The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Rapid Changes in Postprandial Blood Glucose Produce Concentration Differences at Finger, Forearm, and Thigh Sampling Sites
Open accessAbstract
OBJECTIVE—To compare pre- and postmeal capillary blood glucose concentrations measured at the finger, forearm, and thigh in adults with diabetes. RESEARCH DESIGN AND METHODS—For phase 1, capillary blood glucose concentrations were measured at six time points (premeal and at ∼60, 90, 120, 150, and 180 min postmeal) using a blood glucose monitoring system and technician-obtained samples collected from finger, forearm, and thigh sites of 42 adults with diabetes. The finger samples were also tested with a laboratory instrument. For phase 2, ∼14 weeks later, the testing procedures were repeated with 38 subjects from the original study population. RESULTS—Meter finger results were accurate at all time points. Alternate sites tended to produce lower glucose readings compared to finger readings at times when glucose was increasing rapidly (60 and 90 min postmeal). Forearm-to-finger differences correlated with rates of glucose change (r = 0.56, P < 0.001), as did the thigh-to-finger differences (r = 0.52, P < 0.001). Other factors, such as subject age, BMI, diabetes type, and insulin dependence did not have a significant impact on site differences. When the testing procedures were repeated with the same subjects, the pattern of site differences was consistent, although individual results were variable. CONCLUSIONS—Changes in blood glucose immediately after a meal may be identified at finger sites before detection at forearm or thigh sites. Alternate site testing appears to be a useful option for routine self-monitoring before meals; however, patients and clinicians should recognize that results may be different from fingertip results when glucose levels are changing rapidly.
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“When glucose concentrations are rising or have just risen sharply, fingertip capillary glucose concentrations are greater than those in capillary blood from other sites including forearm, thigh and abdomen (Ellison et al. 2002;Jungheim & Koschinsky, 2002;van der Valk et al. 2002), with variable differences in repeated tests on the same subject (Ellison et al. 2002);”
From Glycaemic index methodology (2005) · cites this paper as Ellison et al. 2002
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“The anatomical site from which skin puncture samples are obtained influences results: Use of blood from so-called alternate sites (such as forearm or thigh rather than fingertip) for testing may exhibit a temporal lag between the circulating and measured concentrations of glucose when blood glucose is changing in vivo (117).”
From Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus (2023) · cites this paper as [117]
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Evaluating clinical accuracy of systems for self-monitoring of blood glucose
Clarke, W. L., Cox, D., Gonder-Frederick, L. A., Carter, W., & Pohl, S. L. (1987) · Diabetes Care · doi:10.2337/diacare.10.5.622 · Cited by 1,435
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Kuwa, K., Nakayama, T., Hoshino, T., & Tominaga, M. (2001) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00426-0 · Cited by 142
Tanizawa, Y., Matsuda, K., Matsuo, M., Ohta, Y., Ochi, N., Adachi, M., Koga, M., Mizuno, S., Kajita, M., Tanaka, Y., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.1.114 · Cited by 66
Differences between capillary and venous blood glucose during oral glucose tolerance tests
Larsson-Cohn, U. (1976) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517609081941 · Cited by 65
Risky Delay of Hypoglycemia Detection by Glucose Monitoring at the Arm
Jungheim, K., & Koschinsky, T. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1303-a · Cited by 62
Use of an Automated Device for Alternative Site Blood Glucose Monitoring
Fineberg, S. E., Bergenstal, R. M., Bernstein, R. M., Laffel, L. M., & Schwartz, S. L. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1217 · Cited by 59
High Incidence of Maternal Transmission of Diabetes in Obese Uruguayan Children
Pisabarro, R., Recalde, A., & Chaftare, Y. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1303 · Cited by 38
Capillary-venous differences in blood glucose values during the oral glucose tolerance test.
Eriksson, K. F., Fex, G., & Trell, E. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.5.993a · Cited by 23
Response to Jungheim and Koschinsky
McGarraugh, G. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1304 · Cited by 20
Response to Jungheim and Koschinsky
Pfützner, A., & Forst, T. M. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.638 · Cited by 6
Alternative method for stabilizing carbon dioxide in serum.
Gotelli, G. R., & Kabra, P. M. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.5.993 · Cited by 6
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Brouns, F., Bjorck, I., Frayn, K. N., Gibbs, A. L., Lang, V., Slama, G., & Wolever, T. M. S. (2005) · Nutrition Research Reviews · doi:10.1079/nrr2005100 · Cited by 1,093
Goldstein, D. E., Little, R. R., Lorenz, R. A., Malone, J. I., Nathan, D., Peterson, C. M., & Sacks, D. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1761 · Cited by 625
Assessing Glycemia in Diabetes Using Self-monitoring Blood Glucose and Hemoglobin A 1c
Saudek, C. D., Derr, R. L., & Kalyani, R. R. (2006) · JAMA · doi:10.1001/jama.295.14.1688 · Cited by 373
Prospects and limitations of non-invasive blood glucose monitoring using near-infrared spectroscopy
Yadav, J., Rani, A., Singh, V., & Murari, B. M. (2015) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2015.01.005 · Cited by 394
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Lernmark, Å., Metzger, B. E., Nathan, D. M., & Kirkman, M. S. (2023) · Diabetes Care · doi:10.2337/dci23-0036 · Cited by 351
Metadata
- Authors
- Ellison, J. M., Stegmann, J. M., Colner, S. L., Michael, R. H., Sharma, M. K., Ervin, K. R., & Horwitz, D. L.
- Affiliations
- LifeScan, Milpitas, California
- ORCID
- Horwitz, David L.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-06-01
- Volume
- 25
- Issue
- 6
- Pages
- 961-964
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2154078343
- Semantic Scholar
- e98ef81443d8253dc4e47cf37f2bfa46dd424c26
- Cited by
- 133
- References
- 12
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 6 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 9 · 2012: 4
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- postprandial blood glucose, capillary blood glucose, forearm, thigh, self-monitoring of blood glucose, meter accuracy, diabetes mellitus
- MeSH terms
- Adult, Blood Glucose, Blood Specimen Collection, Capillaries, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Fingers, Forearm, Humans, Leg, Male, Middle Aged, Regression Analysis, Time Factors, Blood Glucose Self-Monitoring, Reproducibility of Results, Postprandial Period
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