The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Polypharmacy and Medication Adherence in Patients With Type 2 Diabetes
Open accessAbstract
OBJECTIVE—To determine medication adherence and predictors of suboptimal adherence in a community cohort of patients with diabetes and to test the hypothesis that adherence decreases with increased number of medicines prescribed. RESEARCH DESIGN AND METHODS—A total of 128 randomly selected patients with type 2 diabetes from a single community health center responded to a pharmacist-administered questionnaire regarding medication use. Survey data were linked to clinical data available from the electronic medical record. We assessed self-reported adherence rates for each diabetes-related medicine, barriers and attitudes regarding medication use, and HbA1c, total cholesterol, and blood pressure levels. RESULTS—Patients were taking a mean of 4.1 (±1.9) diabetes-related medicines. The average 7-day adherence was 6.7 ± 1.1 days. Total number of medicines prescribed was not correlated with medication adherence. Adherence was significantly lower for medicines not felt to be improving current or future health (6.1 vs. 6.9 days out of 7, P < 0.001). Among patients on three or more medicines, 71% (15 of 21 patients) with suboptimal adherence were perfectly adherent with all but one medicine. Side effects were the most commonly reported problem with medication use. Of 29 medicines causing side effects that interfered with adherence, 24 (83%) did so for >1 month, and only 7 (24%) were reported to the patient’s primary care physician. CONCLUSIONS—In this sample, patients reported very high medication adherence rates regardless of number of medicines prescribed. Among patients on multiple medicines, most patients with suboptimal adherence were perfectly adherent to all but one medicine. Unreported side effects and a lack of confidence in immediate or future benefits were significant predictors of suboptimal adherence. Physicians should not feel deterred from prescribing multiple agents in order to achieve adequate control of hyperglycemia, hypertension, and hyperlipidemia.
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Haffner, S. M., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390404 · Cited by 7,000
The summary of diabetes self-care activities measure: results from 7 studies and a revised scale.
Toobert, D. J., Hampson, S. E., & Glasgow, R. E. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.943 · Cited by 2,561
Phillips, L. S., Branch, W. T., Cook, C. B., Doyle, J. P., El-Kebbi, I. M., Gallina, D. L., Miller, C. D., Ziemer, D. C., & Barnes, C. S. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-9-200111060-00012 · Cited by 1,370
Nonadherence in Tuberculosis treatment: Predictors and Consequences in New York City
Pablos-Méndez, M., Knirsch, M., Barr, M., Lerner, M., & Frieden, M. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00402-0 · Cited by 256 · cited 1×
“Results from studies that have assessed concurrent adherence in multidrug therapy for HIV disease (11–13) and for tuberculosis treatment (14,15) may not be generalizable to the treatment of patients with type 2 diabetes, who tend to be older, are often asymptomatic, and take medicines largely for preventive purposes.”
Background
Cited by
Medication Adherence in Type 2 Diabetes: The ENTRED Study 2007, a French Population-Based Study
Tiv, M., Viel, J.-F., Mauny, F., Eschwège, E., Weill, A., Fournier, C., Fagot-Campagna, A., & Penfornis, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032412 · Cited by 245
Association between adherence to pharmacotherapy and outcomes in type 2 diabetes: a meta-analysis
Khunti, K., Seidu, S., Kunutsor, S., & Davies, M. (2017) · Diabetes Care · doi:10.2337/dc16-1925 · Cited by 231
Del Prato, S., Felton, A.-M., Munro, N., Nesto, R., Zimmet, P., & Zinman, B. (2005) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2005.00674.x · Cited by 150
Piette, J. D., Heisler, M., Horne, R., & Caleb Alexander, G. (2006) · Social Science & Medicine · doi:10.1016/j.socscimed.2005.06.045 · Cited by 138
Insulin adherence in patients with diabetes: risk factors for injection omission
Farsaei, S., Radfar, M., Heydari, Z., Abbasi, F., & Qorbani, M. (2014) · Primary care diabetes · doi:10.1016/j.pcd.2014.03.001 · Cited by 106
Metadata
- Authors
- Grant, R. W., Devita, N. G., Singer, D. E., & Meigs, J. B.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2003-05-01
- Volume
- 26
- Issue
- 5
- Pages
- 1408-1412
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2143044822
- Cited by
- 403
- References
- 4
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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