & Lee, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.708547 · Cited by 62 · see citing works
Qudus B Aroyehun, A., Abdul Razak, S., Palaniveloo, K., Nagappan, T., Suraiza Nabila Rahmah, N., Wee Jin, G., Chellappan, D. K., Chellian, J., & Kunnath, A. P. (2020) · Foods · doi:10.3390/foods9091313 · Cited by 66 · see citing works
Son, Y., Lee, H., Son, S.-Y., Lee, C.-H., Kim, S.-Y., & Lim, Y. (2021) · Antioxidants · doi:10.3390/antiox10101546 · Cited by 35 · see citing works
Okamura, T., Hashimoto, Y., Hamaguchi, M., Obora, A., Kojima, T., & Fukui, M. (2020) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2019.04.002 · Cited by 32 · see citing works
Swaminathan, K., Kumar, S. M., Clemens, D. L., & Dey, A. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.022 · Cited by 21 · see citing works
Kara, O., Arsoy, H. A., & Keskin, M. (2023) · Clinical and Experimental Pediatrics · doi:10.3345/cep.2023.00353 · Cited by 9 · see citing works
- Authors
- Bugianesi, E., McCullough, A. J., & Marchesini, G.
- Affiliations
- University of Turin (IT)
- MetroHealth Medical Center (US)
- University of Bologna (IT)
- Corresponding author
- Marchesini, Giulio
- Venue
- Hepatology
- Published
- 2005-11
- Volume
- 42
- Issue
- 5
- Pages
- 987-1000
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2010220662
- Cited by
- 900
- References
- 161
- Citations by year
- 2026: 17 · 2025: 38 · 2024: 34 · 2023: 44 · 2022: 38 · 2021: 53 · 2020: 25 · 2019: 52 · 2018: 43 · 2017: 46 · 2016: 53 · 2015: 57 · 2014: 46 · 2013: 50 · 2012: 33
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- insulin resistance, non-alcoholic fatty liver disease, chronic liver disease, metabolic syndrome, hepatic triglyceride accumulation, adipose tissue, insulin sensitivity, inflammation, liver fibrosis, insulin sensitizers, metformin, thiazolidinediones
- MeSH terms
- Chronic Disease, Fatty Liver, Humans, Insulin Resistance, Liver Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review