The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
A Randomized, Prospective Trial Comparing the Efficacy of Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections Using Insulin Glargine
Open accessAbstract
OBJECTIVE—The efficacy of the insulin analogs now available for multiple daily injection (MDI) and continuous subcutaneous insulin infusion (CSII) therapy in type 1 diabetes has not yet been established in pediatric patients. Our principal aim in this short-term study was to compare the efficacy of CSII to MDI with glargine in lowering HbA1c levels in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS—Thirty-two youth with type 1 diabetes (age 8–21 years) were randomly assigned to receive either MDI treatment with once-daily glargine and premeal/snack insulin aspart or CSII with insulin aspart. Dose titration in both groups was based on home self-monitored blood glucose measurements and monthly HbA1c. HbA1c, total daily insulin dose (TDD), self-monitored blood glucose readings, and adverse events were compared after 16 weeks of therapy. RESULTS—While there was no significant change in the glargine group (HbA1c 8.2% at baseline vs. 8.1% at 16 weeks), youth randomized to CSII had a sharp reduction in HbA1c levels, from 8.1 to 7.2% after 16 weeks of therapy (P < 0.02 vs. baseline and <0.05 vs. glargine group). TDD was unchanged in the glargine group, but significantly dropped with CSII (1.4 units/kg at baseline vs. 0.9 units/kg at 16 weeks, P < 0.01). Both groups had similar basal doses and insulin-to-carbohydrate ratios. Fasting self-monitored blood glucose was similar in both groups, but lunch, dinner, and bedtime readings were significantly lower in the CSII group (P < 0.01). CONCLUSIONS—Lower HbA1c and premeal glucose levels were more achievable in this short-term study with CSII than with glargine-based MDI treatment. CSII is an efficacious treatment to improve metabolic control in youth with type 1 diabetes.
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“However, RCTs that compared insulin pumps and MDI with rapidacting insulin analogs demonstrated a modest improvement in A1C levels in participants on insulin pump therapy (178,179).”
From 7. Diabetes Technology: Standards of Care in Diabetes—2025 (2025) · cites this paper as [178]
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Standards of Medical Care for Patients With Diabetes Mellitus
American Diabetes Association (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s33 · Cited by 614
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Self-citationA Modified Quality-of-Life Measure for Youths: Psychometric Properties
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Safety and effectiveness of insulin pump therapy in children and adolescents with type 1 diabetes
Plotnick, L. P., Clark, L. M., Brancati, F. L., & Erlinger, T. (2003) · Diabetes Care · doi:10.2337/diacare.26.4.1142 · Cited by 216
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Self-citationManiatis, A. K., KLINGENSMITH, G. J., Slover, R. H., Mowry, C. J., & Chase, H. P. (2001) · PEDIATRICS · doi:10.1542/peds.107.2.351 · Cited by 172
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Insulin Pump Therapy in Childhood Diabetes Mellitus
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Standards of medical care in diabetes—2014
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s014 · Cited by 4,572
Standards of medical care in diabetes—2013
American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc13-s011 · Cited by 4,369
“Nevertheless, the increased frequency of use of basal-bolus regimens and insulin pumps in youth from infancy through adolescence has been associated with more children reaching ADA blood glucose targets (416,417) in those families in which both parents and the child with diabetes participate jointly to perform the req…”
BackgroundStandards of medical care in diabetes 2010
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc10-s011 · Cited by 3,470
Standards of medical care in diabetes—2011
American Diabetes Association (2011) · Diabetes Care · doi:10.2337/dc11-s011 · Cited by 2,880
Standards of Medical Care in Diabetes—2012
(2012) · Diabetes Care · doi:10.2337/dc12-s011 · Cited by 2,240
“Nevertheless, the increased frequency of use of basal-bolus regimens and insulin pumps in youth from infancy through adolescence has been associated with more children reaching ADA blood glucose targets (369,370) in those families in which both parents and the child with diabetes participate jointly to perform the req…”
Background
Metadata
- Authors
- Doyle (Boland), E. A., Weinzimer, S. A., Steffen, A. T., Ahern, J. A. H., Vincent, M., & Tamborlane, W. V.
- Affiliations
- From the Department of Pediatrics and the Children’s Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut
- Yale University (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2004-07-01
- Volume
- 27
- Issue
- 7
- Pages
- 1554-1558
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2138976255
- Cited by
- 373
- References
- 15
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 13 · 2018: 14 · 2017: 9 · 2016: 15 · 2015: 19 · 2014: 24 · 2013: 20 · 2012: 23
- FWCI
- 17.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- Novo Nordisk
- National Institutes of Health (5u01hd037251-05)
- National Center for Research Resources (RR06022)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 37251)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- type 1 diabetes, insulin pump therapy, multiple daily insulin injections, insulin glargine, insulin aspart, glycemic control, HbA1c, total daily insulin dose, self-monitoring of blood glucose, pediatric diabetes, adolescents
- MeSH terms
- Insulin Glargine, Adolescent, Adult, Child, Diabetes Mellitus, Type 1, Drug Administration Schedule, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Injections, Subcutaneous, Insulin, Insulin Infusion Systems, Blood Glucose Self-Monitoring, Patient Selection, Postprandial Period, Insulin, Long-Acting
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