Novel agents for the treatment of type 2 diabetes
Open accessAbstract
In Brief Impaired insulin secretion, increased hepatic glucose production, and decreased peripheral glucose utilization are the core defects responsible for the development and progression of type 2 diabetes. However, the pathophysiology of this disease also includes adipocyte insulin resistance (increased lipolysis), reduced incretin secretion/sensitivity, increased glucagon secretion, enhanced renal glucose reabsorption, and brain insulin resistance/neurotransmitter dysfunction. Although current diabetes management focuses on lowering blood glucose, the goal of therapy should be to delay disease progression and eventual treatment failure. Recent innovative treatment approaches target the multiple pathophysiological defects present in type 2 diabetes. Optimal management should include early initiation of combination therapy using multiple drugs with different mechanisms of action. This review examines novel therapeutic options that hold particular promise.
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Asperentin B is a novel inhibitor of PTPase-1B and a vital alternative in T2DM therapy.
“Asperentin B is a novel inhibitor of PTPase-1B and a vital alternative in T2DM therapy (83).”
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- Authors
- DeFronzo, R. A., Triplitt, C. L., Abdul-Ghani, M., & Cersosimo, E.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Diabetes Spectrum
- Publisher
- American Diabetes Association
- Published
- 2014-05-01
- Volume
- 27
- Issue
- 2
- Pages
- 100-112
- ISSN
- 1040-9165 (ISSN-L)
- 1944-7353
- PMC
- PMC4522879
- OpenAlex
- W2092933519
- Cited by
- 83
- References
- 27
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 10 · 2015: 4
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Spectrum (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- type 2 diabetes, insulin secretion, hepatic glucose production, peripheral glucose utilization, lipolysis, incretin secretion, glucagon, renal glucose reabsorption, brain insulin resistance, neurotransmitter dysfunction, combination therapy, disease progression
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