Whole-Grain, Bran, and Cereal Fiber Intakes and Markers of Systemic Inflammation in Diabetic Women
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OBJECTIVE: To evaluate the dietary predictors for the markers of systemic inflammation and endothelial dysfunction in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: We examined whether intakes of whole grains and dietary fiber were associated with inflammatory indicators among 902 diabetic women in the Nurses' Health Study. RESULTS: After adjustment for age, BMI, lifestyle, and dietary covariates, intakes of whole grains and bran were both associated with significantly decreasing trends of C-reactive protein (CRP) (P for trend = 0.03 and 0.007, respectively) and tumor necrosis factor-alpha receptor 2 (TNF-R2) (P for trend = 0.017 and 0.06). High intake of cereal fiber was also inversely associated with the lower levels of CRP (P for trend = 0.03) and TNF-R2 (P for trend = 0.01). The concentrations of CRP and TNF-R2 were 18 and 8% lower in the highest quintile of cereal fiber as compared with the lowest quintile. Dietary glycemic index was positively associated with CRP (P for trend = 0.04) and TNF-R2 (P for trend = 0.0008) levels. The concentrations of CRP and TNF-R2 were 32 and 11% higher, respectively, in the highest quintile of dietary glycemic index as compared with the lowest quintile. CONCLUSIONS: Our data indicate that whole grains and a low-glycemic index diet may reduce systemic inflammation among women with type 2 diabetes.
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RAGE is implicated in atherogenesis and diabetic complications, based on animal studies showing that soluble RAGE inhibits atherosclerosis and nephropathy while RAGE overexpression or ablation affects these conditions.
“Among the AGE receptors, RAGE was shown to be implicated in atherogenesis, based on the observations that soluble RAGE, which is able to bind circulating AGE and other RAGE ligands, and therefore to prevent their pro-inflammatory effects, inhibited the development of atherosclerosis in diabetic apoE 2/2 mice (489)”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [490]
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References 30 · Cited by 261
- Authors
- Qi, L., van Dam, R. M., Liu, S., Franz, M., Mantzoros, C., & Hu, F. B.
- Affiliations
- Brigham and Women's Hospital (US)
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
- University of California, Los Angeles (US)
- Harvard University (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2006-02-01
- Volume
- 29
- Issue
- 2
- Pages
- 207-211
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2117165264
- Cited by
- 261
- References
- 30
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 5 · 2020: 19 · 2019: 22 · 2018: 15 · 2017: 14 · 2016: 10 · 2015: 8 · 2014: 15 · 2013: 18 · 2012: 13
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health (CA 87969)
- National Heart, Lung, and Blood Institute (HL 65582, R01HL065582, HL34594, R01HL034594)
- National Cancer Institute (CA-87969, P01CA087969)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058845, DK58845, P30DK040561)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- whole grains, dietary fiber, cereal fiber, bran, systemic inflammation, C-reactive protein, endothelial dysfunction, type 2 diabetes, women with diabetes, glycemic index, Nurses' Health Study
- MeSH terms
- C-Reactive Protein, Edible Grain, Diabetes Mellitus, Type 2, Dietary Fiber, Female, Humans, Inflammation, Middle Aged, Retrospective Studies, Biomarkers, Multivariate Analysis, Logistic Models, Intercellular Adhesion Molecule-1, E-Selectin, Glycemic Index, Receptors, Tumor Necrosis Factor, Type II
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